NO329105B1 - Karbamatsubstituerte pyrazolopyridiner, fremgangsmåte for fremstilling derav, anvendelse derav samt lagemidler inneholdende forbindelsene - Google Patents

Karbamatsubstituerte pyrazolopyridiner, fremgangsmåte for fremstilling derav, anvendelse derav samt lagemidler inneholdende forbindelsene Download PDF

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Publication number
NO329105B1
NO329105B1 NO20045277A NO20045277A NO329105B1 NO 329105 B1 NO329105 B1 NO 329105B1 NO 20045277 A NO20045277 A NO 20045277A NO 20045277 A NO20045277 A NO 20045277A NO 329105 B1 NO329105 B1 NO 329105B1
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Norway
Prior art keywords
formula
compounds
stands
compound
methyl
Prior art date
Application number
NO20045277A
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English (en)
Norwegian (no)
Other versions
NO20045277L (no
Inventor
Erwin Bischoff
Johannes-Peter Stasch
Achim Feurer
Elke Stahl
Cristina Alonso-Alija
Stefan Weigand
Klaus Muenter
Original Assignee
Bayer Schering Pharma Ag
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=29265155&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO329105(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Publication of NO20045277L publication Critical patent/NO20045277L/no
Publication of NO329105B1 publication Critical patent/NO329105B1/no
Priority to NO2014018C priority Critical patent/NO2014018I2/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
  • Psychiatry (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO20045277A 2002-05-08 2004-12-01 Karbamatsubstituerte pyrazolopyridiner, fremgangsmåte for fremstilling derav, anvendelse derav samt lagemidler inneholdende forbindelsene NO329105B1 (no)

Priority Applications (1)

Application Number Priority Date Filing Date Title
NO2014018C NO2014018I2 (no) 2002-05-08 2014-07-18 Riociguat eller et salt, en enantiomer eller et hydrat derav

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10220570A DE10220570A1 (de) 2002-05-08 2002-05-08 Carbamat-substituierte Pyrazolopyridine
PCT/EP2003/004304 WO2003095451A1 (de) 2002-05-08 2003-04-25 Carbamat-substituierte pyrazolopyridine

Publications (2)

Publication Number Publication Date
NO20045277L NO20045277L (no) 2004-12-01
NO329105B1 true NO329105B1 (no) 2010-08-23

Family

ID=29265155

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20045277A NO329105B1 (no) 2002-05-08 2004-12-01 Karbamatsubstituerte pyrazolopyridiner, fremgangsmåte for fremstilling derav, anvendelse derav samt lagemidler inneholdende forbindelsene
NO2014018C NO2014018I2 (no) 2002-05-08 2014-07-18 Riociguat eller et salt, en enantiomer eller et hydrat derav

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO2014018C NO2014018I2 (no) 2002-05-08 2014-07-18 Riociguat eller et salt, en enantiomer eller et hydrat derav

Country Status (38)

Country Link
US (1) US7173037B2 (cg-RX-API-DMAC7.html)
EP (1) EP1506193B3 (cg-RX-API-DMAC7.html)
JP (1) JP4455321B2 (cg-RX-API-DMAC7.html)
KR (1) KR101011864B1 (cg-RX-API-DMAC7.html)
CN (1) CN1330649C (cg-RX-API-DMAC7.html)
AR (1) AR039789A1 (cg-RX-API-DMAC7.html)
AT (1) ATE330957T1 (cg-RX-API-DMAC7.html)
AU (1) AU2003233061B2 (cg-RX-API-DMAC7.html)
BE (1) BE2014C030I2 (cg-RX-API-DMAC7.html)
BR (1) BRPI0309855B8 (cg-RX-API-DMAC7.html)
CA (1) CA2485143C (cg-RX-API-DMAC7.html)
CU (1) CU23453B7 (cg-RX-API-DMAC7.html)
CY (2) CY1105579T1 (cg-RX-API-DMAC7.html)
DE (2) DE10220570A1 (cg-RX-API-DMAC7.html)
DK (1) DK1506193T3 (cg-RX-API-DMAC7.html)
DO (1) DOP2003000639A (cg-RX-API-DMAC7.html)
EC (1) ECSP045414A (cg-RX-API-DMAC7.html)
ES (1) ES2268363T3 (cg-RX-API-DMAC7.html)
FR (1) FR14C0032I2 (cg-RX-API-DMAC7.html)
GT (1) GT200300101A (cg-RX-API-DMAC7.html)
HR (1) HRP20041166B1 (cg-RX-API-DMAC7.html)
IL (1) IL164958A (cg-RX-API-DMAC7.html)
LU (1) LU92419I2 (cg-RX-API-DMAC7.html)
MX (1) MXPA04011003A (cg-RX-API-DMAC7.html)
MY (1) MY136841A (cg-RX-API-DMAC7.html)
NL (1) NL300659I2 (cg-RX-API-DMAC7.html)
NO (2) NO329105B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ536417A (cg-RX-API-DMAC7.html)
PE (1) PE20040197A1 (cg-RX-API-DMAC7.html)
PL (1) PL214985B1 (cg-RX-API-DMAC7.html)
PT (1) PT1506193E (cg-RX-API-DMAC7.html)
RU (1) RU2339638C9 (cg-RX-API-DMAC7.html)
SI (1) SI1506193T1 (cg-RX-API-DMAC7.html)
TW (1) TWI282792B (cg-RX-API-DMAC7.html)
UA (1) UA78314C2 (cg-RX-API-DMAC7.html)
UY (1) UY27793A1 (cg-RX-API-DMAC7.html)
WO (1) WO2003095451A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200408925B (cg-RX-API-DMAC7.html)

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DE102007061766A1 (de) 2007-12-20 2009-06-25 Bayer Healthcare Ag 4-(4-Cyano-2-thioaryl)-dihydropyrimidinone und ihre Verwendung
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DE102007061763A1 (de) 2007-12-20 2009-06-25 Bayer Healthcare Ag Substituierte azabicyclische Verbindungen und ihre Verwendung
DE102008007400A1 (de) 2008-02-04 2009-08-06 Bayer Healthcare Ag Substituierte Furane und ihre Verwendung
CN102015591B (zh) * 2008-03-04 2014-01-29 艾尼纳制药公司 制备与5-ht2c激动剂(r)-8-氯-1-甲基-2，3，4，5-四氢-1h-3-苯并氮杂卓相关的中间体的方法
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DE10057751A1 (de) 2000-11-22 2002-05-23 Bayer Ag Neue Carbamat-substituierte Pyrazolopyridinderivate
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
CA2429308C (en) * 2000-11-22 2010-09-21 Bayer Aktiengesellschaft Novel lactam-substituted pyrazolopyridine derivatives
DE10122894A1 (de) * 2001-05-11 2002-11-14 Bayer Ag Neue Sulfonat-substituierte Pyrazolopyridinderivate
DE10132416A1 (de) * 2001-07-04 2003-01-16 Bayer Ag Neue Morpholin-überbrückte Pyrazolopyridinderivate
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