CN110511219B - 苯基取代的二氢萘啶类化合物及其用途 - Google Patents
苯基取代的二氢萘啶类化合物及其用途 Download PDFInfo
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- CN110511219B CN110511219B CN201910416791.9A CN201910416791A CN110511219B CN 110511219 B CN110511219 B CN 110511219B CN 201910416791 A CN201910416791 A CN 201910416791A CN 110511219 B CN110511219 B CN 110511219B
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Abstract
Description
时间(min) | A(CH<sub>3</sub>CN,0.1%HCOOH) | B(H<sub>2</sub>O,0.1%HCOOH) |
0-3 | 5-100 | 95-0 |
3-6 | 100 | 0 |
6-6.1 | 100-5 | 0-95 |
6.1-8 | 5 | 95 |
实施例编号 | MR IC<sub>50</sub>(nM) |
实施例1 | 19.45 |
实施例3 | 28.71 |
实施例5 | 17.78 |
实施例7 | 3.44 |
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CN113549066B (zh) * | 2020-04-24 | 2023-07-21 | 年衍药业(珠海)有限公司 | 二氢萘啶类化合物的晶型及其用途 |
CN113549067B (zh) * | 2020-04-24 | 2023-10-03 | 年衍药业(珠海)有限公司 | 二氢萘啶类化合物的晶型及其用途 |
CN113214248B (zh) * | 2021-04-13 | 2022-04-26 | 湖南南新制药股份有限公司 | 一种1,4-二氢-1,6-萘啶衍生物、药物组合物及其用途 |
TW202328127A (zh) * | 2021-09-18 | 2023-07-16 | 大陸商上海拓界生物醫藥科技有限公司 | 取代的1,4-二氫-1,6-萘啶醯胺及其用途 |
CN114149427A (zh) * | 2021-12-18 | 2022-03-08 | 上海鼎雅药物化学科技有限公司 | 非奈利酮及其中间体的合成方法 |
CN115340539B (zh) * | 2022-01-19 | 2024-02-27 | 奥锐特药业股份有限公司 | 制备非奈利酮及其中间体的方法 |
CN115340540A (zh) * | 2022-01-20 | 2022-11-15 | 奥锐特药业股份有限公司 | 制备非奈利酮及其中间体的方法 |
CN114605410B (zh) * | 2022-04-06 | 2023-12-29 | 浙江科聚生物医药有限公司 | 一种非奈利酮原料药的制备方法 |
WO2024022262A1 (zh) * | 2022-07-25 | 2024-02-01 | 深圳信立泰药业股份有限公司 | 一种内皮素a(eta)受体拮抗剂化合物的盐及其制备方法和医药用途 |
WO2024022481A1 (zh) * | 2022-07-29 | 2024-02-01 | 苏中药业集团股份有限公司 | 苯基取代的二氢萘啶类化合物及其制备与用途 |
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WO2019223629A1 (zh) | 2019-11-28 |
CA3100271A1 (en) | 2019-11-28 |
JP7457658B2 (ja) | 2024-03-28 |
JP2021524468A (ja) | 2021-09-13 |
EP3798219A4 (en) | 2022-02-09 |
US20210206760A1 (en) | 2021-07-08 |
CN110511219A (zh) | 2019-11-29 |
EP3798219A1 (en) | 2021-03-31 |
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