MY167872A - Recombinant production of steviol glycosides - Google Patents

Recombinant production of steviol glycosides

Info

Publication number
MY167872A
MY167872A MYPI2012005201A MYPI2012005201A MY167872A MY 167872 A MY167872 A MY 167872A MY PI2012005201 A MYPI2012005201 A MY PI2012005201A MY PI2012005201 A MYPI2012005201 A MY PI2012005201A MY 167872 A MY167872 A MY 167872A
Authority
MY
Malaysia
Prior art keywords
steviol
steviol glycosides
recombinant production
plants
plant cells
Prior art date
Application number
MYPI2012005201A
Other languages
English (en)
Inventor
Ganesh M Kishore
Michael Motion
Paula M Hicks
Jorgen Hansen
Jens Houghton-Larsen
Esben Halkjaer Hansen
Michael Dalgaard Mikkelsen
Sabina Tavares
Charlotte Blom
Original Assignee
Evolva Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evolva Inc filed Critical Evolva Inc
Publication of MY167872A publication Critical patent/MY167872A/en

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    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80Vectors or expression systems specially adapted for eukaryotic hosts for fungi
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    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/56Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L2/00Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
    • A23L2/52Adding ingredients
    • A23L2/60Sweeteners
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/30Artificial sweetening agents
    • A23L27/33Artificial sweetening agents containing sugars or derivatives
    • A23L27/36Terpene glycosides
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    • C07H15/00Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20Carbocyclic rings
    • C07H15/24Condensed ring systems having three or more rings
    • C07H15/256Polyterpene radicals
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    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • C12N9/0036Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C12N9/0038Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6) with a heme protein as acceptor (1.6.2)
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MYPI2012005201A 2010-06-02 2011-06-02 Recombinant production of steviol glycosides MY167872A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35055310P 2010-06-02 2010-06-02
US201161434582P 2011-01-20 2011-01-20
US201161471622P 2011-04-04 2011-04-04

Publications (1)

Publication Number Publication Date
MY167872A true MY167872A (en) 2018-09-26

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Families Citing this family (144)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107436B2 (en) 2011-02-17 2015-08-18 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US9392799B2 (en) 2011-02-17 2016-07-19 Purecircle Sdn Bhd Glucosyl stevia composition
US8318459B2 (en) 2011-02-17 2012-11-27 Purecircle Usa Glucosyl stevia composition
US8790730B2 (en) 2005-10-11 2014-07-29 Purecircle Usa Process for manufacturing a sweetener and use thereof
US9386797B2 (en) 2011-02-17 2016-07-12 Purecircle Sdn Bhd Glucosyl stevia composition
US8257948B1 (en) 2011-02-17 2012-09-04 Purecircle Usa Method of preparing alpha-glucosyl Stevia composition
US8927241B2 (en) 2009-11-10 2015-01-06 Massachusetts Institute Of Technology Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
US8512988B2 (en) 2009-11-10 2013-08-20 Massachusetts Institute Of Technology Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
EP2498625B1 (en) 2009-11-12 2018-10-24 Purecircle Usa Inc. Granulation of a stevia sweetener
US20150344512A1 (en) 2011-12-19 2015-12-03 Purecircle Usa Inc. Methods of purifying steviol glycosides and uses of the same
US10696706B2 (en) 2010-03-12 2020-06-30 Purecircle Usa Inc. Methods of preparing steviol glycosides and uses of the same
EP2544538B1 (en) 2010-03-12 2022-06-15 PureCircle USA Inc. High-purity steviol glycosides
EP2571991A1 (en) * 2010-05-20 2013-03-27 Evolva SA Method of producing isoprenoid compounds in yeast
BR122021005297B1 (pt) 2010-06-02 2022-02-22 Evolva, Inc Método para transferir uma segunda porção de açúcar para uma posição c-2' de uma glicose em um glicosídeo de esteviol
US9284570B2 (en) * 2010-11-30 2016-03-15 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
MX346137B (es) 2010-12-13 2017-03-08 Purecircle Usa Inc Rebaudiosido d altamente soluble.
US9510611B2 (en) 2010-12-13 2016-12-06 Purecircle Sdn Bhd Stevia composition to improve sweetness and flavor profile
WO2012108894A1 (en) 2011-02-10 2012-08-16 Purecircle Usa Stevia composition
US9474296B2 (en) 2011-02-17 2016-10-25 Purecircle Sdn Bhd Glucosyl stevia composition
US11690391B2 (en) 2011-02-17 2023-07-04 Purecircle Sdn Bhd Glucosylated steviol glycoside as a flavor modifier
US9603373B2 (en) 2011-02-17 2017-03-28 Purecircle Sdn Bhd Glucosyl stevia composition
US9894922B2 (en) 2011-05-18 2018-02-20 Purecircle Sdn Bhd Glucosyl rebaudioside C
WO2012166163A1 (en) 2011-05-31 2012-12-06 Purecircle Usa Stevia composition
BR112013030885B1 (pt) 2011-06-03 2019-01-02 Purecircle Usa Inc processo para produzir uma composição de ingrediente alimentício de stevia compreendendo rebaudiosídeo b
PL2720561T3 (pl) 2011-06-20 2019-05-31 Purecircle Usa Inc Kompozycja stewii
US9771434B2 (en) 2011-06-23 2017-09-26 Purecircle Sdn Bhd Products from stevia rebaudiana
JP6262653B2 (ja) 2011-08-08 2018-01-17 エヴォルヴァ エスアー.Evolva Sa. ステビオール配糖体の組換え生産
US10480019B2 (en) 2011-08-10 2019-11-19 Purecircle Sdn Bhd Process for producing high-purity rubusoside
MX377611B (es) 2011-09-07 2025-03-10 Purecircle Usa Inc Edulcorante de estevia altamente soluble.
CN103031283B (zh) * 2011-10-08 2015-07-08 成都华高瑞甜科技有限公司 甜叶菊酶vi及莱鲍迪苷a转化为莱鲍迪苷d的方法
AU2012342114B2 (en) 2011-11-23 2017-12-21 Danstar Ferment Ag Methods and materials for enzymatic synthesis of mogroside compounds
EP3735841A1 (en) 2011-12-19 2020-11-11 PureCircle SDN BHD Methods for purifying steviol glycosides and uses of the same
FR2984743B1 (fr) * 2011-12-23 2014-08-22 Oreal Utilisation cosmetique du steviol, d'un derive glycoside du steviol, ou un de leurs isomeres pour stimuler, restaurer ou reguler le metabolisme des cellules de la peau et des semi-muqueuses.
EA201400836A8 (ru) * 2012-01-23 2016-03-31 ДСМ АйПи АССЕТС Б.В. Получение дитерпена
WO2013137487A1 (ja) 2012-03-16 2013-09-19 サントリーホールディングス株式会社 ステビオール配糖体化酵素およびそれをコードする遺伝子
EP2832858B1 (en) * 2012-03-27 2020-07-08 Suntory Holdings Limited Method for producing steviol glycoside
US20130338348A1 (en) * 2012-03-30 2013-12-19 J.R. Simplot Company Steviol and steviol glycoside formation in plants
EP2852296B1 (en) * 2012-05-22 2021-12-15 PureCircle SDN BHD Process for producing a high-purity steviol glycoside
US9752174B2 (en) * 2013-05-28 2017-09-05 Purecircle Sdn Bhd High-purity steviol glycosides
TW201402599A (zh) 2012-05-30 2014-01-16 Suntory Holdings Ltd 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因
CN103710318B (zh) * 2012-09-29 2017-01-18 中国科学院上海生命科学研究院 利用微生物生产甜菊糖苷类化合物的方法
WO2016050890A2 (en) 2014-10-01 2016-04-07 Evolva Sa Methods and materials for biosynthesis of mogroside compounds
US9932619B2 (en) 2012-12-04 2018-04-03 Evolva Sa Methods and materials for biosynthesis of mogroside compounds
WO2014086890A1 (en) * 2012-12-05 2014-06-12 Evolva Sa Steviol glycoside compositions sensory properties
KR20150115002A (ko) * 2013-02-06 2015-10-13 에볼바 에스아 레바우디오시드 d 및 레바우디오시드 m의 개선된 생산 방법
CN105189771B (zh) 2013-02-11 2019-11-05 埃沃尔瓦公司 在重组宿主中有效产生甜菊醇糖苷
KR101404728B1 (ko) * 2013-02-28 2014-06-09 씨제이제일제당 (주) 스테비오사이드로부터 리바우디오사이드 a를 제조하는 방법
MX358413B (es) * 2013-03-15 2018-08-20 Coca Cola Co Glicosidos de esteviol, sus composiciones y su purificacion.
AU2014273054A1 (en) * 2013-05-31 2015-12-03 Dsm Ip Assets B.V. Extracellular diterpene production
CA2913876A1 (en) * 2013-05-31 2014-12-04 Dsm Ip Assets B.V. Microorganisms for diterpene production
US10952458B2 (en) 2013-06-07 2021-03-23 Purecircle Usa Inc Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier
BR112015030650B1 (pt) 2013-06-07 2021-02-23 Purecircle Usa Inc composição de modificação de sabor e aroma compreendendo glicosídeos de esteviol, seu produto alimentar ou de bebida e seu método para aumentar a intensidade de sabor e aroma ou melhorar a percepção de sal e reduzir o teor de sódio de um produto alimentar ou de bebida
KR101559478B1 (ko) 2013-06-24 2015-10-13 한국생명공학연구원 효소전환법을 이용한 천연 고감미료의 제조방법
AU2014292150B2 (en) * 2013-07-15 2019-04-04 Dsm Ip Assets B.V. Diterpene production
WO2015011209A1 (en) * 2013-07-23 2015-01-29 Dsm Ip Assets B.V. Diterpene production in yarrowia
EP3536697A1 (en) * 2013-07-31 2019-09-11 DSM IP Assets B.V. Recovery of steviol glycosides
CN105658081A (zh) * 2013-07-31 2016-06-08 帝斯曼知识产权资产管理有限公司 甜菊糖苷
WO2015016393A1 (ja) * 2013-08-02 2015-02-05 サントリーホールディングス株式会社 ヘキセノール配糖体化酵素の利用方法
CN103397064B (zh) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
WO2015028324A2 (en) * 2013-08-30 2015-03-05 Evolva Sa A method for producing modified resveratrol
JP6530760B2 (ja) * 2013-11-01 2019-06-12 コナゲン インコーポレーテッド ステビオール配糖体の組換え製造
US10053717B2 (en) 2014-01-31 2018-08-21 University Of Copenhagen Biosynthesis of forskolin and related compounds
US20180020709A1 (en) * 2014-04-16 2018-01-25 Purecircle Usa Inc. Rebaudioside m biosynthetic production and recovery methods
CA2957331A1 (en) 2014-08-11 2016-02-18 Evolva Sa Production of steviol glycosides in recombinant hosts
CN105850727B (zh) 2015-01-23 2018-12-07 谱赛科美国公司 甜叶菊新品种及高rd、rm含量甜菊糖苷的制备
CN105850709B (zh) 2015-01-23 2018-08-21 谱赛科美国公司 甜叶菊新品种817096谱星5号及高rd含量甜菊糖苷的制备
WO2016034942A1 (en) 2014-09-02 2016-03-10 Purecircle Usa Inc. Stevia extracts enriched in rebaudioside d, e, n and/or o and process for the preparation thereof
US10612064B2 (en) 2014-09-09 2020-04-07 Evolva Sa Production of steviol glycosides in recombinant hosts
CN113549664B (zh) 2014-09-19 2025-10-28 谱赛科有限责任公司 高纯度甜菊醇糖苷
WO2016048994A2 (en) * 2014-09-23 2016-03-31 President And Fellows Of Harvard College Systems and methods of cell-free protein synthesis in droplets and other compartments
WO2016049531A1 (en) * 2014-09-26 2016-03-31 Purecircle Usa Inc. Single nucleotide polymorphism (snp) markers for stevia
AU2015327940B2 (en) * 2014-10-03 2020-04-16 Conagen Inc. Non-caloric sweeteners and methods for synthesizing
EP3204506B1 (en) * 2014-10-08 2022-01-12 DSM IP Assets B.V. Steviol glycoside production
CN107109453A (zh) 2014-11-05 2017-08-29 马努斯生物合成股份有限公司 甜菊醇糖苷的微生物产生
US10208326B2 (en) 2014-11-13 2019-02-19 Evolva Sa Methods and materials for biosynthesis of manoyl oxide
CN108522291B (zh) 2015-01-23 2022-01-04 谱赛科美国公司 利用甜叶菊新品种814011谱星3号制备高rm含量甜菊糖苷的方法
EP4148137A1 (en) * 2015-01-30 2023-03-15 Evolva SA Production of steviol glycosides in recombinant hosts
CA2979931A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
CA2987508A1 (en) 2015-05-28 2016-12-01 Evolva Sa Biosynthesis of phenylpropanoids and phenylpropanoid derivatives
CA2987587C (en) 2015-05-29 2022-05-03 Cargill, Incorporated Heat treatment to produce glycosides
JP2018516600A (ja) 2015-05-29 2018-06-28 カーギル・インコーポレイテッド 高いpHを使用してステビオールグリコシドを産生するための発酵方法及びそこから得られる組成物
JP2018521636A (ja) 2015-05-29 2018-08-09 カーギル・インコーポレイテッド 多段階供給を用いる、ステビオール配糖体を生成するための発酵方法
EP3320104B1 (en) * 2015-07-10 2021-11-10 DSM IP Assets B.V. Method for preparing a steviol glycoside composition
EP3319974B1 (en) * 2015-07-10 2024-11-06 DSM IP Assets B.V. Method for reducing kaurenoic acid in a steviol glycoside composition
CA2994288A1 (en) 2015-08-06 2017-02-09 Cargill, Incorporated Fermentation methods for producing steviol glycosides
BR112018002564A2 (pt) 2015-08-07 2018-09-25 Evolva Sa produção de glicosídeos de esteviol em hospedeiros recombinantes
EP3337893B1 (en) 2015-08-21 2023-07-19 Manus Bio Inc. Increasing productivity of e. coli host cells that functionally express p450 enzymes
US9765117B2 (en) 2015-08-24 2017-09-19 Romek Figa Peptides for treating cancer
CA2999638A1 (en) 2015-10-05 2017-04-13 Dsm Ip Assets B.V. Kaurenoic acid hydroxylases
CN115336734A (zh) 2015-10-26 2022-11-15 谱赛科美国股份有限公司 甜菊醇糖苷组合物
WO2017093895A1 (en) 2015-11-30 2017-06-08 Purecircle Sdn Bhd Process for producing high purity steviol glycosides
EP3387136B1 (en) * 2015-12-10 2022-01-05 Evolva SA Production of steviol glycosides in recombinant hosts
CN108712864A (zh) 2015-12-15 2018-10-26 谱赛科美国股份有限公司 甜菊醇糖苷组合物
US20190048356A1 (en) * 2016-03-11 2019-02-14 Evolva Sa Production of steviol glycosides in recombinant hosts
CN109195457A (zh) 2016-04-13 2019-01-11 埃沃尔瓦公司 在重组宿主中产生甜菊醇糖苷
WO2017198681A1 (en) * 2016-05-16 2017-11-23 Evolva Sa Production of steviol glycosides in recombinant hosts
US10815514B2 (en) 2016-05-16 2020-10-27 Evolva Sa Production of steviol glycosides in recombinant hosts
MY198645A (en) * 2016-06-06 2023-09-13 Tate & Lyle Ingredients Americas Llc Glycosylated steviol glycoside compositions and methods of preparing glycosylated steviol glycoside compositions
SG11201810998WA (en) 2016-06-15 2019-01-30 Codexis Inc Engineered beta-glucosidases and glucosylation methods
MY194280A (en) 2016-08-12 2022-11-25 Amyris Inc Udp-dependent glycosyltransferase for high efficiency production of rebaudiosides
JP6842800B2 (ja) 2016-10-21 2021-03-17 ペプシコ・インク 酵素的方法を使用してレバウディオサイドjを調製するための方法
AU2016427130B2 (en) 2016-10-21 2022-08-18 Pepsico, Inc. Method for preparing rebaudioside N using enzymatic method
EP3530746A4 (en) * 2016-10-21 2020-06-24 Pepsico, Inc. METHOD FOR PRODUCING REBAUDIOSIDE C BY ENZYMATIC METHOD
CN110100006A (zh) * 2016-11-07 2019-08-06 埃沃尔瓦公司 重组宿主中甜菊糖苷的生产
WO2018124141A1 (ja) * 2016-12-27 2018-07-05 サントリーホールディングス株式会社 ステビオール配糖体ヘキソース転移酵素およびそれをコードする遺伝子
NZ754394A (en) * 2016-12-27 2023-04-28 Suntory Holdings Ltd Novel steviol glycoside, method for producing same, and sweetener composition containing same
CN108341781B (zh) * 2017-01-25 2021-09-03 中国科学院分子植物科学卓越创新中心 植物次生代谢产物生物合成途径中相关酶类的解析方法
DK3574095T5 (da) 2017-01-26 2024-09-02 Manus Bio Inc Metabolisk manipulation til mikrobiel fremstilling af terpenoidprodukter
IL321402A (en) * 2017-02-03 2025-08-01 Tate & Lyle Solutions Usa Llc Engineered glycosyltransferases and steviol glycoside glucosylation methods
AU2018224036B2 (en) * 2017-02-21 2022-06-09 Duke University Compositions and methods for robust dynamic metabolic control
NZ758479A (en) * 2017-03-31 2023-06-30 Suntory Holdings Ltd Novel steviol glycoside and production method therefor, and sweetener composition containing same
CN110494564B (zh) * 2017-04-12 2024-03-15 三得利控股株式会社 来自甜菊的鼠李糖合成酶及基因
MY206790A (en) * 2017-05-15 2025-01-08 Purecircle Usa Inc High-purity steviol glycosides
WO2018211032A1 (en) 2017-05-17 2018-11-22 Evolva Sa Production of steviol glycosides in recombinant hosts
WO2018229283A1 (en) 2017-06-15 2018-12-20 Evolva Sa Production of mogroside compounds in recombinant hosts
KR20200035981A (ko) * 2017-08-11 2020-04-06 아미리스 인코퍼레이티드 레바우디오사이드의 고효율 생산을 위한 피숨 사티붐 카우렌 산화효소
WO2019055325A2 (en) * 2017-09-12 2019-03-21 Biocapital Holdings, Llc BIOOGICAL DEVICES AND METHODS OF USING THE SAME TO PRODUCE STEVIOL GLYCOSIDES
BR112020009838A2 (pt) * 2017-12-05 2020-11-17 Evolva Sa produção de glicosídeos de esteviol em hospedeiros recombinantes
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
EP3824093B1 (en) 2018-07-16 2024-11-20 Manus Bio, Inc. Production of steviol glycosides through whole cell biotransformation
MX2021001260A (es) 2018-07-30 2021-04-12 Tate & Lyle Solutions Usa Llc Glucosiltransferasas modificadas con ingenieria genetica y metodos de glucosilacion de glucosido de esteviol.
US12234464B2 (en) 2018-11-09 2025-02-25 Ginkgo Bioworks, Inc. Biosynthesis of mogrosides
CN113365492B (zh) 2018-11-20 2023-10-24 谱赛科美国股份有限公司 非整倍体甜菊栽培品种“ap-1”
US11168309B2 (en) 2019-06-25 2021-11-09 Manus Bio Inc. Uridine diphosphate-dependent glycosyltransferase enzyme
KR20220044789A (ko) 2019-08-08 2022-04-11 도아고세이가부시키가이샤 물이해체성 접착제 조성물
CN110592040A (zh) * 2019-09-18 2019-12-20 江苏施宇甜生物科技有限公司 一种用于生产upd糖基转移酶的重组枯草芽孢杆菌的工艺
CN111424065B (zh) * 2020-03-24 2022-08-16 金禾益康(北京)生物科技有限公司 使用糖基转移酶对甜菊糖苷类化合物进行糖基化方法
WO2023006179A1 (en) 2020-07-27 2023-02-02 Dsm Ip Assets B.V. Method to produce retinyl acetate
CN112147253B (zh) * 2020-09-25 2022-04-01 安徽瑞思威尔科技有限公司 一种灵芝酒中42种有效成分的UPC2-PDA-Q-Tof/MS检测方法
EP4232568A1 (en) 2020-10-22 2023-08-30 DSM IP Assets B.V. Microorganisms for diterpene production
EP4269573A4 (en) * 2020-12-23 2025-07-23 Samyang Corp GLYCOSYLTRANSFERASE AND METHOD FOR PREPARING STEVIOL GLUCOSIDE USING SAME
CN112877355A (zh) * 2021-01-22 2021-06-01 杜云龙 一种利用烟草表达三七皂苷的方法
WO2022245988A2 (en) * 2021-05-18 2022-11-24 Biokai, Inc. Production of carotenoids
CN115478060B (zh) * 2021-06-16 2023-11-28 弈柯莱生物科技(集团)股份有限公司 一种糖基转移酶及其应用
WO2023006851A1 (en) 2021-07-27 2023-02-02 Dsm Ip Assets B.V. Fermentative production of retinyl acetate in the presence of ethanol
CN115975827A (zh) * 2021-10-15 2023-04-18 中国科学院分子植物科学卓越创新中心 用于甜茶素生产的宿主细胞及方法
CN118974246A (zh) * 2021-12-24 2024-11-15 株式会社三养社 莱鲍迪苷的生产
CN114703217B (zh) * 2022-03-26 2025-09-02 江苏省中国科学院植物研究所 一种甜菊自交系种子转基因体系的建立方法
CN114752575B (zh) * 2022-04-07 2023-06-13 内蒙古工业大学 一种nad+依赖性脱氢酶基因及其在提高辅酶q10产量中的应用
WO2024010074A1 (ja) 2022-07-07 2024-01-11 サントリーホールディングス株式会社 ステビオール配糖体生合成変異酵素とその利用
CN116162607B (zh) * 2023-01-04 2025-07-01 中国科学院大连化学物理研究所 一种甜菊糖苷糖基转移酶基因及其编码产物与应用
CN116004563B (zh) * 2023-01-17 2023-11-17 华中农业大学 一种茶树类黄酮糖基转移酶及其应用
CN116724112B (zh) * 2023-03-24 2024-02-02 森瑞斯生物科技(深圳)有限公司 HMG-CoA还原酶突变体及其在生产萜类化合物中的应用
WO2024228615A1 (en) * 2023-05-03 2024-11-07 Purecircle Sdn. Bhd. High-purity steviol glycosides

Family Cites Families (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58149697A (ja) 1982-02-27 1983-09-06 Dainippon Ink & Chem Inc β−1,3グリコシルステビオシドの製造方法
JPS59101408A (ja) * 1982-12-02 1984-06-12 Junichi Iwamura 植物生長調整剤
US5198360A (en) 1990-01-19 1993-03-30 Eli Lilly And Company Dna sequence conferring a plaque inhibition phenotype
US6946587B1 (en) 1990-01-22 2005-09-20 Dekalb Genetics Corporation Method for preparing fertile transgenic corn plants
US5484956A (en) 1990-01-22 1996-01-16 Dekalb Genetics Corporation Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin
JPH03277275A (ja) 1990-03-28 1991-12-09 Dainippon Ink & Chem Inc 新規酵素及びその酵素を用いた配糖体の製造方法
US5204253A (en) 1990-05-29 1993-04-20 E. I. Du Pont De Nemours And Company Method and apparatus for introducing biological substances into living cells
US5306862A (en) 1990-10-12 1994-04-26 Amoco Corporation Method and composition for increasing sterol accumulation in higher plants
US5460949A (en) 1990-11-15 1995-10-24 Amoco Corporation Method and composition for increasing the accumulation of squalene and specific sterols in yeast
US5712112A (en) 1992-11-04 1998-01-27 National Science Council Of R.O.C. Gene expression system comprising the promoter region of the alpha-amylase genes
FI960173L (fi) 1993-07-15 1996-03-15 Neose Pharm Inc Menetelmä sakkaridikoostumusten syntetisoimiseksi
US7186891B1 (en) 1996-04-12 2007-03-06 University Of Kentucky, Research Foundation Plant cells and plants expressing chimeric isoprenoid synthases
JPH10117776A (ja) 1996-10-22 1998-05-12 Japan Tobacco Inc インディカイネの形質転換方法
AU9455398A (en) 1997-10-06 1999-04-27 Centre National De La Recherche Scientifique Plant fatty acid hydroxylase genes
US6255557B1 (en) 1998-03-31 2001-07-03 Her Majesty The Queen In Right Of Canada As Represented By The Ministerof Agriculture And Agri-Food Canada Stevia rebaudiana with altered steviol glycoside composition
KR100657388B1 (ko) 1998-04-14 2006-12-13 교와 학꼬 고교 가부시키가이샤 미생물에 의한 이소프레노이드 화합물의 제조 방법
EP0955363A3 (en) 1998-05-06 2004-01-28 F. Hoffmann-La Roche Ag Dna sequences encoding enzymes involved in production of isoprenoids
TWI250210B (en) 1998-05-06 2006-03-01 Dsm Ip Assets Bv An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate
EP2100963B1 (en) 1998-07-06 2011-12-14 DCV Inc. doing business as Bio-Technical Resourses Method of vitamin production
US6531303B1 (en) 1998-07-06 2003-03-11 Arkion Life Sciences Llc Method of producing geranylgeraniol
AR021636A1 (es) 1998-12-17 2002-07-31 Rubicon Forests Holdings Ltd Materiales y metodos para la modificacion del contenido, la composicion y el metabolismo de los isoprenoides
JP2002533090A (ja) 1998-12-23 2002-10-08 ザ、サミュアル、ラバツ、ノゥブル、ファウンデイシャン、インク 植物形質転換法
MXPA01010486A (es) 1999-04-15 2002-03-27 Calgene Llc Secuencias de acido nucleico para proteinas implicadas en la sintesis de tocoferol.
AU4365200A (en) 1999-04-21 2000-11-02 Samuel Roberts Noble Foundation, Inc., The Plant transformation process
WO2001011055A1 (en) 1999-08-04 2001-02-15 Adelbert Bacher Isoprenoid biosynthesis
AU6780700A (en) 1999-08-18 2001-03-13 Paradigm Genetics, Inc. Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration
WO2001083769A2 (en) 2000-05-03 2001-11-08 The Salk Institute For Biological Studies Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis
DE10027821A1 (de) 2000-06-05 2001-12-06 Adelbert Bacher Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg
US20030033626A1 (en) 2000-07-31 2003-02-13 Hahn Frederick M. Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
CA2420555C (en) 2000-08-24 2012-10-23 Jeffrey F. Harper Stress-regulated genes of plants, transgenic plants containing same, and methods of use
US6689601B2 (en) 2000-09-01 2004-02-10 E. I. Du Pont De Nemours And Company High growth methanotropic bacterial strain
US6660507B2 (en) 2000-09-01 2003-12-09 E. I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
US6818424B2 (en) 2000-09-01 2004-11-16 E. I. Du Pont De Nemours And Company Production of cyclic terpenoids
WO2002024865A2 (en) 2000-09-19 2002-03-28 Microbia, Inc. Modulation of secondary metabolite production by zinc binuclear cluster proteins
CN1345963A (zh) * 2000-09-29 2002-04-24 上海博德基因开发有限公司 一种新的多肽——udp糖基转移酶(ugt)及钴胺素结合蛋白9.57和编码这种多肽的多核苷酸
ATE384119T1 (de) 2000-09-29 2008-02-15 Cargill Inc Isoprenoidproduktion
US6949362B2 (en) 2000-12-12 2005-09-27 E. I. Du Pont De Nemours And Company Rhodococcus cloning and expression vectors
WO2002059297A2 (en) 2001-01-25 2002-08-01 Evolva Biotech A/S A library of a collection of cells
US20050003474A1 (en) 2001-01-26 2005-01-06 Desouza Mervyn L. Carotenoid biosynthesis
US20040078846A1 (en) 2002-01-25 2004-04-22 Desouza Mervyn L. Carotenoid biosynthesis
DE10201458A1 (de) 2001-04-11 2002-10-17 Adelbert Bacher Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg
US7034140B2 (en) 2001-04-24 2006-04-25 E.I. Du Pont De Nemours And Company Genes involved in isoprenoid compound production
AU2002316966B2 (en) 2001-06-06 2007-05-17 Dsm Ip Assets B.V. Improved isoprenoid production
EP1402042A2 (en) 2001-06-22 2004-03-31 Syngenta Participations AG Abiotic stress responsive polynucleotides and polypeptides
NZ513755A (en) 2001-08-24 2001-09-28 Ann Rachel Holmes Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs
US20040072311A1 (en) 2001-08-28 2004-04-15 Dicosimo Deana J. Production of cyclic terpenoids
US20040010815A1 (en) 2001-09-26 2004-01-15 Lange B. Markus Identification and characterization of plant genes
US7172886B2 (en) 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
JP2005185101A (ja) 2002-05-30 2005-07-14 National Institute Of Agrobiological Sciences 植物の全長cDNAおよびその利用
US7514597B2 (en) 2002-08-20 2009-04-07 Suntory Limited Glycosyltransferase gene
EP1543115B1 (en) 2002-09-27 2008-05-07 DSM IP Assets B.V. Squalene synthase (sqs) gene
US7098000B2 (en) 2003-06-04 2006-08-29 E. I. Du Pont De Nemoure And Company Method for production of C30-aldehyde carotenoids
KR101190897B1 (ko) 2003-06-12 2012-10-12 디에스엠 아이피 어셋츠 비.브이. 피드백 내성 메발로네이트 키나아제
US7569389B2 (en) 2004-09-30 2009-08-04 Ceres, Inc. Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics
ES2379368T3 (es) 2004-05-21 2012-04-25 The Regents Of The University Of California Método para aumentar la producción de compuestos isoprenoides
CA2559760A1 (en) 2004-07-02 2006-07-06 Metanomics Gmbh Process for the production of fine chemicals
US20060014264A1 (en) 2004-07-13 2006-01-19 Stowers Institute For Medical Research Cre/lox system with lox sites having an extended spacer region
WO2006016395A1 (ja) * 2004-08-09 2006-02-16 National University Corporation Tohoku University Udp−グルクロニル基転移酵素およびその遺伝子
JP5074185B2 (ja) 2004-08-19 2012-11-14 ディーエスエム アイピー アセッツ ビー.ブイ. イソプレノイドの生成
US7923552B2 (en) 2004-10-18 2011-04-12 SGF Holdings, LLC High yield method of producing pure rebaudioside A
WO2006063752A1 (en) 2004-12-14 2006-06-22 Dsm Ip Assets B.V. Improved mevalonate kinase
AU2006219823A1 (en) 2005-03-02 2006-09-08 Metanomics Gmbh Process for the production of fine chemicals
WO2006096392A2 (en) 2005-03-04 2006-09-14 Diversa Corporation Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them
JP4284562B2 (ja) * 2005-03-04 2009-06-24 独立行政法人産業技術総合研究所 Udp−キシロースの製造方法
WO2007022318A2 (en) 2005-08-17 2007-02-22 Cornell Research Foundation Nucleic acids and proteins associated with sucrose accumulation in coffee
EP1916888A4 (en) 2005-08-22 2011-05-18 Co2 Boost Llc DEVICE AND PROCESS FOR GENERATING CO2 USED FOR HARVEST PRODUCTION AND SUBMARINE GARDENING
US8293307B2 (en) 2005-10-11 2012-10-23 Purecircle Sdn Bhd Process for manufacturing a sweetener and use thereof
US20070116833A1 (en) * 2005-11-23 2007-05-24 The Coca-Cola Company High-Potency Sweetener Composition with Calcium and Compositions Sweetened Therewith
EP1971228A1 (en) 2005-11-23 2008-09-24 The Coca-Cola Company Natural high-potency sweetener compositions with improved temporal profile and/or flavor profile, methods for their formulation, and uses
KR100784261B1 (ko) 2006-01-02 2007-12-11 한국과학기술원 탄저균의 포자외막 단백질을 이용한 목적단백질의 미생물표면발현방법
US7927851B2 (en) * 2006-03-21 2011-04-19 Vineland Research And Innovation Centre Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same
EP2090662A3 (en) * 2006-04-05 2012-10-31 Metanomics GmbH Process for the production of a fine chemical
US8114645B2 (en) 2006-05-19 2012-02-14 The Regents Of The University Of California Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels
WO2007147275A1 (en) 2006-06-19 2007-12-27 Givaudan Sa Nucleic acid, polypeptide and its use
WO2008008256A2 (en) 2006-07-07 2008-01-17 The Regents Of The University Of California Methods for enhancing production of isoprenoid compounds by host cells
DK2066778T3 (en) 2006-09-26 2016-04-18 Amyris Biotechnologies Inc PREPARATION OF ISOPRENOIDS AND ISOPRENOID PRECURSORS
US7741119B2 (en) 2006-09-28 2010-06-22 E. I. Du Pont De Nemours And Company Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production
US7629156B2 (en) 2006-09-28 2009-12-08 E.I. Du Pont De Nemours And Company Ethanol production in fermentation of mixed sugars containing xylose
CN101200480B (zh) 2006-12-15 2011-03-30 成都华高药业有限公司 莱鲍迪甙a的提取方法
JP4915917B2 (ja) 2006-12-22 2012-04-11 独立行政法人農業・食品産業技術総合研究機構 ラクト−n−ビオースi及びガラクト−n−ビオースの製造方法
EP2124633B1 (en) 2007-01-22 2012-03-07 Cargill, Incorporated Method of producing purified rebaudioside a compositions using solvent/antisolvent crystallization
US20130071521A1 (en) * 2007-03-14 2013-03-21 Pepsico, Inc. Rebaudioside d sweeteners and food products sweetened with rebaudioside d
JP2008237110A (ja) 2007-03-27 2008-10-09 Institute Of Physical & Chemical Research ステビオール合成酵素遺伝子及びステビオールの製造方法
WO2008144060A2 (en) 2007-05-17 2008-11-27 Tetravitae Bioscience, Inc. Methods and compositions for producing solvents
US20080292775A1 (en) 2007-05-22 2008-11-27 The Coca-Cola Company Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses
WO2009005704A1 (en) 2007-07-03 2009-01-08 The Regents Of The University Of California Methods of increasing isoprenoid or isoprenoid precursor production
JP2009034080A (ja) 2007-08-03 2009-02-19 Sanei Gen Ffi Inc 新規糖転移酵素、及びそれを利用した配糖体の製造
US7964232B2 (en) 2007-09-17 2011-06-21 Pepsico, Inc. Steviol glycoside isomers
CN101939435A (zh) 2007-09-21 2011-01-05 巴斯夫植物科学有限公司 具有增加的产量的植物
EP2214681B1 (en) 2007-12-03 2021-10-20 DSM IP Assets B.V. Novel nutraceutical compositions containing steviol and uses thereof
AU2008343039B2 (en) 2007-12-27 2014-04-24 Heartland Consumer Products, Llc Synergistic sweetening compositions
EP2250268A4 (en) * 2008-02-20 2011-08-24 Ceres Inc IMPROVED NITROGEN USE OF EFFICIENCY PROPERTIES IN PLANT NUCLEOTIDE SEQUENCES AND CORRESPONDING POLYPEPTIDES
TWI475963B (zh) 2008-02-25 2015-03-11 Coca Cola Co 甜菊糖苷a衍生性產物以及製造彼的方法
CN102015995B (zh) 2008-03-03 2014-10-22 焦耳无限科技公司 产生碳基目的产物的二氧化碳固定工程微生物
US9005444B2 (en) 2008-05-13 2015-04-14 Cargill, Incorporated Separation of rebaudioside A from stevia glycosides using chromatography
CN101314776B (zh) 2008-07-11 2010-11-03 南京农业大学 二磷酸尿核甘葡萄糖基转移酶基因及其所编码的蛋白质
WO2010021001A2 (en) 2008-08-19 2010-02-25 Kaushik Ramakrishnan S Process for preparing sweetener from stevia rebaudiana
PL2350110T3 (pl) 2008-10-03 2016-12-30 Nowe glikozydy stewiolowe
CN101720910B (zh) 2008-10-23 2012-07-25 大闽食品(漳州)有限公司 一种甜菊糖甙的制备方法
US8614085B2 (en) 2009-02-27 2013-12-24 Butamax(Tm) Advanced Biofuels Llc Yeast with increased butanol tolerance involving a multidrug efflux pump gene
US20100297722A1 (en) 2009-05-20 2010-11-25 Board Of Trustees Of Southern Illinois University Transgenic moss producing terpenoids
ES2660698T3 (es) 2009-06-08 2018-03-23 Jennewein Biotechnologie Gmbh Síntesis de HMO
AU2010261471A1 (en) 2009-06-16 2011-12-15 Epc (Beijing) Natural Products Co., Ltd. Composition comprising rebaudioside D for reducing or eliminating aftertaste and preparation method thereof
SG178376A1 (en) 2009-09-04 2012-03-29 Redpoint Bio Corp Sweetness enhancers including rebaudioside a or d
CA2773917A1 (en) 2009-09-22 2011-03-31 Redpoint Bio Corporation Novel polymorphs of rebaudioside c and methods for making and using the same
ES2661539T3 (es) 2009-10-15 2018-04-02 Purecircle Sdn Bhd Rebaudiósido D de pureza elevada y aplicaciones
US8299224B2 (en) 2009-10-15 2012-10-30 Purecircle Sdn Bhd High-purity Rebaudioside D
US8703224B2 (en) 2009-11-04 2014-04-22 Pepsico, Inc. Method to improve water solubility of Rebaudioside D
US8512988B2 (en) 2009-11-10 2013-08-20 Massachusetts Institute Of Technology Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
US8993840B2 (en) 2009-11-23 2015-03-31 E I du Pont de Nemours and Compay Sucrose transporter genes for increasing plant seed lipids
CA2783351C (en) 2009-12-10 2021-09-07 Regents Of The University Of Minnesota Tal effector-mediated dna modification
MX2012007607A (es) 2009-12-28 2012-07-20 Coca Cola Co Intensificadores de dulzor, composiciones de los mismos y metodos para su uso.
KR101244315B1 (ko) 2010-10-19 2013-03-14 이화여자대학교 산학협력단 에탄올―저항성 효모 유전자 및 이의 용도
WO2011140329A1 (en) 2010-05-06 2011-11-10 Ceres, Inc. Transgenic plants having increased biomass
EP2571991A1 (en) 2010-05-20 2013-03-27 Evolva SA Method of producing isoprenoid compounds in yeast
EP2575499A2 (en) 2010-05-31 2013-04-10 Vib Vzw The use of transporters to modulate flavor production by yeast
BR122021005297B1 (pt) 2010-06-02 2022-02-22 Evolva, Inc Método para transferir uma segunda porção de açúcar para uma posição c-2' de uma glicose em um glicosídeo de esteviol
US20120021111A1 (en) 2010-07-23 2012-01-26 Aexelon Therapeutics, Inc. Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture
US20120083593A1 (en) 2010-10-01 2012-04-05 Shanghai Yongyou Bioscience Inc. Separation and Purification of Stevioside and Rebaudioside A
US9284570B2 (en) 2010-11-30 2016-03-15 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
KR20130014227A (ko) 2011-07-29 2013-02-07 한국생명공학연구원 신규한 α-글루코실 스테비오사이드 및 이의 제조 방법
JP6126597B2 (ja) 2011-08-08 2017-05-10 エヴォルヴァ エスアー.Evolva Sa. サフラン化合物の組換え生成のための方法および材料
JP6262653B2 (ja) 2011-08-08 2018-01-17 エヴォルヴァ エスアー.Evolva Sa. ステビオール配糖体の組換え生産
AU2012342114B2 (en) 2011-11-23 2017-12-21 Danstar Ferment Ag Methods and materials for enzymatic synthesis of mogroside compounds
CN103159808B (zh) 2011-12-09 2017-03-29 上海泓博智源医药股份有限公司 一种制备天然甜味剂的工艺方法
EP3735841A1 (en) 2011-12-19 2020-11-11 PureCircle SDN BHD Methods for purifying steviol glycosides and uses of the same
EA201400836A8 (ru) 2012-01-23 2016-03-31 ДСМ АйПи АССЕТС Б.В. Получение дитерпена
CN102559528B (zh) 2012-02-09 2013-08-21 南京工业大学 一种产甜叶菊糖基转移酶ugt76g1的基因工程菌及其应用
WO2013137487A1 (ja) * 2012-03-16 2013-09-19 サントリーホールディングス株式会社 ステビオール配糖体化酵素およびそれをコードする遺伝子
EP2852296B1 (en) 2012-05-22 2021-12-15 PureCircle SDN BHD Process for producing a high-purity steviol glycoside
CN103710318B (zh) 2012-09-29 2017-01-18 中国科学院上海生命科学研究院 利用微生物生产甜菊糖苷类化合物的方法
WO2014086890A1 (en) 2012-12-05 2014-06-12 Evolva Sa Steviol glycoside compositions sensory properties
KR20150115002A (ko) 2013-02-06 2015-10-13 에볼바 에스아 레바우디오시드 d 및 레바우디오시드 m의 개선된 생산 방법
CN105189176B (zh) 2013-02-11 2017-11-07 达纳比利时股份有限公司 流体静力和直接驱动传动装置
CN105189771B (zh) 2013-02-11 2019-11-05 埃沃尔瓦公司 在重组宿主中有效产生甜菊醇糖苷
AU2014273054A1 (en) 2013-05-31 2015-12-03 Dsm Ip Assets B.V. Extracellular diterpene production
CA2913876A1 (en) 2013-05-31 2014-12-04 Dsm Ip Assets B.V. Microorganisms for diterpene production
KR101559478B1 (ko) 2013-06-24 2015-10-13 한국생명공학연구원 효소전환법을 이용한 천연 고감미료의 제조방법
AU2014292150B2 (en) 2013-07-15 2019-04-04 Dsm Ip Assets B.V. Diterpene production
WO2015011209A1 (en) 2013-07-23 2015-01-29 Dsm Ip Assets B.V. Diterpene production in yarrowia
EP3536697A1 (en) 2013-07-31 2019-09-11 DSM IP Assets B.V. Recovery of steviol glycosides
CN105658081A (zh) 2013-07-31 2016-06-08 帝斯曼知识产权资产管理有限公司 甜菊糖苷
WO2015016393A1 (ja) 2013-08-02 2015-02-05 サントリーホールディングス株式会社 ヘキセノール配糖体化酵素の利用方法
CN103397064B (zh) 2013-08-14 2015-04-15 苏州汉酶生物技术有限公司 一种酶法制备瑞鲍迪甙m的方法
WO2015028324A2 (en) 2013-08-30 2015-03-05 Evolva Sa A method for producing modified resveratrol
WO2015051454A1 (en) 2013-10-07 2015-04-16 Vineland Research And Innovation Centre Compositions and methods for producing steviol and steviol glycosides
WO2015132411A2 (en) 2014-03-07 2015-09-11 Evolva Sa Methods for recombinant production of saffron compounds
CA2957331A1 (en) 2014-08-11 2016-02-18 Evolva Sa Production of steviol glycosides in recombinant hosts
US10612064B2 (en) 2014-09-09 2020-04-07 Evolva Sa Production of steviol glycosides in recombinant hosts
EP4148137A1 (en) 2015-01-30 2023-03-15 Evolva SA Production of steviol glycosides in recombinant hosts
CA2979931A1 (en) 2015-03-16 2016-09-22 Dsm Ip Assets B.V. Udp-glycosyltransferases
CN104845990A (zh) 2015-06-11 2015-08-19 山东大学 拟南芥糖基转移酶基因ugt73c7在提高植物抗病性中的应用
BR112018002564A2 (pt) 2015-08-07 2018-09-25 Evolva Sa produção de glicosídeos de esteviol em hospedeiros recombinantes

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