AU2001262150A1 - 2-(nitrogen-heterocyclic)pyrimidone derivatives - Google Patents

2-(nitrogen-heterocyclic)pyrimidone derivatives

Info

Publication number
AU2001262150A1
AU2001262150A1 AU2001262150A AU6215001A AU2001262150A1 AU 2001262150 A1 AU2001262150 A1 AU 2001262150A1 AU 2001262150 A AU2001262150 A AU 2001262150A AU 6215001 A AU6215001 A AU 6215001A AU 2001262150 A1 AU2001262150 A1 AU 2001262150A1
Authority
AU
Australia
Prior art keywords
heterocyclic
nitrogen
pyrimidone derivatives
pyrimidone
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001262150A
Inventor
Antonio Almario Garcia
Ryoichi Ando
Jonathan Reid Frost
Adrien Tak Li
Aya Shoda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Mitsubishi Pharma Corp
Original Assignee
Sanofi Synthelabo SA
Mitsubishi Tokyo Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP00400801A external-priority patent/EP1136483A1/en
Priority claimed from EP00400803A external-priority patent/EP1136493A1/en
Priority claimed from EP00400802A external-priority patent/EP1136489A1/en
Application filed by Sanofi Synthelabo SA, Mitsubishi Tokyo Pharmaceuticals Inc filed Critical Sanofi Synthelabo SA
Publication of AU2001262150A1 publication Critical patent/AU2001262150A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
AU2001262150A 2000-03-23 2001-03-22 2-(nitrogen-heterocyclic)pyrimidone derivatives Abandoned AU2001262150A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP00400802 2000-03-23
EP00400801 2000-03-23
EP00400801A EP1136483A1 (en) 2000-03-23 2000-03-23 2-[Piperazinyl]pyrimidone derivatives
EP00400803A EP1136493A1 (en) 2000-03-23 2000-03-23 2-(Thienopyridinyl)pyrimidone, 2-(furopyridinyl)pyrimidone 2-(isoquinolinyl)pyrimidone, 2-(pyridoindolyl)pyrimidone and 2-(benzofuropyridinyl)pyrimidone derivatives
EP00400802A EP1136489A1 (en) 2000-03-23 2000-03-23 2-[Piperidin-1-yl]pyrimidone derivatives
EP00400803 2000-03-23
PCT/EP2001/003639 WO2001070728A1 (en) 2000-03-23 2001-03-22 2-[nitrogen-heterocyclic]pyrimidone derivatives

Publications (1)

Publication Number Publication Date
AU2001262150A1 true AU2001262150A1 (en) 2001-10-03

Family

ID=27223599

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001262150A Abandoned AU2001262150A1 (en) 2000-03-23 2001-03-22 2-(nitrogen-heterocyclic)pyrimidone derivatives

Country Status (2)

Country Link
AU (1) AU2001262150A1 (en)
WO (1) WO2001070728A1 (en)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI241298B (en) 1998-09-25 2005-10-11 Mitsubishi Chem Corp Pyrimidone derivatives
MXPA04002662A (en) 2001-09-21 2004-11-22 Sanofi Aventis 3-substituted-4-pyrimidone derivatives.
AU2002337498B2 (en) 2001-09-21 2006-08-10 Mitsubishi Pharma Corporation 3-substituted-4-pyrimidone derivatives
JP4616003B2 (en) * 2002-12-16 2011-01-19 田辺三菱製薬株式会社 3-substituted-4-pyrimidone derivatives
EP1454910A1 (en) * 2003-03-07 2004-09-08 Sanofi-Synthelabo Substituted pyrimidinyl-2-(diaza-bicyclo-alkyl)-pyrimidone derivatives
EP1454908B1 (en) * 2003-03-07 2008-02-27 Sanofi-Aventis Substituted pyridinyl-2-(diaza-bicyclo-alkyl)-pyrimidinone derivatives
AR043486A1 (en) * 2003-03-07 2005-08-03 Sanofi Aventis DERIVATIVES OF 2- (DIAZA-BICICLO-ALQUIL) -PIRIMIDONA
ATE423102T1 (en) 2003-03-12 2009-03-15 Vertex Pharma 4-SUBSTITUTED-5-CYANO-1H-PYRIMIDINE-6-(TH)IONES AS A GSK-3 INHIBITOR
TWI357408B (en) 2003-03-26 2012-02-01 Mitsubishi Tanabe Pharma Corp 3-substituted-4-pyrimidone derivatives
US7566712B2 (en) 2003-07-16 2009-07-28 Neurogen Corporation Biaryl piperazinyl-pyridine analogues
KR101389246B1 (en) 2004-07-15 2014-04-24 브리스톨-마이어스스퀴브컴파니 Aryl- and heteroaryl-substituted tetrahydroisoquinolines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin
MY145822A (en) 2004-08-13 2012-04-30 Neurogen Corp Substituted biaryl piperazinyl-pyridine analogues
TW200621760A (en) * 2004-09-09 2006-07-01 Mitsubishi Pharma Corp 2-morpholino-4-pyrimidone compound
AU2006282896A1 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
TW200813015A (en) * 2006-03-15 2008-03-16 Mitsubishi Pharma Corp 2-(cyclic amino)-pyrimidone derivatives
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
AR064660A1 (en) * 2006-12-26 2009-04-15 Mitsubishi Tanabe Pharma Corp DERIVATIVES OF PIRIMIDINONA 6-HETEROCICLICA 2-REPLACED, MEDICINES THAT CONTAIN THEM AND USES TO PREVENT AND / OR TREAT NEURODEGENERATIVE DISEASES BETWEEN OTHER
US9156812B2 (en) 2008-06-04 2015-10-13 Bristol-Myers Squibb Company Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
EP2138498A1 (en) * 2008-06-26 2009-12-30 sanofi-aventis Substituted tricyclic derivatives against neurodegenerative diseases
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP5739415B2 (en) 2009-05-12 2015-06-24 ブリストル−マイヤーズ スクウィブ カンパニー (S) -7-([1,2,4] triazolo [1,5-a] pyridin-6-yl) -4- (3,4-dichlorophenyl) -1,2,3,4-tetrahydroisoquinoline Crystal forms and uses thereof
MX2011011901A (en) 2009-05-12 2012-01-20 Albany Molecular Res Inc Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof.
EP2429296B1 (en) 2009-05-12 2017-12-27 Albany Molecular Research, Inc. 7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
CN111943890B (en) * 2014-11-03 2023-10-31 艾欧米制药有限公司 Pharmaceutical compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW520362B (en) * 1996-12-05 2003-02-11 Amgen Inc Substituted pyrimidine compounds and pharmaceutical composition comprising same
TWI241298B (en) * 1998-09-25 2005-10-11 Mitsubishi Chem Corp Pyrimidone derivatives

Also Published As

Publication number Publication date
WO2001070728A1 (en) 2001-09-27

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