HRP20040352B1 - Use of flibanserin in the treatment of sexual disorders - Google Patents

Use of flibanserin in the treatment of sexual disorders

Info

Publication number
HRP20040352B1
HRP20040352B1 HR20040352A HRP20040352A HRP20040352B1 HR P20040352 B1 HRP20040352 B1 HR P20040352B1 HR 20040352 A HR20040352 A HR 20040352A HR P20040352 A HRP20040352 A HR P20040352A HR P20040352 B1 HRP20040352 B1 HR P20040352B1
Authority
HR
Croatia
Prior art keywords
flibanserin
treatment
sexual disorders
medicament
optionally
Prior art date
Application number
HR20040352A
Other languages
Croatian (hr)
Inventor
Robert Evans Kenneth
Borsini Franco
Original Assignee
Boehringer Ingelheim Pharma Gmbh & Co.Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma Gmbh & Co.Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co.Kg
Publication of HRP20040352A2 publication Critical patent/HRP20040352A2/en
Publication of HRP20040352B1 publication Critical patent/HRP20040352B1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Uporaba flibanserina, po izboru u obliku farmakološki prihvatljivih kiselinskih adicijskih soli, naznačena time, da se koristi za pripravu lijeka za liječenje poremećaja spolnog nagona. Patent sadrži još 5 patentnih zahtjeva.The use of flibanserin, optionally in the form of pharmacologically acceptable acid addition salts, for the preparation of a medicament for the treatment of a sex drive disorder. The patent contains 5 more patent claims.

HR20040352A 2001-10-20 2004-04-19 Use of flibanserin in the treatment of sexual disorders HRP20040352B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01125020 2001-10-20
PCT/EP2002/011103 WO2003035072A1 (en) 2001-10-20 2002-10-04 Use of flibanserin in the treatment of sexual disorders

Publications (2)

Publication Number Publication Date
HRP20040352A2 HRP20040352A2 (en) 2005-02-28
HRP20040352B1 true HRP20040352B1 (en) 2012-02-29

Family

ID=8179028

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20040352A HRP20040352B1 (en) 2001-10-20 2004-04-19 Use of flibanserin in the treatment of sexual disorders

Country Status (31)

Country Link
US (9) US7151103B2 (en)
EP (2) EP1446122B1 (en)
JP (3) JP2005506370A (en)
KR (3) KR101235102B1 (en)
CN (4) CN102058597A (en)
AR (2) AR037109A1 (en)
AT (1) ATE327757T1 (en)
AU (1) AU2002333894B2 (en)
BR (1) BR0213358A (en)
CA (1) CA2458067C (en)
CY (1) CY1105082T1 (en)
DE (1) DE60211937T2 (en)
DK (1) DK1446122T5 (en)
EA (1) EA007274B1 (en)
EC (1) ECSP045069A (en)
ES (1) ES2266632T3 (en)
HR (1) HRP20040352B1 (en)
HU (1) HUP0401023A3 (en)
IL (2) IL160389A0 (en)
ME (1) MEP42808A (en)
MX (1) MXPA04003666A (en)
MY (1) MY127290A (en)
NO (1) NO325556B1 (en)
NZ (1) NZ532079A (en)
PL (1) PL208744B1 (en)
PT (1) PT1446122E (en)
RS (1) RS50876B (en)
SI (1) SI1446122T1 (en)
UA (1) UA78974C2 (en)
WO (1) WO2003035072A1 (en)
ZA (1) ZA200401366B (en)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7183410B2 (en) 2001-08-02 2007-02-27 Bidachem S.P.A. Stable polymorph of flibanserin
US20030060475A1 (en) * 2001-08-10 2003-03-27 Boehringer Ingelheim Pharma Kg Method of using flibanserin for neuroprotection
US10675280B2 (en) 2001-10-20 2020-06-09 Sprout Pharmaceuticals, Inc. Treating sexual desire disorders with flibanserin
UA78974C2 (en) 2001-10-20 2007-05-10 Boehringer Ingelheim Pharma Use of flibanserin for treating disorders of sexual desire
US20040048877A1 (en) * 2002-05-22 2004-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions containing flibanserin
US20050065158A1 (en) * 2003-07-16 2005-03-24 Pfizer Inc. Treatment of sexual dysfunction
MXPA06000623A (en) * 2003-07-16 2006-04-11 Pfizer Treatment of sexual dysfunction.
JP4964593B2 (en) 2003-09-25 2012-07-04 セノメド バイオサイエンシーズ,エルエルシー Tetrahydroindolone derivatives for the treatment of neurological conditions
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
WO2005102342A1 (en) * 2004-04-22 2005-11-03 Boehringer Ingelheim International Gmbh New pharmaceutical compositions for the treatment of sexual disorders ii
US20050239798A1 (en) * 2004-04-22 2005-10-27 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the treatment of premenstrual and other female sexual disorders
PL1750766T3 (en) 2004-05-11 2013-12-31 Eb Ip Lybrido B V Pharmaceutical formulations and uses thereof in the treatment of female sexual dysfunction
US20060025420A1 (en) * 2004-07-30 2006-02-02 Boehringer Ingelheimn International GmbH Pharmaceutical compositions for the treatment of female sexual disorders
CA2576812A1 (en) * 2004-09-03 2006-03-09 Boehringer Ingelheim International Gmbh Method for the treatment of attention deficit hyperactivity disorder
EP1858516A1 (en) * 2005-03-04 2007-11-28 Boehringer Ingelheim International GmbH Pharmaceutical compositions for the treatment and/or prevention of depression
US20060199805A1 (en) * 2005-03-04 2006-09-07 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders
WO2006096439A2 (en) * 2005-03-04 2006-09-14 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases
EP1904182A2 (en) * 2005-05-06 2008-04-02 Boehringer Ingelheim International GmbH Method for the treatment of drug abuse with flibanserin
US20060264512A1 (en) * 2005-05-19 2006-11-23 Boehringer Ingelheim International Gmbh Method for the treatment of sexual dysfunction due to medical conditions
EP1888071A1 (en) * 2005-05-19 2008-02-20 Boehringer Ingelheim International GmbH Method for the treatment of drug-induced sexual dysfunction
JP2009500440A (en) * 2005-07-12 2009-01-08 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Pharmaceutical composition for treating libido disorder
ES2646326T3 (en) 2005-08-03 2017-12-13 Sprout Pharmaceuticals, Inc. Use of flibanserin in the treatment of obesity
US7923449B2 (en) 2005-10-29 2011-04-12 Boehringer Ingelheim International Gmbh Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders
US20070123540A1 (en) * 2005-10-29 2007-05-31 Angelo Ceci Sexual desire enhancing medicaments comprising benzimidazolone derivatives
US20070105869A1 (en) * 2005-11-08 2007-05-10 Stephane Pollentier Use of flibanserin for the treatment of pre-menopausal sexual desire disorders
EP1790343A1 (en) * 2005-11-11 2007-05-30 Emotional Brain B.V. Pharmaceuticals formulations and uses thereof in the treatment of female sexual dysfunction
CA2680789C (en) * 2006-03-28 2016-02-16 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
CA2649938A1 (en) * 2006-05-09 2007-11-15 Boehringer Ingelheim International Gmbh Use of flibanserin for the treatment of post-menopausal sexual desire disorders
EP2037927B1 (en) * 2006-06-30 2010-01-27 Boehringer Ingelheim International GmbH Flibanserin for the treatment of urinary incontinence and related diseases
CA2657043A1 (en) * 2006-07-14 2008-01-17 Boehringer Ingelheim International Gmbh Use of flibanserin for the treatment of sexual disorders in females
CA2657045A1 (en) * 2006-07-14 2008-01-17 Boehringer Ingelheim International Gmbh Combinations of flibanserin with caffeine, process for their preparation and use thereof as medicaments
MX2009001551A (en) 2006-08-14 2009-02-20 Boehringer Ingelheim Int Formulations of flibanserin and method for manufacturing the same.
CL2007002214A1 (en) 2006-08-14 2008-03-07 Boehringer Ingelheim Int PHARMACEUTICAL COMPOSITION IN THE FORM OF COMPRESSED, WHERE AT LEAST THE LENGTH OF THE COMPRESSED IN THE PREVIOUS STATE OF THE APPLICATION IS AT LEAST 7/12 OF THE PILOR DIAMETER OF THE PATIENT AND AFTER INGERING IT IN THE FOOD STATE, THE LENGTH OF THE COMP
MX2009002031A (en) 2006-08-25 2009-03-06 Boehringer Ingelheim Int Controlled release system and method for manufacturing the same.
EP1925307A1 (en) * 2006-11-03 2008-05-28 Emotional Brain B.V. Use of 3-alpha-androstanediol in the treatment of sexual dysfunction
ATE524446T1 (en) 2006-12-20 2011-09-15 Boehringer Ingelheim Int SULFATED BENZIMIDAZOLONE DERIVATIVES WITH MIXED SEROTONIN RECEPTOR AFFINITY
WO2008090742A1 (en) * 2007-01-23 2008-07-31 National University Corporation Hokkaido University Non-human animal for eye disease model
EP2129400A2 (en) * 2007-03-28 2009-12-09 Boehringer Ingelheim International GmbH Pharmaceutical compositions comprising flibanserin and a further agent in the treatment of sexual disorders
UY31335A1 (en) 2007-09-12 2009-04-30 VASOMOTOR SYMPTOMS TREATMENT
CA2686480A1 (en) 2008-12-15 2010-06-15 Boehringer Ingelheim International Gmbh New salts
DE102011012712A1 (en) 2011-03-01 2012-09-06 Frank Lehmann-Horn Use of aldosterone receptor antagonists for the treatment of female sexual dysfunction
US9353067B2 (en) 2011-04-10 2016-05-31 Atir Holding S.A. Heterocyclic compounds and uses thereof in the treatment of sexual disorders
CA2881388A1 (en) * 2012-08-06 2014-02-13 S1 Pharmaceuticals, Inc. Treatment regimens
CN104926734B (en) * 2015-07-07 2017-04-05 苏州立新制药有限公司 The preparation method of flibanserin
WO2017100324A1 (en) * 2015-12-10 2017-06-15 Repros Therapeutics Inc. Combination therapy for treating female hypoactive sexual desire disorders

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0526434A1 (en) * 1991-07-30 1993-02-03 BOEHRINGER INGELHEIM ITALIA S.p.A. Benzimidazolone derivatives as 5-HT1A and 5-HT2 antagonists
WO2001021593A1 (en) * 1999-09-22 2001-03-29 Boehringer Ingelheim Italia S.P.A. New benzimidazolone derivatives having mixed serotonine and dopamine receptors affinity

Family Cites Families (149)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US479739A (en) * 1892-07-26 dimond
US3096248A (en) 1959-04-06 1963-07-02 Rexall Drug & Chemical Company Method of making an encapsulated tablet
US3406178A (en) * 1964-02-04 1968-10-15 Monsanto Chem Australia Ltd Preparation of 2-substituted benzimidazoles
US3362956A (en) * 1965-08-19 1968-01-09 Sterling Drug Inc 1-[(heterocyclyl)-lower-alkyl]-4-substituted-piperazines
US4200641A (en) * 1976-12-21 1980-04-29 Janssen Pharmaceutica, N.V. 1-[(Heterocyclyl)-alkyl]-4-diarylmethoxy piperidine derivatives
IL57569A0 (en) 1978-06-20 1979-10-31 Synthelabo Phenylpiperazine derivative,their preparation and pharmaceutical compositions containing them
DE3000979A1 (en) 1980-01-12 1981-07-23 Dr. Karl Thomae Gmbh, 7950 Biberach NEW DIPYRIDAMOL RETARD FORMS AND METHOD FOR THEIR PRODUCTION
DE3126703A1 (en) 1981-07-07 1983-01-27 Dr. Karl Thomae Gmbh, 7950 Biberach BROMHEXIN RETARD FORM AND METHOD FOR THEIR PRODUCTION
JPS58134033A (en) 1982-02-02 1983-08-10 Fujisawa Pharmaceut Co Ltd Drug composition
IT1176613B (en) * 1984-08-14 1987-08-18 Ravizza Spa PHARMACOLOGICALLY ACTIVE PIPERAZINIC DERIVATIVES AND PROCESS FOR THEIR PREPARATION
IE58370B1 (en) 1985-04-10 1993-09-08 Lundbeck & Co As H Indole derivatives
GB8607294D0 (en) * 1985-04-17 1986-04-30 Ici America Inc Heterocyclic amide derivatives
DE3620643A1 (en) 1985-06-22 1987-01-22 Sandoz Ag Thiazoles, their preparation and use
HUT43600A (en) 1985-06-22 1987-11-30 Sandoz Ag Process for production of new thiazole derivatives and medical compound containing those
GB8601160D0 (en) 1986-01-17 1986-02-19 Fujisawa Pharmaceutical Co Heterocyclic compounds
US5036088A (en) * 1986-06-09 1991-07-30 Pfizer Inc. Antiallergy and antiinflammatory agents, compositions and use
JPH0784462B2 (en) * 1986-07-25 1995-09-13 日清製粉株式会社 Benzimidazole derivative
US4968508A (en) 1987-02-27 1990-11-06 Eli Lilly And Company Sustained release matrix
US4792452A (en) 1987-07-28 1988-12-20 E. R. Squibb & Sons, Inc. Controlled release formulation
GB8830312D0 (en) 1988-12-28 1989-02-22 Lundbeck & Co As H Heterocyclic compounds
US4954503A (en) * 1989-09-11 1990-09-04 Hoechst-Roussel Pharmaceuticals, Inc. 3-(1-substituted-4-piperazinyl)-1H-indazoles
PT98628A (en) 1990-08-09 1992-06-30 Massachusetts Inst Technology PHARMACEUTICAL COMPOSITIONS BASED ON FOR EXAMPLE SERTRALINE
DE69129839T2 (en) 1990-08-24 1999-02-11 Shinetsu Chemical Co COATING BASE FOR A PHARMACEUTICAL FILM AND METHOD FOR PRODUCING THE SAME
NZ241613A (en) 1991-02-27 1993-06-25 Janssen Pharmaceutica Nv Highlighting intagliations in tablets
SE9100860D0 (en) 1991-03-22 1991-03-22 Kabi Pharmacia Ab NEW USE
FR2675800A1 (en) 1991-04-26 1992-10-30 Rhone Poulenc Rorer Sa HETEROCYCLIC ANTISEROTONINE DERIVATIVES AND PREPARATION AND MEDICAMENTS CONTAINING SAME.
HUT68769A (en) 1991-05-07 1995-07-28 Merck & Co Inc FIBRINOGéN RECEPTOR ANTAGONIST COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AS EFFECTIVE SUBSTANCE
US5407686A (en) 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
DE4216364A1 (en) 1991-12-14 1993-11-25 Thomae Gmbh Dr K Pyridyl derivs. with antithrombotic properties
US5225417A (en) 1992-01-21 1993-07-06 G. D. Searle & Co. Opioid agonist compounds
US5492907A (en) 1992-12-09 1996-02-20 The United States Of America As Represented By The Department Of Health & Human Services Antipsychotic composition and method of treatment
WO1994022460A1 (en) 1993-04-05 1994-10-13 University Patents, Inc. Diagnosis and treatment of erectile dysfunction
FR2707294B1 (en) 1993-07-06 1995-09-29 Pf Medicament New derivatives of 3,5-dioxo- (2H, 4H) -1,2,4-triazine, their preparation and their application in human therapy.
GB9401090D0 (en) 1994-01-21 1994-03-16 Glaxo Lab Sa Chemical compounds
DE69523155T2 (en) 1994-06-14 2002-02-07 Pfizer BENZIMIDAZOLONE DERIVATIVES WITH CENTRAL DOPAMINERIC ACTIVITY
NZ291223A (en) 1994-08-23 1998-12-23 Smithkline Beecham Plc Medicament containing ibuprofen and codeine, and a carrier containing a hydrogenated vegetable oil as a lubricant
DE69531476T2 (en) 1994-09-12 2004-06-09 Lilly Industries Ltd., Basingstoke Serotonergic modulators
JPH08143476A (en) 1994-11-18 1996-06-04 Japan Tobacco Inc Medicinal agent release-controlling membrane and solid preparation
FR2727682A1 (en) 1994-12-02 1996-06-07 Pf Medicament NOVEL DERIVATIVES OF 3,5-DIOXO- (2H, 4H) -1,2,4-TRIAZINES, THEIR PREPARATION AND THEIR USE AS A MEDICINAL PRODUCT
US5552412A (en) 1995-01-09 1996-09-03 Pfizer Inc 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen2-ol compounds which are useful for treating osteoporosis
US5883094A (en) * 1995-04-24 1999-03-16 Pfizer Inc. Benzimidazolone derivatives with central dopaminergic activity
US5854290A (en) 1995-09-21 1998-12-29 Amy F. T. Arnsten Use of guanfacine in the treatment of behavioral disorders
US6083947A (en) * 1996-01-29 2000-07-04 The Regents Of The University Of California Method for treating sexual dysfunctions
GB9613423D0 (en) 1996-06-26 1996-08-28 Lilly Industries Ltd Pharmaceutical compounds
US5916916A (en) 1996-10-10 1999-06-29 Eli Lilly And Company 1-aryloxy-2-arylnaphthyl compounds, intermediates, compositions, and methods
DE69729950T2 (en) 1996-11-06 2005-07-28 Wockhardt Europe Ltd. Released-release drug delivery system for acid labile drugs
CA2273351A1 (en) 1996-12-02 1998-06-11 Merck Sharp & Dohme Limited Use of nk-1 receptor antagonists for treating sexual dysfunction
US5859246A (en) 1997-01-30 1999-01-12 Neurogen Corporation 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands
US20040023948A1 (en) 1997-03-24 2004-02-05 Green Richard David Fast-dispersing dosage form containing 5-HT1 agonists
GB9706089D0 (en) 1997-03-24 1997-05-14 Scherer Ltd R P Pharmaceutical composition
ATE277606T1 (en) 1997-06-11 2004-10-15 Procter & Gamble FILM-COATED TABLET FOR IMPROVED TOLERABILITY IN THE UPPER GITTERIAL TRACT
ATE241341T1 (en) 1997-09-10 2003-06-15 Takeda Chemical Industries Ltd STABILIZED PHARMACEUTICAL COMPOSITION
SE9703375D0 (en) 1997-09-18 1997-09-18 Astra Ab A new combination
CH692199A8 (en) 1997-10-09 2002-06-14 Cermol S.A. PYRIDIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS
JP3724157B2 (en) 1997-10-30 2005-12-07 コニカミノルタホールディングス株式会社 Video observation device
FR2775188B1 (en) 1998-02-23 2001-03-09 Lipha IMMEDIATE RELEASE ORAL EXTENDED RELEASE GALENIC FORM COMPRISING AN ABSORPTION PROMOTING AGENT AND USE OF THE ABSORPTION PROMOTING AGENT
WO1999059584A1 (en) 1998-05-20 1999-11-25 Schering Corporation Combination of phentolamine and cyclic gmp phosphodiesterase inhibitors for the treatment of sexual dysfunction
CA2332253A1 (en) 1998-05-21 1999-11-25 Eli Lilly And Company Combination therapy for treatment of depression
US20020151543A1 (en) 1998-05-28 2002-10-17 Sepracor Inc. Compositions and methods employing R (-) fluoxetine and other active ingredients
CA2334551A1 (en) 1998-06-11 1999-12-16 Merck & Co., Inc. Spiropiperidine derivatives as melanocortin receptor agonists
US6068846A (en) 1998-08-05 2000-05-30 Melaleuca, Incorporated Methods and materials for treating depression and mood disorder
EP0982030A3 (en) 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands
UA67802C2 (en) 1998-10-23 2004-07-15 Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. CONTROLLED-RELEASE FORMULATIONS FOR ORAL ADMINISTRATION CONTAINING cGMP PDE-5 INHIBITOR (VARIANTS), METHOD FOR ITS PREPARATION AND METHOD FOR TREATING ERECTILE DYSFUNCTION
WO2000028993A1 (en) * 1998-11-19 2000-05-25 Nortran Pharmaceuticals, Inc. Serotonin ligands as pro-erectile compounds
US6680071B1 (en) 1999-03-03 2004-01-20 R. P. Scherer Technologies, Inc. Opioid agonist in a fast dispersing dosage form
AU4465200A (en) 1999-04-16 2000-11-02 Dr. Reddy's Research Foundation Novel polymorphic forms of an antidiabetic agent: process for their preparation and a pharmaceutical composition containing them
CN1461216A (en) 1999-04-28 2003-12-10 呼吸器有限公司 Compound for use as medicament for treatment of disorders involving bronchocontraction
IT1312310B1 (en) 1999-05-07 2002-04-15 Recordati Ind Chimica E Farma USE OF SELECTIVE 1B ADRENERGIC RECEPTOR ANTAGONISTS TO IMPROVE SEXUAL DYSFUNCTION
US6579968B1 (en) 1999-06-29 2003-06-17 Palatin Technologies, Inc. Compositions and methods for treatment of sexual dysfunction
US20030055070A1 (en) 1999-07-01 2003-03-20 Wilma Harrison Phosphodiesterase type 5 (PDE5) inhibitors for the treatment of selective serotonin reuptake inhibitor (SSR) induced sexual dysfunction
US6346548B1 (en) 1999-08-16 2002-02-12 Cephalon, Inc. Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
DE19961334A1 (en) 1999-12-17 2001-06-21 Roehm Gmbh Injection molding process for neutral and acid group-containing (meth) acrylate copolymers
WO2001062236A2 (en) 2000-02-24 2001-08-30 Pharmacia & Upjohn Company New drug combinations comprising a norepinephrine reuptake inhibitor and an antimuscarinic agent
BR0111567A (en) 2000-06-28 2003-05-06 Pfizer Prod Inc Melanocortin Receptor Ligands
US6960597B2 (en) 2000-06-30 2005-11-01 Orth-Mcneil Pharmaceutical, Inc. Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists
US20020052370A1 (en) 2000-07-06 2002-05-02 Barber Christopher Gordon Cyclopentyl-substituted glutaramide derivatives as inhibitors of neutral endopeptidase
US20040198706A1 (en) 2003-03-11 2004-10-07 Carrara Dario Norberto R. Methods and formulations for transdermal or transmucosal application of active agents
WO2002024661A2 (en) 2000-09-19 2002-03-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg New n, n'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors
US6521623B1 (en) 2000-09-19 2003-02-18 Boehringer Ingelheim Pharma Kg N,N'-disubstituted benzimidazolone derivatives with affinity at the serotonin and dopamine receptors
AU2001293804A1 (en) 2000-09-19 2002-04-02 Boehringer Ingelheim Pharma Kg New benzimidazolone derivatives displaying affinity at the serotonin and dopamine receptors
US6586435B2 (en) 2000-09-19 2003-07-01 Boehringer Ingelheim Pharma Kg Benzimidazolone derivatives displaying affinity at the serotonin and dopamine receptors
WO2002041894A2 (en) 2000-11-22 2002-05-30 Abbott Laboratories Selective dopamine d4 receptor agonists for treating sexual dysfunction
GB0105893D0 (en) 2001-03-09 2001-04-25 Pfizer Ltd Pharmaceutically active compounds
GB0106446D0 (en) 2001-03-15 2001-05-02 Vernalis Res Ltd Chemical compounds
BR0208455A (en) 2001-03-28 2004-03-02 Pfizer N-phenpropylcyclopentyl substituted glutaramide derivatives as ns inhibitors for fsad
ES2267627T3 (en) 2001-05-11 2007-03-16 Jurgen K. Dr. Beck FLIBASERINE FOR THE TREATMENT OF ESTRAPIRAMIDAL MOVEMENT DISORDERS.
US6627646B2 (en) 2001-07-17 2003-09-30 Sepracor Inc. Norastemizole polymorphs
EP1411940B1 (en) 2001-07-18 2008-10-15 Merck & Co., Inc. Bridged piperidine derivatives as melanocortin receptor agonists
DE60231070D1 (en) 2001-07-30 2009-03-19 Spectrum Pharmaceuticals Inc Arylpiperazine bound purine derivatives
CA2450093C (en) 2001-08-02 2008-09-23 Bidachem S.P.A. Stable polymorph of flibanserin, technical process for its preparation and the use thereof for preparing medicaments
US7183410B2 (en) * 2001-08-02 2007-02-27 Bidachem S.P.A. Stable polymorph of flibanserin
DE10138273A1 (en) 2001-08-10 2003-02-27 Boehringer Ingelheim Pharma Medicines with neuroprotective effects
US20030060475A1 (en) 2001-08-10 2003-03-27 Boehringer Ingelheim Pharma Kg Method of using flibanserin for neuroprotection
HUP0202719A3 (en) 2001-08-21 2006-01-30 Pfizer Prod Inc Pharmaceutical compositions for the treatment of female sexual dysfunctions
DE10149674A1 (en) 2001-10-09 2003-04-24 Apogepha Arzneimittel Gmbh Orally administered composition for sustained release of propiverine, useful for treatment of hypertonic bladder disorders, especially by once-daily administration
UA78974C2 (en) 2001-10-20 2007-05-10 Boehringer Ingelheim Pharma Use of flibanserin for treating disorders of sexual desire
DE10209982A1 (en) 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Dosage form to be administered orally for poorly soluble basic active ingredients
US20040048877A1 (en) 2002-05-22 2004-03-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions containing flibanserin
EA007185B1 (en) 2002-05-22 2006-08-25 Бёрингер Ингельхайм Фарма Гмбх Унд Ко. Кг New pharmaceutical compositions containing flibanserin polymorph a
EP1551393A4 (en) 2002-07-30 2010-06-16 Peter Migaly Combination therapy for depression, prevention of suicide, and varous medical and psychiatric conditions
US20040116532A1 (en) 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
GB0225908D0 (en) 2002-11-06 2002-12-11 Pfizer Ltd Treatment of female sexual dysfunction
US20040132697A1 (en) 2002-11-06 2004-07-08 Pfizer Inc. Treatment of female sexual dysfunction
US20040147581A1 (en) 2002-11-18 2004-07-29 Pharmacia Corporation Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
WO2004063864A2 (en) 2003-01-06 2004-07-29 Laura Berman Method and system for computerized sexual function assessment of female users
WO2004069339A1 (en) 2003-01-29 2004-08-19 Psychogenics Inc. Treatment for attention-deficit hyperactivity disorder
US20050037983A1 (en) 2003-03-11 2005-02-17 Timothy Dinan Compositions and methods for the treatment of depression and other affective disorders
US20050065158A1 (en) 2003-07-16 2005-03-24 Pfizer Inc. Treatment of sexual dysfunction
MXPA06000623A (en) 2003-07-16 2006-04-11 Pfizer Treatment of sexual dysfunction.
EP1510133A1 (en) * 2003-09-01 2005-03-02 Belovo S.A., Egg Science & Technology Balanced oil composition
US7700652B2 (en) 2003-09-11 2010-04-20 Xenoport, Inc. Treating urinary incontinence using prodrugs of GABA analogs
WO2005044238A1 (en) 2003-11-07 2005-05-19 Ranbaxy Laboratories Limited Modified release solid dosage form of amphetamine salts
WO2005102342A1 (en) 2004-04-22 2005-11-03 Boehringer Ingelheim International Gmbh New pharmaceutical compositions for the treatment of sexual disorders ii
US20050239798A1 (en) 2004-04-22 2005-10-27 Boehringer Ingelheim Pharmaceuticals, Inc. Method for the treatment of premenstrual and other female sexual disorders
US20060014757A1 (en) 2004-07-14 2006-01-19 Boehringer Ingelheim Pharmaceuticals Method for the treatment of anorexia nervosa
US20060025420A1 (en) 2004-07-30 2006-02-02 Boehringer Ingelheimn International GmbH Pharmaceutical compositions for the treatment of female sexual disorders
CA2576812A1 (en) 2004-09-03 2006-03-09 Boehringer Ingelheim International Gmbh Method for the treatment of attention deficit hyperactivity disorder
JP2008516909A (en) 2004-10-18 2008-05-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Use of β-3 agonists to treat prostate and lower urogenital tract diseases
WO2006096439A2 (en) 2005-03-04 2006-09-14 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of schizophrenia and related diseases
EP1858516A1 (en) 2005-03-04 2007-11-28 Boehringer Ingelheim International GmbH Pharmaceutical compositions for the treatment and/or prevention of depression
US20060199805A1 (en) 2005-03-04 2006-09-07 Boehringer Ingelheim International Gmbh Pharmaceutical compositions for the treatment and/or prevention of anxiety disorders
EP1904182A2 (en) 2005-05-06 2008-04-02 Boehringer Ingelheim International GmbH Method for the treatment of drug abuse with flibanserin
US20060258640A1 (en) 2005-05-13 2006-11-16 Boehringer Ingelheim International Gmbh Use of Flibanserin in the treatment of chronic pain
EP1888071A1 (en) 2005-05-19 2008-02-20 Boehringer Ingelheim International GmbH Method for the treatment of drug-induced sexual dysfunction
US20060264512A1 (en) 2005-05-19 2006-11-23 Boehringer Ingelheim International Gmbh Method for the treatment of sexual dysfunction due to medical conditions
RU2408368C2 (en) 2005-06-27 2011-01-10 Биовэйл Лэборэториз Интернэшнл С.Р.Л. Modified release bupropion salt preparations
ES2646326T3 (en) 2005-08-03 2017-12-13 Sprout Pharmaceuticals, Inc. Use of flibanserin in the treatment of obesity
CN101467409A (en) 2005-08-16 2009-06-24 伟俄内克斯研究公司 Packet detection
HU227490B1 (en) 2005-08-26 2011-07-28 Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag Sustained release pharmaceutical preparation containing carvedilol
US20080275082A1 (en) 2005-09-30 2008-11-06 Jeffrey Brum Pharmaceutical Composition
US20070123540A1 (en) 2005-10-29 2007-05-31 Angelo Ceci Sexual desire enhancing medicaments comprising benzimidazolone derivatives
US7923449B2 (en) 2005-10-29 2011-04-12 Boehringer Ingelheim International Gmbh Benzimidazolone derivatives for the treatment of premenstrual and other female sexual disorders
US20070105869A1 (en) 2005-11-08 2007-05-10 Stephane Pollentier Use of flibanserin for the treatment of pre-menopausal sexual desire disorders
AU2007211101B2 (en) 2006-01-27 2013-05-02 Adare Pharmaceuticals, Inc. Drug delivery systems comprising weakly basic drugs and organic acids
JP2009526821A (en) 2006-02-18 2009-07-23 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Novel pharmaceutical composition for the treatment of attention deficit hyperactivity disorder
WO2007096300A1 (en) 2006-02-20 2007-08-30 Boehringer Ingelheim International Gmbh Benzimidazolone derivatives for the treatment of urinary incontinence
WO2007099070A1 (en) 2006-02-28 2007-09-07 Boehringer Ingelheim International Gmbh Treatment of prevention of valvular heart disease with flibanserin
CA2649938A1 (en) 2006-05-09 2007-11-15 Boehringer Ingelheim International Gmbh Use of flibanserin for the treatment of post-menopausal sexual desire disorders
EP2037927B1 (en) 2006-06-30 2010-01-27 Boehringer Ingelheim International GmbH Flibanserin for the treatment of urinary incontinence and related diseases
CA2657045A1 (en) 2006-07-14 2008-01-17 Boehringer Ingelheim International Gmbh Combinations of flibanserin with caffeine, process for their preparation and use thereof as medicaments
CA2657043A1 (en) 2006-07-14 2008-01-17 Boehringer Ingelheim International Gmbh Use of flibanserin for the treatment of sexual disorders in females
CL2007002214A1 (en) 2006-08-14 2008-03-07 Boehringer Ingelheim Int PHARMACEUTICAL COMPOSITION IN THE FORM OF COMPRESSED, WHERE AT LEAST THE LENGTH OF THE COMPRESSED IN THE PREVIOUS STATE OF THE APPLICATION IS AT LEAST 7/12 OF THE PILOR DIAMETER OF THE PATIENT AND AFTER INGERING IT IN THE FOOD STATE, THE LENGTH OF THE COMP
MX2009001551A (en) 2006-08-14 2009-02-20 Boehringer Ingelheim Int Formulations of flibanserin and method for manufacturing the same.
MX2009002031A (en) 2006-08-25 2009-03-06 Boehringer Ingelheim Int Controlled release system and method for manufacturing the same.
ATE524446T1 (en) 2006-12-20 2011-09-15 Boehringer Ingelheim Int SULFATED BENZIMIDAZOLONE DERIVATIVES WITH MIXED SEROTONIN RECEPTOR AFFINITY
EP2129400A2 (en) 2007-03-28 2009-12-09 Boehringer Ingelheim International GmbH Pharmaceutical compositions comprising flibanserin and a further agent in the treatment of sexual disorders
US8486452B2 (en) 2007-07-20 2013-07-16 Mylan Pharmaceuticals Inc. Stabilized tolterodine tartrate formulations
UY31335A1 (en) 2007-09-12 2009-04-30 VASOMOTOR SYMPTOMS TREATMENT
CA2686480A1 (en) 2008-12-15 2010-06-15 Boehringer Ingelheim International Gmbh New salts

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0526434A1 (en) * 1991-07-30 1993-02-03 BOEHRINGER INGELHEIM ITALIA S.p.A. Benzimidazolone derivatives as 5-HT1A and 5-HT2 antagonists
WO2001021593A1 (en) * 1999-09-22 2001-03-29 Boehringer Ingelheim Italia S.P.A. New benzimidazolone derivatives having mixed serotonine and dopamine receptors affinity

Also Published As

Publication number Publication date
WO2003035072A1 (en) 2003-05-01
CA2458067C (en) 2009-02-10
US20130096137A1 (en) 2013-04-18
MY127290A (en) 2006-11-30
CN101347431A (en) 2009-01-21
US10307420B2 (en) 2019-06-04
US20190000842A1 (en) 2019-01-03
EP1446122A1 (en) 2004-08-18
UA78974C2 (en) 2007-05-10
HUP0401023A2 (en) 2004-08-30
US20180055839A1 (en) 2018-03-01
BR0213358A (en) 2004-10-26
DE60211937T2 (en) 2006-12-28
CN102125557A (en) 2011-07-20
US9782403B2 (en) 2017-10-10
CN1571670A (en) 2005-01-26
CN102058597A (en) 2011-05-18
KR20090130196A (en) 2009-12-18
EP1674102A1 (en) 2006-06-28
EA007274B1 (en) 2006-08-25
KR20040047931A (en) 2004-06-05
US20150342948A1 (en) 2015-12-03
MXPA04003666A (en) 2004-07-22
DK1446122T5 (en) 2006-08-14
US20170100392A1 (en) 2017-04-13
CA2458067A1 (en) 2003-05-01
ATE327757T1 (en) 2006-06-15
PL208744B1 (en) 2011-06-30
US8227471B2 (en) 2012-07-24
US10098876B2 (en) 2018-10-16
JP2005506370A (en) 2005-03-03
PT1446122E (en) 2006-08-31
ZA200401366B (en) 2005-01-26
US20030104980A1 (en) 2003-06-05
NO325556B1 (en) 2008-06-16
US9468639B2 (en) 2016-10-18
KR20110132479A (en) 2011-12-07
US7151103B2 (en) 2006-12-19
US20070072872A1 (en) 2007-03-29
EP1446122B1 (en) 2006-05-31
IL160389A (en) 2010-05-31
US20150011563A1 (en) 2015-01-08
JP2012067134A (en) 2012-04-05
DK1446122T3 (en) 2006-07-03
HRP20040352A2 (en) 2005-02-28
PL367358A1 (en) 2005-02-21
IL160389A0 (en) 2004-07-25
JP2007131631A (en) 2007-05-31
RS50876B (en) 2010-08-31
AU2002333894B2 (en) 2007-11-01
ES2266632T3 (en) 2007-03-01
CY1105082T1 (en) 2010-03-03
HUP0401023A3 (en) 2004-10-28
MEP42808A (en) 2011-05-10
NO20041588L (en) 2004-04-19
DE60211937D1 (en) 2006-07-06
SI1446122T1 (en) 2006-10-31
KR101235102B1 (en) 2013-02-20
AR037109A1 (en) 2004-10-20
AR077480A2 (en) 2011-08-31
EA200400481A1 (en) 2004-10-28
ECSP045069A (en) 2004-05-28
NZ532079A (en) 2007-03-30
YU30004A (en) 2006-08-17
US20140057923A1 (en) 2014-02-27

Similar Documents

Publication Publication Date Title
HRP20040352B1 (en) Use of flibanserin in the treatment of sexual disorders
RS51961B (en) Use of flibanserin for the treatment of pre-menopausal sexual desiredisorders
BR0114799A (en) Cyanophenoxy carboxylic acid compounds and compositions for releasing active agents
CY1106645T1 (en) 1,2,4 TRIAMINOBENZENE DERIVATIVES USEFUL FOR THE THERAPEUTIC TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM
CY1105120T1 (en) THE TREATMENT OF RESPIRATORY DISEASES
CY1108105T1 (en) IVANDRONIC ACID FOR THERAPEUTIC TREATMENT AND PREVENTION OF OSTEOPOROSIS
WO2006060507A3 (en) Compositions comprising immunomodulatory compounds and the use thereof for the treatment of immunodeficiency disorders
RS54398B1 (en) Use of flibanserin for the treatment of post-menopausal sexual desire disorders
ATE541562T1 (en) IBUPROFEN SUSPENSION
WO2002088100A3 (en) Deuterated 3-piperidinopropiophenone and medicaments containing said compounds
BR0211063A (en) Salts of anticonvulsant derivatives
EP1440689A3 (en) Treatment of neurotic disorders
BR9916887A (en) Use of pyrimidine derivatives
ECSP045242A (en) Ambroxol for the treatment of painful conditions in the oral and pharyngeal cavity
SE0002729D0 (en) Novel compound form
EE05241B1 (en) Use of the α-halogenoacryl derivative of distamycin
MY130445A (en) Novel formulations of alpha-2, 4-disulfophenyl-n-tert-butylnitrone
CY1105105T1 (en) USE OF 2-[N,N-DI(CARBOXYMEXYL) AMINO]-3-CYANO-4-CARBOXYMETHYL-THIOPHENE-5-CARBOXYLIC ACID DISTRONIUM SALT FOR THE DELIVERY OF DRUGS INTENDED FOR THE TREATMENT OF GASTRODUODENA OF PAIN
WO2003009835A3 (en) Novel use of 2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane and its physiologically acceptable salts
IS2214B (en) Treatment of migraine by administering alpha-lipoic acid or its derivatives
RS51316B (en) Novel use of (r)-(-)-2-/5-(4-fluorophenyl)-3- pyridylmethylaminomethyl/-chromane and its physiologically acceptable salts
ECSP034632A (en) USE OF 6-DIMETILAMINOMETIL-1-FENIL-CICLOHEXACO SUBSTITUTED COMPOUNDS IN URINARY INCONTINENCE THERAPY
HRP20050497B1 (en) Use of levocetirizine for the persistent allergic rhinitis
MXPA01009032A (en) Pharmaceutical composition for preventing or treating a disease associated with an excess of il-12-production.
DE60226126D1 (en) USE OF GAMMA-GT INHIBITORS FOR THE TREATMENT OF CHRONIC DEGENERATIVE DISEASES

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
B1PR Patent granted
ODRP Renewal fee for the maintenance of a patent

Payment date: 20130927

Year of fee payment: 12

PBON Lapse due to non-payment of renewal fee

Effective date: 20141004