MXPA04000140A - Derivados de beta-hidroxiamina utiles en el tratamiento de enfermedad de alzheimer. - Google Patents

Derivados de beta-hidroxiamina utiles en el tratamiento de enfermedad de alzheimer.

Info

Publication number
MXPA04000140A
MXPA04000140A MXPA04000140A MXPA04000140A MXPA04000140A MX PA04000140 A MXPA04000140 A MX PA04000140A MX PA04000140 A MXPA04000140 A MX PA04000140A MX PA04000140 A MXPA04000140 A MX PA04000140A MX PA04000140 A MXPA04000140 A MX PA04000140A
Authority
MX
Mexico
Prior art keywords
beta
alzheimer
disease
treatment
derivatives useful
Prior art date
Application number
MXPA04000140A
Other languages
English (en)
Inventor
Varghese John
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of MXPA04000140A publication Critical patent/MXPA04000140A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/84—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6

Abstract

La invencion se refiere a compuestos de alcohol sustituido de la formula (I), en donde X, R1, R2, R3, RN, R20 y Rc se definen en la presente. Los compuestos son utiles en el tratamiento o prevencion de la enfermedad de Alzheimer y de manera mas especifica a compuestos que son capaces de medir la beta-secretasa una enzima que escinde con proteina precursora amiloide para producir peptido beta-amiloide (A- beta), y un componente principal de las placas amiloides encontradas en los cerebros de los pacientes con Alzheimer.
MXPA04000140A 2001-06-27 2002-06-27 Derivados de beta-hidroxiamina utiles en el tratamiento de enfermedad de alzheimer. MXPA04000140A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30121001P 2001-06-27 2001-06-27
US32339601P 2001-09-18 2001-09-18
US33273601P 2001-11-19 2001-11-19
PCT/US2002/020754 WO2003002122A1 (en) 2001-06-27 2002-06-27 Beta-hydroxyamine derivatives useful in treatment of alzheimer's disease

Publications (1)

Publication Number Publication Date
MXPA04000140A true MXPA04000140A (es) 2004-06-03

Family

ID=27404798

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04000140A MXPA04000140A (es) 2001-06-27 2002-06-27 Derivados de beta-hidroxiamina utiles en el tratamiento de enfermedad de alzheimer.

Country Status (7)

Country Link
US (2) US6982264B2 (es)
EP (1) EP1401452A1 (es)
JP (1) JP2005500319A (es)
BR (1) BR0210721A (es)
CA (1) CA2452039A1 (es)
MX (1) MXPA04000140A (es)
WO (1) WO2003002122A1 (es)

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US20030083518A1 (en) 2003-05-01
US20060178345A1 (en) 2006-08-10
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JP2005500319A (ja) 2005-01-06
US6982264B2 (en) 2006-01-03

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