KR20220103810A - Jak1 억제제용 지속 방출 복용 형태 - Google Patents

Jak1 억제제용 지속 방출 복용 형태 Download PDF

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Publication number
KR20220103810A
KR20220103810A KR1020227023370A KR20227023370A KR20220103810A KR 20220103810 A KR20220103810 A KR 20220103810A KR 1020227023370 A KR1020227023370 A KR 1020227023370A KR 20227023370 A KR20227023370 A KR 20227023370A KR 20220103810 A KR20220103810 A KR 20220103810A
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South Korea
Prior art keywords
sustained release
dosage forms
fluoro
acetonitrile
pyrrolo
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KR1020227023370A
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English (en)
Korean (ko)
Inventor
크리쉬나스와미 옐레스와람
바브니쉬 파리크
딜립 피. 모디
트럽티 셰트
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인사이트 코포레이션
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
KR1020227023370A 2013-08-07 2014-08-06 Jak1 억제제용 지속 방출 복용 형태 Ceased KR20220103810A (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201361863325P 2013-08-07 2013-08-07
US61/863,325 2013-08-07
US201361913066P 2013-12-06 2013-12-06
US61/913,066 2013-12-06
PCT/US2014/049940 WO2015021153A1 (en) 2013-08-07 2014-08-06 Sustained release dosage forms for a jak1 inhibitor
KR1020217018433A KR102419714B1 (ko) 2013-08-07 2014-08-06 Jak1 억제제용 지속 방출 복용 형태

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020217018433A Division KR102419714B1 (ko) 2013-08-07 2014-08-06 Jak1 억제제용 지속 방출 복용 형태

Publications (1)

Publication Number Publication Date
KR20220103810A true KR20220103810A (ko) 2022-07-22

Family

ID=51383933

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020227023370A Ceased KR20220103810A (ko) 2013-08-07 2014-08-06 Jak1 억제제용 지속 방출 복용 형태
KR1020217018433A Active KR102419714B1 (ko) 2013-08-07 2014-08-06 Jak1 억제제용 지속 방출 복용 형태
KR1020167006096A Ceased KR20160045081A (ko) 2013-08-07 2014-08-06 Jak1 억제제용 지속 방출 복용 형태

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020217018433A Active KR102419714B1 (ko) 2013-08-07 2014-08-06 Jak1 억제제용 지속 방출 복용 형태
KR1020167006096A Ceased KR20160045081A (ko) 2013-08-07 2014-08-06 Jak1 억제제용 지속 방출 복용 형태

Country Status (31)

Country Link
US (5) US9655854B2 (https=)
EP (2) EP3721873A1 (https=)
JP (6) JP6334700B2 (https=)
KR (3) KR20220103810A (https=)
CN (3) CN105579032A (https=)
AU (3) AU2014305989B2 (https=)
BR (1) BR122020001831A8 (https=)
CA (2) CA2920108C (https=)
CL (1) CL2016000292A1 (https=)
CR (3) CR20190343A (https=)
CY (1) CY1123314T1 (https=)
DK (1) DK3030227T3 (https=)
EA (1) EA201690357A1 (https=)
ES (1) ES2792549T3 (https=)
HR (1) HRP20200955T1 (https=)
HU (1) HUE049345T2 (https=)
IL (2) IL277554B2 (https=)
LT (1) LT3030227T (https=)
MX (2) MX394928B (https=)
MY (2) MY195091A (https=)
PE (2) PE20160223A1 (https=)
PH (3) PH12019502074B1 (https=)
PL (1) PL3030227T3 (https=)
PT (1) PT3030227T (https=)
RS (1) RS60469B1 (https=)
SG (3) SG11201600815WA (https=)
SI (1) SI3030227T1 (https=)
SM (1) SMT202000315T1 (https=)
TW (3) TWI822248B (https=)
UA (1) UA120499C2 (https=)
WO (1) WO2015021153A1 (https=)

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KR20150036210A (ko) 2007-06-13 2015-04-07 인사이트 코포레이션 야누스 키나제 억제제（Ｒ）―３―（４―（７Ｈ―피롤로［２，３－ｄ］피리미딘―4―일）―1Ｈ―피라졸―1―일）―３―사이클로펜틸프로판니트릴의 염
AR076794A1 (es) 2009-05-22 2011-07-06 Incyte Corp Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo [2,3-d]pirimidinas y pirrol-3-il-pirrolo [2,3-d ]pirimidinas como inhibidores de la quinasa janus y composiciones farmaceuticas que los contienen
SI2432472T1 (sl) 2009-05-22 2019-11-29 Incyte Holdings Corp 3-(4-(7H-pirolo(2,3-d)pirimidin-4-il)-1H-pirazol-1-il)oktan- ali heptan-nitril kot inhibitorji JAK
EP3354652B1 (en) 2010-03-10 2020-05-06 Incyte Holdings Corporation Piperidin-4-yl azetidine derivatives as jak1 inhibitors
PE20130216A1 (es) 2010-05-21 2013-02-27 Incyte Corp Formulacion topica para un inhibidor de jak
PE20140146A1 (es) 2010-11-19 2014-02-06 Incyte Corp Derivados de pirrolopiridina y pirrolopirimidina sustituidos con ciclobutilo como inhibidores de jak
CN103797010B (zh) 2011-06-20 2016-02-24 因塞特控股公司 作为jak抑制剂的氮杂环丁烷基苯基、吡啶基或吡嗪基甲酰胺衍生物
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
TWI646099B (zh) 2012-11-01 2019-01-01 英塞特控股公司 作爲ｊａｋ抑制劑之三環稠合噻吩衍生物
PH12020551186B1 (en) 2012-11-15 2024-03-20 Incyte Holdings Corp Sustained-release dosage forms of ruxolitinib
ES2649156T3 (es) 2013-01-14 2018-01-10 Incyte Holdings Corporation Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim
PE20191245A1 (es) 2013-01-15 2019-09-18 Incyte Holdings Corp Compuestos de tiazolcarboxamidas y piridinacarboxamida utiles como inhibidores de quinasa pim
RS62867B1 (sr) 2013-03-06 2022-02-28 Incyte Holdings Corp Postupci i intermedijeri za dobijanje inhibitora jak
HUE033587T2 (hu) 2013-05-17 2017-12-28 Incyte Corp Bipirazol-származékok mint JAK inhibitorok
SMT202000315T1 (it) * 2013-08-07 2020-07-08 Incyte Corp Forme di dosaggio a rilascio prolungato per un inibitore di jak1
EA201690458A1 (ru) 2013-08-23 2016-07-29 Инсайт Корпорейшн Фуро- и тиенопиридинкарбоксамиды, используемые в качестве ингибиторов pim-киназы
SI3129021T1 (sl) 2014-04-08 2021-07-30 Incyte Corporation Zdravljenje malignosti B-celic s kombinacijo zaviralcev JAK in PI3K
MA39987A (fr) 2014-04-30 2017-03-08 Incyte Corp Procédés de préparation d'un inhibiteur de jak1 et nouvelles formes associées
US9498467B2 (en) 2014-05-30 2016-11-22 Incyte Corporation Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
TW201618783A (zh) 2014-08-07 2016-06-01 艾森塔製藥公司 以布魯頓(Bruton)氏酪胺酸激酶(BTK)佔據和BTK再合成速率為基礎之治療癌症、免疫和自體免疫疾病及發炎性疾病之方法
WO2016196244A1 (en) 2015-05-29 2016-12-08 Incyte Corporation Pyridineamine compounds useful as pim kinase inhibitors
TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Ｐｉｍ激酶抑制劑之鹽
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