AU2002234010A1 - Benzamidine derivatives - Google Patents

Benzamidine derivatives

Info

Publication number
AU2002234010A1
AU2002234010A1 AU2002234010A AU3401002A AU2002234010A1 AU 2002234010 A1 AU2002234010 A1 AU 2002234010A1 AU 2002234010 A AU2002234010 A AU 2002234010A AU 3401002 A AU3401002 A AU 3401002A AU 2002234010 A1 AU2002234010 A1 AU 2002234010A1
Authority
AU
Australia
Prior art keywords
benzamidine derivatives
benzamidine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002234010A
Inventor
Ellen W. Baxter
Samuel O. Nortey
Allen B Reitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceuticals Inc
Original Assignee
Ortho McNeil Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc
Publication of AU2002234010A1 publication Critical patent/AU2002234010A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/195—Radicals derived from nitrogen analogues of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
AU2002234010A 2000-12-14 2001-12-11 Benzamidine derivatives Abandoned AU2002234010A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25565800P 2000-12-14 2000-12-14
US60/255,658 2000-12-14
PCT/US2001/047894 WO2002048122A2 (en) 2000-12-14 2001-12-11 Benzamidine derivatives

Publications (1)

Publication Number Publication Date
AU2002234010A1 true AU2002234010A1 (en) 2002-06-24

Family

ID=22969324

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002234010A Abandoned AU2002234010A1 (en) 2000-12-14 2001-12-11 Benzamidine derivatives

Country Status (3)

Country Link
US (1) US6887876B2 (en)
AU (1) AU2002234010A1 (en)
WO (1) WO2002048122A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141650C1 (en) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Safe transdermal therapeutic system for administration of fentanyl or analogous analgesics, having matrix layer of carboxy group-free polyacrylate adhesive providing high permeation rate
NZ572901A (en) 2003-06-27 2010-06-25 Janssen Pharmaceutica Nv Tricyclic delta opioid modulators
WO2005005478A2 (en) * 2003-07-02 2005-01-20 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with g protein-coupled opioid receptor; delta 1 (oprd1)
WO2005033073A2 (en) 2003-10-01 2005-04-14 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
AU2004303790A1 (en) * 2003-12-12 2005-07-07 Eli Lilly And Company Opioid receptor antagonists
US20110104186A1 (en) 2004-06-24 2011-05-05 Nicholas Valiante Small molecule immunopotentiators and assays for their detection
CN100335468C (en) * 2004-06-25 2007-09-05 中国医学科学院药物研究所 Diaryl amidine compound, its production, medicinal composition and use
EA200700403A1 (en) 2004-08-05 2007-08-31 Янссен Фармацевтика Н.В. TRICYCLIC δ-OPIOID MODULATORS
SE0402485D0 (en) * 2004-10-13 2004-10-13 Astrazeneca Ab Polymorph of N, N-Diethyl-4- (3-Fluorophenyl-Piperidin-4-Ylidene-Methyl) -Benzamide Hydrochloride Salt
JP2008525481A (en) * 2004-12-22 2008-07-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Tricyclic δ-opioid modulator
MX2007007627A (en) 2004-12-22 2008-01-28 Johnson & Johnson Tricyclic o-opioid modulators.
CN101115751A (en) 2004-12-22 2008-01-30 詹森药业有限公司 Tricyclic delta-opioid modulators
BRPI0606402A2 (en) 2005-01-06 2009-06-23 Janssen Pharmaceutica Nv tricyclic delta-opioid modulators
US7598261B2 (en) 2005-03-31 2009-10-06 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
BRPI0611885A2 (en) 2005-06-16 2010-10-05 Janssen Pharmaceutica Nv tricyclic opioid modulators
US7576207B2 (en) 2006-04-06 2009-08-18 Adolor Corporation Spirocyclic heterocyclic derivatives and methods of their use
EP2399577A1 (en) 2006-09-12 2011-12-28 Adolor Corporation Use of N-containing spirocompounds for the enhancement of cognitive function
CN107098876B (en) * 2016-02-23 2021-04-06 江苏恒瑞医药股份有限公司 Phenyl propionamide derivative, preparation method and medical application thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3962248A (en) 1972-04-04 1976-06-08 Sandoz, Inc. Process for making 11-piperazino-diazepines, oxazepines, thiazepines and azepines
US3793322A (en) 1972-12-15 1974-02-19 Usv Pharma Corp 1,4-disubstituted piperazines
GB9202238D0 (en) * 1992-02-03 1992-03-18 Wellcome Found Compounds
SE9504661D0 (en) 1995-12-22 1995-12-22 Astra Pharma Inc New compounds
TW548271B (en) 1996-12-20 2003-08-21 Astra Pharma Inc Novel piperidine derivatives having an exocyclic double bond with analgesic effects
SE9604786D0 (en) * 1996-12-20 1996-12-20 Astra Pharma Inc New compounds
ATE306472T1 (en) * 1997-12-24 2005-10-15 Ortho Mcneil Pharm Inc (4)-(ARYL(PIPERIDIN-4-YL) AMINOBENZAMIDE DERIVATIVES THAT BIND TO DELTA-OPIOID RECEPTOR

Also Published As

Publication number Publication date
WO2002048122A2 (en) 2002-06-20
US20020123489A1 (en) 2002-09-05
US6887876B2 (en) 2005-05-03
WO2002048122A3 (en) 2002-09-12

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