KR101331768B1 - Atp 결합 카세트 수송체의 헤테로사이클릭 조정제 - Google Patents
Atp 결합 카세트 수송체의 헤테로사이클릭 조정제 Download PDFInfo
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- KR101331768B1 KR101331768B1 KR1020087013765A KR20087013765A KR101331768B1 KR 101331768 B1 KR101331768 B1 KR 101331768B1 KR 1020087013765 A KR1020087013765 A KR 1020087013765A KR 20087013765 A KR20087013765 A KR 20087013765A KR 101331768 B1 KR101331768 B1 KR 101331768B1
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- KR
- South Korea
- Prior art keywords
- optionally substituted
- aliphatic
- mmol
- heteroaryl
- aryl
- Prior art date
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- 0 C*C1(**CC1)C(*(*)C1=CC=C**1)=O Chemical compound C*C1(**CC1)C(*(*)C1=CC=C**1)=O 0.000 description 3
- LSDCSRVRGXXTPZ-UHFFFAOYSA-N CC(CCCCCCc1ccccc1)=O Chemical compound CC(CCCCCCc1ccccc1)=O LSDCSRVRGXXTPZ-UHFFFAOYSA-N 0.000 description 1
- DWPKOECQUMNPMM-UHFFFAOYSA-N CC1(O)[I]=CC=C1 Chemical compound CC1(O)[I]=CC=C1 DWPKOECQUMNPMM-UHFFFAOYSA-N 0.000 description 1
- QPJVMBTYPHYUOC-UHFFFAOYSA-N COC(c1ccccc1)=O Chemical compound COC(c1ccccc1)=O QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 description 1
- ZODAOVNETBTTJX-UHFFFAOYSA-N COc1ccc(C(c(cc2)ccc2OC)O)cc1 Chemical compound COc1ccc(C(c(cc2)ccc2OC)O)cc1 ZODAOVNETBTTJX-UHFFFAOYSA-N 0.000 description 1
- DMSREMBKNFWOOD-UHFFFAOYSA-N COc1ccc(C(c(cc2)ccc2OC)Sc(cc2)ccc2-c2cccc(N)n2)cc1 Chemical compound COc1ccc(C(c(cc2)ccc2OC)Sc(cc2)ccc2-c2cccc(N)n2)cc1 DMSREMBKNFWOOD-UHFFFAOYSA-N 0.000 description 1
- MBHWWXLKTJIIAC-UHFFFAOYSA-N COc1ccc(C(c(cc2)ccc2OC)Sc(cc2)ccc2-c2nc(NC(C3(CC3)c3ccc4OCOc4c3)=O)ccc2)cc1 Chemical compound COc1ccc(C(c(cc2)ccc2OC)Sc(cc2)ccc2-c2nc(NC(C3(CC3)c3ccc4OCOc4c3)=O)ccc2)cc1 MBHWWXLKTJIIAC-UHFFFAOYSA-N 0.000 description 1
- VIEUPUCHSLSNTG-UHFFFAOYSA-N COc1ccc(C(c(cc2)ccc2OC)Sc2ccc(B(O)O)cc2)cc1 Chemical compound COc1ccc(C(c(cc2)ccc2OC)Sc2ccc(B(O)O)cc2)cc1 VIEUPUCHSLSNTG-UHFFFAOYSA-N 0.000 description 1
- APESEXCROXLTNP-UHFFFAOYSA-N Cc(cc1)cc([O](C)=C)c1N Chemical compound Cc(cc1)cc([O](C)=C)c1N APESEXCROXLTNP-UHFFFAOYSA-N 0.000 description 1
- SUSQOBVLVYHIEX-UHFFFAOYSA-N N#CCc1ccccc1 Chemical compound N#CCc1ccccc1 SUSQOBVLVYHIEX-UHFFFAOYSA-N 0.000 description 1
- BKLJUYPLUWUEOQ-UHFFFAOYSA-N Nc1nc(Br)ccc1 Chemical compound Nc1nc(Br)ccc1 BKLJUYPLUWUEOQ-UHFFFAOYSA-N 0.000 description 1
- AUVSUPMVIZXUOG-UHFFFAOYSA-N OB(c(cc1)ccc1S)O Chemical compound OB(c(cc1)ccc1S)O AUVSUPMVIZXUOG-UHFFFAOYSA-N 0.000 description 1
- GQVOGFKCJASOGD-UHFFFAOYSA-N OC(C1(C2(CC2)CCCC1)c1ccccc1)=O Chemical compound OC(C1(C2(CC2)CCCC1)c1ccccc1)=O GQVOGFKCJASOGD-UHFFFAOYSA-N 0.000 description 1
- UNYWNRTZUCJKPY-UHFFFAOYSA-N OC(C1(CC1)c1ccc2OCCc2c1)=O Chemical compound OC(C1(CC1)c1ccc2OCCc2c1)=O UNYWNRTZUCJKPY-UHFFFAOYSA-N 0.000 description 1
- RRWKJVZZARHFPB-UHFFFAOYSA-N OC(C1(CC1)c1ccc2[o]ccc2c1)=O Chemical compound OC(C1(CC1)c1ccc2[o]ccc2c1)=O RRWKJVZZARHFPB-UHFFFAOYSA-N 0.000 description 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N c1ccncn1 Chemical compound c1ccncn1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/12—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to ring carbon atoms
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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