ES2180664T3 - Derivados de aril- y heteroarilsulfonamida, obtencion y uso de los mismos en calidad de antagonistas de endotelina. - Google Patents
Derivados de aril- y heteroarilsulfonamida, obtencion y uso de los mismos en calidad de antagonistas de endotelina.Info
- Publication number
- ES2180664T3 ES2180664T3 ES95941660T ES95941660T ES2180664T3 ES 2180664 T3 ES2180664 T3 ES 2180664T3 ES 95941660 T ES95941660 T ES 95941660T ES 95941660 T ES95941660 T ES 95941660T ES 2180664 T3 ES2180664 T3 ES 2180664T3
- Authority
- ES
- Spain
- Prior art keywords
- signifies
- alkyl
- phenyl
- heterocyclyl
- substituted phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/67—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfonamide groups, bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Steroid Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
COMPUESTOS DE FORMULA (I) DONDE R 1 SIGNIFICA FENILO, FENILO SUSTITUIDO O HETEROCICLO; R{SUP,2} SIGNIFICA FENILO O FENILO SUSTITUIDO; R{SUP,3} SIGNIFICA HIDROGENO, ALQUILO DE BAJO PESO MOLECULAR, CIANO, CARBOXI, CARBOXI ESTERIFICADO, FENILO, FENILO SUSTITUIDO, HETEROCICLO O UN RESIDUO - CONR{SUP,5}R{SUP,6} O - NR{SUP,5}COR{SUP,7}; R{SUP,4} SIGNIFICA HIDROGENO O ALQUILO DE BAJO PESO MOLECULAR; R{SUP,5} SIGNIFICA HIDROGENO O UN RESIDUO R{SUP,7}, Y R{SUP,6} SIGNIFICA - (CH{SUB,2}){SUB,M}R{SUP,7}; O R{SUP,5} Y R{SUP,6} JUNTO AL ATOMO DE N ASOCIADO A ELLOS SIGNIFICA UN RESTO HETEROCICLO; R{SUP,7} SIGNIFICA FENILO, FENILO SUSTITUIDO, CICLOALQUILO, HETEROCICLO, ALQUILO DE BAJO PESO MOLECULAR, CIANOALQUILO DE BAJO PESO MOLECULAR, HIDROXIALQUILO DE BAJO PESO MOLECULAR, DI - ALQUILAMINO DE BAJO PESO MOLECULAR ALQUILO DE BAJO PESO MOLECULAR, CARBOXIALQUILO DE BAJO PESO MOLECULAR, ALCOXICARBONILO DE BAJO PESO MOLECULAR - ALQUILO DE BAJO PESO MOLECULAR, ALCOXICARBONILAMINO DE BAJO PESO MOLECULAR ALQUILODE BAJO PESO MOLECULAR O FENILO - ALCOXICARBONILO DE BAJO PESO MOLECULAR; R{SUP,A} SIGNIFICA HIDROGENO, ALQUILO DE BAJO PESO MOLECULAR O HIDROXI; R{SUP,B} SIGNIFICA HIDROGENO O ALQUILO DE BAJO PESO MOLECULAR; Z SIGNIFICA HIDROXI, AMINO O UN RESIDUO - OR{SUP,8}, - OC(O)NHR{SUP,8}, - OC(O)OR{SUP,8}, NHC(O)NHR{SUP,8} O - NHC(O)OR{SUP,8}; R{SUP,8} SIGNIFICA HETEROCICLO, FENILO, FENILO SUSTITUIDO O ALQUILO DE BAJO PESO MOLECULAR; A E Y SIGNIFICAN INDEPENDIENTEMENTE OXIGENO O AZUFRE; X SIGNIFICA NITROGENO O CH; M SIGNIFICA 0, 1 O 2; Y N SIGNIFICA 0, 1 O 2; Y SALES UTILES FARMACEUTICAMENTE; SON INHIBIDORES DE LOS RECEPTORES DE ENDOTELINA. POR TANTO PUEDEN UTILIZARSE PARA EL TRATAMIENTO DE ALTERACIONES ASOCIADAS A LAS ACTIVIDADES DE ENDOTELINA, ESPECIALMENTE TRASTORNOS CIRCULATORIOS COMO HIPERTENSION, ISQUEMIA, VASOESPASMO Y ANGINA DE PECHO.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH383894 | 1994-12-20 | ||
| CH307995 | 1995-10-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2180664T3 true ES2180664T3 (es) | 2003-02-16 |
Family
ID=31189207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES95941660T Expired - Lifetime ES2180664T3 (es) | 1994-12-20 | 1995-12-04 | Derivados de aril- y heteroarilsulfonamida, obtencion y uso de los mismos en calidad de antagonistas de endotelina. |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US5962682A (es) |
| EP (1) | EP0799206B1 (es) |
| JP (1) | JP2930731B2 (es) |
| KR (1) | KR100432843B1 (es) |
| CN (1) | CN1136192C (es) |
| AT (1) | ATE223899T1 (es) |
| AU (1) | AU695255B2 (es) |
| BR (1) | BR9510533A (es) |
| CA (1) | CA2208011A1 (es) |
| CZ (1) | CZ289090B6 (es) |
| DE (1) | DE69528198T2 (es) |
| DK (1) | DK0799206T3 (es) |
| ES (1) | ES2180664T3 (es) |
| FI (1) | FI116622B (es) |
| HU (1) | HUT77307A (es) |
| IL (1) | IL116410A (es) |
| MA (1) | MA23745A1 (es) |
| MX (1) | MX9704588A (es) |
| MY (1) | MY113214A (es) |
| NO (1) | NO308297B1 (es) |
| NZ (1) | NZ297774A (es) |
| PT (1) | PT799206E (es) |
| RU (1) | RU2163598C2 (es) |
| TW (1) | TW474920B (es) |
| WO (1) | WO1996019455A1 (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5962490A (en) | 1987-09-25 | 1999-10-05 | Texas Biotechnology Corporation | Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6613804B2 (en) | 1993-05-20 | 2003-09-02 | Encysive Pharmaceuticals, Inc. | Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6541498B2 (en) | 1993-05-20 | 2003-04-01 | Texas Biotechnology | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| US6342610B2 (en) | 1993-05-20 | 2002-01-29 | Texas Biotechnology Corp. | N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6376523B1 (en) | 1994-05-20 | 2002-04-23 | Texas Biotechnology Corporation | Benzenesulfonamides and the use thereof to modulate the activity of endothelin |
| DK0799206T3 (da) * | 1994-12-20 | 2003-01-27 | Hoffmann La Roche | Aryl- og heteroaryl-sulfonamidderivater, fremstillingen deraf og anvendelsen deraf som endothelinantagonister |
| US5977117A (en) | 1996-01-05 | 1999-11-02 | Texas Biotechnology Corporation | Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin |
| US5804585A (en) | 1996-04-15 | 1998-09-08 | Texas Biotechnology Corporation | Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin |
| US6653331B2 (en) * | 1996-07-03 | 2003-11-25 | Pharmacia & Upjohn Company | Targeted drug delivery using sulfonamide derivatives |
| HU227183B1 (en) | 1997-04-28 | 2010-09-28 | Encysive Pharmaceuticals Inc | Sulfonamide derivatives and pharmaceutical compositions containing them for the treatment of endothelin-mediated disorders |
| US5783705A (en) | 1997-04-28 | 1998-07-21 | Texas Biotechnology Corporation | Process of preparing alkali metal salys of hydrophobic sulfonamides |
| US6191170B1 (en) * | 1998-01-13 | 2001-02-20 | Tularik Inc. | Benzenesulfonamides and benzamides as therapeutic agents |
| CA2315614C (en) | 1999-07-29 | 2004-11-02 | Pfizer Inc. | Pyrazoles |
| CN1407973A (zh) * | 1999-12-22 | 2003-04-02 | 埃科特莱茵药品有限公司 | 丁炔二醇衍生物 |
| CA2395684C (en) | 1999-12-31 | 2012-01-03 | Texas Biotechnology Corporation | Sulfonamides and derivatives thereof that modulate the activity of endothelin |
| US6387915B2 (en) | 2000-05-31 | 2002-05-14 | Pfizer Inc. | Isoxazole-sulfonamide endothelin antagonists |
| US6670362B2 (en) | 2000-09-20 | 2003-12-30 | Pfizer Inc. | Pyridazine endothelin antagonists |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| NZ541234A (en) | 2002-12-20 | 2008-06-30 | Amgen Inc | Asthma and allergic inflammation modulators |
| WO2004074438A2 (en) * | 2003-02-14 | 2004-09-02 | Smithkline Beecham Corporation | Ccr8 antagonists |
| WO2004073619A2 (en) * | 2003-02-14 | 2004-09-02 | Smithkline Beecham Corporation | Ccr8 antagonists |
| CA2707789A1 (en) | 2007-12-19 | 2009-07-09 | Amgen Inc. | Phenyl acetic acid derivatives as inflammation modulators |
| WO2010015623A1 (en) * | 2008-08-05 | 2010-02-11 | Farmaprojects, S. A. | Process for the preparation of endothelin receptor antagonists |
| AR076221A1 (es) | 2009-04-09 | 2011-05-26 | Astrazeneca Ab | Derivado de pirazol [4,5-e] pirimidina y su uso para tratar diabetes y obesidad |
| CN110092743B (zh) * | 2018-01-30 | 2022-03-15 | 中国医学科学院药物研究所 | 苯甲酰胺类化合物及其制备方法、用途和药物组合物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1521932A (en) * | 1976-03-08 | 1978-08-16 | Labaz | Sulphonamide derivatives and process for preparing the same |
| GB8708233D0 (en) * | 1987-04-07 | 1987-05-13 | Smith Kline French Lab | Pharmaceutically active compounds |
| EP0472053B1 (en) * | 1990-08-20 | 1998-06-17 | Eisai Co., Ltd. | Sulfonamide derivatives |
| TW270116B (es) * | 1991-04-25 | 1996-02-11 | Hoffmann La Roche | |
| RU2086544C1 (ru) * | 1991-06-13 | 1997-08-10 | Хоффманн-Ля Рош АГ | Бензолсульфонамидные производные пиримидина или их соли, фармацевтическая композиция для лечения заболеваний, связанных с активностью эндотелина |
| NZ247440A (en) * | 1992-05-06 | 1995-04-27 | Squibb & Sons Inc | Phenyl sulphonamide derivatives, preparation and pharmaceutical compositions thereof |
| TW287160B (es) * | 1992-12-10 | 1996-10-01 | Hoffmann La Roche | |
| IL111959A (en) * | 1993-12-17 | 2000-07-16 | Tanabe Seiyaku Co | N-(polysubstituted pyrimidin-4-yl) benzenesulfonamide derivatives their preparation and pharmaceutical compositions containing them |
| GB9504854D0 (en) * | 1994-03-31 | 1995-04-26 | Zeneca Ltd | Nitrogen derivatives |
| DK0799206T3 (da) * | 1994-12-20 | 2003-01-27 | Hoffmann La Roche | Aryl- og heteroaryl-sulfonamidderivater, fremstillingen deraf og anvendelsen deraf som endothelinantagonister |
-
1995
- 1995-12-04 DK DK95941660T patent/DK0799206T3/da active
- 1995-12-04 US US08/860,985 patent/US5962682A/en not_active Expired - Fee Related
- 1995-12-04 NZ NZ297774A patent/NZ297774A/xx unknown
- 1995-12-04 AU AU43016/96A patent/AU695255B2/en not_active Ceased
- 1995-12-04 JP JP8519459A patent/JP2930731B2/ja not_active Expired - Fee Related
- 1995-12-04 WO PCT/EP1995/004762 patent/WO1996019455A1/en active IP Right Grant
- 1995-12-04 CA CA002208011A patent/CA2208011A1/en not_active Abandoned
- 1995-12-04 HU HU9701811A patent/HUT77307A/hu unknown
- 1995-12-04 CN CNB951969595A patent/CN1136192C/zh not_active Expired - Fee Related
- 1995-12-04 EP EP95941660A patent/EP0799206B1/en not_active Expired - Lifetime
- 1995-12-04 CZ CZ19971873A patent/CZ289090B6/cs not_active IP Right Cessation
- 1995-12-04 DE DE69528198T patent/DE69528198T2/de not_active Expired - Fee Related
- 1995-12-04 RU RU97112144/04A patent/RU2163598C2/ru active
- 1995-12-04 BR BR9510533A patent/BR9510533A/pt not_active IP Right Cessation
- 1995-12-04 PT PT95941660T patent/PT799206E/pt unknown
- 1995-12-04 KR KR1019970704136A patent/KR100432843B1/ko not_active IP Right Cessation
- 1995-12-04 AT AT95941660T patent/ATE223899T1/de not_active IP Right Cessation
- 1995-12-04 ES ES95941660T patent/ES2180664T3/es not_active Expired - Lifetime
- 1995-12-06 TW TW084113009A patent/TW474920B/zh active
- 1995-12-15 MA MA24096A patent/MA23745A1/fr unknown
- 1995-12-15 IL IL11641095A patent/IL116410A/xx not_active IP Right Cessation
- 1995-12-18 MY MYPI95003929A patent/MY113214A/en unknown
-
1997
- 1997-06-18 FI FI972629A patent/FI116622B/fi not_active IP Right Cessation
- 1997-06-19 MX MX9704588A patent/MX9704588A/es not_active IP Right Cessation
- 1997-06-19 NO NO972841A patent/NO308297B1/no not_active IP Right Cessation
-
1999
- 1999-03-05 US US09/263,034 patent/US6133442A/en not_active Expired - Fee Related
Also Published As
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