|
US2088897A
(en)
*
|
1935-03-25 |
1937-08-03 |
Goss Printing Press Co Ltd |
Printing press
|
|
US2557381A
(en)
*
|
1946-08-09 |
1951-06-19 |
William C Huebner |
Multiple unit printing press
|
|
DE2234089C3
(de)
*
|
1972-07-08 |
1975-01-23 |
Automatic Druckmaschinenfabrik Dr. W. Hinniger U. Soehne, 1000 Berlin |
Offset-Rollen-Rotationsdruckmaschine
|
|
GB1581233A
(en)
*
|
1976-06-02 |
1980-12-10 |
Drg Uk Ltd |
Printing press
|
|
US4201706A
(en)
*
|
1978-09-22 |
1980-05-06 |
Burton, Parsons & Company, Inc. |
Treatment of corneal edema
|
|
US4454151A
(en)
*
|
1982-03-22 |
1984-06-12 |
Syntex (U.S.A.) Inc. |
Use of pyrrolo pyrroles in treatment of ophthalmic diseases
|
|
US4515722A
(en)
*
|
1982-03-30 |
1985-05-07 |
Merck & Co., Inc. |
Phosphatidyl inositol analogs useful as anti-inflammatory/analgesic agents
|
|
US4474806A
(en)
*
|
1982-05-10 |
1984-10-02 |
Merck & Co., Inc. |
Sulfonyl or carbonyl inositol derivatives useful as anti-inflammatory/analgesic agents
|
|
IT1164225B
(it)
|
1983-05-13 |
1987-04-08 |
Anic Spa |
Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione
|
|
DE3405663A1
(de)
|
1984-02-17 |
1985-08-22 |
Merck Patent Gmbh, 6100 Darmstadt |
Verfahren zur herstellung von scyllo-inosit
|
|
SE465305B
(sv)
*
|
1986-04-16 |
1991-08-26 |
Perstorp Ab |
Anvaendning av inositolfosfat foer framstaellning av ett laekemedel
|
|
US5545632A
(en)
|
1984-10-23 |
1996-08-13 |
Perstorp Ab |
Method of treating retroviral disease
|
|
US5023248A
(en)
*
|
1984-10-23 |
1991-06-11 |
Perstorp Ab |
Method of treating diabetes with inositol triphosphate
|
|
US5128332A
(en)
*
|
1984-10-23 |
1992-07-07 |
Perstorp Ab |
Method of treating cardiovascular diseases using inositoltrisphosphate
|
|
US5407924A
(en)
|
1984-10-23 |
1995-04-18 |
Perstorp Ab |
Method of treating pain using inositol triphosphate
|
|
SE465951B
(sv)
*
|
1984-10-23 |
1991-11-25 |
Perstorp Ab |
Isomer av inositoltrifosfat foeretraedesvis i saltform foer anvaendning som terapeutiskt eller profylaktiskt medel samt kompositioner daerav
|
|
US5330979A
(en)
|
1984-10-23 |
1994-07-19 |
Perstorp Ab |
Method of treating renal disorders with inositoltriphosphate
|
|
US4735902A
(en)
*
|
1984-10-23 |
1988-04-05 |
Matti Siren |
Stabilized composition containing inositoltriphosphate
|
|
IL74497A
(en)
*
|
1985-03-05 |
1990-02-09 |
Proterra Ag |
Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives
|
|
DE3610107A1
(de)
*
|
1986-03-26 |
1987-10-08 |
Voith Gmbh J M |
Stellvorrichtung zum verstellen einer walze
|
|
US5057507A
(en)
*
|
1986-04-16 |
1991-10-15 |
Perstorp Ab |
Method of alleviating bone damage with inositoltriphosphate
|
|
US5135923A
(en)
|
1986-04-16 |
1992-08-04 |
Perstorp Ab |
Method of treating cardiovascular diseases
|
|
US4758420A
(en)
*
|
1986-07-14 |
1988-07-19 |
The Dow Chemical Company |
Solvent extraction of polychlorinated organic compounds from porous materials
|
|
US4952396A
(en)
*
|
1986-11-19 |
1990-08-28 |
Linus Pauling Institute Of Science & Medicine |
Method of using phytic acid for inhibiting tumor growth
|
|
US4847082A
(en)
*
|
1987-01-21 |
1989-07-11 |
Robert Sabin |
Method of treatment of Alzheimer's disease using phytic acid
|
|
US4758430A
(en)
*
|
1987-01-21 |
1988-07-19 |
Robert Sabin |
Method of treatment of Alzheimer's disease using phytic acid
|
|
HU201906B
(en)
*
|
1987-03-04 |
1991-01-28 |
Sandoz Ag |
Process for producing phenyl-carbamate derivative and acid additional salts and pharmaceutical compositions containing them
|
|
JPH067158Y2
(ja)
|
1987-03-18 |
1994-02-23 |
株式会社藤井合金製作所 |
配管端末の防水構造
|
|
FI95572C
(fi)
*
|
1987-06-22 |
1996-02-26 |
Eisai Co Ltd |
Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
|
|
DE3808142A1
(de)
*
|
1988-03-11 |
1989-09-21 |
Goebel Gmbh Maschf |
Lagereinrichtung
|
|
DE3814752C1
(enExample)
*
|
1988-04-30 |
1989-08-31 |
J.M. Voith Gmbh, 7920 Heidenheim, De |
|
|
US5334618A
(en)
*
|
1991-04-04 |
1994-08-02 |
The Children's Medical Center Corporation |
Method of preventing NMDA receptor-mediated neuronal damage
|
|
JPH03102492A
(ja)
|
1989-06-12 |
1991-04-26 |
Mitsui Eng & Shipbuild Co Ltd |
自動販売機のデータ送信システムおよび複合機能型自動販売機
|
|
SE8904355D0
(sv)
*
|
1989-12-21 |
1989-12-21 |
Perstorp Ab |
Medicament
|
|
US5111814A
(en)
*
|
1990-07-06 |
1992-05-12 |
Thomas Jefferson University |
Laryngeal pacemaker
|
|
US5217959A
(en)
*
|
1990-09-06 |
1993-06-08 |
Robert Sabin |
Method of treating multiple sclerosis with phytic acid
|
|
JP2984043B2
(ja)
|
1990-09-18 |
1999-11-29 |
旭化成工業株式会社 |
ミオ・イノシトールデヒドロゲナーゼおよびその製造法
|
|
US5112814A
(en)
*
|
1990-10-24 |
1992-05-12 |
Robert Sabin |
Method of treatment of Parkinson's disease using phytic acid
|
|
SE9102068L
(sv)
*
|
1991-07-03 |
1993-01-04 |
Perstorp Ab |
Derivat av inositol, kompositioner innehaallande dessa samt anvaendning daerav
|
|
JPH05192163A
(ja)
|
1991-09-30 |
1993-08-03 |
Suntory Ltd |
イノシトールデヒドロゲナーゼ遺伝子
|
|
ATE128708T1
(de)
|
1991-12-18 |
1995-10-15 |
Schering Corp |
Imidazolylalkyl- piperazin und -diazepin derivate als histamin h3 agonisten/antagonisten.
|
|
SE469260B
(sv)
*
|
1992-02-25 |
1993-06-14 |
Perstorp Ab |
En farmaceutisk komposition med foerbaettrad biotillgaenglighet avseende inositolfosfat
|
|
JP3251976B2
(ja)
|
1992-06-23 |
2002-01-28 |
旭化成株式会社 |
ミオ・イノシトールデヒドロゲナーゼを生産する実質上純粋な微生物
|
|
US5351616A
(en)
*
|
1992-08-13 |
1994-10-04 |
Man Roland Druckmaschinen Ag |
Rotary web printing machine, particularly for printing on thick or carton-type stock webs with replaceable plate cylinders
|
|
DE4229494A1
(de)
|
1992-09-04 |
1994-03-10 |
Basotherm Gmbh |
Arzneimittel zur topischen Anwendung am Auge zur Behandlung des erhöhten intraokularen Drucks
|
|
NZ256610A
(en)
*
|
1992-10-05 |
1997-03-24 |
Virginia Tech Intell Prop |
Synthesis of epoxydiol intermediates in the preparation of inositols and inosose; epoxydiols
|
|
US5840294A
(en)
*
|
1993-03-29 |
1998-11-24 |
Queen's University At Kingston |
Method for treating amyloidosis
|
|
US5972328A
(en)
*
|
1993-03-29 |
1999-10-26 |
Queen's University At Kingston |
Method for treating amyloidosis
|
|
US5643562A
(en)
*
|
1993-03-29 |
1997-07-01 |
Queen's University Of Kingston |
Method for treating amyloidosis
|
|
EP0619369B2
(en)
*
|
1993-04-05 |
2009-09-30 |
Aveve N.V. |
Phytate hydrolysis and enzyme composition for hydrolyzing phytate
|
|
ATE176779T1
(de)
*
|
1993-08-11 |
1999-03-15 |
Hokko Chem Ind Co |
Verfahren zur herstellung von d-chiro inositol
|
|
US5412080A
(en)
|
1993-08-25 |
1995-05-02 |
President And Fellow Of Harvard College |
Enterobactin compounds
|
|
SE502574C2
(sv)
*
|
1994-01-25 |
1995-11-13 |
Perstorp Ab |
En farmaceutisk komposition med förbättrad biotillgänglighet hos inositolfosfat
|
|
DE4408025A1
(de)
*
|
1994-03-10 |
1995-09-14 |
Koenig & Bauer Ag |
Druckwerk für eine Mehrfarbenrollenrotationsdruckmaschine
|
|
DE4430693B4
(de)
*
|
1994-08-30 |
2005-12-22 |
Man Roland Druckmaschinen Ag |
Antriebe für eine Rollenrotations-Offsetdruckmaschine
|
|
US5550166A
(en)
|
1995-03-17 |
1996-08-27 |
Ostlund; Richard E. |
Pinitol and derivatives thereof for the treatment of metabolic disorders
|
|
US5858326A
(en)
*
|
1995-06-06 |
1999-01-12 |
Neurochem, Inc. |
Methods of increasing amyloid deposition
|
|
US6221645B1
(en)
*
|
1995-06-07 |
2001-04-24 |
Elan Pharmaceuticals, Inc. |
β-secretase antibody
|
|
JP3630344B2
(ja)
|
1995-11-17 |
2005-03-16 |
北興化学工業株式会社 |
イノシトール立体異性体の製造方法
|
|
AU1153097A
(en)
*
|
1996-06-07 |
1998-01-05 |
Eisai Co. Ltd. |
Stable polymorphs of donepezil (1-benzyl-4-{(5,6-dimethoxy-1-indanon)-2-yl}methylpiperidine ) hydrochloride and process for production
|
|
TW513409B
(en)
*
|
1996-06-07 |
2002-12-11 |
Eisai Co Ltd |
Polymorphs of donepezil hydrochloride
|
|
US6232486B1
(en)
*
|
1996-06-11 |
2001-05-15 |
Nutrimed Biotech |
Molecular probes and modulators for PI-PLC and PI 3-kinase
|
|
TW506836B
(en)
*
|
1996-06-14 |
2002-10-21 |
Janssen Pharmaceutica Nv |
Fast-dissolving galanthamine hydrobromide tablet
|
|
US5880099A
(en)
*
|
1996-09-20 |
1999-03-09 |
The Regents Of The University Of California |
Inositol polyphosphates and methods of using same
|
|
US5977078A
(en)
*
|
1996-09-20 |
1999-11-02 |
The Regents Of The Univesity Of California |
Inositol polyphosphate derivatives and methods of using same
|
|
US6218506B1
(en)
|
1997-02-05 |
2001-04-17 |
Northwestern University |
Amyloid β protein (globular assembly and uses thereof)
|
|
US20030068316A1
(en)
|
1997-02-05 |
2003-04-10 |
Klein William L. |
Anti-ADDL antibodies and uses thereof
|
|
ES2253810T3
(es)
|
1997-03-10 |
2006-06-01 |
Loma Linda University Medical Center |
Uso de r-aines para la prevencion de la enfermedad de alzheimer.
|
|
US5998485A
(en)
|
1997-06-16 |
1999-12-07 |
Cedars-Sinai Medical Center |
Method for modulating immune response with inositol
|
|
US6153603A
(en)
*
|
1997-06-27 |
2000-11-28 |
Perstorp Ab |
Method of treating angiogenesis in tumor tissue
|
|
GB9801899D0
(en)
|
1998-01-29 |
1998-03-25 |
Univ London |
Neurotrophic properties of ipgs analogues
|
|
DE19805898C2
(de)
*
|
1998-02-13 |
2003-09-18 |
Roland Man Druckmasch |
Druckwerk für eine Rollenrotationsdruckmaschine
|
|
US6720190B1
(en)
*
|
1998-03-27 |
2004-04-13 |
Ole Hindsgaul |
Methods for screening compound libraries
|
|
US5981168A
(en)
*
|
1998-05-15 |
1999-11-09 |
The University Of British Columbia |
Method and composition for modulating amyloidosis
|
|
US6227110B1
(en)
*
|
1998-06-23 |
2001-05-08 |
Heidelberger Druckmaschinen Ag |
Wet printing press with throw-off mechanism
|
|
US6310073B1
(en)
*
|
1998-07-28 |
2001-10-30 |
Queen's University At Kingston |
Methods and compositions to treat glycosaminoglycan-associated molecular interactions
|
|
AUPP589398A0
(en)
|
1998-09-14 |
1998-10-08 |
Walter And Eliza Hall Institute Of Medical Research, The |
Immunogenic compositions and uses thereof
|
|
CN1198936C
(zh)
|
1998-09-24 |
2005-04-27 |
法玛西雅厄普约翰美国公司 |
阿尔茨海默氏疾病分泌酶
|
|
AUPP675898A0
(en)
|
1998-10-27 |
1998-11-19 |
Walter And Eliza Hall Institute Of Medical Research, The |
A method of activating t cells and agents useful for same
|
|
US6221856B1
(en)
|
1999-02-03 |
2001-04-24 |
Inologic, Inc. |
Inositol derivatives for inhibiting superoxide anion production
|
|
CN1390232A
(zh)
*
|
1999-02-10 |
2003-01-08 |
艾兰制药公司 |
人β分泌酶、抑制剂、其组合物和用途
|
|
GB2389182B
(en)
|
1999-02-10 |
2004-02-04 |
Elan Pharm Inc |
Method of purifying b-secretase
|
|
WO2000050391A1
(en)
|
1999-02-26 |
2000-08-31 |
Merck & Co., Inc. |
Novel sulfonamide compounds and uses thereof
|
|
US6818430B1
(en)
*
|
1999-06-07 |
2004-11-16 |
Hokko Chemical Industry Co., Ltd. |
Process for producing L-epi-2-inosose and novel process for producing epi-inositol
|
|
CA2376420A1
(en)
|
1999-06-15 |
2000-12-21 |
Elan Pharmaceuticals, Inc. |
Statine-derived tetrapeptide inhibitors of beta-secretase
|
|
US6864240B1
(en)
*
|
1999-06-15 |
2005-03-08 |
Elan Pharmaceuticals, Inc. |
Dipeptide inhibitors of β-secretase
|
|
EP1237547A2
(en)
|
1999-07-09 |
2002-09-11 |
Isis Innovation Limited |
Compounds for inhibiting diseases and preparing cells for transplantation
|
|
DE19937805A1
(de)
*
|
1999-08-10 |
2001-02-15 |
Roland Man Druckmasch |
Druckwerk
|
|
DE19937803A1
(de)
*
|
1999-08-10 |
2001-02-15 |
Roland Man Druckmasch |
Druckwerk
|
|
DE19937796B4
(de)
*
|
1999-08-10 |
2007-03-22 |
Man Roland Druckmaschinen Ag |
Druckwerk
|
|
US20020052311A1
(en)
*
|
1999-09-03 |
2002-05-02 |
Beka Solomon |
Methods and compostions for the treatment and/or diagnosis of neurological diseases and disorders
|
|
US6329256B1
(en)
*
|
1999-09-24 |
2001-12-11 |
Advanced Micro Devices, Inc. |
Self-aligned damascene gate formation with low gate resistance
|
|
JP2001163810A
(ja)
|
1999-09-30 |
2001-06-19 |
Microbial Chem Res Found |
1d−キロ−イノシトールの新規合成方法および中間体
|
|
DE60032781D1
(de)
|
1999-10-18 |
2007-02-15 |
Muscletech Res And Dev Inc |
Nahrungsmittelzusatz zur zunahme der fettarmen körpermasse und kraft
|
|
US7728043B2
(en)
*
|
1999-10-22 |
2010-06-01 |
Kim Darrick S H L |
Methods for treatment of beta-amyloid protein-induced ocular disease
|
|
EP1230220A1
(en)
|
1999-11-09 |
2002-08-14 |
Eli Lilly And Company |
Beta-aminoacid compounds useful for inhibiting beta-amyloid peptide release and/or its synthesis
|
|
AU1569401A
(en)
|
1999-11-09 |
2001-06-06 |
Eli Lilly And Company |
Beta-aminoacid compounds useful for inhibiting beta-amyloid peptide release and/or its synthesis
|
|
DE19963944C1
(de)
*
|
1999-12-31 |
2001-06-13 |
Koenig & Bauer Ag |
Verfahren zum Einstellen einer Walze einer Druckmaschine
|
|
AU779875B2
(en)
*
|
2000-01-24 |
2005-02-17 |
Merck Sharp & Dohme Limited |
Gamma-secretase inhibitors
|
|
DE10008215B4
(de)
*
|
2000-02-23 |
2013-03-28 |
Manroland Web Systems Gmbh |
Druckwerk für eine Rotationsdruckmaschine mit Kreuzschlitten
|
|
GB0005251D0
(en)
|
2000-03-03 |
2000-04-26 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
US20030144255A1
(en)
*
|
2000-03-06 |
2003-07-31 |
Bain Allen I |
Compositions for prevention and treatment of dementia
|
|
US7365196B2
(en)
|
2000-03-20 |
2008-04-29 |
Merck Sharp & Dohme Ltd. |
Sulphonamido-substituted bridged bicycloalkyl derivatives
|
|
JP2003528071A
(ja)
*
|
2000-03-23 |
2003-09-24 |
エラン ファーマスーティカルズ インコーポレイテッド |
アルツハイマー病治療用組成物および方法
|
|
GB0008710D0
(en)
|
2000-04-07 |
2000-05-31 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
CA2406383A1
(en)
|
2000-04-13 |
2001-10-25 |
Mayo Foundation For Medical Education And Research |
A.beta.42 lowering agents
|
|
US6939857B2
(en)
*
|
2000-05-12 |
2005-09-06 |
Rodaris Pharmaceuticals Limited |
Compounds and their uses
|
|
US6716826B2
(en)
*
|
2000-05-12 |
2004-04-06 |
Rodaris Pharmaceuticals Limited |
Compounds and their uses
|
|
US20040110743A1
(en)
|
2000-05-19 |
2004-06-10 |
Masaomi Miyamato |
-Secretase inhibitors
|
|
GB0015627D0
(en)
|
2000-06-26 |
2000-08-16 |
Rademacher Group Limited |
Phosphoglycan messengers and their medical uses
|
|
ATE302751T1
(de)
|
2000-06-30 |
2005-09-15 |
Elan Pharm Inc |
Verbindungen zur behandlung der alzheimerischen krankheit
|
|
PE20020276A1
(es)
*
|
2000-06-30 |
2002-04-06 |
Elan Pharm Inc |
COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
|
|
DE10031955A1
(de)
|
2000-06-30 |
2002-01-17 |
Deutsches Krebsforsch |
Curcumin-Derivate mit gegenüber Curcumin verbesserter Wasserlöslichkeit und diese enthaltende Arzneimittel
|
|
US6846813B2
(en)
*
|
2000-06-30 |
2005-01-25 |
Pharmacia & Upjohn Company |
Compounds to treat alzheimer's disease
|
|
GB0016681D0
(en)
*
|
2000-07-06 |
2000-08-23 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
US6559891B1
(en)
*
|
2000-08-15 |
2003-05-06 |
Sony Corporation |
Method and apparatus to generate tri-level HDTV synchronization pulses
|
|
AU1074702A
(en)
|
2000-11-02 |
2002-05-15 |
Merck Sharp & Dohme |
Sulfamides as gamma-secretase inhibitors
|
|
AU2002243323B2
(en)
|
2000-11-02 |
2007-07-12 |
The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services |
Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof
|
|
WO2002055715A1
(fr)
|
2001-01-15 |
2002-07-18 |
Hokko Chemical Industry Co., Ltd. |
Adn codant pour une d-myo-inositol 1-épimérase
|
|
ATE554763T1
(de)
*
|
2001-02-06 |
2012-05-15 |
Quadra Logic Tech Inc |
Photodynamische therapie der mit der altersbezogenen makuladegeneration verbundenen okkulten chorioidalen neovaskularisation
|
|
EP1233021A3
(en)
*
|
2001-02-20 |
2002-11-20 |
Pfizer Products Inc. |
An inhibitor of Beta amyloid cleavage enzyme
|
|
AU2002306848A1
(en)
|
2001-03-23 |
2002-10-08 |
Elan Pharmaceuticals, Inc. |
Methods of treating alzheimer's disease with piperidin derivates
|
|
AU2002338305A1
(en)
*
|
2001-04-09 |
2002-10-21 |
Koenig And Bauer Aktiengesellschaft |
Printing couple in a printing machine with a pivotal transfer cylinder
|
|
JP2004534017A
(ja)
|
2001-04-27 |
2004-11-11 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
Baceのインヒビター
|
|
JP2004534771A
(ja)
|
2001-05-22 |
2004-11-18 |
イーラン ファーマスーティカルズ、インコーポレイテッド |
アザヒドロキシル化エチルアミン化合物
|
|
DE60229846D1
(de)
|
2001-05-22 |
2008-12-24 |
Merck & Co Inc |
Beta-secretase-substrat und seine verwendung
|
|
MXPA03011046A
(es)
|
2001-06-01 |
2004-06-25 |
Elan Pharm Inc |
Hidroxialquilaminas.
|
|
US6684775B2
(en)
*
|
2001-06-07 |
2004-02-03 |
Heidelberger Druckmaschinen Ag |
Printing unit with roll-away inkers
|
|
MXPA03011399A
(es)
|
2001-06-08 |
2004-07-01 |
Elan Pharm Inc |
Metodos para tratar la enfermedad de alzheimer.
|
|
US7361688B2
(en)
|
2001-06-11 |
2008-04-22 |
Elan Pharmaceuticals, Inc. |
Substituted aminoalcohols useful in treatment of Alzheimer's disease
|
|
MXPA03011466A
(es)
|
2001-06-12 |
2004-07-01 |
Elan Pharm Inc |
Macrociclos utiles en tratamiento de enfermedades de alzheimer.
|
|
WO2002100399A1
(en)
|
2001-06-12 |
2002-12-19 |
Elan Pharmaceuticals, Inc. |
Macrocycles useful in the treatment of alzheimer's disease
|
|
MXPA03011521A
(es)
|
2001-06-13 |
2004-03-18 |
Elan Pharm Inc |
Aminadioles para tratamiento de enfermedad de alzheimer.
|
|
ATE323489T1
(de)
|
2001-06-25 |
2006-05-15 |
Elan Pharm Inc |
Verwendung von bicyklischen verbindungen für die behandlung von alzheimer
|
|
JP3981597B2
(ja)
|
2001-06-25 |
2007-09-26 |
北興化学工業株式会社 |
シロ−イノソースの製造法及びシロ−イノシトールの製造法
|
|
MXPA04000140A
(es)
|
2001-06-27 |
2004-06-03 |
Elan Pharm Inc |
Derivados de beta-hidroxiamina utiles en el tratamiento de enfermedad de alzheimer.
|
|
BR0211118A
(pt)
|
2001-07-10 |
2004-10-26 |
Elan Pharm Inc |
Composto, métodos para o tratamento ou prevenção de doenças e para fabricar um composto, intermediário, e, uso de um composto ou sal
|
|
BR0211122A
(pt)
|
2001-07-10 |
2004-10-26 |
Elan Pharm Inc |
Composto, métodos para o tratamento ou prevenção de doenças e para fabricar um composto, intermediário, e, uso de um composto ou sal
|
|
US7053109B2
(en)
|
2001-07-10 |
2006-05-30 |
Pharmacia & Upjohn Company |
Aminediols for the treatment of Alzheimer's disease
|
|
US20030181531A1
(en)
*
|
2003-02-11 |
2003-09-25 |
David Sherris |
Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases
|
|
WO2003007944A1
(en)
|
2001-07-20 |
2003-01-30 |
Qlt, Inc. |
Treatment of macular edema with photodynamic therapy
|
|
WO2003013527A1
(en)
|
2001-08-03 |
2003-02-20 |
Schering Corporation |
Sulfonamide derivatives as gamma secretase inhibitors
|
|
BR0211698A
(pt)
*
|
2001-08-03 |
2004-11-09 |
Schering Corp |
Inibidores de gama-secretase
|
|
JP2005506979A
(ja)
|
2001-08-28 |
2005-03-10 |
ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー |
オキソ置換及びヒドロキシ置換炭化水素のキナルドイル−アミン誘導体を使用するアルツハイマー病の治療方法
|
|
DE10145322A1
(de)
*
|
2001-09-14 |
2003-04-03 |
Ina Schaeffler Kg |
Lageranordnung für Zylinder, Walzen oder Trommeln
|
|
MXPA04002785A
(es)
|
2001-09-24 |
2004-07-29 |
Elan Pharm Inc |
Aminas sustituidas para tratamiento de enfermedad de alzheimer.
|
|
CA2462851A1
(en)
|
2001-10-04 |
2003-04-10 |
Elan Pharmaceuticals, Inc. |
Hydroxypropylamines
|
|
MXPA04003244A
(es)
|
2001-10-05 |
2004-07-08 |
Elan Pharm Inc |
Alilamidas utiles para tratamiento de enfermedad de alzheimer.
|
|
EP1448218A4
(en)
|
2001-10-23 |
2009-01-14 |
Oklahoma Med Res Found |
BETA SECRETASE INHIBITORS AND METHODS OF USE
|
|
JP2005535559A
(ja)
|
2001-10-29 |
2005-11-24 |
ファルマシア・アンド・アップジョン・カンパニー・エルエルシー |
アルツハイマー病を治療するためのヒドロキシ置換アミド
|
|
IL161881A0
(en)
|
2001-11-08 |
2005-11-20 |
Upjohn Co |
N,N'-substituted-1,3-diamino-2-hydroxypropane derivatives
|
|
RS54204A
(sr)
|
2001-11-19 |
2006-12-15 |
Elan Pharmaceuticals Inc. |
3,4-disupstituisani, 3,5-disupstituisani i 3,4,5- supstituisani piperidini i piperazini
|
|
MXPA04004903A
(es)
|
2001-11-21 |
2005-06-06 |
Elan Pharm Inc |
Derivados de aminoacido utiles para el tratamiento de la enfermedad de alzheimer.
|
|
CA2469130A1
(en)
|
2001-12-04 |
2003-06-12 |
Elan Pharmaceuticals, Inc. |
Peptide isosteres containing a heterocycle useful in the treatment of alzheimer's disease
|
|
MXPA04005428A
(es)
|
2001-12-06 |
2004-12-06 |
Elan Pharm Inc |
Hidroxietilaminas substituidas.
|
|
CH698246B1
(de)
|
2001-12-20 |
2009-06-30 |
Hoffmann La Roche |
Test zur Identifizierung von Inhibitoren von Beta-Sekretasen.
|
|
CA2472617A1
(en)
|
2002-01-04 |
2003-07-17 |
Elan Pharmaceuticals, Inc. |
Substituted amino carboxamides for the treatment of alzheimer's disease
|
|
WO2003057165A2
(en)
|
2002-01-04 |
2003-07-17 |
The Rockefeller University |
COMPOSITIONS AND METHODS FOR PREVENTION AND TREATMENT OF AMYLOID-β PEPTIDE-RELATED DISORDERS
|
|
CA2473441A1
(en)
|
2002-01-18 |
2003-07-24 |
The Genetics Company Inc. |
Beta-secretase inhibitors
|
|
US7053220B2
(en)
|
2002-02-01 |
2006-05-30 |
Elan Pharmaceuticals, Inc. |
Hydroxyalkanoyl aminopyrazoles and related compounds
|
|
TW200302717A
(en)
*
|
2002-02-06 |
2003-08-16 |
Schering Corp |
Novel gamma secretase inhibitors
|
|
US7256186B2
(en)
*
|
2002-02-06 |
2007-08-14 |
Schering Corporation |
Gamma secretase inhibitors
|
|
US20040171614A1
(en)
|
2002-02-06 |
2004-09-02 |
Schering-Plough Corporation |
Novel gamma secretase inhibitors
|
|
JP4404643B2
(ja)
|
2002-04-24 |
2010-01-27 |
啓 森 |
ガンマセクレターゼ阻害剤
|
|
US20040058313A1
(en)
*
|
2002-04-24 |
2004-03-25 |
Abreu Marcio Marc |
Compositions, targets, methods and devices for the therapy of ocular and periocular disorders
|
|
EP1503998B1
(en)
*
|
2002-05-01 |
2009-07-01 |
MERCK SHARP & DOHME LTD. |
Heteroaryl substituted spirocyclic sufamides for inhibition of gamma secretase
|
|
AU2003229024A1
(en)
|
2002-05-07 |
2003-11-11 |
Elan Pharmaceuticals, Inc. |
Succinoyl aminopyrazoles and related compounds
|
|
DE10223666B4
(de)
*
|
2002-05-28 |
2006-06-14 |
Windmöller & Hölscher Kg |
Farbwerksaufbau bei Flexodruckmaschinen
|
|
US6723755B2
(en)
|
2002-06-12 |
2004-04-20 |
Piotr Chomczynski |
Method of treating rosacea
|
|
WO2003103652A1
(en)
|
2002-06-11 |
2003-12-18 |
Elan Pharmaceuticals, Inc. |
METHODS OF TREATING ALZHEIMER’S DISEASE USING AROMATICALLY SUBSTITUTED ω-AMINO-ALKANOIC ACID AMIDES AND ALKANOIC ACID DIAMIDES
|
|
US20060154926A1
(en)
|
2002-06-11 |
2006-07-13 |
Elan Pharmaceuticals, Inc. |
Methods of treating alzheimer's disease using aryl alkanoic acid amides
|
|
WO2004002478A1
(en)
|
2002-06-27 |
2004-01-08 |
Elan Pharmaceuticals, Inc. |
Methods for treating alzheimer's disease using hydroxyethylene compounds containing a heterocyclic amide bond isostere
|
|
GB0217909D0
(en)
|
2002-08-01 |
2002-09-11 |
Du Pont |
Chintzed stretch fabrics
|
|
GB0218041D0
(en)
|
2002-08-02 |
2002-09-11 |
Merck Sharp & Dohme |
Chemical process
|
|
US7557137B2
(en)
|
2002-08-05 |
2009-07-07 |
Bristol-Myers Squibb Company |
Gamma-lactams as beta-secretase inhibitors
|
|
US7294642B2
(en)
|
2002-09-06 |
2007-11-13 |
Elan Pharmaceuticals, Inc. |
1,3-Diamino-2-hydroxypropane pro-drug derivatives
|
|
UY27967A1
(es)
|
2002-09-10 |
2004-05-31 |
Pfizer |
Acetil 2-hindroxi-1,3-diaminoalcanos
|
|
JP2006501282A
(ja)
|
2002-09-27 |
2006-01-12 |
イーラン ファーマスーティカルズ、インコーポレイテッド |
アルツハイマー病治療のための化合物
|
|
CN102345966A
(zh)
|
2002-09-30 |
2012-02-08 |
Bp北美公司 |
减少二氧化碳排放物的系统和方法
|
|
WO2004031400A2
(en)
|
2002-10-01 |
2004-04-15 |
Northwestern University |
Amyloid beta-derived diffusible ligands (addls), addl-surrogates, addl-binding molecules, and uses thereof
|
|
GB0223038D0
(en)
|
2002-10-04 |
2002-11-13 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
GB0223039D0
(en)
|
2002-10-04 |
2002-11-13 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
AU2002344514A1
(en)
*
|
2002-10-17 |
2004-05-25 |
Jingyu Liang |
A natural compound useful for treating diabetes, its preparation and use
|
|
BR0316629A
(pt)
|
2002-11-27 |
2005-10-11 |
Elan Pharm Inc |
Uréias e carbamatos substituìdos
|
|
JP2006510662A
(ja)
|
2002-12-11 |
2006-03-30 |
ファルマシア・アンド・アップジョン・カンパニー・エルエルシー |
α7ニコチン性アセチルコリン受容体アゴニストとその他の化合物との組合せによる疾患の治療
|
|
FR2848452B1
(fr)
|
2002-12-12 |
2007-04-06 |
Aventis Pharma Sa |
Application des inhibiteurs de recapture intestinale des acides biliaires pour la prevention et le traitement de la maladie d'alzheimer
|
|
PL378405A1
(pl)
|
2003-02-04 |
2006-04-03 |
F. Hoffmann-La Roche Ag |
Pochodne malonoamidu jako inhibitory <$Egamma> - sekretazy
|
|
EP1603548A4
(en)
|
2003-02-05 |
2007-10-10 |
Myriad Genetics Inc |
METHOD AND COMPOSITION FOR THE TREATMENT OF NEURODEEGENERATIVE DISEASES
|
|
US7521481B2
(en)
|
2003-02-27 |
2009-04-21 |
Mclaurin Joanne |
Methods of preventing, treating and diagnosing disorders of protein aggregation
|
|
GB0308318D0
(en)
|
2003-04-10 |
2003-05-14 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
TW200505418A
(en)
|
2003-04-21 |
2005-02-16 |
Elan Pharm Inc |
Phenacyl 2-hydroxy-3-diaminoalkanes
|
|
CA2523232A1
(en)
|
2003-04-21 |
2004-11-04 |
Elan Pharmaceuticals, Inc. |
(hetero) arylamide 2-hydroxy-3-diaminoalkanes for use in the treatment of alzheimer's disease
|
|
WO2004101562A2
(en)
|
2003-05-13 |
2004-11-25 |
Schering Corporation |
Bridged n-arylsulfonylpiperidines as gamma-secretase inhibitors
|
|
EP1644346A1
(en)
|
2003-05-16 |
2006-04-12 |
MERCK SHARP & DOHME LTD. |
Cyclic sulfonamides for inhibition of gamma-secretase
|
|
US7060698B2
(en)
|
2003-05-19 |
2006-06-13 |
Hoffmann-La Roche Inc. |
Benzoxazepinone derivatives
|
|
CA2528496C
(en)
|
2003-06-05 |
2011-04-12 |
Elan Pharmaceuticals, Inc. |
Acylated amino acid amidyl pyrazoles and related compounds
|
|
AU2004255183A1
(en)
|
2003-06-30 |
2005-01-20 |
Merck & Co., Inc. |
N-alkyl phenylcarboxamide beta-secretase inhibitors for the treatment of Alzheimer's disease
|
|
CN1909897A
(zh)
|
2003-07-01 |
2007-02-07 |
默克公司 |
用于治疗阿尔茨海默病的苯基羧化物β-分泌酶抑制剂
|
|
EP1671129A1
(en)
|
2003-07-21 |
2006-06-21 |
Angiogenetics Sweden AB |
Compounds and methods for promoting angiogenesis by using a gamma-secretase inhibitor or inhibiting the gamma-secretase pathway
|
|
GB0318447D0
(en)
|
2003-08-05 |
2003-09-10 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
AR045218A1
(es)
|
2003-08-08 |
2005-10-19 |
Schering Corp |
Aminas ciclicas inhibidoras de bace-1 que poseen una benzamida sustituyente; composiciones farmaceuticas que las contienen y su uso en la fabricacion de medicamentos para tratar enfermedades cognitivas o neurodegenerativas.
|
|
JP2007502278A
(ja)
|
2003-08-14 |
2007-02-08 |
メルク エンド カムパニー インコーポレーテッド |
アルツハイマー病の治療のための大員環β−セクレターゼ阻害剤
|
|
EP1667984B1
(en)
|
2003-09-24 |
2011-05-18 |
Merck Sharp & Dohme Ltd. |
Gamma-secretase inhibitors
|
|
KR100793095B1
(ko)
|
2003-10-01 |
2008-01-10 |
주식회사 프로메디텍 |
Bace 저해효능을 가진 신규한 술폰 아미드 유도체
|
|
ATE396973T1
(de)
|
2003-10-03 |
2008-06-15 |
Merck & Co Inc |
Benzylether- und benzylamino-beta-sekretase- hemmer zur behandlung von alzheimer-krankheit
|
|
GB0323258D0
(en)
*
|
2003-10-04 |
2003-11-05 |
Merck Sharp & Dohme |
Therapeutic compounds
|
|
PL1673347T3
(pl)
|
2003-10-06 |
2016-01-29 |
Hoffmann La Roche |
Podstawione pochodne dibenzo-azepiny i benzo-diazepiny użyteczne jako inhibitory gamma-sekretazy
|
|
ES2404554T3
(es)
|
2003-10-14 |
2013-05-28 |
Hokko Chemical Industry Co., Ltd. |
Método para producir escilo-inositol
|
|
US20050171112A1
(en)
*
|
2003-11-03 |
2005-08-04 |
Probiodrug Ag |
Combinations useful for the treatment of neuronal disorders
|
|
GB0326039D0
(en)
*
|
2003-11-07 |
2003-12-10 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
ES2232302B1
(es)
|
2003-11-07 |
2006-08-01 |
Universitat De Les Illes Balears |
Myo-inositol hexafosfato para uso topico.
|
|
CA2544203A1
(en)
|
2003-11-11 |
2005-05-19 |
F. Hoffmann-La Roche Ag |
Phosphinic acids derivatives, beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
JP4576386B2
(ja)
|
2003-11-24 |
2010-11-04 |
メルク・シャープ・エンド・ドーム・コーポレイション |
アルツハイマー病治療用のベンジルエーテルおよびベンジルアミノ系β−セクレターゼ阻害薬
|
|
KR100785537B1
(ko)
|
2003-11-28 |
2007-12-12 |
에프. 호프만-라 로슈 아게 |
베타-세크레타제의 저해제로서의 테트론산 및 테트람산
|
|
EP1697308B1
(en)
|
2003-12-19 |
2014-03-19 |
Merck Sharp & Dohme Corp. |
Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
WO2005063796A1
(en)
|
2003-12-31 |
2005-07-14 |
Posco |
Inhibitors of amyloid precursor protein processing
|
|
DE602004011400T2
(de)
|
2004-01-29 |
2009-01-22 |
Cellzome Ag |
Behandlung von neurodegenerativen krankheiten mit gpr49
|
|
AU2004315399B2
(en)
|
2004-01-29 |
2009-08-06 |
Cellzome Ag |
Treatment of neurodegenerative diseases by the use of ATP7A-modulators
|
|
JP2007530583A
(ja)
|
2004-03-25 |
2007-11-01 |
イーラン ファーマスーティカルズ、インコーポレイテッド |
2−アミノ−及び2−チオ置換されている1,3−ジアミノプロパン
|
|
AU2005230878A1
(en)
|
2004-03-30 |
2005-10-20 |
Merck & Co., Inc. |
2-aminothiazole compounds useful as aspartyl protease inhibitors
|
|
AU2005230681B2
(en)
|
2004-04-05 |
2009-07-30 |
Schering Corporation |
Novel gamma secretase inhibitors
|
|
US7847100B2
(en)
|
2004-04-20 |
2010-12-07 |
Merck, Sharp & Dohme, Inc. |
1,3,5-substituted phenyl derivative compounds useful as beta-secretase inhibitors for the treatment of Alzheimer's disease
|
|
EP1740581B1
(en)
|
2004-04-20 |
2012-08-22 |
Merck Sharp & Dohme Corp. |
2, 4, 6-substituted pyridyl derivative compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
US7449599B2
(en)
*
|
2004-05-13 |
2008-11-11 |
Merck + Co Inc. |
Phenyl carboxamide compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
US20060004096A1
(en)
*
|
2004-05-28 |
2006-01-05 |
Joseph Larner |
Method of Treating Endothelial Dysfunction, Oxidative Stress and Related Diseases
|
|
JP4406327B2
(ja)
|
2004-06-29 |
2010-01-27 |
儀昭 新田 |
タイヤチップ製造装置
|
|
US8193250B2
(en)
|
2004-10-22 |
2012-06-05 |
Mount Sinai School Of Medicine |
Compositions and methods for treating alzheimer's disease and related disorders and promoting a healthy nervous system
|
|
US20080306166A1
(en)
*
|
2004-11-17 |
2008-12-11 |
Mclaurin Joanne |
Compositions and Methods For Treatment of Disorders of Protein Aggregation
|
|
WO2006088705A1
(en)
|
2005-02-14 |
2006-08-24 |
Wyeth |
Terphenyl guanidines as [beta symbol] -secretase inhibitors
|
|
WO2006112000A1
(ja)
|
2005-03-30 |
2006-10-26 |
The Niigata Institute Of Science And Technology |
大腸菌変異株による2-デオキシ-シロ-イノソースの合成および精製する方法並びに得られた2-デオキシ-シロ-イノソース
|
|
KR20060105233A
(ko)
|
2005-04-02 |
2006-10-11 |
삼성전자주식회사 |
하이브리드 디스크, 그 기록 및/또는 재생 장치 및 방법
|
|
WO2007002220A2
(en)
|
2005-06-21 |
2007-01-04 |
Bristol-Myers Squibb Company |
Aminoacetamide acyl guanidines as beta-secretase inhibitors
|
|
WO2007011810A1
(en)
|
2005-07-18 |
2007-01-25 |
Merck & Co., Inc. |
Spiropiperidine beta-secretase inhibitors for the treatment of alzheimer's disease
|
|
US20090182021A1
(en)
|
2005-08-03 |
2009-07-16 |
Nanternet Philippe G |
Tricyclic Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease
|
|
US7338974B2
(en)
|
2005-08-12 |
2008-03-04 |
Bristol-Myers Squibb Company |
Macrocyclic diaminopropanes as beta-secretase inhibitors
|
|
JP2009511568A
(ja)
|
2005-10-13 |
2009-03-19 |
ワラタ ファーマシューティカルズ, インコーポレイテッド |
イノシトール誘導体、ならびに異常なタンパク質の折りたたみまたは凝集、あるいはアミロイドの形成、沈着、蓄積または残存を特徴とする疾患の処置におけるその使用
|
|
EP1966198B1
(en)
*
|
2005-10-25 |
2011-03-16 |
Janssen Pharmaceutica NV |
2-amino-3,4-dihydro-pyrido[3,4-d]pyrimidine derivatives useful as inhibitors of beta-secretase (bace)
|
|
US20070197452A1
(en)
|
2006-02-17 |
2007-08-23 |
Mclaurin Joanne |
Treatment of amyloid-related diseases
|
|
CA2579188A1
(en)
|
2006-02-17 |
2007-08-17 |
Joanne Mclaurin |
Treatment of amyloid-related diseases
|
|
US20070197453A1
(en)
|
2006-02-17 |
2007-08-23 |
Mclaurin Joanne |
Compositions and methods for treatment of disorders of protein aggregation
|
|
EA200801967A1
(ru)
|
2006-03-09 |
2009-04-28 |
Ворэта Фармэсьютиклз Инк. |
Дозированная лекарственная форма на основе циклогексанового полиола (варианты), способ ее получения, способ лечения болезни альцгеймера с ее помощью и циклогексановый полиол в качестве средства при изготовлении лекарственного средства
|
|
CA2652238A1
(en)
|
2006-05-18 |
2007-11-29 |
Merck Frosst Canada Ltd. |
Phenanthrene derivatives as mpges-1 inhibitors
|
|
US20110028719A1
(en)
|
2006-05-19 |
2011-02-03 |
Jacek Slon-Usakiewicz |
Screening methods for amyloid beta modulators
|
|
EP1884531A1
(en)
|
2006-07-30 |
2008-02-06 |
Lonza Compounds GmbH & Co. KG |
Sheet molding compounds (smc) comprising thermosetting resins based on renewable resources
|
|
EP2061317A4
(en)
|
2006-08-25 |
2010-06-30 |
Allan Basbaum |
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|
|
EP2063807A4
(en)
|
2006-09-06 |
2010-03-31 |
Aortx Inc |
PROSTHETIC CARDIAC VALVES, SUPPORT STRUCTURES, AND SYSTEMS AND METHODS FOR IMPLANTATION THEREOF
|
|
US20100173960A1
(en)
|
2006-09-21 |
2010-07-08 |
Antonio Cruz |
The Combination of a Cyclohexanehexol and a NSAID for the Treatment of Neurodegenerative Diseases
|
|
WO2008061373A1
(en)
|
2006-11-24 |
2008-05-29 |
Waratah Pharmaceuticals Inc. |
Combination treatments for alzheimer's disease and similar diseases
|
|
CN101686986A
(zh)
|
2006-12-29 |
2010-03-31 |
诺尔姆奥克西斯公司 |
环多醇和其衍生物及其治疗应用
|
|
WO2008098371A1
(en)
|
2007-02-16 |
2008-08-21 |
The Royal Institution For The Advancement Of Learning/Mcgill University |
Compositions and method for reducing amyloid beta in a mammal
|
|
EP2656839A1
(en)
|
2007-04-12 |
2013-10-30 |
Waratah Pharmaceuticals, Inc. |
Use of Cyclohexanehexol Derivatives in the Treatment of Ocular Diseases
|
|
WO2008124931A1
(en)
|
2007-04-12 |
2008-10-23 |
Joanne Mclaurin |
Use of cyclohexanehexol derivatives in the treatment of amyotrophic lateral sclerosis
|
|
WO2008124929A1
(en)
|
2007-04-12 |
2008-10-23 |
Joanne Mclaurin |
USE OF CYCLOHEXANEHEXOL DERIVATIVES IN THE TREATMENT OF α-SYNUCLEINOPATHIES
|
|
CA2683548A1
(en)
|
2007-04-12 |
2008-10-23 |
Joanne Mclaurin |
Use of cyclohexanehexol derivatives for the treatment of polyglutamine diseases
|
|
JP5034916B2
(ja)
|
2007-12-10 |
2012-09-26 |
富士通セミコンダクター株式会社 |
性能評価モデル生成方法、システム性能評価方法、及び性能評価モデル生成装置
|
|
KR20110040972A
(ko)
|
2008-08-06 |
2011-04-20 |
인비스타 테크놀러지스 에스.에이.알.엘. |
일회용 위생용품 및 의류의 성분에 유용한 탄성 복합 구조물의 제조 방법
|
|
AU2009290612B2
(en)
*
|
2008-09-15 |
2015-05-14 |
Transition Therapeutics Ireland Limited |
Methods of treatment of hyperuricemia and associated disease states
|
|
EP2349233A4
(en)
|
2008-10-09 |
2012-04-18 |
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USE OF SCYLLO-INOSITOLS FOR THE TREATMENT OF DISORDERS ASSOCIATED WITH MACULAR DEGENERATION
|
|
WO2012173808A1
(en)
|
2011-06-03 |
2012-12-20 |
Elan Pharmaceuticals, Inc. |
Scyllo-inositol for the treatment of behavioral and psychiatric disorders
|