US3923059A - Medicament injector - Google Patents

Medicament injector Download PDF

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Publication number
US3923059A
US3923059A US40558373A US3923059A US 3923059 A US3923059 A US 3923059A US 40558373 A US40558373 A US 40558373A US 3923059 A US3923059 A US 3923059A
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Prior art keywords
vial
plug
cylindrical member
tip
end
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Expired - Lifetime
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Robert W Ogle
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IMS Ltd
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IMS Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2089Containers or vials which are to be joined to each other in order to mix their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M3/00Medical syringes, e.g. enemata; Irrigators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/24Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M5/2422Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule
    • A61M5/2429Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic using emptying means to expel or eject media, e.g. pistons, deformation of the ampoule, or telescoping of the ampoule by telescoping of ampoules or carpules with the syringe body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/201Piercing means having one piercing end
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2003Accessories used in combination with means for transfer or mixing of fluids, e.g. for activating fluid flow, separating fluids, filtering fluid or venting
    • A61J1/2006Piercing means
    • A61J1/2013Piercing means having two piercing ends
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • A61J1/14Details, e.g. provisions for hanging or shape retaining means; Accessories therefor, e.g. inlet or outlet ports, filters or caps
    • A61J1/20Arrangements for transferring or mixing fluids, e.g. from vial to syringe
    • A61J1/2096Combination of a vial and a syringe for transferring or mixing their contents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M5/32Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/329Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles characterised by features of the needle shaft
    • A61M5/3291Shafts with additional lateral openings

Abstract

This patent describes a novel medicament injector device for the addition of concentrated medication to rubber stoppered solution containers comprising: a cylindrical vial having an open end and a closed end, a resilient plug adapted to be inserted at least partially through the open end of the vial; the plug forming a seal engagement with the walls of the vial with a press fit; a cylindrical member having one closed end, the cylindrical member holding a needle extending inwardly into the cylindrical member and having a sharpened inner end; the cylindrical member having a tip extending outwardly from the closed end. The tip has an elongated member of generally uniform circular cross-section and a central fluid passage extending substantially the length thereof. The tip terminates in a pointed end in a zone of reduced cross-section, the zone having at least one fluid passage which communicates with the central fluid passage and forms an oblique angle with respect thereto. Interlocking means on the cylindrical member and cooperating interlocking means on the plug are provided whereby upon interlocking of the plug with the cylindrical member, the vial is first held in an assembled but non-operating position and upon further interlocking of the plug with the cylindrical member, the plug is adapted to be pierced by the needle and the needle communicated with the vial without the application of substantial axial pressure on the plug and the plug is locked securely to the cylindrical member to permit aspiration upon withdrawal of the vial or to permit expulsion of the contents of the vial into the solution container upon exertion of pressure on the vial. The pointed tip is adapted to pierce the stopper of the container without cutting loose pieces from the stopper and without the loss of any vacuum within the container.

Description

Primary Examiner-John D. Yasko Attorney, Agent, or Firm-Wills, Green & Mueth [57] ABSTRACT This patent describes a novel medicament injector de- United States Patent 1191 1111 3,923,059

Ogle Dec. 2, 1975 MEDICAMENT INJECTOR vice for the addition of concentrated medication to [75] Inventor: Robert og'le, Newport Beach, rubber stoppered solution containers comprising: a cycalif. lindrical vial having an open end and a closed end, a

' resilient plug adapted to be inserted at least partially Assigneei 1M5 Limited, South El Monte, Cfllifthrough the open end of the vial; the plug forming a [22] Filed oct 11 1973 seal engagement with the walls of the vial with a press fit; a cylindrical member having one closed end, the

[ PP 405,533 cylindrical member holding a needle extending in- Related U S Application Da'ta wardly into the cylindrical member and having a [6 C t, f f s r N 158 770 J l sharpened inner end; the cylindrical member having a o e u y tip extending outwardly from the closed end. The tip e has an elongated member of generally uniform circular cross-section and a central fluid passage extending 128/237 g z f z substantially the length thereof. The tip terminates in [58] Fie'ld 233 234 a pointed end in a zone of reduced cross-section, the

128/272 221 8 N C zone having at least one fluid passage which communicates with the central fluid passage and forms an oblique angle with respect thereto. interlocking means ['56] References Clted on the cylindrical member and cooperating interlock- UNITED STATES PATENTS ing means on the plug are provided whereby upon in- 56l,059 5/18 6 Mit h ll et al... 123/213 N terlocking of the plug with the cylindrical member, the

. v via] is first in an assembled but non. opgrating p0- 2183709] 6/1958 MCMm" et 128/214 C sition and upon further interlocking of the plug with the cylindrical member, the plug is adapted to be 3064652 11/1962 corcoranet 5 D x pierced by the needle and the needle communicated 3:207:374 9/1965 Holmes at 128/272 Ux with the vial without the application of substantial 3,376,866 4/1968 Ogle 128/272 x anal Pressure the P and the P g 15 locked 3,552,387 1/1971 Stevens 128/272 r ly to the cylindrical member to permit aspiration upon withdrawal of the vial or to permit expulsion of ZxQZ'Z SI OR SZZMC the contents of the vial into the solution container 519,998 e gium upon exertion of pressure on the vial. The pointed tip is adapted to pierce the stopper of the container without cutting loose pieces from the stopper and without the loss of any vacuum within the container.

6 Claims, 10 Drawing Figures U.S; Patent Dec. 2,1975 She et10f3 3,923,059

us. Patent De.2,1975' *sh'eetz ofg 3,923,059

US. Patent Dec. 2, 1975 Sheet 3 Of?) 3,923,059

MEDICAMENT INJECTOR BACKGROUND OF THE INVENTION This application is a continuation-in-part of application Ser. No. 158,770, filed July 1, 1971, now abandoned, the disclosure of which is expressly incorporated herein by reference.

The present invention is concerned with a device which is useful for the addition of medicinal solutions to intravenous solution containers. Various devices have been proposed for this purpose. In general, the devices involve the use of various complicated glass or plastic molded parts. The present invention, it is believed, represents a substantial advance in the art in that all of the parts present in the device can be made of readily moldable plastic and/or rubber with the exception of the vial, which vial is a simple shell vial of utter simplicity, and a conventional needle. In short, the device of the present invention can be made on a more economical basis and affords a device which is adapted to be pre-loaded at a central plant, used once at the time of injection into an intravenous bottle, and thereafter disposed of. It is becoming recognized in the art that the ultimate in the packaging of any medication is in the form of pre-loaded disposable devices. The present invention makes the application of this principal possible for the first time to the addition of medicament to intravenous solution containers. It is accordingly anticipated that this invention will be widely adopted in the art.

SUMMARY OF THE INVENTION Briefly, the present invention comprises a novel medicament injector device for the addition of concentrated medication to rubber stoppered solution containers comprising: a cylindrical vial having an open end and a closed end, a resilient plug adapted to be inserted at least partially through said open end of said vial; said plug forming a sealing engagement with the walls of said vial with a press fit; a cylindrical member having one closed end, said cylindrical member holding a needle extending inwardly into said cylindrical member and having a sharpened inner end; said cylindrical member having a tip extending outwardly from said closed end, said tip being an elongated member ofgenerally uniform circular cross-section and having a central fluid passage extending substantially the length of the tip, said tip terminating in a pointed end in a zone of reduced cross-section, said zone having at least one fluid passage which communicates with said central fluid passage and forms an oblique angle with respect thereto; interlocking means on said cylindrical member and cooperating interlocking means on said plug, whereby upon interlocking of said plug with said cylindrical member said vial is first held in an assembled but non-operating position and upon further interlocking of said plug with said cylindrical member, said plug is adapted to be pierced by said needle and said needle communicated with said vial without the application of substantial axial pressure on said plug and said plug is locked securely to said cylindrical member to permit aspiration upon withdrawal of said vial or to permit expulsion of the contents of said vial into said solution container upon exertion of pressure on said vial, said pointed tip being adapted to pierce the stopper of said container without cutting loose pieces from the stopper and without the loss of any vacuum within said container.

It is an object of the present invention to provide a novel device for the packaging of medication.

More particularly, it is an object of the present invention to provide for the packaging of medication in a disposable device.

Still another object of the present invention is to provide a disposable device for use in the addition of medication to intravenous solution bottles.

These and other objects and advantages of the invention will be apparent from the more detailed description which follows taken in conjunction with the accompanying drawings.

At present, intravenous solutions may or may not be supplied under vacuum. Some bottled intravenous solutions are vacuum packaged. Others are not. The intravenous solutions in flexible plastic bags are not packaged under vacuum. The present invention obviates the problem of adding medication to the intravenous solution packages since the device of this invention forces the medication into the package under positive pressure. Fluid transfer is not dependent upon a vacuum being present in the package.

Further, the device of the present invention includes a significant safety feature. Additives for intravenous solutions actually contain medication in a concentration unsuitable for direct injection into the human body. In fact, many of these additives are fatal if directly injected. The large point on the device of this invention prevents the accidental injection of the concentrated medication into the body. The pointed tip of this invention also prevents coring of the rubber closure on the intravenous solution. Coring results in bits of rubber falling into the solution which can result in the injection of this dangerous blood clotting material into the patient. The pointed tip pierces the rubber rather than cutting it. The hole enlarges and stretches around the diameter of the tip. Thus, vacuum is maintained in vacuum packaged solutions. The problem created by the flap cut by a biased tip is avoided. In this invention, the tip can be twisted or rotated without the cutting off of a rubber piece whereas such manipulation of a biased tip creates the possibility of the flap being cut off as the tip is rotated to the flap adjoinment resulting in the dropping or rubber into the solution.

DESCRIPTION OF THE PREFERRED EMBODIMENTS Turning to the drawings:

FIG. 1 shows a perspective view of one embodiment of the device of the present invention in a disassembled state.

FIG. 2 is a sectional view of the tip portion of the device of FIG. 1.

FIG. 3 shows, in disassembled form and sectional view, the device of FIG. 1 in relationship to a typical intravenous solution bottle.

FIG. 4 shows, in assembled form, the use of the device of FIGS. 1 and 3 for the injection of medication into an intravenous solution bottle.

FIG. 5 shows in sectional view the adaptation to the present invention to a conventional hypodermic syringe.

FIG. 6 is a perspective view of the open end of the vial and associated stopper.

FIG. 7 is another view showing the operation of FIGS. 1 and 3.

FIG. 8 is a side view of the discharge end of one type of tip used in the devices of this invention.

FIG. 9 is an enlarged view of the discharge opening in the tip of FIG. 8.

FIG. 10 is a sectional view along the line 10 10 in FIG. 9.

Turning to the drawings in greater detail, the holder of FIGS. 1, 3 and 7 comprises a generally cylindrical hollow tubular holder 10 having an open end 12 and a closed end 14. The cylindrical vial 16 has a resilient stopper 18 in its open end sealing on the inside walls of the vial 16. The stopper 18 generally, although not necessarily, has a thin imperforate central diaphragm portion. The stopper 18 is provided with an externally threaded projection 20 thereon. The tubular holder 10 has a needle 22 therein and a tip 24 on its exterior which tip is provided with a fluid passage 26 extending to angled passages 28 and 30 which terminate in openings 32 and 34. The tip 24 has a sharp pointed end adapted to puncture the stopper on an intravenous solution bottle.

Within the tubular holder 10, there is provided a thrust portion 36. The lower end of needle 22 communicates with the hole 38 in the closed end of the tubular holder 10. The upper end of needle 22 has a sharp terminal portion 40 having a hole 42 therein. The thrust portion 36 may also have internal threads 44 in proximity to its upper end, the threads on the projection 20 and the threads 44 being adapted when made up to cause said sharp terminal portion 40 of the needle to puncture said stopper 18. When the projection 20 is made up with threads 44, the stopper 18 functions as a piston to expel the contents of the vial 16 through needle 22 and passage 26 as said vial 16 is advanced into said tubular holder 10.

In operation, the vial 16 containing liquid medication is partially made up with the holder 10 simply by turning the vial and the threads on projection into the threads 44. The tip 24 is then used to pierce the stopper 46 on an intravenous solution bottle 48. The threads are then further made up until the thread 20 on the stopper 18 are fully made up with threads 44 as shown in FIG. 4. At this point, the sharp terminal portion 40 has punctured the stopper 18. By applying a slight further force on the vial, the vial can be advanced into the holder causing the stopper to expel the contents of the vial through the tip as shown in FIG. 4 into an intravenous solution bottle 48. The contents of the intravenous bottle is then administered to the patient in a manner familiar to those skilled in the art.

During storage, the tip 24 may be provided with a protective cover 50. This cover is removed prior to use.

All parts of this invention are preferably made of plastic, save for the vial 16 and the stopper 18. The vial is normally a glass shell vial and the stopper is made of a resilient rubber which is compatible with the medication contained in the vial.

In FIG. 5, a conventional syringe 52 provided with a reciprocating plunger 54 is used. The tip 56 is constructed substantially as previously described.

A resilient plug or stopper 18 is provided having a central bore 66 extending through the plug and bridged by the imperforate diaphragm which is punctured in use by the needle. The stopper 18 has a reduced section provided with male threads 70 and an enlarged section 72 provided with outstanding rings 74, 76, and 78. The vial 16 may be placed in an ordinary filling machine as commonly used by pharmaceutical manufacturers and filled with a liquid injectable. Thereafter, the stopper 18 may be inserted in the vial 16 to the extent that all three of the rings 74, 76, and 78 are contained within the vial. A holder 80 is provided which is generally cylindrical in form and has formed therein a second cylindrical member 82. The holder 80 is provided with an outwardly extending flange 84 at its open end. The interior of the cylindrical member 82 adjacent its outer end is provided with a series of female threads adapted to mate with male threads of the plug 64. The threads as just described engage with a loose fit so as to present substantially no frictional resistance to the making up of the threads and certainly insufficient resistance to overcome the press fit of the rings 74, 76, and 78 within the via] 16. The holder is provided with a closed end 88 and an outwardly extending boss having a bore 92 therein in which is securely cemented, as by an epoxy cement, a needle which has an inwardly extending sharpened end.

Assuming that the holder or syringe is made of plastic, the tip portion 104 as shown in FIGS. 8 10 can be separately molded, from plastic, and spun-welded to the holder or syringe barrel. The tip is normally provided with two openings 106 and 108. However, three or even four openings are possible, and of course, a single opening can be provided where speedy discharge is not required. The edges 110 of the tip 104 are quite sharp to provide cutting surfaces. The point 112 facilitates the initial puncturing of the stopper on the intravenous solution bottle.

Having fully described the invention it is intended that it be limited only by the lawful scope of the appended claims.

I claim:

1. A novel medicament injector device for the addition of concentrated medication to rubber stoppered solution containers comprising: a cylindrical vial having an open end and a closed end, a resilient plug adapted to be inserted at least partially through said open end of said vial; said plug forming a sealing engagement with the walls of said vial with a press fit; a cylindrical member having one closed end, said cylindrical member holding a needle extending inwardly into said cylindrical member and having a sharpened inner end; said cylindrical member having a tip extending outwardly from said closed end, said tip surrounding and extending from the lower end of said needle portion said tip being an elongated member of generally uniform circular cross-section and having a central fluid passage extending substantially the length of the tip, said tip terminating in a pointed end in a zone of reduced cross-section, said zone having at least one fluid passage which communicates with said central fluid passage and forms an oblique angle with respect thereto; interlocking means on said cylindrical member and cooperating interlocking means on said plug, whereby upon interlocking of said plug with said cylindrical member said vial is first held in an assembled but non-operating position and upon further interlocking of said plug with said cylindrical member, said plug is adapted to be pierced by said needle and said needle communicated with said vial without the application of substantial axial pressure on said plug and said plug is locked securely to said cylindrical member to permit aspiration upon withdrawal of said vial or to permit expulsion of the contents of said vial into said solution container upon exertion of pressure on said vial, said pointed tip being adapted to pierce the stopper of said container without cutting loose pieces from the stopper and without the loss of any vacuum within said container.

2. The device of claim 1 wherein said zone has two fluid passages forming an acute angle with respect to each other, the pointed end being positioned between said passages and being symmetrically disposed around a line running longitudinally of said central fluid passage.

3. The device of claim 1 wherein each of said two fluid passages terminates at flat surfaces on opposite sides of said tip, the cross-section of said tip otherwise being round.

4. In combination, a novel medicament injector device comprising: a cylindrical vial having an open end and a closed end, a resilient plug adapted to be inserted at least partially through said open end of said vial; said plug forming a sealing engagement with the walls of said vial with a press fit; a cylindrical member having one closed end, said cylindrical member holding a needle extending inwardly into said cylindrical member and having a sharpened inner end; said cylindrical member having a tip extending outwardly from said closed end, said tip surrounding and extending from the lower end of said needle portion said tip being an elongated member of generally uniform circular crosssection and having a central fluid passage extending substantially the length of the tip, said tip terminating in a pointed end in a zone of reduced cross-section, said zone having at least one fluid passage which communicates with said central fluid passage and forms an oblique angle with respect thereto; interlocking means on said cylindrical member and cooperating interlocking means on said plug, whereby upon interlocking of said plug with said cylindrical member said vial is first held in an assembled but non-operating position and upon further interlocking of said plug with said cylindrical member, said plug is adapted to be pierced by said needle and said needle communicated with said vial without the application of substantial axial pressure on said plug and said plug is locked securely to said cylindrical member to permit aspiration upon withdrawal of said vial or to permit expulsion of the contents of said vial into said solution container upon exertion of pressure on said vial, and a container of intravenous solution, said container having a sealing member at one end thereof, said tip piercing said sealing member whereby the contents of said vial are transferred to said container by the exertion of pressure on said vial.

5. The device of claim 4 wherein said zone has two fluid passages forming an acute angle with respect to each other, the pointed end being positioned between said passages and being symmetrically disposed around a line running longitudinally of said central fluid passage.

6. The device of claim 4 wherein each of said two fluid passages terminates at flat surfaces on opposite sides of said tip, the cross-section of said tip otherwise being round.

Claims (6)

1. A novel medicament injector device for the addition of concentrated medication to rubber stoppered solution containers comprising: a cylindrical vial having an open end and a closed end, a resilient plug adapted to be inserted at least partially through said open end of said vial; said plug forming a sealing engagement with the walls of said vial with a press fit; a cylindrical member having one closed end, said cylindrical member holding a needle extending inwardly into said cylindrical member and having a sharpened inner end; said cylindrical member having a tip extending outwardly from said closed end, said tip surrounding and extending from the lower end of said needle portion said tip being an elongated member of generally uniform circular cross-section and having a central fluid passage extending substantially the length of the tip, said tip terminating in a pointed end in a zone of reduced cross-section, said zone having at least one fluid passage which communicates with said central fluid passage and forms an oblique angle with respect thereto; interlocking means on said cylindrical member and cooperating interlocking means on said plug, whereby upon interlocking of said plug with said cylindrical member said vial is first held in an assembled but non-operating position and upon further interlocking of said plug with said cylindrical member, said plug is adapted to be pierced by said needle and said needle communicated with said vial without the application of substantial axial pressure on said plug and said plug is locked securely to said cylindrical member to permit aspiration upon withdrawal of said vial or to permit expulsion of the contents of said vial into said solution container upon exertion of pressure on said vial, said pointed tip being adapted to pierce the stopper of said container without cutting loose pieces from the stopper and without the loss of any vacuum within said container.
2. The device of claim 1 wherein said zone has two fluid passages forming an acute angle with respect to each other, the pointed end being positioned between said passages and being symmetrically disposed around a line running longitudinally of said central fluid passage.
3. The device of claim 1 wherein each of said two fluid passages terminates at flat surfaces on opposite sides of said tip, the cross-section of said tip otherwise being round.
4. In combination, a novel medicament injector device comprising: a cylindrical vial having an open end and a closed end, a resilient plug adapted to be inserted at least partially through said open end of said vial; said plug forming a sealing engagement with the walls of said vial with a press fit; a cylindrical member having one closed end, said cylindrical member holding a needle extending inwardly into said cylindrical member and having a sharpened inner end; said cylindrical member having a tip extending outwardly from said closed end, said tip surrounding and extending from the lower end of said needle portion said tip being an elongated member of generally uniform circular cross-section and having a central fluid passage extending substantially the length of the tip, said tip terminating in a pointed end in a zone of reduced cross-section, said zone having at least one fluid passage which communicates with said central fluid passage and forms an oblique angle with respect thereto; interlocking means on said cylindrical member and cooperating interlocking means on said plug, whereby upon interlocking of said plug with said cylindrical member said vial is first held in an assembled but non-operating position and upon further interlocking of said plug with said cylindrical member, said plug is adapted to be pierced by said needle and said needle communicated with said vial without the application of substantial axial pressure on said plug and said plug is locked securely to said cylindrical member to permit aspiration upon withdrawal of said vial or to permit expulsion of the contents of said vial into said solution container upon exertion of pressure on said vial, and a container of intravenous solution, said container having a sealing member at one end thereof, said tip piercing said sealing member whereby the contents of said vial are transferred to said container by the exertion of pressure on said vial.
5. The device of claim 4 wherein said zone has two fluid passages forming an acute angle with respect to each other, the pointed end being positioned between said passages and being symmetrically disposed around a line running longitudinally of said central fluid passage.
6. The device of claim 4 wherein each of said two fluid passages terminates at flat surfaces on opposite sides of said tip, the cross-section of said tip otherwise being round.
US3923059A 1971-07-01 1973-10-11 Medicament injector Expired - Lifetime US3923059A (en)

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Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200100A (en) * 1978-04-20 1980-04-29 Aluminum Company Of America Additive transfer unit with piercing member having a penetratable protective tip
US4253459A (en) * 1979-11-19 1981-03-03 Aluminum Company Of America Additive transfer unit with stabilized sealing means
US4361253A (en) * 1980-08-04 1982-11-30 Instrumentation Laboratory Inc. Liquid transfer device
DE3631341A1 (en) * 1985-09-14 1987-04-23 Pfeiffer Erich Gmbh & Co Kg Discharging device for free-flowing media
US4693235A (en) * 1984-11-23 1987-09-15 Duffour Et Igon S.A. (D.I.) Gas heating process and apparatus
US4886495A (en) * 1987-07-08 1989-12-12 Duoject Medical Systems Inc. Vial-based prefilled syringe system for one or two component medicaments
US4946069A (en) * 1987-10-10 1990-08-07 Ing. Erich Pfeiffer Gmbh & Co. Kg Dispenser for manually discharging flowable media
US5114411A (en) * 1990-11-19 1992-05-19 Habley Medical Technology Corporation Multi-chamber vial
EP0486894A1 (en) * 1990-11-21 1992-05-27 Promo Pack Sa Single-dose spray-dispenser for endonasal adminstration of liquid medicaments
US5169388A (en) * 1990-06-07 1992-12-08 Gensia Pharmaceuticals, Inc. Pressure-activated medication dispenser
US5308347A (en) * 1991-09-18 1994-05-03 Fujisawa Pharmaceutical Co., Ltd. Transfusion device
US5364369A (en) * 1987-07-08 1994-11-15 Reynolds David L Syringe
EP0692235A1 (en) * 1994-07-14 1996-01-17 International Medication Systems (U.K.) Ltd. Mixing & dispensing apparatus
US5533993A (en) * 1994-10-05 1996-07-09 International Medication Systems, Limited Medication injector with protected cannula and Y-site lockout
US5562616A (en) * 1995-03-01 1996-10-08 Habley Medical Technology Corporation Semi-automatic reconstituting system for binary oncolytic pharmaceuticals
US5709668A (en) * 1991-01-16 1998-01-20 Senetek Plc Automatic medicament injector employing non-coring needle
DE3645354C2 (en) * 1985-09-14 2003-05-08 Pfeiffer Erich Gmbh & Co Kg Disposable medicament sprayer discharge mechanism
WO2003047669A1 (en) * 2001-11-30 2003-06-12 Star Syringe Limited Syringe
WO2002102295A3 (en) * 2001-05-23 2003-11-27 Elan Pharma Int Ltd Spike for liquid transfer device, liquid transfer device including spike, and method of transferring liquids using the same
US6852103B2 (en) 1997-12-04 2005-02-08 Baxter International Inc. Sliding reconstitution device with seal
US6890328B2 (en) 1998-09-15 2005-05-10 Baxter International Inc. Sliding reconstitution device for a diluent container
US7358505B2 (en) 1998-09-15 2008-04-15 Baxter International Inc. Apparatus for fabricating a reconstitution assembly
US20080172001A1 (en) * 2006-10-16 2008-07-17 Reynolds David L Reconstitution system for mixing the contents of a vial containing a first substance with a second substance stored in a cartridge
US7425209B2 (en) 1998-09-15 2008-09-16 Baxter International Inc. Sliding reconstitution device for a diluent container
WO2009130463A1 (en) * 2008-04-22 2009-10-29 Star Syringe Limited Syringe with integrally formed piercing member and luer slip
US7641851B2 (en) 2003-12-23 2010-01-05 Baxter International Inc. Method and apparatus for validation of sterilization process
US20150359710A1 (en) * 2013-01-31 2015-12-17 Yiling DING Medicinal cefoxitin vial, and dispensing apparatus and injection apparatus thereof

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US561059A (en) * 1896-05-26 Hypodermic syringe
US648858A (en) * 1900-03-14 1900-05-01 Charles B Dolge Embalming-needle.
US2837091A (en) * 1953-05-05 1958-06-03 Abbott Lab Drip meter connecting means
US2855931A (en) * 1955-12-09 1958-10-14 Frank E Brown Dispenser
US3030954A (en) * 1957-11-12 1962-04-24 Baxter Don Inc Administration set
US3064652A (en) * 1960-02-11 1962-11-20 Baxter Don Inc Transfusion equipment
US3207374A (en) * 1963-11-14 1965-09-21 Burroughs Wellcome Co Dispenser
US3376866A (en) * 1965-07-23 1968-04-09 Robert W. Ogle Medicament injector with attached vial
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Publication number Priority date Publication date Assignee Title
US561059A (en) * 1896-05-26 Hypodermic syringe
US648858A (en) * 1900-03-14 1900-05-01 Charles B Dolge Embalming-needle.
US2837091A (en) * 1953-05-05 1958-06-03 Abbott Lab Drip meter connecting means
US2855931A (en) * 1955-12-09 1958-10-14 Frank E Brown Dispenser
US3030954A (en) * 1957-11-12 1962-04-24 Baxter Don Inc Administration set
US3064652A (en) * 1960-02-11 1962-11-20 Baxter Don Inc Transfusion equipment
US3207374A (en) * 1963-11-14 1965-09-21 Burroughs Wellcome Co Dispenser
US3376866A (en) * 1965-07-23 1968-04-09 Robert W. Ogle Medicament injector with attached vial
US3552387A (en) * 1968-07-16 1971-01-05 Peter A Stevens Combination syringe and vial

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200100A (en) * 1978-04-20 1980-04-29 Aluminum Company Of America Additive transfer unit with piercing member having a penetratable protective tip
US4253459A (en) * 1979-11-19 1981-03-03 Aluminum Company Of America Additive transfer unit with stabilized sealing means
US4361253A (en) * 1980-08-04 1982-11-30 Instrumentation Laboratory Inc. Liquid transfer device
US4693235A (en) * 1984-11-23 1987-09-15 Duffour Et Igon S.A. (D.I.) Gas heating process and apparatus
US4921142A (en) * 1985-09-14 1990-05-01 Ing. Erich Pfeiffer Gmbh & Co. Kg Manually operable fluid dispenser
DE3631341A1 (en) * 1985-09-14 1987-04-23 Pfeiffer Erich Gmbh & Co Kg Discharging device for free-flowing media
DE3645354C2 (en) * 1985-09-14 2003-05-08 Pfeiffer Erich Gmbh & Co Kg Disposable medicament sprayer discharge mechanism
US4886495A (en) * 1987-07-08 1989-12-12 Duoject Medical Systems Inc. Vial-based prefilled syringe system for one or two component medicaments
US5137511A (en) * 1987-07-08 1992-08-11 Duoject Medical Systems Inc. Syringe
US5364369A (en) * 1987-07-08 1994-11-15 Reynolds David L Syringe
US4946069A (en) * 1987-10-10 1990-08-07 Ing. Erich Pfeiffer Gmbh & Co. Kg Dispenser for manually discharging flowable media
US5169388A (en) * 1990-06-07 1992-12-08 Gensia Pharmaceuticals, Inc. Pressure-activated medication dispenser
WO1992008506A1 (en) * 1990-11-19 1992-05-29 Habley Medical Technology Corporation Multi-chamber vial
US5114411A (en) * 1990-11-19 1992-05-19 Habley Medical Technology Corporation Multi-chamber vial
EP0486894A1 (en) * 1990-11-21 1992-05-27 Promo Pack Sa Single-dose spray-dispenser for endonasal adminstration of liquid medicaments
US5289818A (en) * 1990-11-21 1994-03-01 Promo Pack S.A. Single-dose spray-dispenser for endonasal administration of liquid medicaments
US5709668A (en) * 1991-01-16 1998-01-20 Senetek Plc Automatic medicament injector employing non-coring needle
US5308347A (en) * 1991-09-18 1994-05-03 Fujisawa Pharmaceutical Co., Ltd. Transfusion device
EP0692235A1 (en) * 1994-07-14 1996-01-17 International Medication Systems (U.K.) Ltd. Mixing & dispensing apparatus
US5533993A (en) * 1994-10-05 1996-07-09 International Medication Systems, Limited Medication injector with protected cannula and Y-site lockout
US5562616A (en) * 1995-03-01 1996-10-08 Habley Medical Technology Corporation Semi-automatic reconstituting system for binary oncolytic pharmaceuticals
US6852103B2 (en) 1997-12-04 2005-02-08 Baxter International Inc. Sliding reconstitution device with seal
US6890328B2 (en) 1998-09-15 2005-05-10 Baxter International Inc. Sliding reconstitution device for a diluent container
US8226627B2 (en) 1998-09-15 2012-07-24 Baxter International Inc. Reconstitution assembly, locking device and method for a diluent container
US7358505B2 (en) 1998-09-15 2008-04-15 Baxter International Inc. Apparatus for fabricating a reconstitution assembly
US7425209B2 (en) 1998-09-15 2008-09-16 Baxter International Inc. Sliding reconstitution device for a diluent container
US6719719B2 (en) 1998-11-13 2004-04-13 Elan Pharma International Limited Spike for liquid transfer device, liquid transfer device including spike, and method of transferring liquids using the same
WO2002102295A3 (en) * 2001-05-23 2003-11-27 Elan Pharma Int Ltd Spike for liquid transfer device, liquid transfer device including spike, and method of transferring liquids using the same
WO2003047669A1 (en) * 2001-11-30 2003-06-12 Star Syringe Limited Syringe
US7641851B2 (en) 2003-12-23 2010-01-05 Baxter International Inc. Method and apparatus for validation of sterilization process
US8022375B2 (en) 2003-12-23 2011-09-20 Baxter International Inc. Method and apparatus for validation of sterilization
US20080172001A1 (en) * 2006-10-16 2008-07-17 Reynolds David L Reconstitution system for mixing the contents of a vial containing a first substance with a second substance stored in a cartridge
US8100154B2 (en) * 2006-10-16 2012-01-24 Duoject Medical Systems Inc. Reconstitution system for mixing the contents of a vial containing a first substance with a second substance stored in a cartridge
US20110112487A1 (en) * 2008-04-22 2011-05-12 Marc Andrew Koska Syringe with integrally formed piercing member and luer slip
GB2471420A (en) * 2008-04-22 2010-12-29 Star Syringe Ltd Syringe with integrally formed piercing member and luer slip
WO2009130463A1 (en) * 2008-04-22 2009-10-29 Star Syringe Limited Syringe with integrally formed piercing member and luer slip
GB2471420B (en) * 2008-04-22 2012-10-10 Star Syringe Ltd Syringe with integrally formed piercing member and luer slip
CN102014990B (en) 2008-04-22 2013-03-27 星赛瑞有限公司 Syringe with integrally formed piercing member and luer slip
US20150359710A1 (en) * 2013-01-31 2015-12-17 Yiling DING Medicinal cefoxitin vial, and dispensing apparatus and injection apparatus thereof

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