NO20070877L - Aryl- og heteroaryl substituerte tetrahydroisoquinoliner og bruk derav for a blokkere gjenopptak av norepinefrin, dopamin og serotonin - Google Patents

Aryl- og heteroaryl substituerte tetrahydroisoquinoliner og bruk derav for a blokkere gjenopptak av norepinefrin, dopamin og serotonin

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Publication number
NO20070877L
NO20070877L NO20070877A NO20070877A NO20070877L NO 20070877 L NO20070877 L NO 20070877L NO 20070877 A NO20070877 A NO 20070877A NO 20070877 A NO20070877 A NO 20070877A NO 20070877 L NO20070877 L NO 20070877L
Authority
NO
Norway
Prior art keywords
pyridinyl
benzooksazolyl
isoquinolinyl
norepinephrine
serotonin
Prior art date
Application number
NO20070877A
Other languages
English (en)
Inventor
Peter Robert Guzzo
Shuang Liu
Bruce F Molino
Barry A Berkowitz
James P Beck
Marlene Cohen
Original Assignee
Amr Technology Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amr Technology Inc filed Critical Amr Technology Inc
Publication of NO20070877L publication Critical patent/NO20070877L/no

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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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    • C07D495/04—Ortho-condensed systems

Abstract

Forbindelsene ifølge den foreliggende oppfinnelsen er representert ved den kjemiske strukturen som er vist i formel (I) hvor: Karbonatomet betegnet med * er i R- eller S-konfigurasjonen; og X er en kondensert bisyklisk karbosykel eller heterosykel valgt fra gruppen bestående av benzofuranyl, benzo[6]tiofenyl, benzoisotiazolyl, benzoisoksazolyl, indazolyl, indolyl, isoindolyl, indolizinyl, benzoimidazolyl, benzooksazolyl, benzotiazolyl, benzotriazolyl, imidazo[l,2-a]pyridinyl, pyrazolo[l,5-a]pyridinyl, [l,2,4]triazolo[4,3-a]pyridinyl, tieno[2,3-6]pyridinyl, tieno[3,2-b]pyridinyl, lH-pyrrolo[2,3-b]pyridinyl, indenyl, indanyl, dihydrobenzosykloheptenyl, tetrahydrobenzosykloheptenyl, dihydrobenzotiofenyl, dihydrobenzofuranyl, indolinyl, naftyl, tetrahydronaftyl, kinolinyl, isokinolinyl, 4H-kinolizinyl, 9aH-kinolizinyl, kinazolinyl, cinnolinyl, ftalazinyl, kinoksalinyl, benzo[l,2,3]triazinyl, benzo[l,2,4]triazinyl, 2H-kromenyl, 4H-kromenyl og en kondensert bisyklisk karbosykel eller kondensert bisyklisk heterosykel eventuelt substituert med fra 1 til 4 substituenter som definert i R14; og hvor R1, R2, R3, R4, R5, R6, R7, R8 og R14 er som definert her.
NO20070877A 2004-07-15 2007-02-15 Aryl- og heteroaryl substituerte tetrahydroisoquinoliner og bruk derav for a blokkere gjenopptak av norepinefrin, dopamin og serotonin NO20070877L (no)

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