JP6177127B2 - ステビオールグリコシドの組換え生成 - Google Patents
ステビオールグリコシドの組換え生成 Download PDFInfo
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- JP6177127B2 JP6177127B2 JP2013513355A JP2013513355A JP6177127B2 JP 6177127 B2 JP6177127 B2 JP 6177127B2 JP 2013513355 A JP2013513355 A JP 2013513355A JP 2013513355 A JP2013513355 A JP 2013513355A JP 6177127 B2 JP6177127 B2 JP 6177127B2
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- steviol
- seq
- steviol glycoside
- polypeptide
- residue
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- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/56—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical directly bound to a condensed ring system having three or more carbocyclic rings, e.g. daunomycin, adriamycin
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- A23L27/30—Artificial sweetening agents
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- C12N9/0073—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with NADH or NADPH as one donor, and incorporation of one atom of oxygen 1.14.13
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- Proteomics, Peptides & Aminoacids (AREA)
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35055310P | 2010-06-02 | 2010-06-02 | |
| US61/350,553 | 2010-06-02 | ||
| US201161434582P | 2011-01-20 | 2011-01-20 | |
| US61/434,582 | 2011-01-20 | ||
| US201161471622P | 2011-04-04 | 2011-04-04 | |
| US61/471,622 | 2011-04-04 | ||
| PCT/US2011/038967 WO2011153378A1 (en) | 2010-06-02 | 2011-06-02 | Recombinant Production of Steviol Glycosides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
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Families Citing this family (144)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9392799B2 (en) | 2011-02-17 | 2016-07-19 | Purecircle Sdn Bhd | Glucosyl stevia composition |
| US9386797B2 (en) | 2011-02-17 | 2016-07-12 | Purecircle Sdn Bhd | Glucosyl stevia composition |
| US8257948B1 (en) | 2011-02-17 | 2012-09-04 | Purecircle Usa | Method of preparing alpha-glucosyl Stevia composition |
| US8790730B2 (en) | 2005-10-11 | 2014-07-29 | Purecircle Usa | Process for manufacturing a sweetener and use thereof |
| US9107436B2 (en) | 2011-02-17 | 2015-08-18 | Purecircle Sdn Bhd | Glucosylated steviol glycoside as a flavor modifier |
| US8318459B2 (en) | 2011-02-17 | 2012-11-27 | Purecircle Usa | Glucosyl stevia composition |
| EP2594648B1 (en) | 2009-11-10 | 2016-03-16 | Massachusetts Institute of Technology | Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway |
| US8927241B2 (en) | 2009-11-10 | 2015-01-06 | Massachusetts Institute Of Technology | Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway |
| US10004245B2 (en) | 2009-11-12 | 2018-06-26 | Purecircle Sdn Bhd | Granulation of a stevia sweetener |
| US20150344512A1 (en) | 2011-12-19 | 2015-12-03 | Purecircle Usa Inc. | Methods of purifying steviol glycosides and uses of the same |
| US10696706B2 (en) | 2010-03-12 | 2020-06-30 | Purecircle Usa Inc. | Methods of preparing steviol glycosides and uses of the same |
| EP2544538B1 (en) | 2010-03-12 | 2022-06-15 | PureCircle USA Inc. | High-purity steviol glycosides |
| EP2571991A1 (en) * | 2010-05-20 | 2013-03-27 | Evolva SA | Method of producing isoprenoid compounds in yeast |
| BR122021005297B1 (pt) | 2010-06-02 | 2022-02-22 | Evolva, Inc | Método para transferir uma segunda porção de açúcar para uma posição c-2' de uma glicose em um glicosídeo de esteviol |
| US9284570B2 (en) * | 2010-11-30 | 2016-03-15 | Massachusetts Institute Of Technology | Microbial production of natural sweeteners, diterpenoid steviol glycosides |
| MX346137B (es) | 2010-12-13 | 2017-03-08 | Purecircle Usa Inc | Rebaudiosido d altamente soluble. |
| US9510611B2 (en) | 2010-12-13 | 2016-12-06 | Purecircle Sdn Bhd | Stevia composition to improve sweetness and flavor profile |
| US10362797B2 (en) | 2011-02-10 | 2019-07-30 | Purecircle Sdn Bhd | Stevia composition |
| US9603373B2 (en) | 2011-02-17 | 2017-03-28 | Purecircle Sdn Bhd | Glucosyl stevia composition |
| US11690391B2 (en) | 2011-02-17 | 2023-07-04 | Purecircle Sdn Bhd | Glucosylated steviol glycoside as a flavor modifier |
| US9474296B2 (en) | 2011-02-17 | 2016-10-25 | Purecircle Sdn Bhd | Glucosyl stevia composition |
| US9894922B2 (en) | 2011-05-18 | 2018-02-20 | Purecircle Sdn Bhd | Glucosyl rebaudioside C |
| WO2012166163A1 (en) | 2011-05-31 | 2012-12-06 | Purecircle Usa | Stevia composition |
| PL2713762T3 (pl) | 2011-06-03 | 2017-07-31 | Purecircle Usa | Kompozycja stewii |
| ES2713573T3 (es) | 2011-06-20 | 2019-05-22 | Purecircle Usa Inc | Composición de estevia |
| US9771434B2 (en) | 2011-06-23 | 2017-09-26 | Purecircle Sdn Bhd | Products from stevia rebaudiana |
| KR20200057799A (ko) * | 2011-08-08 | 2020-05-26 | 에볼바 에스아 | 스테비올 글리코시드의 재조합 생산 |
| US10480019B2 (en) | 2011-08-10 | 2019-11-19 | Purecircle Sdn Bhd | Process for producing high-purity rubusoside |
| EP2753189B1 (en) | 2011-09-07 | 2020-12-16 | Purecircle Usa Inc. | Highly soluble stevia sweetener |
| CN103031283B (zh) * | 2011-10-08 | 2015-07-08 | 成都华高瑞甜科技有限公司 | 甜叶菊酶vi及莱鲍迪苷a转化为莱鲍迪苷d的方法 |
| IN2014CN03557A (enExample) | 2011-11-23 | 2015-10-09 | Evolva Sa | |
| RU2728234C2 (ru) | 2011-12-19 | 2020-07-28 | Дзе Кока-Кола Компани | Композиции, содержащие ребаудиозид х |
| FR2984743B1 (fr) * | 2011-12-23 | 2014-08-22 | Oreal | Utilisation cosmetique du steviol, d'un derive glycoside du steviol, ou un de leurs isomeres pour stimuler, restaurer ou reguler le metabolisme des cellules de la peau et des semi-muqueuses. |
| AU2013211605B2 (en) * | 2012-01-23 | 2017-04-06 | Dsm Ip Assets B.V. | Diterpene production |
| CA2867112C (en) * | 2012-03-16 | 2021-04-20 | Suntory Holdings Limited | Steviol glucosyltransferases and genes encoding the same |
| CA2867572C (en) * | 2012-03-27 | 2023-02-21 | Suntory Holdings Limited | Method for producing steviol glycoside |
| US20130338348A1 (en) * | 2012-03-30 | 2013-12-19 | J.R. Simplot Company | Steviol and steviol glycoside formation in plants |
| US9752174B2 (en) | 2013-05-28 | 2017-09-05 | Purecircle Sdn Bhd | High-purity steviol glycosides |
| MX352678B (es) * | 2012-05-22 | 2017-12-04 | Purecircle Sdn Bhd | Glucosidos de esteviol de alta pureza. |
| TW201402599A (zh) | 2012-05-30 | 2014-01-16 | Suntory Holdings Ltd | 甜菊糖苷糖苷轉化酵素及編碼該酵素之基因 |
| CA2886893C (en) | 2012-09-29 | 2019-05-07 | Yong Wang | Method for producing stevioside compounds by microorganism |
| JP2015536157A (ja) | 2012-12-04 | 2015-12-21 | エヴォルヴァ エスアー.Evolva Sa. | モグロシド化合物の生合成のための方法および材料 |
| US20150342234A1 (en) * | 2012-12-05 | 2015-12-03 | Evolva Sa | Steviol Glycoside Compositions Sensory Properties |
| CA2899276C (en) * | 2013-02-06 | 2022-11-01 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| SG10201705993YA (en) * | 2013-02-11 | 2017-08-30 | Evolva Sa | Efficient production of steviol glycosides in recombinant hosts |
| KR101404728B1 (ko) * | 2013-02-28 | 2014-06-09 | 씨제이제일제당 (주) | 스테비오사이드로부터 리바우디오사이드 a를 제조하는 방법 |
| EP2970354B1 (en) | 2013-03-15 | 2018-05-30 | The Coca-Cola Company | Steviol glycosides and their compositions |
| WO2014191581A2 (en) * | 2013-05-31 | 2014-12-04 | Dsm Ip Assets B.V. | Microorganisms for diterpene production |
| CN105247064A (zh) * | 2013-05-31 | 2016-01-13 | 帝斯曼知识产权资产管理有限公司 | 细胞外的二萜生产 |
| US10952458B2 (en) | 2013-06-07 | 2021-03-23 | Purecircle Usa Inc | Stevia extract containing selected steviol glycosides as flavor, salty and sweetness profile modifier |
| CN105682467A (zh) | 2013-06-07 | 2016-06-15 | 谱赛科美国股份有限公司 | 含有选择的甜叶菊醇糖苷作为香、咸和甜度特征修饰物的甜叶菊提取物 |
| KR101559478B1 (ko) | 2013-06-24 | 2015-10-13 | 한국생명공학연구원 | 효소전환법을 이용한 천연 고감미료의 제조방법 |
| CN108064135A (zh) * | 2013-07-15 | 2018-05-22 | 帝斯曼知识产权资产管理有限公司 | 二萜的生产 |
| WO2015011209A1 (en) * | 2013-07-23 | 2015-01-29 | Dsm Ip Assets B.V. | Diterpene production in yarrowia |
| MX2016000825A (es) * | 2013-07-31 | 2016-05-24 | Dsm Ip Assets Bv | Glicosidos de esteviol. |
| WO2015014959A1 (en) * | 2013-07-31 | 2015-02-05 | Dsm Ip Assets B.V. | Recovery of steviol glycosides |
| AU2014297224A1 (en) | 2013-08-02 | 2016-03-03 | Suntory Holdings Limited | Method for using hexenol glycosyl transferase |
| CN103397064B (zh) | 2013-08-14 | 2015-04-15 | 苏州汉酶生物技术有限公司 | 一种酶法制备瑞鲍迪甙m的方法 |
| US20160215306A1 (en) * | 2013-08-30 | 2016-07-28 | Evolva Sa | Method for producing modified resveratrol |
| ES2709439T3 (es) | 2013-11-01 | 2019-04-16 | Conagen Inc | Producción recombinante de glucósidos de esteviol |
| WO2015113569A1 (en) | 2014-01-31 | 2015-08-06 | University Of Copenhagen | Biosynthesis of forskolin and related compounds |
| US20180020709A1 (en) * | 2014-04-16 | 2018-01-25 | Purecircle Usa Inc. | Rebaudioside m biosynthetic production and recovery methods |
| CA2957331A1 (en) | 2014-08-11 | 2016-02-18 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| MX2017002764A (es) | 2014-09-02 | 2017-05-04 | Purecircle Sdn Bhd | Extractos de estevia. |
| CN105850727B (zh) | 2015-01-23 | 2018-12-07 | 谱赛科美国公司 | 甜叶菊新品种及高rd、rm含量甜菊糖苷的制备 |
| US10612064B2 (en) | 2014-09-09 | 2020-04-07 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| MX389746B (es) | 2014-09-19 | 2025-03-20 | Purecircle Sdn Bhd | Esteviol glicosidos de alta pureza. |
| WO2016048994A2 (en) * | 2014-09-23 | 2016-03-31 | President And Fellows Of Harvard College | Systems and methods of cell-free protein synthesis in droplets and other compartments |
| US10370673B2 (en) | 2014-09-26 | 2019-08-06 | Purecircle Sdn Bhd | Single nucleotide polymorphism (SNP) markers for stevia |
| JP2017529860A (ja) | 2014-10-01 | 2017-10-12 | エヴォルヴァ エスアー.Evolva Sa. | モグロシド化合物の生合成のための方法および材料 |
| CN106714578B (zh) * | 2014-10-03 | 2020-07-28 | 康纳根有限公司 | 无热量甜味剂及合成方法 |
| EP3204506B1 (en) * | 2014-10-08 | 2022-01-12 | DSM IP Assets B.V. | Steviol glycoside production |
| WO2016073740A1 (en) * | 2014-11-05 | 2016-05-12 | Manus Biosynthesis, Inc. | Microbial production of steviol glycosides |
| US10208326B2 (en) | 2014-11-13 | 2019-02-19 | Evolva Sa | Methods and materials for biosynthesis of manoyl oxide |
| CN109006460B (zh) * | 2015-01-23 | 2022-03-22 | 谱赛科美国公司 | 甜叶菊新品种817096谱星5号及高rd含量甜菊糖苷的制备 |
| CN108522291B (zh) | 2015-01-23 | 2022-01-04 | 谱赛科美国公司 | 利用甜叶菊新品种814011谱星3号制备高rm含量甜菊糖苷的方法 |
| US10364450B2 (en) | 2015-01-30 | 2019-07-30 | Evolva Sa | Production of steviol glycoside in recombinant hosts |
| WO2016146711A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| JP6799010B2 (ja) | 2015-05-28 | 2020-12-09 | エヴォルヴァ エスアー.Evolva Sa. | フェニルプロパノイドおよびフェニルプロパノイド誘導体の生合成 |
| BR112017025705B1 (pt) | 2015-05-29 | 2022-05-10 | Cargill, Incorporated | Método de liberação de glicosídeos de esteviol de uma célula hospedeira |
| EP3303553B1 (en) * | 2015-05-29 | 2022-07-27 | Cargill, Incorporated | Fermentation methods for producing steviol glycosides using high ph |
| BR112017025709B1 (pt) | 2015-05-29 | 2024-03-05 | Cargill, Incorporated | Método para produzir glicosídeos de esteviol |
| CN107820394A (zh) | 2015-07-10 | 2018-03-20 | 帝斯曼知识产权资产管理有限公司 | 甜菊醇糖苷组合物 |
| EP3319974B1 (en) * | 2015-07-10 | 2024-11-06 | DSM IP Assets B.V. | Method for reducing kaurenoic acid in a steviol glycoside composition |
| AU2016301190A1 (en) | 2015-08-06 | 2018-02-15 | Cargill, Incorporated | Fermentation methods for producing steviol glycosides |
| WO2017025362A1 (en) * | 2015-08-07 | 2017-02-16 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US10774314B2 (en) | 2015-08-21 | 2020-09-15 | Manus Bio Inc. | Increasing productivity of E. coli host cells that functionally express P450 enzymes |
| US9765117B2 (en) | 2015-08-24 | 2017-09-19 | Romek Figa | Peptides for treating cancer |
| WO2017060318A2 (en) | 2015-10-05 | 2017-04-13 | Dsm Ip Assets B.V. | Kaurenoic acid hydroxylases |
| CN115299547A (zh) | 2015-10-26 | 2022-11-08 | 谱赛科美国股份有限公司 | 甜菊醇糖苷组合物 |
| EP3384039B1 (en) | 2015-11-30 | 2025-04-30 | Purecircle SDN BHD | PROCESS FOR THE PRODUCTION OF HIGH PURITY STEVIOL GLYCOSIDES |
| BR112018011611A2 (pt) * | 2015-12-10 | 2018-11-27 | Evolva Sa | produção de glicosídeos de esteviol em hospedeiros recombinantes |
| CN108712864A (zh) | 2015-12-15 | 2018-10-26 | 谱赛科美国股份有限公司 | 甜菊醇糖苷组合物 |
| EP3426791A1 (en) * | 2016-03-11 | 2019-01-16 | Evolva SA | Production of steviol glycosides in recombinant hosts |
| CA3020671A1 (en) | 2016-04-13 | 2017-10-19 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| CN109312378A (zh) | 2016-05-16 | 2019-02-05 | 埃沃尔瓦公司 | 在重组宿主中产生甜菊醇糖苷 |
| JP2019519212A (ja) * | 2016-05-16 | 2019-07-11 | エヴォルヴァ エスアー.Evolva Sa. | 組換え宿主内でのステビオールグリコシドの産生 |
| CN109689878A (zh) * | 2016-06-06 | 2019-04-26 | 泰特&莱尔组分美国公司 | 糖基化甜菊醇糖苷组合物和制备糖基化甜菊醇糖苷组合物的方法 |
| CN109715182A (zh) | 2016-06-15 | 2019-05-03 | 科德克希思公司 | 工程化β-葡糖苷酶和葡糖基化方法 |
| PT3497222T (pt) | 2016-08-12 | 2022-02-09 | Amyris Inc | Glicosiltransferase dependente de udp para produção de eficácia elevada de rebaudiosídeos |
| CN116574775A (zh) | 2016-10-21 | 2023-08-11 | 百事可乐公司 | 一种酶法制备瑞鲍迪甙j的方法 |
| MX2019004629A (es) * | 2016-10-21 | 2019-06-06 | Pepsico Inc | Metodo para preparar rebaudiosido c mediante el uso del metodo enzimatico. |
| WO2018072213A1 (zh) | 2016-10-21 | 2018-04-26 | 苏州汉酶生物技术有限公司 | 一种酶法制备瑞鲍迪甙n的方法 |
| CN110100006A (zh) * | 2016-11-07 | 2019-08-06 | 埃沃尔瓦公司 | 重组宿主中甜菊糖苷的生产 |
| EP3564369A4 (en) | 2016-12-27 | 2020-07-29 | Suntory Holdings Limited | STEVIOL GLYCOSIDE HEXOSE TRANSFERASE AND CODING GENE FOR THIS |
| MY204430A (en) * | 2016-12-27 | 2024-08-28 | Suntory Holdings Ltd | Novel steviol glycoside, method for producing same, and sweetener composition containing same |
| CN108341781B (zh) * | 2017-01-25 | 2021-09-03 | 中国科学院分子植物科学卓越创新中心 | 植物次生代谢产物生物合成途径中相关酶类的解析方法 |
| UA127758C2 (uk) | 2017-01-26 | 2023-12-27 | Манус Байо, Інк. | Метаболічний інжиніринг мікробного продукування терпеноїдного продукту |
| US20180223264A1 (en) * | 2017-02-03 | 2018-08-09 | Codexis, Inc. | Engineered glycosyltransferases and steviol glycoside glucosylation methods |
| KR102357193B1 (ko) * | 2017-02-21 | 2022-02-04 | 듀크 유니버시티 | 견고한 동적 대사 조절을 위한 조성물 및 방법 |
| WO2018181515A1 (ja) * | 2017-03-31 | 2018-10-04 | サントリーホールディングス株式会社 | 新規ステビオール配糖体およびその製造方法、ならびにそれを含む甘味料組成物 |
| JP7011649B2 (ja) * | 2017-04-12 | 2022-02-10 | サントリーホールディングス株式会社 | ステビア由来ラムノース合成酵素及び遺伝子 |
| US20200157594A1 (en) * | 2017-05-15 | 2020-05-21 | Purecircle Usa Inc. | High-purity steviol glycosides |
| WO2018211032A1 (en) | 2017-05-17 | 2018-11-22 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| EP3638804A1 (en) | 2017-06-15 | 2020-04-22 | Evolva SA | Production of mogroside compounds in recombinant hosts |
| CN111263815A (zh) * | 2017-08-11 | 2020-06-09 | 阿迈瑞斯公司 | 用于高效生成瑞鲍迪苷的豌豆贝壳杉烯氧化酶 |
| US11365417B2 (en) | 2017-09-12 | 2022-06-21 | Bio Capital Holdings, LLC | Biological devices and methods of use thereof to produce steviol glycosides |
| BR112020009838A2 (pt) | 2017-12-05 | 2020-11-17 | Evolva Sa | produção de glicosídeos de esteviol em hospedeiros recombinantes |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| CA3106633A1 (en) * | 2018-07-16 | 2020-01-23 | Manus Bio, Inc. | Production of steviol glycosides through whole cell biotransformation |
| BR112021001661A8 (pt) | 2018-07-30 | 2022-08-09 | Codexis Inc | Glicosiltransferase modificada, polinucleotídeo modificado, vetor, célula hospedeira, métodos para produzir pelo menos uma glicosiltransferase modificada, para produzir pelo menos uma variante de sacarose sintase, para glicosilação de um substrato, para produzir rebaudiosídeo m, rebaudiosídeo a e/ou rebaudiosídeo i e rebaudiosídeo d, composição, sacarose sintase modificada, pelo menos um rebaudiosídeo, rebaudiosídeo m, rebaudiosídeo a, rebaudiosídeo i, e, rebaudiosídeo d. |
| CA3118924A1 (en) | 2018-11-09 | 2020-05-14 | Ginkgo Bioworks, Inc. | Biosynthesis of mogrosides |
| US12029179B2 (en) | 2018-11-20 | 2024-07-09 | Purecircle Usa Inc. | Aneuploid stevia cultivar ‘AP-1’ |
| KR102709594B1 (ko) * | 2019-06-25 | 2024-09-26 | 마누스 바이오, 인크. | 우리딘 다이포스페이트-의존성 글라이코실트랜스퍼라제 효소 |
| EP4011993A4 (en) | 2019-08-08 | 2023-07-19 | Toagosei Co., Ltd. | ADHESIVE COMPOSITION THAT DISINTEGRATES EASILY IN WATER |
| CN110592040A (zh) * | 2019-09-18 | 2019-12-20 | 江苏施宇甜生物科技有限公司 | 一种用于生产upd糖基转移酶的重组枯草芽孢杆菌的工艺 |
| CN111424065B (zh) * | 2020-03-24 | 2022-08-16 | 金禾益康(北京)生物科技有限公司 | 使用糖基转移酶对甜菊糖苷类化合物进行糖基化方法 |
| WO2023006179A1 (en) | 2020-07-27 | 2023-02-02 | Dsm Ip Assets B.V. | Method to produce retinyl acetate |
| CN112147253B (zh) * | 2020-09-25 | 2022-04-01 | 安徽瑞思威尔科技有限公司 | 一种灵芝酒中42种有效成分的UPC2-PDA-Q-Tof/MS检测方法 |
| US20250290081A1 (en) | 2020-10-22 | 2025-09-18 | Dsm Ip Assets B.V. | Microorganisms for diterpene production |
| US20250320470A1 (en) * | 2020-12-23 | 2025-10-16 | Samyang Corporation | Glycosyltransferase and steviol glucoside preparation method using same |
| CN112877355A (zh) * | 2021-01-22 | 2021-06-01 | 杜云龙 | 一种利用烟草表达三七皂苷的方法 |
| WO2022245988A2 (en) * | 2021-05-18 | 2022-11-24 | Biokai, Inc. | Production of carotenoids |
| CN115478060B (zh) * | 2021-06-16 | 2023-11-28 | 弈柯莱生物科技(集团)股份有限公司 | 一种糖基转移酶及其应用 |
| WO2023006851A1 (en) | 2021-07-27 | 2023-02-02 | Dsm Ip Assets B.V. | Fermentative production of retinyl acetate in the presence of ethanol |
| CN115975827A (zh) * | 2021-10-15 | 2023-04-18 | 中国科学院分子植物科学卓越创新中心 | 用于甜茶素生产的宿主细胞及方法 |
| JP2025500510A (ja) * | 2021-12-24 | 2025-01-09 | サムヤン コーポレイション | 糖転移酵素変異体、およびこれを利用したステビオール配糖体の製造方法 |
| CN114703217B (zh) * | 2022-03-26 | 2025-09-02 | 江苏省中国科学院植物研究所 | 一种甜菊自交系种子转基因体系的建立方法 |
| CN114752575B (zh) * | 2022-04-07 | 2023-06-13 | 内蒙古工业大学 | 一种nad+依赖性脱氢酶基因及其在提高辅酶q10产量中的应用 |
| JPWO2024010074A1 (enExample) | 2022-07-07 | 2024-01-11 | ||
| CN116162607B (zh) * | 2023-01-04 | 2025-07-01 | 中国科学院大连化学物理研究所 | 一种甜菊糖苷糖基转移酶基因及其编码产物与应用 |
| CN116004563B (zh) * | 2023-01-17 | 2023-11-17 | 华中农业大学 | 一种茶树类黄酮糖基转移酶及其应用 |
| WO2024197447A1 (zh) * | 2023-03-24 | 2024-10-03 | 森瑞斯生物科技(深圳)有限公司 | HMG-CoA还原酶突变体及其在生产萜类化合物中的应用 |
| WO2024228615A1 (en) * | 2023-05-03 | 2024-11-07 | Purecircle Sdn. Bhd. | High-purity steviol glycosides |
Family Cites Families (153)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58149697A (ja) | 1982-02-27 | 1983-09-06 | Dainippon Ink & Chem Inc | β−1,3グリコシルステビオシドの製造方法 |
| JPS59101408A (ja) * | 1982-12-02 | 1984-06-12 | Junichi Iwamura | 植物生長調整剤 |
| US5198360A (en) | 1990-01-19 | 1993-03-30 | Eli Lilly And Company | Dna sequence conferring a plaque inhibition phenotype |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| US6946587B1 (en) | 1990-01-22 | 2005-09-20 | Dekalb Genetics Corporation | Method for preparing fertile transgenic corn plants |
| JPH03277275A (ja) | 1990-03-28 | 1991-12-09 | Dainippon Ink & Chem Inc | 新規酵素及びその酵素を用いた配糖体の製造方法 |
| US5204253A (en) | 1990-05-29 | 1993-04-20 | E. I. Du Pont De Nemours And Company | Method and apparatus for introducing biological substances into living cells |
| US5306862A (en) | 1990-10-12 | 1994-04-26 | Amoco Corporation | Method and composition for increasing sterol accumulation in higher plants |
| US5460949A (en) | 1990-11-15 | 1995-10-24 | Amoco Corporation | Method and composition for increasing the accumulation of squalene and specific sterols in yeast |
| US5712112A (en) | 1992-11-04 | 1998-01-27 | National Science Council Of R.O.C. | Gene expression system comprising the promoter region of the alpha-amylase genes |
| FI960173L (fi) | 1993-07-15 | 1996-03-15 | Neose Pharm Inc | Menetelmä sakkaridikoostumusten syntetisoimiseksi |
| US7186891B1 (en) | 1996-04-12 | 2007-03-06 | University Of Kentucky, Research Foundation | Plant cells and plants expressing chimeric isoprenoid synthases |
| JPH10117776A (ja) | 1996-10-22 | 1998-05-12 | Japan Tobacco Inc | インディカイネの形質転換方法 |
| EP1021551A1 (en) | 1997-10-06 | 2000-07-26 | Centre National De La Recherche Scientifique | Plant fatty acid hydroxylase genes |
| US6255557B1 (en) | 1998-03-31 | 2001-07-03 | Her Majesty The Queen In Right Of Canada As Represented By The Ministerof Agriculture And Agri-Food Canada | Stevia rebaudiana with altered steviol glycoside composition |
| US6806076B1 (en) | 1998-04-14 | 2004-10-19 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing isoprenoid compounds by microorganisms and a method for screening compounds with antibiotic or weeding activity |
| EP0955363A3 (en) | 1998-05-06 | 2004-01-28 | F. Hoffmann-La Roche Ag | Dna sequences encoding enzymes involved in production of isoprenoids |
| TWI250210B (en) | 1998-05-06 | 2006-03-01 | Dsm Ip Assets Bv | An isolated DNA sequence coding for an enzyme involved in the mevalonate pathway or the pathway from isopentenyl pyrophosphate to farnesyl pyrophosphate |
| ES2534937T3 (es) | 1998-07-06 | 2015-04-30 | Dcv Inc. Doing Business As Bio-Technical Resourses | Procedimiento de producción de vitaminas |
| US6531303B1 (en) | 1998-07-06 | 2003-03-11 | Arkion Life Sciences Llc | Method of producing geranylgeraniol |
| AR021636A1 (es) | 1998-12-17 | 2002-07-31 | Rubicon Forests Holdings Ltd | Materiales y metodos para la modificacion del contenido, la composicion y el metabolismo de los isoprenoides |
| CA2352488A1 (en) | 1998-12-23 | 2000-06-29 | The Samuel Roberts Noble Foundation, Inc. | Plant transformation process |
| CN100387721C (zh) | 1999-04-15 | 2008-05-14 | 卡尔根尼有限公司 | 编码参与类异戊二烯合成的蛋白质的核酸序列 |
| EP1171618A2 (en) | 1999-04-21 | 2002-01-16 | The Samuel Roberts Noble Foundation | Plant transformation process |
| ATE373715T1 (de) | 1999-08-04 | 2007-10-15 | Adelbert Bacher | Isoprenoid biosynthese |
| AU6780700A (en) | 1999-08-18 | 2001-03-13 | Paradigm Genetics, Inc. | Methods and apparatus for transformation of monocotyledenous plants using agrobacterium in combination with vacuum filtration |
| AU2001269685A1 (en) | 2000-05-03 | 2001-11-12 | The Salk Institute For Biological Studies | Crystallization of 4-diphosphocytidyl-2-c-methylerythritol synthesis |
| DE10027821A1 (de) | 2000-06-05 | 2001-12-06 | Adelbert Bacher | Der Mevalonat-unabhängige Isoprenoidbiosyntheseweg |
| AU2001278098A1 (en) | 2000-07-31 | 2002-02-13 | Frederick M. Hahn | Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms |
| WO2002016655A2 (en) | 2000-08-24 | 2002-02-28 | The Scripps Research Institute | Stress-regulated genes of plants, transgenic plants containing same, and methods of use |
| US6660507B2 (en) | 2000-09-01 | 2003-12-09 | E. I. Du Pont De Nemours And Company | Genes involved in isoprenoid compound production |
| US6689601B2 (en) | 2000-09-01 | 2004-02-10 | E. I. Du Pont De Nemours And Company | High growth methanotropic bacterial strain |
| US6818424B2 (en) | 2000-09-01 | 2004-11-16 | E. I. Du Pont De Nemours And Company | Production of cyclic terpenoids |
| AU2001291114A1 (en) | 2000-09-19 | 2002-04-02 | Microbia, Inc. | Modulation of secondary metabolite production by zinc binuclear cluster proteins |
| CN1345963A (zh) * | 2000-09-29 | 2002-04-24 | 上海博德基因开发有限公司 | 一种新的多肽——udp糖基转移酶(ugt)及钴胺素结合蛋白9.57和编码这种多肽的多核苷酸 |
| WO2002026933A2 (en) | 2000-09-29 | 2002-04-04 | Cargill Incorporated | Isoprenoid production |
| US6949362B2 (en) | 2000-12-12 | 2005-09-27 | E. I. Du Pont De Nemours And Company | Rhodococcus cloning and expression vectors |
| CA2474172C (en) | 2001-01-25 | 2012-07-10 | Evolva Ltd. | A library of a collection of cells |
| US20040078846A1 (en) | 2002-01-25 | 2004-04-22 | Desouza Mervyn L. | Carotenoid biosynthesis |
| US20050003474A1 (en) | 2001-01-26 | 2005-01-06 | Desouza Mervyn L. | Carotenoid biosynthesis |
| DE10201458A1 (de) | 2001-04-11 | 2002-10-17 | Adelbert Bacher | Intermediate und Enzyme des Mevalonat-unabhängigen Isoprenoidbiosyntheseweg |
| US7034140B2 (en) | 2001-04-24 | 2006-04-25 | E.I. Du Pont De Nemours And Company | Genes involved in isoprenoid compound production |
| DE60228439D1 (de) | 2001-06-06 | 2008-10-02 | Dsm Ip Assets Bv | Verbesserte isoprenoid herstellung |
| AU2002341541A1 (en) | 2001-06-22 | 2003-03-03 | Syngenta Participations Ag | Abiotic stress responsive polynucleotides and polypeptides |
| NZ513755A (en) | 2001-08-24 | 2001-09-28 | Ann Rachel Holmes | Protein expression system in yeast comprising a vector encoding a heterologous membrane protein and its application in screening for drugs |
| US20040072311A1 (en) | 2001-08-28 | 2004-04-15 | Dicosimo Deana J. | Production of cyclic terpenoids |
| US20040010815A1 (en) | 2001-09-26 | 2004-01-15 | Lange B. Markus | Identification and characterization of plant genes |
| US7172886B2 (en) | 2001-12-06 | 2007-02-06 | The Regents Of The University Of California | Biosynthesis of isopentenyl pyrophosphate |
| JP2005185101A (ja) | 2002-05-30 | 2005-07-14 | National Institute Of Agrobiological Sciences | 植物の全長cDNAおよびその利用 |
| EP1544300B1 (en) | 2002-08-20 | 2009-09-30 | Suntory Holdings Limited | Novel glycosyltransferase genes |
| US7351564B2 (en) | 2002-09-27 | 2008-04-01 | Dsm Ip Assets B.V. | SQS gene |
| US7098000B2 (en) | 2003-06-04 | 2006-08-29 | E. I. Du Pont De Nemoure And Company | Method for production of C30-aldehyde carotenoids |
| US7422884B2 (en) | 2003-06-12 | 2008-09-09 | Dsm Ip Assetts B.V. | Feedback-resistant mevalonate kinases |
| US7569389B2 (en) | 2004-09-30 | 2009-08-04 | Ceres, Inc. | Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics |
| ATE537269T1 (de) | 2004-05-21 | 2011-12-15 | Univ California | Verfahren zur verbesserung der herstellung von isoprenoid-zusammensetzungen |
| CA2559760A1 (en) | 2004-07-02 | 2006-07-06 | Metanomics Gmbh | Process for the production of fine chemicals |
| US20060014264A1 (en) | 2004-07-13 | 2006-01-19 | Stowers Institute For Medical Research | Cre/lox system with lox sites having an extended spacer region |
| WO2006016395A1 (ja) | 2004-08-09 | 2006-02-16 | National University Corporation Tohoku University | Udp−グルクロニル基転移酵素およびその遺伝子 |
| US7572609B2 (en) | 2004-08-19 | 2009-08-11 | Dsm Ip Assets B.V. | Production of isoprenoids |
| US7923552B2 (en) | 2004-10-18 | 2011-04-12 | SGF Holdings, LLC | High yield method of producing pure rebaudioside A |
| CN101080490B (zh) | 2004-12-14 | 2012-08-15 | 帝斯曼知识产权资产管理有限公司 | 改进的甲羟戊酸激酶 |
| EP2194140A2 (en) | 2005-03-02 | 2010-06-09 | Metanomics GmbH | Process for the production of fine chemicals |
| JP4284562B2 (ja) * | 2005-03-04 | 2009-06-24 | 独立行政法人産業技術総合研究所 | Udp−キシロースの製造方法 |
| WO2006096392A2 (en) | 2005-03-04 | 2006-09-14 | Diversa Corporation | Enzymes involved in astaxanthin, carotenoid and isoprenoid biosynthetic pathways, genes encoding them and methods of making and using them |
| WO2007022318A2 (en) | 2005-08-17 | 2007-02-22 | Cornell Research Foundation | Nucleic acids and proteins associated with sucrose accumulation in coffee |
| EP1916888A4 (en) | 2005-08-22 | 2011-05-18 | Co2 Boost Llc | DEVICE AND PROCESS FOR GENERATING CO2 USED FOR HARVEST PRODUCTION AND SUBMARINE GARDENING |
| US8293307B2 (en) | 2005-10-11 | 2012-10-23 | Purecircle Sdn Bhd | Process for manufacturing a sweetener and use thereof |
| US20070116833A1 (en) * | 2005-11-23 | 2007-05-24 | The Coca-Cola Company | High-Potency Sweetener Composition with Calcium and Compositions Sweetened Therewith |
| CN103393062B (zh) | 2005-11-23 | 2016-08-31 | 可口可乐公司 | 具有改良时间变化形廓及/或风味形廓的天然高效甜味剂组成物与其调和方法和用途 |
| KR100784261B1 (ko) | 2006-01-02 | 2007-12-11 | 한국과학기술원 | 탄저균의 포자외막 단백질을 이용한 목적단백질의 미생물표면발현방법 |
| US7927851B2 (en) | 2006-03-21 | 2011-04-19 | Vineland Research And Innovation Centre | Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same |
| CA2644273A1 (en) | 2006-04-05 | 2008-03-27 | Metanomics Gmbh | Process for the production of a fine chemical |
| WO2007136847A2 (en) | 2006-05-19 | 2007-11-29 | The Regents Of The University Of California | Methods for increasing isoprenoid and isoprenoid precursor production by modulating fatty acid levels |
| EP2035827B1 (en) | 2006-06-19 | 2012-10-17 | Givaudan S.A. | Nucleic acid, polypeptide and its use |
| WO2008008256A2 (en) | 2006-07-07 | 2008-01-17 | The Regents Of The University Of California | Methods for enhancing production of isoprenoid compounds by host cells |
| DK3020799T3 (da) | 2006-09-26 | 2020-09-21 | Amyris Biotechnologies Inc | Fremstilling af isoprenoider og isoprenoid-prækursorer |
| US7741119B2 (en) | 2006-09-28 | 2010-06-22 | E. I. Du Pont De Nemours And Company | Xylitol synthesis mutant of xylose-utilizing zymomonas for ethanol production |
| US7629156B2 (en) | 2006-09-28 | 2009-12-08 | E.I. Du Pont De Nemours And Company | Ethanol production in fermentation of mixed sugars containing xylose |
| CN101200480B (zh) | 2006-12-15 | 2011-03-30 | 成都华高药业有限公司 | 莱鲍迪甙a的提取方法 |
| JP4915917B2 (ja) | 2006-12-22 | 2012-04-11 | 独立行政法人農業・食品産業技術総合研究機構 | ラクト−n−ビオースi及びガラクト−n−ビオースの製造方法 |
| JP5307730B2 (ja) | 2007-01-22 | 2013-10-02 | カーギル・インコーポレイテッド | 溶媒/貧溶媒晶析を用いる精製レバウディオサイドa組成物の製法 |
| US20130071521A1 (en) * | 2007-03-14 | 2013-03-21 | Pepsico, Inc. | Rebaudioside d sweeteners and food products sweetened with rebaudioside d |
| JP2008237110A (ja) | 2007-03-27 | 2008-10-09 | Institute Of Physical & Chemical Research | ステビオール合成酵素遺伝子及びステビオールの製造方法 |
| WO2008144060A2 (en) | 2007-05-17 | 2008-11-27 | Tetravitae Bioscience, Inc. | Methods and compositions for producing solvents |
| US20080292775A1 (en) | 2007-05-22 | 2008-11-27 | The Coca-Cola Company | Delivery Systems for Natural High-Potency Sweetener Compositions, Methods for Their Formulation, and Uses |
| WO2009005704A1 (en) | 2007-07-03 | 2009-01-08 | The Regents Of The University Of California | Methods of increasing isoprenoid or isoprenoid precursor production |
| JP2009034080A (ja) | 2007-08-03 | 2009-02-19 | Sanei Gen Ffi Inc | 新規糖転移酵素、及びそれを利用した配糖体の製造 |
| US7964232B2 (en) | 2007-09-17 | 2011-06-21 | Pepsico, Inc. | Steviol glycoside isomers |
| EP2594645A3 (en) | 2007-09-21 | 2013-11-06 | BASF Plant Science GmbH | Plants with increased yield |
| ES2901901T3 (es) | 2007-12-03 | 2022-03-24 | Dsm Ip Assets Bv | Nuevas composiciones nutracéuticas que contienen esteviol y uso de las mismas |
| NZ586358A (en) * | 2007-12-27 | 2013-04-26 | Mcneil Nutritionals Llc | Synergistic sweetening compositions comprising sucralose and a purified extract of stevia |
| CN102007214A (zh) * | 2008-02-20 | 2011-04-06 | 塞瑞斯公司 | 赋予植物提高的氮利用效率特性的核苷酸序列和相应的多肽 |
| TWI475963B (zh) * | 2008-02-25 | 2015-03-11 | Coca Cola Co | 甜菊糖苷a衍生性產物以及製造彼的方法 |
| EP2285948B1 (en) | 2008-03-03 | 2014-01-08 | Joule Unlimited Technologies, Inc. | Engineered co2 fixing microorganisms producing carbon-based products of interest |
| WO2009140394A1 (en) | 2008-05-13 | 2009-11-19 | Cargill, Incorporated | Separation of rebaudioside a from stevia glycosides using chromatography |
| CN101314776B (zh) | 2008-07-11 | 2010-11-03 | 南京农业大学 | 二磷酸尿核甘葡萄糖基转移酶基因及其所编码的蛋白质 |
| WO2010021001A2 (en) | 2008-08-19 | 2010-02-25 | Kaushik Ramakrishnan S | Process for preparing sweetener from stevia rebaudiana |
| ES2592377T3 (es) | 2008-10-03 | 2016-11-29 | Morita Kagaku Kogyo Co., Ltd. | Nuevos glucósidos de esteviol |
| CN101720910B (zh) | 2008-10-23 | 2012-07-25 | 大闽食品(漳州)有限公司 | 一种甜菊糖甙的制备方法 |
| US8614085B2 (en) | 2009-02-27 | 2013-12-24 | Butamax(Tm) Advanced Biofuels Llc | Yeast with increased butanol tolerance involving a multidrug efflux pump gene |
| US20100297722A1 (en) | 2009-05-20 | 2010-11-25 | Board Of Trustees Of Southern Illinois University | Transgenic moss producing terpenoids |
| MY182355A (en) | 2009-06-08 | 2021-01-20 | Chr Hansen Hmo Gmbh | Hmo synthesis |
| PL2482676T3 (pl) | 2009-06-16 | 2015-03-31 | Epc Beijing Natural Products Co Ltd | Zmniejszanie lub eliminowanie posmaku w słodziku przy użyciu rebaudiozydu D |
| MX2012002749A (es) | 2009-09-04 | 2012-07-04 | Redpoint Bio Corp | Aumentadores de dulzura incluyendo rebaudiosido a o d. |
| AU2010298437B2 (en) | 2009-09-22 | 2014-06-19 | Redpoint Bio Corporation | Novel polymorphs of rebaudioside C and methods for making and using the same |
| US8299224B2 (en) | 2009-10-15 | 2012-10-30 | Purecircle Sdn Bhd | High-purity Rebaudioside D |
| ES2457641T3 (es) | 2009-10-15 | 2014-04-28 | Purecircle Sdn Bhd | Procedimiento para preparar rebaudiósido D de pureza elevada |
| US8703224B2 (en) | 2009-11-04 | 2014-04-22 | Pepsico, Inc. | Method to improve water solubility of Rebaudioside D |
| EP2594648B1 (en) | 2009-11-10 | 2016-03-16 | Massachusetts Institute of Technology | Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway |
| WO2011062748A1 (en) | 2009-11-23 | 2011-05-26 | E.I. Du Pont De Nemours And Company | Sucrose transporter genes for increasing plant seed lipids |
| WO2011072246A2 (en) | 2009-12-10 | 2011-06-16 | Regents Of The University Of Minnesota | Tal effector-mediated dna modification |
| RU2572756C2 (ru) | 2009-12-28 | 2016-01-20 | Дзе Кока-Кола Компании | Усилители сладости, их композиции и способы применения |
| KR101244315B1 (ko) | 2010-10-19 | 2013-03-14 | 이화여자대학교 산학협력단 | 에탄올―저항성 효모 유전자 및 이의 용도 |
| WO2011140329A1 (en) | 2010-05-06 | 2011-11-10 | Ceres, Inc. | Transgenic plants having increased biomass |
| EP2571991A1 (en) | 2010-05-20 | 2013-03-27 | Evolva SA | Method of producing isoprenoid compounds in yeast |
| WO2011151326A2 (en) | 2010-05-31 | 2011-12-08 | Vib Vzw | The use of transporters to modulate flavor production by yeast |
| BR122021005297B1 (pt) | 2010-06-02 | 2022-02-22 | Evolva, Inc | Método para transferir uma segunda porção de açúcar para uma posição c-2' de uma glicose em um glicosídeo de esteviol |
| US20120021111A1 (en) | 2010-07-23 | 2012-01-26 | Aexelon Therapeutics, Inc. | Natural Low Caloric Sweetener Compositions for Use in Beverages, Foods and Pharmaceuticals, and Their Methods of Manufacture |
| US20120083593A1 (en) | 2010-10-01 | 2012-04-05 | Shanghai Yongyou Bioscience Inc. | Separation and Purification of Stevioside and Rebaudioside A |
| US9284570B2 (en) | 2010-11-30 | 2016-03-15 | Massachusetts Institute Of Technology | Microbial production of natural sweeteners, diterpenoid steviol glycosides |
| KR20130014227A (ko) | 2011-07-29 | 2013-02-07 | 한국생명공학연구원 | 신규한 α-글루코실 스테비오사이드 및 이의 제조 방법 |
| RU2676730C2 (ru) | 2011-08-08 | 2019-01-10 | Эвольва Са. | Способы и вещества для основанного на рекомбинации получения соединений шафрана |
| KR20200057799A (ko) | 2011-08-08 | 2020-05-26 | 에볼바 에스아 | 스테비올 글리코시드의 재조합 생산 |
| IN2014CN03557A (enExample) | 2011-11-23 | 2015-10-09 | Evolva Sa | |
| CN103159808B (zh) | 2011-12-09 | 2017-03-29 | 上海泓博智源医药股份有限公司 | 一种制备天然甜味剂的工艺方法 |
| RU2728234C2 (ru) | 2011-12-19 | 2020-07-28 | Дзе Кока-Кола Компани | Композиции, содержащие ребаудиозид х |
| AU2013211605B2 (en) | 2012-01-23 | 2017-04-06 | Dsm Ip Assets B.V. | Diterpene production |
| CN102559528B (zh) | 2012-02-09 | 2013-08-21 | 南京工业大学 | 一种产甜叶菊糖基转移酶ugt76g1的基因工程菌及其应用 |
| CA2867112C (en) * | 2012-03-16 | 2021-04-20 | Suntory Holdings Limited | Steviol glucosyltransferases and genes encoding the same |
| MX352678B (es) | 2012-05-22 | 2017-12-04 | Purecircle Sdn Bhd | Glucosidos de esteviol de alta pureza. |
| CA2886893C (en) | 2012-09-29 | 2019-05-07 | Yong Wang | Method for producing stevioside compounds by microorganism |
| US20150342234A1 (en) | 2012-12-05 | 2015-12-03 | Evolva Sa | Steviol Glycoside Compositions Sensory Properties |
| CA2899276C (en) | 2013-02-06 | 2022-11-01 | Evolva Sa | Methods for improved production of rebaudioside d and rebaudioside m |
| EP2953809B1 (en) | 2013-02-11 | 2016-12-28 | Dana Belgium N.V. | Hydrostatic and direct drive transmission |
| SG10201705993YA (en) | 2013-02-11 | 2017-08-30 | Evolva Sa | Efficient production of steviol glycosides in recombinant hosts |
| WO2014191581A2 (en) | 2013-05-31 | 2014-12-04 | Dsm Ip Assets B.V. | Microorganisms for diterpene production |
| CN105247064A (zh) | 2013-05-31 | 2016-01-13 | 帝斯曼知识产权资产管理有限公司 | 细胞外的二萜生产 |
| KR101559478B1 (ko) | 2013-06-24 | 2015-10-13 | 한국생명공학연구원 | 효소전환법을 이용한 천연 고감미료의 제조방법 |
| CN108064135A (zh) | 2013-07-15 | 2018-05-22 | 帝斯曼知识产权资产管理有限公司 | 二萜的生产 |
| WO2015011209A1 (en) | 2013-07-23 | 2015-01-29 | Dsm Ip Assets B.V. | Diterpene production in yarrowia |
| WO2015014959A1 (en) | 2013-07-31 | 2015-02-05 | Dsm Ip Assets B.V. | Recovery of steviol glycosides |
| MX2016000825A (es) | 2013-07-31 | 2016-05-24 | Dsm Ip Assets Bv | Glicosidos de esteviol. |
| AU2014297224A1 (en) | 2013-08-02 | 2016-03-03 | Suntory Holdings Limited | Method for using hexenol glycosyl transferase |
| CN103397064B (zh) | 2013-08-14 | 2015-04-15 | 苏州汉酶生物技术有限公司 | 一种酶法制备瑞鲍迪甙m的方法 |
| US20160215306A1 (en) | 2013-08-30 | 2016-07-28 | Evolva Sa | Method for producing modified resveratrol |
| WO2015051454A1 (en) | 2013-10-07 | 2015-04-16 | Vineland Research And Innovation Centre | Compositions and methods for producing steviol and steviol glycosides |
| US20170067063A1 (en) | 2014-03-07 | 2017-03-09 | Evolva Sa | Methods for Recombinant Production of Saffron Compounds |
| CA2957331A1 (en) | 2014-08-11 | 2016-02-18 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US10612064B2 (en) | 2014-09-09 | 2020-04-07 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
| US10364450B2 (en) | 2015-01-30 | 2019-07-30 | Evolva Sa | Production of steviol glycoside in recombinant hosts |
| WO2016146711A1 (en) | 2015-03-16 | 2016-09-22 | Dsm Ip Assets B.V. | Udp-glycosyltransferases |
| CN104845990A (zh) | 2015-06-11 | 2015-08-19 | 山东大学 | 拟南芥糖基转移酶基因ugt73c7在提高植物抗病性中的应用 |
| WO2017025362A1 (en) | 2015-08-07 | 2017-02-16 | Evolva Sa | Production of steviol glycosides in recombinant hosts |
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