KR100509388B1 - 세린 프로테아제, 특히 간염 ｃ 바이러스 ｎｓ３ 프로테아제의 저해제 - Google Patents

세린 프로테아제, 특히 간염 ｃ 바이러스 ｎｓ３ 프로테아제의 저해제 Download PDF

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KR100509388B1
KR100509388B1 KR10-1999-7003372A KR19997003372A KR100509388B1 KR 100509388 B1 KR100509388 B1 KR 100509388B1 KR 19997003372 A KR19997003372 A KR 19997003372A KR 100509388 B1 KR100509388 B1 KR 100509388B1
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alkyl
aryl
heterocyclyl
heteroaryl
compound
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Korean (ko)
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KR20000049263A (ko
Inventor
로저 디 텅
스코트 엘 하버슨
데비드 디 데인인거
마크 에이 무코
고빈다 라오 비세티
루크 제이 파머
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버텍스 파마슈티칼스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
KR10-1999-7003372A 1996-10-18 1997-10-17 세린 프로테아제, 특히 간염 ｃ 바이러스 ｎｓ３ 프로테아제의 저해제 Expired - Fee Related KR100509388B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2829096P 1996-10-18 1996-10-18
US60/028,290 1996-10-18

Publications (2)

Publication Number Publication Date
KR20000049263A KR20000049263A (ko) 2000-07-25
KR100509388B1 true KR100509388B1 (ko) 2005-08-23

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KR10-1999-7003372A Expired - Fee Related KR100509388B1 (ko) 1996-10-18 1997-10-17 세린 프로테아제, 특히 간염 ｃ 바이러스 ｎｓ３ 프로테아제의 저해제

Country Status (33)

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US (5) US6265380B1 (cg-RX-API-DMAC10.html)
EP (3) EP2314598A1 (cg-RX-API-DMAC10.html)
JP (3) JP4080541B2 (cg-RX-API-DMAC10.html)
KR (1) KR100509388B1 (cg-RX-API-DMAC10.html)
CN (1) CN1133649C (cg-RX-API-DMAC10.html)
AP (1) AP1019A (cg-RX-API-DMAC10.html)
AT (1) ATE212037T1 (cg-RX-API-DMAC10.html)
BG (1) BG103392A (cg-RX-API-DMAC10.html)
BR (1) BR9712544B1 (cg-RX-API-DMAC10.html)
CA (1) CA2268391A1 (cg-RX-API-DMAC10.html)
CZ (1) CZ298749B6 (cg-RX-API-DMAC10.html)
DE (1) DE69709671T2 (cg-RX-API-DMAC10.html)
DK (1) DK0932617T3 (cg-RX-API-DMAC10.html)
EA (1) EA001915B1 (cg-RX-API-DMAC10.html)
EE (1) EE04023B1 (cg-RX-API-DMAC10.html)
ES (1) ES2169880T3 (cg-RX-API-DMAC10.html)
GE (1) GEP20012471B (cg-RX-API-DMAC10.html)
HU (1) HU227742B1 (cg-RX-API-DMAC10.html)
ID (1) ID21649A (cg-RX-API-DMAC10.html)
IL (3) IL129407A0 (cg-RX-API-DMAC10.html)
IN (1) IN183120B (cg-RX-API-DMAC10.html)
IS (1) IS5028A (cg-RX-API-DMAC10.html)
MX (1) MXPA05003026A (cg-RX-API-DMAC10.html)
NO (2) NO329751B1 (cg-RX-API-DMAC10.html)
NZ (1) NZ335276A (cg-RX-API-DMAC10.html)
PL (2) PL194025B1 (cg-RX-API-DMAC10.html)
PT (1) PT932617E (cg-RX-API-DMAC10.html)
SK (1) SK286105B6 (cg-RX-API-DMAC10.html)
TR (1) TR199901602T2 (cg-RX-API-DMAC10.html)
TW (1) TW530065B (cg-RX-API-DMAC10.html)
UA (2) UA79749C2 (cg-RX-API-DMAC10.html)
WO (1) WO1998017679A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA979327B (cg-RX-API-DMAC10.html)

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