SE0102764D0 - Compounds - Google Patents

Compounds

Info

Publication number
SE0102764D0
SE0102764D0 SE0102764A SE0102764A SE0102764D0 SE 0102764 D0 SE0102764 D0 SE 0102764D0 SE 0102764 A SE0102764 A SE 0102764A SE 0102764 A SE0102764 A SE 0102764A SE 0102764 D0 SE0102764 D0 SE 0102764D0
Authority
SE
Sweden
Prior art keywords
compounds
preparation
glk
iif
glucokinase
Prior art date
Application number
SE0102764A
Other languages
English (en)
Swedish (sv)
Inventor
Scott Boyd
Peter Caulkett
Rodney Hargreaves
Suzanne Howcroft
Cliff Jones
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Priority to SE0102764A priority Critical patent/SE0102764D0/xx
Publication of SE0102764D0 publication Critical patent/SE0102764D0/xx
Priority to EP06001806A priority patent/EP1661568B1/en
Priority to PCT/GB2002/003745 priority patent/WO2003015774A1/en
Priority to AT04028298T priority patent/ATE334678T1/de
Priority to EP06009486A priority patent/EP1695705B1/en
Priority to CN200910224498A priority patent/CN101704797A/zh
Priority to CA2457410A priority patent/CA2457410C/en
Priority to DE60227122T priority patent/DE60227122D1/de
Priority to PT06001808T priority patent/PT1661563E/pt
Priority to SI200230559T priority patent/SI1568367T1/sl
Priority to AT06001809T priority patent/ATE397928T1/de
Priority to AT06001808T priority patent/ATE396720T1/de
Priority to JP2003520733A priority patent/JP3987829B2/ja
Priority to ES06001807T priority patent/ES2307239T3/es
Priority to EP06001809A priority patent/EP1669068B1/en
Priority to ES06001806T priority patent/ES2312050T3/es
Priority to DK06001807T priority patent/DK1661569T3/da
Priority to DE60219698T priority patent/DE60219698T3/de
Priority to EP04028298A priority patent/EP1529530B3/en
Priority to BR0212008-9A priority patent/BR0212008A/pt
Priority to ES06001810T priority patent/ES2312051T3/es
Priority to DK04028297T priority patent/DK1568367T5/da
Priority to DK04028298T priority patent/DK1529530T5/da
Priority to ES04028297T priority patent/ES2285341T7/es
Priority to HU0401213A priority patent/HUP0401213A3/hu
Priority to AU2002321462A priority patent/AU2002321462B2/en
Priority to EP04028297A priority patent/EP1568367B3/en
Priority to MXPA04001500A priority patent/MXPA04001500A/es
Priority to ES06001809T priority patent/ES2308609T3/es
Priority to AT06001805T priority patent/ATE397926T1/de
Priority to DE60228143T priority patent/DE60228143D1/de
Priority to EP06001805A priority patent/EP1661567B1/en
Priority to DE60227119T priority patent/DE60227119D1/de
Priority to UA2004020927A priority patent/UA83182C2/ru
Priority to PT04028298T priority patent/PT1529530E/pt
Priority to AT06001807T priority patent/ATE397927T1/de
Priority to ES06001796T priority patent/ES2307237T3/es
Priority to EP06001807A priority patent/EP1661569B1/en
Priority to DE60228770T priority patent/DE60228770D1/de
Priority to PT06001807T priority patent/PT1661569E/pt
Priority to CNA2009101454369A priority patent/CN101584691A/zh
Priority to DE60226914T priority patent/DE60226914D1/de
Priority to KR1020047002287A priority patent/KR100920439B1/ko
Priority to SI200230710T priority patent/SI1661569T1/sl
Priority to ES06001805T priority patent/ES2307238T3/es
Priority to CN02820347A priority patent/CN100577163C/zh
Priority to EP08161275A priority patent/EP1987831A1/en
Priority to AT02755165T priority patent/ATE323487T1/de
Priority to AT06001806T priority patent/ATE406891T1/de
Priority to PT06001809T priority patent/PT1669068E/pt
Priority to DE60227121T priority patent/DE60227121D1/de
Priority to CN2008101903170A priority patent/CN101492416B/zh
Priority to DE60227120T priority patent/DE60227120D1/de
Priority to DK06001809T priority patent/DK1669068T3/da
Priority to DE60210782T priority patent/DE60210782T2/de
Priority to EP06001810A priority patent/EP1669069B1/en
Priority to EP06001796A priority patent/EP1674097B1/en
Priority to AT06001810T priority patent/ATE407672T1/de
Priority to NZ531193A priority patent/NZ531193A/en
Priority to SI200230703T priority patent/SI1661563T1/sl
Priority to EP02755165A priority patent/EP1420784B1/en
Priority to RU2004104333/15A priority patent/RU2329043C9/ru
Priority to PL02368970A priority patent/PL368970A1/xx
Priority to DE60228897T priority patent/DE60228897D1/de
Priority to DE60213678T priority patent/DE60213678T3/de
Priority to IL16021902A priority patent/IL160219A0/xx
Priority to ES06009486T priority patent/ES2309862T3/es
Priority to DK06001808T priority patent/DK1661563T3/da
Priority to AT04028297T priority patent/ATE359781T1/de
Priority to EP06001808A priority patent/EP1661563B1/en
Priority to AT06009486T priority patent/ATE403427T1/de
Priority to SI200230410T priority patent/SI1529530T1/sl
Priority to ES04028298T priority patent/ES2270263T7/es
Priority to AT06001796T priority patent/ATE397929T1/de
Priority to HK04107483.5A priority patent/HK1064598B/en
Priority to SI200230709T priority patent/SI1669068T1/sl
Priority to PT04028297T priority patent/PT1568367E/pt
Priority to ES06001808T priority patent/ES2306300T3/es
Priority to US10/486,496 priority patent/US7390908B2/en
Priority to TW097137990A priority patent/TWI333855B/zh
Priority to ARP020103107A priority patent/AR037898A1/es
Priority to ZA200401015A priority patent/ZA200401015B/xx
Priority to IS7150A priority patent/IS7150A/is
Priority to NO20040686A priority patent/NO20040686L/no
Priority to CO04022003A priority patent/CO5560563A2/es
Priority to HK05108225.5A priority patent/HK1076042B/en
Priority to HK06110634.5A priority patent/HK1089958B/en
Priority to HK06113586.7A priority patent/HK1093429B/en
Priority to HK05111879.8A priority patent/HK1079692B/en
Priority to JP2005168987A priority patent/JP4441446B2/ja
Priority to HK06110673.7A priority patent/HK1089960B/en
Priority to HK06110762.9A priority patent/HK1089966B/en
Priority to HK06110988.7A priority patent/HK1090291B/en
Priority to HK06111020.5A priority patent/HK1090292B/en
Priority to HK06111482.6A priority patent/HK1090839B/en
Priority to CY20061101565T priority patent/CY1105746T1/el
Priority to CY20071100836T priority patent/CY1107683T1/el
Priority to US12/024,561 priority patent/US7524957B2/en
Priority to CY20081100851T priority patent/CY1108254T1/el
Priority to CY20081100873T priority patent/CY1108267T1/el
Priority to CY20081100889T priority patent/CY1108276T1/el
Priority to US12/363,899 priority patent/US7951830B2/en
Priority to IL203923A priority patent/IL203923A/en
Priority to MYPI2010005251A priority patent/MY146279A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/44—Acylated amino or imino radicals
    • C07D277/46—Acylated amino or imino radicals by carboxylic acids, or sulfur or nitrogen analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
SE0102764A 2001-08-17 2001-08-17 Compounds SE0102764D0 (sv)

Priority Applications (104)

Application Number Priority Date Filing Date Title
SE0102764A SE0102764D0 (sv) 2001-08-17 2001-08-17 Compounds
EP06001806A EP1661568B1 (en) 2001-08-17 2002-08-15 Compounds effecting Glucokinase
PCT/GB2002/003745 WO2003015774A1 (en) 2001-08-17 2002-08-15 Compounds effecting glucokinase
AT04028298T ATE334678T1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende verbindungen
EP06009486A EP1695705B1 (en) 2001-08-17 2002-08-15 Compounds effecting glucokinase
CN200910224498A CN101704797A (zh) 2001-08-17 2002-08-15 影响葡糖激酶的化合物
CA2457410A CA2457410C (en) 2001-08-17 2002-08-15 Compounds effecting glucokinase
DE60227122T DE60227122D1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende Verbindungen
PT06001808T PT1661563E (pt) 2001-08-17 2002-08-15 Compostos com efeito sobre a glucocinase
SI200230559T SI1568367T1 (sl) 2001-08-17 2002-08-15 Spojine, ki vplivajo na glukokinazo
AT06001809T ATE397928T1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende verbindungen
AT06001808T ATE396720T1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende verbindungen
JP2003520733A JP3987829B2 (ja) 2001-08-17 2002-08-15 グルコキナーゼ化合物
ES06001807T ES2307239T3 (es) 2001-08-17 2002-08-15 Compuestos que ejercen accion sobre la glucoquinasa.
EP06001809A EP1669068B1 (en) 2001-08-17 2002-08-15 Compounds effecting Glucokinase
ES06001806T ES2312050T3 (es) 2001-08-17 2002-08-15 Compuestos que tienen efecto sobre glucoquinasa.
DK06001807T DK1661569T3 (da) 2001-08-17 2002-08-15 Forbindelser, der påvirker glucokinase
DE60219698T DE60219698T3 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende Verbindungen
EP04028298A EP1529530B3 (en) 2001-08-17 2002-08-15 Compounds affecting glucokinase
BR0212008-9A BR0212008A (pt) 2001-08-17 2002-08-15 Uso de um composto ou de um sal, solvato ou pró-medicamento deste, composição farmacêutica, composto ou um sal, solvato ou pró-medicamento deste, e, processo para a preparação deste
ES06001810T ES2312051T3 (es) 2001-08-17 2002-08-15 Compuestos que ejercen efecto sobre la glucoquinasa.
DK04028297T DK1568367T5 (da) 2001-08-17 2002-08-15 Glucokinase påvirkende forbindelser
DK04028298T DK1529530T5 (da) 2001-08-17 2002-08-15 Glucokinase påvirkende forbindelser
ES04028297T ES2285341T7 (es) 2001-08-17 2002-08-15 Compuestos que ejercen una accion sobre la glucoquinasa.
HU0401213A HUP0401213A3 (en) 2001-08-17 2002-08-15 Compounds effecting glucokinase, process for their preparation and their use for production of pharmaceutical compositions
AU2002321462A AU2002321462B2 (en) 2001-08-17 2002-08-15 Compounds effecting glucokinase
EP04028297A EP1568367B3 (en) 2001-08-17 2002-08-15 Compounds effecting glucokinase
MXPA04001500A MXPA04001500A (es) 2001-08-17 2002-08-15 Compuestos que tienen un efecto sobre la glucocinasa.
ES06001809T ES2308609T3 (es) 2001-08-17 2002-08-15 Compuestos que ejercen efecto sobre la glucoquinasa.
AT06001805T ATE397926T1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende verbindungen
DE60228143T DE60228143D1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende Verbindungen
EP06001805A EP1661567B1 (en) 2001-08-17 2002-08-15 Compounds effecting Glucokinase
DE60227119T DE60227119D1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende Verbindungen
UA2004020927A UA83182C2 (en) 2001-08-17 2002-08-15 Compounds effecting glucokinase
PT04028298T PT1529530E (pt) 2001-08-17 2002-08-15 Compostos que afectam a clucocinase
AT06001807T ATE397927T1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende verbindungen
ES06001796T ES2307237T3 (es) 2001-08-17 2002-08-15 Compuestos que ejercen efecto sobre la glucoquinasa.
EP06001807A EP1661569B1 (en) 2001-08-17 2002-08-15 Compounds effecting glucokinase
DE60228770T DE60228770D1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende Verbindungen
PT06001807T PT1661569E (pt) 2001-08-17 2002-08-15 Compostos com efeito sobre a glucocinase
CNA2009101454369A CN101584691A (zh) 2001-08-17 2002-08-15 影响葡糖激酶的化合物
DE60226914T DE60226914D1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende Verbindungen
KR1020047002287A KR100920439B1 (ko) 2001-08-17 2002-08-15 글루코키나제에 작용하는 화합물
SI200230710T SI1661569T1 (sl) 2001-08-17 2002-08-15 Spojine, ki učinkujejo na glukokinazo
ES06001805T ES2307238T3 (es) 2001-08-17 2002-08-15 Compuestos que ejercen accion sobre la glucoquinasa.
CN02820347A CN100577163C (zh) 2001-08-17 2002-08-15 影响葡糖激酶的化合物
EP08161275A EP1987831A1 (en) 2001-08-17 2002-08-15 Compounds effecting glucokinase
AT02755165T ATE323487T1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende verbindungen
AT06001806T ATE406891T1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende verbindungen
PT06001809T PT1669068E (pt) 2001-08-17 2002-08-15 Compostos com efeito sobre a glucocinase
DE60227121T DE60227121D1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende Verbindungen
CN2008101903170A CN101492416B (zh) 2001-08-17 2002-08-15 影响葡糖激酶的化合物
DE60227120T DE60227120D1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende Verbindungen
DK06001809T DK1669068T3 (da) 2001-08-17 2002-08-15 Forbindelser, der påvirker glucokinase
DE60210782T DE60210782T2 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende verbindungen
EP06001810A EP1669069B1 (en) 2001-08-17 2002-08-15 Compounds effecting glukokinase
EP06001796A EP1674097B1 (en) 2001-08-17 2002-08-15 Compounds effecting glucokinase
AT06001810T ATE407672T1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende verbindungen
NZ531193A NZ531193A (en) 2001-08-17 2002-08-15 Compounds effecting glucokinase
SI200230703T SI1661563T1 (sl) 2001-08-17 2002-08-15 Spojina, ki učinkuje na glukokinazo
EP02755165A EP1420784B1 (en) 2001-08-17 2002-08-15 Compounds effecting glucokinase
RU2004104333/15A RU2329043C9 (ru) 2001-08-17 2002-08-15 Соединения, воздействующие на глюкокиназу
PL02368970A PL368970A1 (en) 2001-08-17 2002-08-15 Compounds effecting glucokinase
DE60228897T DE60228897D1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende Verbindungen
DE60213678T DE60213678T3 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende Verbindungen
IL16021902A IL160219A0 (en) 2001-08-17 2002-08-15 Compounds effecting glucokinase
ES06009486T ES2309862T3 (es) 2001-08-17 2002-08-15 Compuestos que ejercen efecto sobre la glucoquinasa.
DK06001808T DK1661563T3 (da) 2001-08-17 2002-08-15 Forbindelser der påvirker ghicokinase
AT04028297T ATE359781T1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende verbindungen
EP06001808A EP1661563B1 (en) 2001-08-17 2002-08-15 Compound effecting Glucokinase
AT06009486T ATE403427T1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende verbindungen
SI200230410T SI1529530T1 (sl) 2001-08-17 2002-08-15 Spojine, ki vplivajo na glukokinazo
ES04028298T ES2270263T7 (es) 2001-08-17 2002-08-15 Compuestos que ejercen una accion sobre la glucoquinasa.
AT06001796T ATE397929T1 (de) 2001-08-17 2002-08-15 Glukokinase beeinflussende verbindungen
HK04107483.5A HK1064598B (en) 2001-08-17 2002-08-15 Compounds effecting glucokinase
SI200230709T SI1669068T1 (sl) 2001-08-17 2002-08-15 Spojine, ki učinkujejo na glukokinazo
PT04028297T PT1568367E (pt) 2001-08-17 2002-08-15 Compostos com um efeito sobre a glucocinase
ES06001808T ES2306300T3 (es) 2001-08-17 2002-08-15 Compuesto que ejerce efecto sobre la glucoquinasa.
US10/486,496 US7390908B2 (en) 2001-08-17 2002-08-15 Compounds effecting glucokinase
TW097137990A TWI333855B (en) 2001-08-17 2002-08-16 Benzamide compounds, process for preparation thereof, and pharmaceutical compositions for treating or preventing a disease or medical condition mediated through glucokinase (glk) comprising same
ARP020103107A AR037898A1 (es) 2001-08-17 2002-08-16 Compuesto de benzamida, uso de un compuesto de benzamida en la fabricacion de un medicamento, proceso para su preparacion y composicion farmaceutica que lo comprende
ZA200401015A ZA200401015B (en) 2001-08-17 2004-02-06 Compounds effecting glucokinase.
IS7150A IS7150A (is) 2001-08-17 2004-02-13 Efnasambönd sem hafa áhrif á glúkókínasa
NO20040686A NO20040686L (no) 2001-08-17 2004-02-17 Forbindelser som pavirker glukokinase
CO04022003A CO5560563A2 (es) 2001-08-17 2004-03-10 Compuestos derivados de benzamida de formula iif que afectan la glucocinasa
HK05108225.5A HK1076042B (en) 2001-08-17 2004-09-28 Compounds affecting glucokinase
HK06110634.5A HK1089958B (en) 2001-08-17 2004-09-28 Compounds effecting glucokinase
HK06113586.7A HK1093429B (en) 2001-08-17 2004-09-28 Compounds effecting glucokinase
HK05111879.8A HK1079692B (en) 2001-08-17 2004-09-28 Compounds effecting glucokinase
JP2005168987A JP4441446B2 (ja) 2001-08-17 2005-06-09 グルコキナーゼ化合物
HK06110673.7A HK1089960B (en) 2001-08-17 2006-09-25 Compound effecting glucokinase
HK06110762.9A HK1089966B (en) 2001-08-17 2006-09-27 Compounds effecting glucokinase
HK06110988.7A HK1090291B (en) 2001-08-17 2006-10-04 Compounds effecting glucokinase
HK06111020.5A HK1090292B (en) 2001-08-17 2006-10-05 Compounds effecting glukokinase
HK06111482.6A HK1090839B (en) 2001-08-17 2006-10-18 Compounds effecting glucokinase
CY20061101565T CY1105746T1 (el) 2001-08-17 2006-11-01 Eνωσεις που επηρεαζουν τη γλυκοκιναση
CY20071100836T CY1107683T1 (el) 2001-08-17 2007-06-22 Ενωσεις που επηρεαζουν τη γλυκοκιναση
US12/024,561 US7524957B2 (en) 2001-08-17 2008-02-01 Compounds effecting glucokinase
CY20081100851T CY1108254T1 (el) 2001-08-17 2008-08-12 Ενωσεις που επηρεαζουν τη γλυκοκιναση
CY20081100873T CY1108267T1 (el) 2001-08-17 2008-08-18 Ενωσεις που επηρεαζουν τη γλυκοκιναση
CY20081100889T CY1108276T1 (el) 2001-08-17 2008-08-21 Ενωσεις που επηρεαζουν τη γλυκοκιναση
US12/363,899 US7951830B2 (en) 2001-08-17 2009-02-02 Compounds effecting glucokinase
IL203923A IL203923A (en) 2001-08-17 2010-02-11 Benzamide compounds, pharmaceutical compositions comprising them, use thereof in the preparation of medicaments and as medicaments and processes for the preparation of such compounds
MYPI2010005251A MY146279A (en) 2001-08-17 2010-11-09 Compounds affecting glucokinase

Applications Claiming Priority (1)

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SE0102764A SE0102764D0 (sv) 2001-08-17 2001-08-17 Compounds

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US (3) US7390908B2 (https=)
EP (12) EP1661567B1 (https=)
JP (2) JP3987829B2 (https=)
KR (1) KR100920439B1 (https=)
CN (4) CN101704797A (https=)
AR (1) AR037898A1 (https=)
AT (11) ATE397928T1 (https=)
AU (1) AU2002321462B2 (https=)
BR (1) BR0212008A (https=)
CA (1) CA2457410C (https=)
CO (1) CO5560563A2 (https=)
CY (5) CY1105746T1 (https=)
DE (11) DE60228770D1 (https=)
DK (5) DK1529530T5 (https=)
ES (10) ES2309862T3 (https=)
HU (1) HUP0401213A3 (https=)
IL (2) IL160219A0 (https=)
IS (1) IS7150A (https=)
MX (1) MXPA04001500A (https=)
MY (1) MY146279A (https=)
NO (1) NO20040686L (https=)
NZ (1) NZ531193A (https=)
PL (1) PL368970A1 (https=)
PT (5) PT1661569E (https=)
RU (1) RU2329043C9 (https=)
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