JP7280044B2 - 肺癌の検出方法 - Google Patents
肺癌の検出方法 Download PDFInfo
- Publication number
- JP7280044B2 JP7280044B2 JP2018553958A JP2018553958A JP7280044B2 JP 7280044 B2 JP7280044 B2 JP 7280044B2 JP 2018553958 A JP2018553958 A JP 2018553958A JP 2018553958 A JP2018553958 A JP 2018553958A JP 7280044 B2 JP7280044 B2 JP 7280044B2
- Authority
- JP
- Japan
- Prior art keywords
- single nucleotide
- ditto
- sample
- tumor
- snv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims description 120
- 208000020816 lung neoplasm Diseases 0.000 title claims description 39
- 206010058467 Lung neoplasm malignant Diseases 0.000 title claims description 37
- 201000005202 lung cancer Diseases 0.000 title claims description 37
- 206010028980 Neoplasm Diseases 0.000 claims description 148
- 239000002773 nucleotide Substances 0.000 claims description 90
- 125000003729 nucleotide group Chemical group 0.000 claims description 82
- 230000003321 amplification Effects 0.000 claims description 64
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 64
- 230000035772 mutation Effects 0.000 claims description 63
- 150000007523 nucleic acids Chemical class 0.000 claims description 56
- 238000006243 chemical reaction Methods 0.000 claims description 46
- 108020004707 nucleic acids Proteins 0.000 claims description 44
- 102000039446 nucleic acids Human genes 0.000 claims description 44
- 238000012163 sequencing technique Methods 0.000 claims description 43
- 108091093088 Amplicon Proteins 0.000 claims description 41
- 238000007403 mPCR Methods 0.000 claims description 39
- 206010041823 squamous cell carcinoma Diseases 0.000 claims description 29
- 239000011541 reaction mixture Substances 0.000 claims description 22
- 108700028369 Alleles Proteins 0.000 claims description 20
- 210000004369 blood Anatomy 0.000 claims description 17
- 239000008280 blood Substances 0.000 claims description 17
- 201000005243 lung squamous cell carcinoma Diseases 0.000 claims description 14
- -1 nucleotide triphosphates Chemical class 0.000 claims description 9
- 230000002441 reversible effect Effects 0.000 claims description 7
- 239000001226 triphosphate Substances 0.000 claims description 6
- 235000011178 triphosphate Nutrition 0.000 claims description 6
- 238000001574 biopsy Methods 0.000 claims description 3
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 238000001712 DNA sequencing Methods 0.000 claims 1
- 239000000523 sample Substances 0.000 description 81
- 238000003752 polymerase chain reaction Methods 0.000 description 60
- 238000003556 assay Methods 0.000 description 59
- 108020004414 DNA Proteins 0.000 description 57
- 108090000623 proteins and genes Proteins 0.000 description 32
- 201000011510 cancer Diseases 0.000 description 31
- 208000009956 adenocarcinoma Diseases 0.000 description 29
- 239000012634 fragment Substances 0.000 description 24
- 238000003908 quality control method Methods 0.000 description 24
- 238000000137 annealing Methods 0.000 description 23
- 238000004458 analytical method Methods 0.000 description 22
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 21
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 21
- 238000009826 distribution Methods 0.000 description 20
- 238000001514 detection method Methods 0.000 description 19
- 206010018910 Haemolysis Diseases 0.000 description 15
- 230000008588 hemolysis Effects 0.000 description 15
- 239000000203 mixture Substances 0.000 description 15
- 238000012360 testing method Methods 0.000 description 15
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 14
- 239000011777 magnesium Substances 0.000 description 14
- 229910052749 magnesium Inorganic materials 0.000 description 14
- 230000000875 corresponding effect Effects 0.000 description 13
- 238000002474 experimental method Methods 0.000 description 13
- 238000002844 melting Methods 0.000 description 13
- 230000008018 melting Effects 0.000 description 13
- 210000001519 tissue Anatomy 0.000 description 13
- 238000003745 diagnosis Methods 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 230000000869 mutational effect Effects 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 11
- 238000013461 design Methods 0.000 description 10
- 239000000539 dimer Substances 0.000 description 10
- 210000004072 lung Anatomy 0.000 description 10
- 238000007481 next generation sequencing Methods 0.000 description 10
- OKIZCWYLBDKLSU-UHFFFAOYSA-M N,N,N-Trimethylmethanaminium chloride Chemical compound [Cl-].C[N+](C)(C)C OKIZCWYLBDKLSU-UHFFFAOYSA-M 0.000 description 8
- 238000012549 training Methods 0.000 description 8
- 238000007482 whole exome sequencing Methods 0.000 description 8
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 7
- 102000053602 DNA Human genes 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 6
- 108010006785 Taq Polymerase Proteins 0.000 description 6
- 239000011324 bead Substances 0.000 description 6
- 210000001165 lymph node Anatomy 0.000 description 6
- 230000001915 proofreading effect Effects 0.000 description 6
- 238000011282 treatment Methods 0.000 description 6
- GUAHPAJOXVYFON-ZETCQYMHSA-N (8S)-8-amino-7-oxononanoic acid zwitterion Chemical compound C[C@H](N)C(=O)CCCCCC(O)=O GUAHPAJOXVYFON-ZETCQYMHSA-N 0.000 description 5
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 5
- 238000004422 calculation algorithm Methods 0.000 description 5
- 230000037437 driver mutation Effects 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- 230000008569 process Effects 0.000 description 5
- 230000035945 sensitivity Effects 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 4
- 238000012408 PCR amplification Methods 0.000 description 4
- 239000007983 Tris buffer Substances 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000013642 negative control Substances 0.000 description 4
- 238000012803 optimization experiment Methods 0.000 description 4
- 238000011176 pooling Methods 0.000 description 4
- 239000002096 quantum dot Substances 0.000 description 4
- 239000007790 solid phase Substances 0.000 description 4
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 4
- 206010027476 Metastases Diseases 0.000 description 3
- 230000006907 apoptotic process Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 230000001351 cycling effect Effects 0.000 description 3
- 102000052116 epidermal growth factor receptor activity proteins Human genes 0.000 description 3
- 108700015053 epidermal growth factor receptor activity proteins Proteins 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 239000010931 gold Substances 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 229910001629 magnesium chloride Inorganic materials 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000009401 metastasis Effects 0.000 description 3
- YOHYSYJDKVYCJI-UHFFFAOYSA-N n-[3-[[6-[3-(trifluoromethyl)anilino]pyrimidin-4-yl]amino]phenyl]cyclopropanecarboxamide Chemical compound FC(F)(F)C1=CC=CC(NC=2N=CN=C(NC=3C=C(NC(=O)C4CC4)C=CC=3)C=2)=C1 YOHYSYJDKVYCJI-UHFFFAOYSA-N 0.000 description 3
- 238000005457 optimization Methods 0.000 description 3
- 238000005309 stochastic process Methods 0.000 description 3
- 238000002560 therapeutic procedure Methods 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 238000007400 DNA extraction Methods 0.000 description 2
- 108060002716 Exonuclease Proteins 0.000 description 2
- 102100030708 GTPase KRas Human genes 0.000 description 2
- 101000584612 Homo sapiens GTPase KRas Proteins 0.000 description 2
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 description 2
- 108091034117 Oligonucleotide Proteins 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
- 108010002747 Pfu DNA polymerase Proteins 0.000 description 2
- 108010010677 Phosphodiesterase I Proteins 0.000 description 2
- 235000014443 Pyrus communis Nutrition 0.000 description 2
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 235000011089 carbon dioxide Nutrition 0.000 description 2
- 230000004709 cell invasion Effects 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
- 239000013522 chelant Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000002299 complementary DNA Substances 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 102000013165 exonuclease Human genes 0.000 description 2
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 2
- 229910052737 gold Inorganic materials 0.000 description 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 description 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 description 2
- 238000012165 high-throughput sequencing Methods 0.000 description 2
- 238000007849 hot-start PCR Methods 0.000 description 2
- 238000009396 hybridization Methods 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 201000005249 lung adenocarcinoma Diseases 0.000 description 2
- 208000037841 lung tumor Diseases 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000007170 pathology Effects 0.000 description 2
- 235000021317 phosphate Nutrition 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 230000010076 replication Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 230000000392 somatic effect Effects 0.000 description 2
- 238000012289 standard assay Methods 0.000 description 2
- 230000008685 targeting Effects 0.000 description 2
- 230000009790 vascular invasion Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 102100033793 ALK tyrosine kinase receptor Human genes 0.000 description 1
- 208000010507 Adenocarcinoma of Lung Diseases 0.000 description 1
- 206010068873 Adenosquamous cell carcinoma Diseases 0.000 description 1
- 108091023037 Aptamer Proteins 0.000 description 1
- 208000035404 Autolysis Diseases 0.000 description 1
- 201000000274 Carcinosarcoma Diseases 0.000 description 1
- ZEOWTGPWHLSLOG-UHFFFAOYSA-N Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F Chemical compound Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F ZEOWTGPWHLSLOG-UHFFFAOYSA-N 0.000 description 1
- 206010057248 Cell death Diseases 0.000 description 1
- 108010009392 Cyclin-Dependent Kinase Inhibitor p16 Proteins 0.000 description 1
- 102100024812 DNA (cytosine-5)-methyltransferase 3A Human genes 0.000 description 1
- 108010024491 DNA Methyltransferase 3A Proteins 0.000 description 1
- 108010017826 DNA Polymerase I Proteins 0.000 description 1
- 102000004594 DNA Polymerase I Human genes 0.000 description 1
- 206010061818 Disease progression Diseases 0.000 description 1
- 102100031480 Dual specificity mitogen-activated protein kinase kinase 1 Human genes 0.000 description 1
- 101710146526 Dual specificity mitogen-activated protein kinase kinase 1 Proteins 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 102100031780 Endonuclease Human genes 0.000 description 1
- 108010042407 Endonucleases Proteins 0.000 description 1
- 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 description 1
- 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 description 1
- 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 description 1
- 101710182389 Fibroblast growth factor receptor 2 Proteins 0.000 description 1
- 102100035108 High affinity nerve growth factor receptor Human genes 0.000 description 1
- 102100027768 Histone-lysine N-methyltransferase 2D Human genes 0.000 description 1
- 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 description 1
- 101000779641 Homo sapiens ALK tyrosine kinase receptor Proteins 0.000 description 1
- 101000596894 Homo sapiens High affinity nerve growth factor receptor Proteins 0.000 description 1
- 101001045848 Homo sapiens Histone-lysine N-methyltransferase 2B Proteins 0.000 description 1
- 101001008894 Homo sapiens Histone-lysine N-methyltransferase 2D Proteins 0.000 description 1
- 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 description 1
- 101000653374 Homo sapiens Methylcytosine dioxygenase TET2 Proteins 0.000 description 1
- 101001030211 Homo sapiens Myc proto-oncogene protein Proteins 0.000 description 1
- 101000605639 Homo sapiens Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Proteins 0.000 description 1
- 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 description 1
- 101000686031 Homo sapiens Proto-oncogene tyrosine-protein kinase ROS Proteins 0.000 description 1
- 101000579425 Homo sapiens Proto-oncogene tyrosine-protein kinase receptor Ret Proteins 0.000 description 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 1
- 101000687905 Homo sapiens Transcription factor SOX-2 Proteins 0.000 description 1
- 102000004034 Kelch-Like ECH-Associated Protein 1 Human genes 0.000 description 1
- 108090000484 Kelch-Like ECH-Associated Protein 1 Proteins 0.000 description 1
- 239000005411 L01XE02 - Gefitinib Substances 0.000 description 1
- 239000005551 L01XE03 - Erlotinib Substances 0.000 description 1
- 229940124647 MEK inhibitor Drugs 0.000 description 1
- JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
- 238000007476 Maximum Likelihood Methods 0.000 description 1
- 102100030803 Methylcytosine dioxygenase TET2 Human genes 0.000 description 1
- 102100038895 Myc proto-oncogene protein Human genes 0.000 description 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 1
- 206010028851 Necrosis Diseases 0.000 description 1
- 102000048238 Neuregulin-1 Human genes 0.000 description 1
- 108090000556 Neuregulin-1 Proteins 0.000 description 1
- 102000007530 Neurofibromin 1 Human genes 0.000 description 1
- 108010085793 Neurofibromin 1 Proteins 0.000 description 1
- 102100023181 Neurogenic locus notch homolog protein 1 Human genes 0.000 description 1
- 108010029755 Notch1 Receptor Proteins 0.000 description 1
- 108700020796 Oncogene Proteins 0.000 description 1
- 102000043276 Oncogene Human genes 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 description 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 description 1
- 102100038332 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Human genes 0.000 description 1
- 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 102100023347 Proto-oncogene tyrosine-protein kinase ROS Human genes 0.000 description 1
- 102100028286 Proto-oncogene tyrosine-protein kinase receptor Ret Human genes 0.000 description 1
- 241000205156 Pyrococcus furiosus Species 0.000 description 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 1
- 101100483399 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) CDC34 gene Proteins 0.000 description 1
- 102100026715 Serine/threonine-protein kinase STK11 Human genes 0.000 description 1
- 101710181599 Serine/threonine-protein kinase STK11 Proteins 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 241000589500 Thermus aquaticus Species 0.000 description 1
- 102100024270 Transcription factor SOX-2 Human genes 0.000 description 1
- 108700025716 Tumor Suppressor Genes Proteins 0.000 description 1
- 102000044209 Tumor Suppressor Genes Human genes 0.000 description 1
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 description 1
- 102000015098 Tumor Suppressor Protein p53 Human genes 0.000 description 1
- 102100033254 Tumor suppressor ARF Human genes 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 201000008395 adenosquamous carcinoma Diseases 0.000 description 1
- 230000006154 adenylylation Effects 0.000 description 1
- 229960001686 afatinib Drugs 0.000 description 1
- ULXXDDBFHOBEHA-CWDCEQMOSA-N afatinib Chemical compound N1=CN=C2C=C(O[C@@H]3COCC3)C(NC(=O)/C=C/CN(C)C)=CC2=C1NC1=CC=C(F)C(Cl)=C1 ULXXDDBFHOBEHA-CWDCEQMOSA-N 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 230000003527 anti-angiogenesis Effects 0.000 description 1
- 230000037429 base substitution Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- JJWKPURADFRFRB-UHFFFAOYSA-N carbonyl sulfide Chemical compound O=C=S JJWKPURADFRFRB-UHFFFAOYSA-N 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000007385 chemical modification Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000013068 control sample Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 229960002465 dabrafenib Drugs 0.000 description 1
- BFSMGDJOXZAERB-UHFFFAOYSA-N dabrafenib Chemical compound S1C(C(C)(C)C)=NC(C=2C(=C(NS(=O)(=O)C=3C(=CC=CC=3F)F)C=CC=2)F)=C1C1=CC=NC(N)=N1 BFSMGDJOXZAERB-UHFFFAOYSA-N 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005750 disease progression Effects 0.000 description 1
- 238000010494 dissociation reaction Methods 0.000 description 1
- 230000005593 dissociations Effects 0.000 description 1
- 229960003668 docetaxel Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 229960001433 erlotinib Drugs 0.000 description 1
- AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 229960002584 gefitinib Drugs 0.000 description 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 description 1
- 210000004602 germ cell Anatomy 0.000 description 1
- 230000002962 histologic effect Effects 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011528 liquid biopsy Methods 0.000 description 1
- 238000007477 logistic regression Methods 0.000 description 1
- 229910001425 magnesium ion Inorganic materials 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 238000013507 mapping Methods 0.000 description 1
- 238000000491 multivariate analysis Methods 0.000 description 1
- JTSLALYXYSRPGW-UHFFFAOYSA-N n-[5-(4-cyanophenyl)-1h-pyrrolo[2,3-b]pyridin-3-yl]pyridine-3-carboxamide Chemical compound C=1C=CN=CC=1C(=O)NC(C1=C2)=CNC1=NC=C2C1=CC=C(C#N)C=C1 JTSLALYXYSRPGW-UHFFFAOYSA-N 0.000 description 1
- 230000021597 necroptosis Effects 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- 238000007857 nested PCR Methods 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000037438 passenger mutation Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 230000009443 proangiogenesis Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000000611 regression analysis Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 102200006531 rs121913529 Human genes 0.000 description 1
- 102200006539 rs121913529 Human genes 0.000 description 1
- 102200006538 rs121913530 Human genes 0.000 description 1
- 238000007480 sanger sequencing Methods 0.000 description 1
- 230000028043 self proteolysis Effects 0.000 description 1
- 229950010746 selumetinib Drugs 0.000 description 1
- CYOHGALHFOKKQC-UHFFFAOYSA-N selumetinib Chemical compound OCCONC(=O)C=1C=C2N(C)C=NC2=C(F)C=1NC1=CC=C(Br)C=C1Cl CYOHGALHFOKKQC-UHFFFAOYSA-N 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000002864 sequence alignment Methods 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 108010068698 spleen exonuclease Proteins 0.000 description 1
- 238000013179 statistical model Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 229960004066 trametinib Drugs 0.000 description 1
- LIRYPHYGHXZJBZ-UHFFFAOYSA-N trametinib Chemical compound CC(=O)NC1=CC=CC(N2C(N(C3CC3)C(=O)C3=C(NC=4C(=CC(I)=CC=4)F)N(C)C(=O)C(C)=C32)=O)=C1 LIRYPHYGHXZJBZ-UHFFFAOYSA-N 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 229960003862 vemurafenib Drugs 0.000 description 1
- GPXBXXGIAQBQNI-UHFFFAOYSA-N vemurafenib Chemical compound CCCS(=O)(=O)NC1=CC=C(F)C(C(=O)C=2C3=CC(=CN=C3NC=2)C=2C=CC(Cl)=CC=2)=C1F GPXBXXGIAQBQNI-UHFFFAOYSA-N 0.000 description 1
- 238000012070 whole genome sequencing analysis Methods 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662323589P | 2016-04-15 | 2016-04-15 | |
| US62/323,589 | 2016-04-15 | ||
| PCT/US2017/028013 WO2017181202A2 (en) | 2016-04-15 | 2017-04-17 | Methods for lung cancer detection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019517781A JP2019517781A (ja) | 2019-06-27 |
| JP2019517781A5 JP2019517781A5 (enExample) | 2020-10-15 |
| JP7280044B2 true JP7280044B2 (ja) | 2023-05-23 |
Family
ID=59215913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018553958A Active JP7280044B2 (ja) | 2016-04-15 | 2017-04-17 | 肺癌の検出方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US12146195B2 (enExample) |
| EP (1) | EP3443119B8 (enExample) |
| JP (1) | JP7280044B2 (enExample) |
| CN (1) | CN109477138A (enExample) |
| AU (1) | AU2017249594B2 (enExample) |
| CA (1) | CA3016360A1 (enExample) |
| DK (1) | DK3443119T3 (enExample) |
| ES (1) | ES2913468T3 (enExample) |
| RU (1) | RU2760913C2 (enExample) |
| WO (1) | WO2017181202A2 (enExample) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10081839B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| WO2011041485A1 (en) | 2009-09-30 | 2011-04-07 | Gene Security Network, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| CA3207599A1 (en) | 2010-05-18 | 2011-11-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| BR112013016193B1 (pt) | 2010-12-22 | 2019-10-22 | Natera Inc | método ex vivo para determinar se um suposto pai é o pai biológico de um feto que está em gestação em uma gestante e relatório |
| BR112013020220B1 (pt) | 2011-02-09 | 2020-03-17 | Natera, Inc. | Método para determinar o estado de ploidia de um cromossomo em um feto em gestação |
| DK3246416T3 (da) | 2011-04-15 | 2024-09-02 | Univ Johns Hopkins | Sikkert sekventeringssystem |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| ES2886507T5 (es) | 2012-10-29 | 2024-11-15 | Univ Johns Hopkins | Prueba de Papanicolaou para cánceres de ovario y de endometrio |
| US10577655B2 (en) | 2013-09-27 | 2020-03-03 | Natera, Inc. | Cell free DNA diagnostic testing standards |
| EP3134541B1 (en) | 2014-04-21 | 2020-08-19 | Natera, Inc. | Detecting copy number variations (cnv) of chromosomal segments in cancer |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| WO2017027653A1 (en) | 2015-08-11 | 2017-02-16 | The Johns Hopkins University | Assaying ovarian cyst fluid |
| EP4488686A3 (en) | 2016-04-14 | 2025-04-30 | Guardant Health, Inc. | Methods for early detection of cancer |
| RU2760913C2 (ru) | 2016-04-15 | 2021-12-01 | Натера, Инк. | Способы выявления рака легкого |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| CA3049139A1 (en) | 2017-02-21 | 2018-08-30 | Natera, Inc. | Compositions, methods, and kits for isolating nucleic acids |
| CN111868260B (zh) | 2017-08-07 | 2025-02-21 | 约翰斯霍普金斯大学 | 用于评估和治疗癌症的方法和材料 |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| WO2019161244A1 (en) | 2018-02-15 | 2019-08-22 | Natera, Inc. | Methods for isolating nucleic acids with size selection |
| WO2019195268A2 (en) | 2018-04-02 | 2019-10-10 | Grail, Inc. | Methylation markers and targeted methylation probe panels |
| US12024738B2 (en) | 2018-04-14 | 2024-07-02 | Natera, Inc. | Methods for cancer detection and monitoring |
| US11482303B2 (en) | 2018-06-01 | 2022-10-25 | Grail, Llc | Convolutional neural network systems and methods for data classification |
| US11189361B2 (en) | 2018-06-28 | 2021-11-30 | International Business Machines Corporation | Functional analysis of time-series phylogenetic tumor evolution tree |
| US11211148B2 (en) * | 2018-06-28 | 2021-12-28 | International Business Machines Corporation | Time-series phylogenetic tumor evolution trees |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| AU2019351130B2 (en) | 2018-09-27 | 2025-10-23 | GRAIL, Inc | Methylation markers and targeted methylation probe panel |
| US11581062B2 (en) | 2018-12-10 | 2023-02-14 | Grail, Llc | Systems and methods for classifying patients with respect to multiple cancer classes |
| CN113365630A (zh) * | 2018-12-21 | 2021-09-07 | 库拉肿瘤学公司 | 用于鳞状细胞癌的疗法 |
| WO2020247263A1 (en) | 2019-06-06 | 2020-12-10 | Natera, Inc. | Methods for detecting immune cell dna and monitoring immune system |
| CN115516108A (zh) | 2020-02-14 | 2022-12-23 | 约翰斯霍普金斯大学 | 评估核酸的方法和材料 |
| US11475981B2 (en) | 2020-02-18 | 2022-10-18 | Tempus Labs, Inc. | Methods and systems for dynamic variant thresholding in a liquid biopsy assay |
| US11211147B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing |
| US11211144B2 (en) | 2020-02-18 | 2021-12-28 | Tempus Labs, Inc. | Methods and systems for refining copy number variation in a liquid biopsy assay |
| WO2021243045A1 (en) | 2020-05-29 | 2021-12-02 | Natera, Inc. | Methods for detection of donor-derived cell-free dna |
| AU2022226186A1 (en) | 2021-02-25 | 2023-09-07 | Natera, Inc. | Methods for detection of donor-derived cell-free dna in transplant recipients of multiple organs |
| US20240309472A1 (en) | 2021-03-18 | 2024-09-19 | Natera, Inc. | Methods for determination of transplant rejection |
| US20240003888A1 (en) | 2022-05-17 | 2024-01-04 | Guardant Health, Inc. | Methods for identifying druggable targets and treating cancer |
| WO2023244735A2 (en) | 2022-06-15 | 2023-12-21 | Natera, Inc. | Methods for determination and monitoring of transplant rejection by measuring rna |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015164432A1 (en) | 2014-04-21 | 2015-10-29 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| WO2016009224A1 (en) | 2014-07-18 | 2016-01-21 | Cancer Research Technology Limited | A method for detecting a genetic variant |
Family Cites Families (620)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3957654A (en) | 1974-02-27 | 1976-05-18 | Becton, Dickinson And Company | Plasma separator with barrier to eject sealant |
| US4040785A (en) | 1976-10-18 | 1977-08-09 | Technicon Instruments Corporation | Lysable blood preservative composition |
| US5242794A (en) | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4935342A (en) | 1986-12-01 | 1990-06-19 | Syngene, Inc. | Method of isolating and purifying nucleic acids from biological samples |
| US4942124A (en) | 1987-08-11 | 1990-07-17 | President And Fellows Of Harvard College | Multiplex sequencing |
| WO1989004838A1 (en) | 1987-11-25 | 1989-06-01 | Immunex Corporation | Interleukin-1 receptors |
| US5319071A (en) | 1987-11-25 | 1994-06-07 | Immunex Corporation | Soluble interleukin-1 receptors |
| IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| US5350683A (en) | 1990-06-05 | 1994-09-27 | Immunex Corporation | DNA encoding type II interleukin-1 receptors |
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US5645988A (en) | 1991-05-08 | 1997-07-08 | The United States Of America As Represented By The Department Of Health And Human Services | Methods of identifying drugs with selective effects against cancer cells |
| US5262329A (en) | 1991-06-13 | 1993-11-16 | Carver Jr Edward L | Method for improved multiple species blood analysis |
| ES2091976T3 (es) | 1991-06-20 | 1996-11-16 | Hoffmann La Roche | Metodos perfeccionados para la amplificacion del acido nucleico. |
| US5569582A (en) | 1991-07-15 | 1996-10-29 | Institute Of Molecular Biology & Technology | Rapid amplification and detection of nucleic acids |
| IL103935A0 (en) | 1991-12-04 | 1993-05-13 | Du Pont | Method for the identification of microorganisms by the utilization of directed and arbitrary dna amplification |
| US5976790A (en) | 1992-03-04 | 1999-11-02 | The Regents Of The University Of California | Comparative Genomic Hybridization (CGH) |
| GB9305984D0 (en) | 1993-03-23 | 1993-05-12 | Royal Free Hosp School Med | Predictive assay |
| US5714320A (en) | 1993-04-15 | 1998-02-03 | University Of Rochester | Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides |
| EP0708649B1 (en) | 1993-07-05 | 2003-05-28 | Sheffield Teaching Hospitals National Health Service Trust | Preparation and stabilisation of cells |
| WO1995006137A1 (en) | 1993-08-27 | 1995-03-02 | Australian Red Cross Society | Detection of genes |
| CH686982A5 (fr) | 1993-12-16 | 1996-08-15 | Maurice Stroun | Méthode pour le diagnostic de cancers. |
| SE9400522D0 (sv) | 1994-02-16 | 1994-02-16 | Ulf Landegren | Method and reagent for detecting specific nucleotide sequences |
| US5716776A (en) | 1994-03-04 | 1998-02-10 | Mark H. Bogart | Enrichment by preferential mitosis of fetal lymphocytes from a maternal blood sample |
| US5891734A (en) | 1994-08-01 | 1999-04-06 | Abbott Laboratories | Method for performing automated analysis |
| US6025128A (en) | 1994-09-29 | 2000-02-15 | The University Of Tulsa | Prediction of prostate cancer progression by analysis of selected predictive parameters |
| US6479235B1 (en) | 1994-09-30 | 2002-11-12 | Promega Corporation | Multiplex amplification of short tandem repeat loci |
| PE64396A1 (es) | 1995-01-23 | 1997-01-28 | Hoffmann La Roche | Proteina accesoria del receptor de la interleucina 1 |
| US5648220A (en) | 1995-02-14 | 1997-07-15 | New England Medical Center Hospitals, Inc. | Methods for labeling intracytoplasmic molecules |
| WO1996036736A2 (en) | 1995-05-19 | 1996-11-21 | Abbott Laboratories | Wide dynamic range nucleic acid detection using an aggregate primer series |
| US6720140B1 (en) | 1995-06-07 | 2004-04-13 | Invitrogen Corporation | Recombinational cloning using engineered recombination sites |
| US5733729A (en) | 1995-09-14 | 1998-03-31 | Affymetrix, Inc. | Computer-aided probability base calling for arrays of nucleic acid probes on chips |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US5736033A (en) | 1995-12-13 | 1998-04-07 | Coleman; Charles M. | Separator float for blood collection tubes with water swellable material |
| US6852487B1 (en) | 1996-02-09 | 2005-02-08 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays |
| US6156504A (en) | 1996-03-15 | 2000-12-05 | The Penn State Research Foundation | Detection of extracellular tumor-associated nucleic acid in blood plasma or serum using nucleic acid amplification assays |
| ES2347854T5 (es) | 1996-03-26 | 2014-07-24 | Michael S. Kopreski | Método que permite el uso de RNA extracelular extraído de plasma o suero para detectar, monitorizar o evaluar un cáncer |
| US6108635A (en) | 1996-05-22 | 2000-08-22 | Interleukin Genetics, Inc. | Integrated disease information system |
| US6300077B1 (en) | 1996-08-14 | 2001-10-09 | Exact Sciences Corporation | Methods for the detection of nucleic acids |
| US6100029A (en) | 1996-08-14 | 2000-08-08 | Exact Laboratories, Inc. | Methods for the detection of chromosomal aberrations |
| US6221654B1 (en) | 1996-09-25 | 2001-04-24 | California Institute Of Technology | Method and apparatus for analysis and sorting of polynucleotides based on size |
| US5860917A (en) | 1997-01-15 | 1999-01-19 | Chiron Corporation | Method and apparatus for predicting therapeutic outcomes |
| US5824467A (en) | 1997-02-25 | 1998-10-20 | Celtrix Pharmaceuticals | Methods for predicting drug response |
| US20010051341A1 (en) | 1997-03-04 | 2001-12-13 | Isis Innovation Limited | Non-invasive prenatal diagnosis |
| GB9704444D0 (en) | 1997-03-04 | 1997-04-23 | Isis Innovation | Non-invasive prenatal diagnosis |
| EP0866071B1 (en) | 1997-03-20 | 2004-10-20 | F. Hoffmann-La Roche Ag | Modified primers |
| ATE364718T1 (de) | 1997-04-01 | 2007-07-15 | Solexa Ltd | Verfahren zur vervielfältigung von nukleinsäure |
| US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
| US20020119478A1 (en) | 1997-05-30 | 2002-08-29 | Diagen Corporation | Methods for detection of nucleic acid sequences in urine |
| US5994148A (en) | 1997-06-23 | 1999-11-30 | The Regents Of University Of California | Method of predicting and enhancing success of IVF/ET pregnancy |
| US6833242B2 (en) | 1997-09-23 | 2004-12-21 | California Institute Of Technology | Methods for detecting and sorting polynucleotides based on size |
| US6124120A (en) | 1997-10-08 | 2000-09-26 | Yale University | Multiple displacement amplification |
| NZ505499A (en) | 1998-01-23 | 2002-07-26 | Immunex Corp | Accessory protein-like DNA and polypeptides |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| US6406671B1 (en) | 1998-12-05 | 2002-06-18 | Becton, Dickinson And Company | Device and method for separating components of a fluid sample |
| ATE347616T1 (de) | 1999-04-30 | 2006-12-15 | Cyclops Genome Sciences Ltd | Ribonukleinsäurederivate |
| US6180349B1 (en) | 1999-05-18 | 2001-01-30 | The Regents Of The University Of California | Quantitative PCR method to enumerate DNA copy number |
| US7058517B1 (en) | 1999-06-25 | 2006-06-06 | Genaissance Pharmaceuticals, Inc. | Methods for obtaining and using haplotype data |
| US6964847B1 (en) | 1999-07-14 | 2005-11-15 | Packard Biosciences Company | Derivative nucleic acids and uses thereof |
| GB9917307D0 (en) | 1999-07-23 | 1999-09-22 | Sec Dep Of The Home Department | Improvements in and relating to analysis of DNA |
| NZ531466A (en) | 1999-07-23 | 2005-06-24 | Sec Dep Home Dept | Use of single nucleotide polymorphisms (SNPs) to identify individuals in forensic investigations |
| US6440706B1 (en) | 1999-08-02 | 2002-08-27 | Johns Hopkins University | Digital amplification |
| US6251604B1 (en) | 1999-08-13 | 2001-06-26 | Genopsys, Inc. | Random mutagenesis and amplification of nucleic acid |
| EP1244811A1 (en) | 1999-11-10 | 2002-10-02 | Ligochem Inc. | Method for isolating dna from a proteinaceous medium and kit for performing method |
| US20030148301A1 (en) | 1999-12-10 | 2003-08-07 | Toshiya Aono | Method of detecting nucleotide polymorphism |
| US6221603B1 (en) | 2000-02-04 | 2001-04-24 | Molecular Dynamics, Inc. | Rolling circle amplification assay for nucleic acid analysis |
| EP1259643B1 (en) | 2000-02-07 | 2008-10-15 | Illumina, Inc. | Nucleic acid detection methods using universal priming |
| US7955794B2 (en) | 2000-09-21 | 2011-06-07 | Illumina, Inc. | Multiplex nucleic acid reactions |
| US7582420B2 (en) | 2001-07-12 | 2009-09-01 | Illumina, Inc. | Multiplex nucleic acid reactions |
| US7510834B2 (en) | 2000-04-13 | 2009-03-31 | Hidetoshi Inoko | Gene mapping method using microsatellite genetic polymorphism markers |
| US6828098B2 (en) | 2000-05-20 | 2004-12-07 | The Regents Of The University Of Michigan | Method of producing a DNA library using positional amplification based on the use of adaptors and nick translation |
| CA2409774A1 (en) | 2000-05-23 | 2001-11-29 | Variagenics, Inc. | Methods for genetic analysis of dna to detect sequence variances |
| US7087414B2 (en) | 2000-06-06 | 2006-08-08 | Applera Corporation | Methods and devices for multiplexing amplification reactions |
| US6605451B1 (en) | 2000-06-06 | 2003-08-12 | Xtrana, Inc. | Methods and devices for multiplexing amplification reactions |
| EP1356088A2 (en) | 2000-06-07 | 2003-10-29 | Baylor College of Medicine | Compositions and methods for array-based nucleic acid hybridization |
| US7058616B1 (en) | 2000-06-08 | 2006-06-06 | Virco Bvba | Method and system for predicting resistance of a disease to a therapeutic agent using a neural network |
| GB0016742D0 (en) | 2000-07-10 | 2000-08-30 | Simeg Limited | Diagnostic method |
| US6858412B2 (en) | 2000-10-24 | 2005-02-22 | The Board Of Trustees Of The Leland Stanford Junior University | Direct multiplex characterization of genomic DNA |
| US20020107640A1 (en) | 2000-11-14 | 2002-08-08 | Ideker Trey E. | Methods for determining the true signal of an analyte |
| AU2002243263A1 (en) | 2000-11-15 | 2002-07-24 | Roche Diagnostics Corporation | Methods and reagents for identifying rare fetal cells in the material circulation |
| WO2002044411A1 (en) | 2000-12-01 | 2002-06-06 | Rosetta Inpharmatics, Inc. | Use of profiling for detecting aneuploidy |
| US7218764B2 (en) | 2000-12-04 | 2007-05-15 | Cytokinetics, Inc. | Ploidy classification method |
| AR031640A1 (es) | 2000-12-08 | 2003-09-24 | Applied Research Systems | Amplificacion isotermica de acidos nucleicos en un soporte solido |
| JP2002300894A (ja) | 2001-02-01 | 2002-10-15 | Inst Of Physical & Chemical Res | 一塩基多型タイピング方法 |
| US20020182622A1 (en) | 2001-02-01 | 2002-12-05 | Yusuke Nakamura | Method for SNP (single nucleotide polymorphism) typing |
| CA2439402A1 (en) | 2001-03-02 | 2002-09-12 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Pcr method |
| WO2002073504A1 (en) | 2001-03-14 | 2002-09-19 | Gene Logic, Inc. | A system and method for retrieving and using gene expression data from multiple sources |
| US6489135B1 (en) | 2001-04-17 | 2002-12-03 | Atairgintechnologies, Inc. | Determination of biological characteristics of embryos fertilized in vitro by assaying for bioactive lipids in culture media |
| FR2824144B1 (fr) | 2001-04-30 | 2004-09-17 | Metagenex S A R L | Methode de diagnostic prenatal sur cellule foetale isolee du sang maternel |
| US7392199B2 (en) | 2001-05-01 | 2008-06-24 | Quest Diagnostics Investments Incorporated | Diagnosing inapparent diseases from common clinical tests using Bayesian analysis |
| WO2002090505A2 (en) | 2001-05-09 | 2002-11-14 | Virginia Commonwealth University | Multiple sequencible and ligatible structures for genomic analysis |
| US20040126760A1 (en) | 2001-05-17 | 2004-07-01 | Natalia Broude | Novel compositions and methods for carrying out multple pcr reactions on a single sample |
| US7026121B1 (en) | 2001-06-08 | 2006-04-11 | Expression Diagnostics, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| US20030054386A1 (en) | 2001-06-22 | 2003-03-20 | Stylianos Antonarakis | Method for detecting diseases caused by chromosomal imbalances |
| WO2003010537A1 (en) | 2001-07-24 | 2003-02-06 | Curagen Corporation | Family based tests of association using pooled dna and snp markers |
| ES2367280T3 (es) | 2001-07-25 | 2011-11-02 | Oncomedx Inc. | Métodos para evaluar estados patológicos usando arn extracelular. |
| US7297778B2 (en) | 2001-07-25 | 2007-11-20 | Affymetrix, Inc. | Complexity management of genomic DNA |
| US6958211B2 (en) | 2001-08-08 | 2005-10-25 | Tibotech Bvba | Methods of assessing HIV integrase inhibitor therapy |
| JP2005501236A (ja) | 2001-08-23 | 2005-01-13 | イムニベスト・コーポレイション | 分析用の細胞および生物学的検体の安定化 |
| US6807491B2 (en) | 2001-08-30 | 2004-10-19 | Hewlett-Packard Development Company, L.P. | Method and apparatus for combining gene predictions using bayesian networks |
| US6927028B2 (en) | 2001-08-31 | 2005-08-09 | Chinese University Of Hong Kong | Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA |
| AUPR749901A0 (en) | 2001-09-06 | 2001-09-27 | Monash University | Method of identifying chromosomal abnormalities and prenatal diagnosis |
| US7153656B2 (en) | 2001-09-11 | 2006-12-26 | Los Alamos National Security, Llc | Nucleic acid sequence detection using multiplexed oligonucleotide PCR |
| US8986944B2 (en) | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
| US20040014067A1 (en) | 2001-10-12 | 2004-01-22 | Third Wave Technologies, Inc. | Amplification methods and compositions |
| EP1442139A4 (en) | 2001-10-12 | 2005-01-26 | Univ Queensland | SELECTION AND AMPLIFICATION OF MULTIPLE GENETIC MARKERS |
| US7297485B2 (en) | 2001-10-15 | 2007-11-20 | Qiagen Gmbh | Method for nucleic acid amplification that results in low amplification bias |
| US6617137B2 (en) | 2001-10-15 | 2003-09-09 | Molecular Staging Inc. | Method of amplifying whole genomes without subjecting the genome to denaturing conditions |
| US20030119004A1 (en) | 2001-12-05 | 2003-06-26 | Wenz H. Michael | Methods for quantitating nucleic acids using coupled ligation and amplification |
| US7198897B2 (en) | 2001-12-19 | 2007-04-03 | Brandeis University | Late-PCR |
| DE60123448T2 (de) | 2001-12-24 | 2007-08-23 | Prof. Wolfgang Holzgreve | Verfahren zur nicht-invasiven Diagnose von Transplantationen und Transfusionen |
| US20040115629A1 (en) | 2002-01-09 | 2004-06-17 | Panzer Scott R | Molecules for diagnostics and therapeutics |
| JP2005514956A (ja) | 2002-01-18 | 2005-05-26 | ジェンザイム・コーポレーション | 胎児ｄｎａの検出および対立遺伝子の定量化のための方法 |
| JP2005516310A (ja) | 2002-02-01 | 2005-06-02 | ロゼッタ インファーマティクス エルエルシー | 遺伝子を特定し、形質に関連する経路を明らかにするコンピュータ・システムおよび方法 |
| US7736892B2 (en) | 2002-02-25 | 2010-06-15 | Kansas State University Research Foundation | Cultures, products and methods using umbilical cord matrix cells |
| US6977162B2 (en) | 2002-03-01 | 2005-12-20 | Ravgen, Inc. | Rapid analysis of variations in a genome |
| CA2477761A1 (en) | 2002-03-01 | 2003-09-12 | Ravgen, Inc. | Methods for detection of genetic disorders |
| US20060229823A1 (en) | 2002-03-28 | 2006-10-12 | Affymetrix, Inc. | Methods and computer software products for analyzing genotyping data |
| US7241281B2 (en) | 2002-04-08 | 2007-07-10 | Thermogenesis Corporation | Blood component separation method and apparatus |
| US7211191B2 (en) | 2004-09-30 | 2007-05-01 | Thermogenesis Corp. | Blood component separation method and apparatus |
| US20040096874A1 (en) | 2002-04-11 | 2004-05-20 | Third Wave Technologies, Inc. | Characterization of CYP 2D6 genotypes |
| US20030235848A1 (en) | 2002-04-11 | 2003-12-25 | Matt Neville | Characterization of CYP 2D6 alleles |
| US7208317B2 (en) | 2002-05-02 | 2007-04-24 | The University Of North Carolina At Chapel Hill | In Vitro mutagenesis, phenotyping, and gene mapping |
| US20070178478A1 (en) | 2002-05-08 | 2007-08-02 | Dhallan Ravinder S | Methods for detection of genetic disorders |
| US7442506B2 (en) | 2002-05-08 | 2008-10-28 | Ravgen, Inc. | Methods for detection of genetic disorders |
| US7727720B2 (en) | 2002-05-08 | 2010-06-01 | Ravgen, Inc. | Methods for detection of genetic disorders |
| US20040009518A1 (en) | 2002-05-14 | 2004-01-15 | The Chinese University Of Hong Kong | Methods for evaluating a disease condition by nucleic acid detection and fractionation |
| US20040229231A1 (en) | 2002-05-28 | 2004-11-18 | Frudakis Tony N. | Compositions and methods for inferring ancestry |
| US7097976B2 (en) | 2002-06-17 | 2006-08-29 | Affymetrix, Inc. | Methods of analysis of allelic imbalance |
| US7108976B2 (en) | 2002-06-17 | 2006-09-19 | Affymetrix, Inc. | Complexity management of genomic DNA by locus specific amplification |
| US20050009069A1 (en) | 2002-06-25 | 2005-01-13 | Affymetrix, Inc. | Computer software products for analyzing genotyping |
| CA2491117A1 (en) | 2002-06-28 | 2004-01-08 | Orchid Biosciences, Inc. | Methods and compositions for analyzing compromised samples using single nucleotide polymorphism panels |
| EP1388812A1 (en) | 2002-07-04 | 2004-02-11 | Ronald E. Dr. Kates | Method for training a learning-capable system |
| JP4116856B2 (ja) | 2002-10-02 | 2008-07-09 | 富士フイルム株式会社 | １塩基多型の検出方法 |
| US7459273B2 (en) | 2002-10-04 | 2008-12-02 | Affymetrix, Inc. | Methods for genotyping selected polymorphism |
| AU2003285861A1 (en) | 2002-10-07 | 2004-05-04 | University Of Medicine And Dentistry Of New Jersey | High throughput multiplex dna sequence amplifications |
| US10229244B2 (en) | 2002-11-11 | 2019-03-12 | Affymetrix, Inc. | Methods for identifying DNA copy number changes using hidden markov model based estimations |
| EP1578994A2 (en) | 2002-11-11 | 2005-09-28 | Affymetrix, Inc. | Methods for identifying dna copy number changes |
| EP2031070B1 (en) | 2002-12-04 | 2013-07-17 | Life Technologies Corporation | Multiplex amplification of polynucleotides |
| EP2469077B1 (de) | 2003-01-02 | 2020-05-27 | Wobben Properties GmbH | Windenergieanlage mit einem Rotorblatt |
| DE602004021902D1 (de) | 2003-01-17 | 2009-08-20 | Univ Boston | Haplotypanalyse |
| WO2004065628A1 (en) | 2003-01-21 | 2004-08-05 | Guoliang Fu | Quantitative multiplex detection of nucleic acids |
| CA2513535C (en) | 2003-01-29 | 2012-06-12 | 454 Corporation | Bead emulsion nucleic acid amplification |
| US7575865B2 (en) | 2003-01-29 | 2009-08-18 | 454 Life Sciences Corporation | Methods of amplifying and sequencing nucleic acids |
| EP1599608A4 (en) | 2003-03-05 | 2007-07-18 | Genetic Technologies Ltd | Identification of fetal DNA and fetal cell marker in maternal plasma or serum |
| EP1606417A2 (en) | 2003-03-07 | 2005-12-21 | Rubicon Genomics Inc. | In vitro dna immortalization and whole genome amplification using libraries generated from randomly fragmented dna |
| US20040197832A1 (en) | 2003-04-03 | 2004-10-07 | Mor Research Applications Ltd. | Non-invasive prenatal genetic diagnosis using transcervical cells |
| EP1627075A4 (en) | 2003-05-09 | 2006-09-20 | Univ Tsinghua | METHODS AND PREPARATIONS FOR OPTIMIZING MULTIPLEX PCR STARTERS |
| CN101410008A (zh) | 2003-05-28 | 2009-04-15 | 先锋高级育种国际公司 | 植物育种方法 |
| US20040259100A1 (en) | 2003-06-20 | 2004-12-23 | Illumina, Inc. | Methods and compositions for whole genome amplification and genotyping |
| WO2005012578A1 (en) | 2003-07-31 | 2005-02-10 | Sequenom, Inc. | Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions for genotyping of polymorphisms |
| US8346482B2 (en) | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
| AU2003263660A1 (en) | 2003-08-29 | 2005-03-16 | Pantarhei Bioscience B.V. | Prenatal diagnosis of down syndrome by detection of fetal rna markers in maternal blood |
| AU2004270220B2 (en) | 2003-09-05 | 2009-03-05 | The Chinese University Of Hong Kong | Method for non-invasive prenatal diagnosis |
| US20050053950A1 (en) | 2003-09-08 | 2005-03-10 | Enrique Zudaire Ubani | Protocol and software for multiplex real-time PCR quantification based on the different melting temperatures of amplicons |
| WO2005028645A1 (ja) | 2003-09-24 | 2005-03-31 | Kyushu Tlo Company, Limited | ＭＤＲ１遺伝子の５’制御領域におけるＳＮＰｓ |
| WO2005030999A1 (en) | 2003-09-25 | 2005-04-07 | Dana-Farber Cancer Institute, Inc | Methods to detect lineage-specific cells |
| CN101985619B (zh) | 2003-10-08 | 2014-08-20 | 波士顿大学信托人 | 染色体异常的产前诊断方法 |
| CA2482097C (en) | 2003-10-13 | 2012-02-21 | F. Hoffmann-La Roche Ag | Methods for isolating nucleic acids |
| ATE435301T1 (de) | 2003-10-16 | 2009-07-15 | Sequenom Inc | Nicht invasiver nachweis fötaler genetischer merkmale |
| US20050221341A1 (en) | 2003-10-22 | 2005-10-06 | Shimkets Richard A | Sequence-based karyotyping |
| US20070212689A1 (en) | 2003-10-30 | 2007-09-13 | Bianchi Diana W | Prenatal Diagnosis Using Cell-Free Fetal DNA in Amniotic Fluid |
| US20050164252A1 (en) | 2003-12-04 | 2005-07-28 | Yeung Wah Hin A. | Methods using non-genic sequences for the detection, modification and treatment of any disease or improvement of functions of a cell |
| US7892732B2 (en) | 2004-01-12 | 2011-02-22 | Roche Nimblegen, Inc. | Method of performing PCR amplification on a microarray |
| US20100216151A1 (en) | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
| US20100216153A1 (en) | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
| US20060046258A1 (en) | 2004-02-27 | 2006-03-02 | Lapidus Stanley N | Applications of single molecule sequencing |
| US7035740B2 (en) | 2004-03-24 | 2006-04-25 | Illumina, Inc. | Artificial intelligence and global normalization methods for genotyping |
| JP4437050B2 (ja) | 2004-03-26 | 2010-03-24 | 株式会社日立製作所 | 診断支援システム、診断支援方法および診断支援サービスの提供方法 |
| WO2005094363A2 (en) | 2004-03-30 | 2005-10-13 | New York University | System, method and software arrangement for bi-allele haplotype phasing |
| JP4756032B2 (ja) | 2004-03-31 | 2011-08-24 | アトナーゲン アクチエンゲゼルシャフト | 胎児赤血球細胞に対して特異性を有するモノクローナル抗体 |
| US7414118B1 (en) | 2004-04-14 | 2008-08-19 | Applied Biosystems Inc. | Modified oligonucleotides and applications thereof |
| US7468249B2 (en) | 2004-05-05 | 2008-12-23 | Biocept, Inc. | Detection of chromosomal disorders |
| JP2008501340A (ja) | 2004-06-02 | 2008-01-24 | ニユー・イングランド・バイオレイブス・インコーポレイテツド | ショットガン配列データからの機能推定 |
| US7709194B2 (en) | 2004-06-04 | 2010-05-04 | The Chinese University Of Hong Kong | Marker for prenatal diagnosis and monitoring |
| AU2005255024C1 (en) | 2004-06-14 | 2010-09-09 | The Board Of Trustees Of The University Of Illinois | Antibodies binding to CD34+/CD36+ fetal but not to adult cells |
| EP1786924A4 (en) | 2004-07-06 | 2008-10-01 | Genera Biosystems Pty Ltd | METHOD FOR DETECTING ANEUPLOIDIA |
| CA2571942A1 (en) | 2004-07-14 | 2006-02-23 | Wyeth | Compositions and methods of purifying myelin-associated glycoprotein (mag) |
| DE102004036285A1 (de) | 2004-07-27 | 2006-02-16 | Advalytix Ag | Verfahren zum Bestimmen der Häufigkeit von Sequenzen einer Probe |
| US20060040300A1 (en) | 2004-08-09 | 2006-02-23 | Generation Biotech, Llc | Method for nucleic acid isolation and amplification |
| EP1789786A4 (en) | 2004-08-18 | 2008-02-13 | Abbott Molecular Inc | DETERMINING DATA QUALITY AND / OR SEGMENTAL ANEUMS USING A COMPUTER SYSTEM |
| JP4810164B2 (ja) | 2004-09-03 | 2011-11-09 | 富士フイルム株式会社 | 核酸分離精製方法 |
| US8024128B2 (en) | 2004-09-07 | 2011-09-20 | Gene Security Network, Inc. | System and method for improving clinical decisions by aggregating, validating and analysing genetic and phenotypic data |
| US20060088574A1 (en) | 2004-10-25 | 2006-04-27 | Manning Paul B | Nutritional supplements |
| WO2006047481A2 (en) | 2004-10-22 | 2006-05-04 | Redpath Integrated Pathology, Inc. | Enhanced amplifiability of minute fixative-treated tissue samples, minute stained cytology samples, and other minute sources of dna |
| US20060134662A1 (en) | 2004-10-25 | 2006-06-22 | Pratt Mark R | Method and system for genotyping samples in a normalized allelic space |
| US9109256B2 (en) | 2004-10-27 | 2015-08-18 | Esoterix Genetic Laboratories, Llc | Method for monitoring disease progression or recurrence |
| CA2585784A1 (en) | 2004-11-17 | 2006-05-26 | Mosaic Reproductive Health And Genetics, Llc | Methods of determining human egg competency |
| CA2588296A1 (en) | 2004-11-24 | 2006-06-01 | Neuromolecular Pharmaceuticals, Inc. | Composition comprising an nmda receptor antagonist and levodopa and use thereof for treating neurological disease |
| US20070042384A1 (en) | 2004-12-01 | 2007-02-22 | Weiwei Li | Method for isolating and modifying DNA from blood and body fluids |
| WO2006091979A2 (en) | 2005-02-25 | 2006-08-31 | The Regents Of The University Of California | Full karyotype single cell chromosome analysis |
| US20060234264A1 (en) | 2005-03-14 | 2006-10-19 | Affymetrix, Inc. | Multiplex polynucleotide synthesis |
| US7618777B2 (en) | 2005-03-16 | 2009-11-17 | Agilent Technologies, Inc. | Composition and method for array hybridization |
| CA3147058A1 (en) | 2005-03-18 | 2006-09-21 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis, monitoring or predicting preeclampsia |
| US7645576B2 (en) | 2005-03-18 | 2010-01-12 | The Chinese University Of Hong Kong | Method for the detection of chromosomal aneuploidies |
| US20060228721A1 (en) | 2005-04-12 | 2006-10-12 | Leamon John H | Methods for determining sequence variants using ultra-deep sequencing |
| JP2008538496A (ja) | 2005-04-12 | 2008-10-30 | ４５４ ライフ サイエンシーズ コーポレイション | ウルトラディープ配列決定を用いて配列変異体を決定するための方法 |
| US20090280479A1 (en) | 2005-05-27 | 2009-11-12 | John Wayne Cancer Institute | Use of free circulating dna for diagnosis, prognosis, and treatment of cancer funding |
| US20070077570A1 (en) | 2005-05-31 | 2007-04-05 | Applera Corporation | Multiplexed amplification of short nucleic acids |
| EP2477029A1 (en) | 2005-06-02 | 2012-07-18 | Fluidigm Corporation | Analysis using microfluidic partitioning devices |
| US7601499B2 (en) | 2005-06-06 | 2009-10-13 | 454 Life Sciences Corporation | Paired end sequencing |
| EP1907571B1 (en) | 2005-06-15 | 2017-04-26 | Complete Genomics Inc. | Nucleic acid analysis by random mixtures of non-overlapping fragments |
| WO2007011903A2 (en) | 2005-07-15 | 2007-01-25 | Applera Corporation | Analyzing messenger rna and micro rna in the same reaction mixture |
| US20070020640A1 (en) | 2005-07-21 | 2007-01-25 | Mccloskey Megan L | Molecular encoding of nucleic acid templates for PCR and other forms of sequence analysis |
| RU2290078C1 (ru) | 2005-07-25 | 2006-12-27 | Евгений Владимирович Новичков | Способ прогнозирования рецидива серозного рака яичников |
| US11111543B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US9424392B2 (en) | 2005-11-26 | 2016-08-23 | Natera, Inc. | System and method for cleaning noisy genetic data from target individuals using genetic data from genetically related individuals |
| US8515679B2 (en) | 2005-12-06 | 2013-08-20 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US20070178501A1 (en) | 2005-12-06 | 2007-08-02 | Matthew Rabinowitz | System and method for integrating and validating genotypic, phenotypic and medical information into a database according to a standardized ontology |
| US10083273B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US11111544B2 (en) | 2005-07-29 | 2021-09-07 | Natera, Inc. | System and method for cleaning noisy genetic data and determining chromosome copy number |
| US20070027636A1 (en) | 2005-07-29 | 2007-02-01 | Matthew Rabinowitz | System and method for using genetic, phentoypic and clinical data to make predictions for clinical or lifestyle decisions |
| US8532930B2 (en) | 2005-11-26 | 2013-09-10 | Natera, Inc. | Method for determining the number of copies of a chromosome in the genome of a target individual using genetic data from genetically related individuals |
| US10081839B2 (en) | 2005-07-29 | 2018-09-25 | Natera, Inc | System and method for cleaning noisy genetic data and determining chromosome copy number |
| EP1924704B1 (en) | 2005-08-02 | 2011-05-25 | Rubicon Genomics, Inc. | Compositions and methods for processing and amplification of dna, including using multiple enzymes in a single reaction |
| WO2007030680A2 (en) | 2005-09-07 | 2007-03-15 | Rigel Pharmaceuticals, Inc. | Triazole derivatives useful as axl inhibitors |
| GB0522310D0 (en) | 2005-11-01 | 2005-12-07 | Solexa Ltd | Methods of preparing libraries of template polynucleotides |
| GB0523276D0 (en) | 2005-11-15 | 2005-12-21 | London Bridge Fertility | Chromosomal analysis by molecular karyotyping |
| EP3599609A1 (en) | 2005-11-26 | 2020-01-29 | Natera, Inc. | System and method for cleaning noisy genetic data and using data to make predictions |
| US20070172853A1 (en) | 2005-12-02 | 2007-07-26 | The General Hospital Corporation | Use of deletion polymorphisms to predict, prevent, and manage histoincompatibility |
| WO2007070482A2 (en) | 2005-12-14 | 2007-06-21 | Xueliang Xia | Microarray-based preimplantation genetic diagnosis of chromosomal abnormalities |
| CN101365803B (zh) | 2005-12-22 | 2013-03-20 | 关键基因股份有限公司 | 采用高通量测序技术的改进的转录谱描述策略 |
| TR201910868T4 (tr) | 2006-02-02 | 2019-08-21 | Univ Leland Stanford Junior | Dijital analizle invazif olmayan fetal genetik tarama. |
| WO2007092538A2 (en) | 2006-02-07 | 2007-08-16 | President And Fellows Of Harvard College | Methods for making nucleotide probes for sequencing and synthesis |
| WO2007091064A1 (en) | 2006-02-08 | 2007-08-16 | Solexa Limited | End modification to prevent over-representation of fragments |
| US20100184043A1 (en) | 2006-02-28 | 2010-07-22 | University Of Louisville Research Foundation | Detecting Genetic Abnormalities |
| US8609338B2 (en) | 2006-02-28 | 2013-12-17 | University Of Louisville Research Foundation, Inc. | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
| WO2007100911A2 (en) | 2006-02-28 | 2007-09-07 | University Of Louisville Research Foundation | Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms |
| EP2007874A4 (en) | 2006-03-13 | 2009-06-10 | Veridex Llc | PROPAGATION OF PRIMARY CELLS |
| WO2007111937A1 (en) | 2006-03-23 | 2007-10-04 | Applera Corporation | Directed enrichment of genomic dna for high-throughput sequencing |
| US20080038733A1 (en) | 2006-03-28 | 2008-02-14 | Baylor College Of Medicine | Screening for down syndrome |
| JP2009072062A (ja) | 2006-04-07 | 2009-04-09 | Institute Of Physical & Chemical Research | 核酸の５’末端を単離するための方法およびその適用 |
| WO2007121276A2 (en) | 2006-04-12 | 2007-10-25 | Biocept, Inc. | Enrichment of circulating fetal dna |
| US7901884B2 (en) | 2006-05-03 | 2011-03-08 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis and monitoring |
| US7702468B2 (en) | 2006-05-03 | 2010-04-20 | Population Diagnostics, Inc. | Evaluating genetic disorders |
| WO2007140417A2 (en) | 2006-05-31 | 2007-12-06 | Sequenom, Inc. | Methods and compositions for the extraction and amplification of nucleic acid from a sample |
| WO2007146819A2 (en) | 2006-06-09 | 2007-12-21 | Brigham And Women's Hospital, Inc. | Methods for identifying and using snp panels |
| EP3425058A1 (en) | 2006-06-14 | 2019-01-09 | Verinata Health, Inc | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| EP2024512A4 (en) | 2006-06-14 | 2009-12-09 | Artemis Health Inc | METHOD FOR DIAGNOSIS OF FEDERAL ANOMALIES |
| US8372584B2 (en) | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
| AU2007260676A1 (en) | 2006-06-14 | 2007-12-21 | Artemis Health, Inc. | Rare cell analysis using sample splitting and DNA tags |
| US20080026390A1 (en) | 2006-06-14 | 2008-01-31 | Roland Stoughton | Diagnosis of Fetal Abnormalities by Comparative Genomic Hybridization Analysis |
| WO2008111990A1 (en) | 2006-06-14 | 2008-09-18 | Cellpoint Diagnostics, Inc. | Rare cell analysis using sample splitting and dna tags |
| US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| EP2029779A4 (en) | 2006-06-14 | 2010-01-20 | Living Microsystems Inc | HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS |
| US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
| EP2035540A2 (en) | 2006-06-15 | 2009-03-18 | Stratagene | System for isolating biomolecules from a sample |
| AU2007260750A1 (en) | 2006-06-16 | 2007-12-21 | Sequenom, Inc. | Methods and compositions for the amplification, detection and quantification of nucleic acid from a sample |
| US20080182244A1 (en) | 2006-08-04 | 2008-07-31 | Ikonisys, Inc. | Pre-Implantation Genetic Diagnosis Test |
| EP2057282A4 (en) | 2006-08-24 | 2010-10-27 | Univ Massachusetts Medical | MAPPING GENOMIC INTERACTIONS |
| EP2064332B1 (en) | 2006-09-14 | 2012-07-18 | Ibis Biosciences, Inc. | Targeted whole genome amplification method for identification of pathogens |
| US20080085836A1 (en) | 2006-09-22 | 2008-04-10 | Kearns William G | Method for genetic testing of human embryos for chromosome abnormalities, segregating genetic disorders with or without a known mutation and mitochondrial disorders following in vitro fertilization (IVF), embryo culture and embryo biopsy |
| US20110039258A1 (en) | 2006-10-16 | 2011-02-17 | Celula Inc. | Methods and compositions for differential expansion of fetal cells in maternal blood and their use |
| WO2008051928A2 (en) | 2006-10-23 | 2008-05-02 | The Salk Institute For Biological Studies | Target-oriented whole genome amplification of nucliec acids |
| KR100825367B1 (ko) | 2006-11-07 | 2008-04-28 | 전남대학교산학협력단 | 표지자로서 미토콘드리아 유전자 과변이부위를 이용하는조혈모세포이식 후 생착능 평가방법 및 키트 |
| US20110045462A1 (en) | 2006-11-14 | 2011-02-24 | The Regents Of The University Of California | Digital analysis of gene expression |
| JP2010509922A (ja) | 2006-11-16 | 2010-04-02 | ジェネンテック インコーポレイテッド | 腫瘍と関連している遺伝的変異 |
| WO2008059578A1 (en) | 2006-11-16 | 2008-05-22 | Olympus Corporation | Multiplex pcr method |
| WO2008079374A2 (en) | 2006-12-21 | 2008-07-03 | Wang Eric T | Methods and compositions for selecting and using single nucleotide polymorphisms |
| WO2008081451A2 (en) | 2007-01-03 | 2008-07-10 | Monaliza Medical Ltd. | Methods and kits for analyzing genetic material of a fetus |
| US20080164204A1 (en) | 2007-01-08 | 2008-07-10 | Mehdi Hatamian | Valve for facilitating and maintaining separation of fluids and materials |
| AU2008204338B2 (en) | 2007-01-11 | 2014-03-06 | Erasmus University Medical Center | Circular chromosome conformation capture (4C) |
| WO2008093098A2 (en) | 2007-02-02 | 2008-08-07 | Illumina Cambridge Limited | Methods for indexing samples and sequencing multiple nucleotide templates |
| US20100129792A1 (en) | 2007-02-06 | 2010-05-27 | Gerassimos Makrigiorgos | Direct monitoring and pcr amplification of the dosage and dosage difference between target genetic regions |
| AU2008213634B2 (en) | 2007-02-08 | 2013-09-05 | Sequenom, Inc. | Nucleic acid-based tests for RhD typing, gender determination and nucleic acid quantification |
| EP2140386A2 (en) | 2007-03-16 | 2010-01-06 | Gene Security Network | System and method for cleaning noisy genetic data and determining chromsome copy number |
| CN101680027A (zh) | 2007-03-16 | 2010-03-24 | 454生命科学公司 | 检测hiv耐药变异体的系统和方法 |
| WO2008118988A1 (en) | 2007-03-26 | 2008-10-02 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| JP5262230B2 (ja) | 2007-03-28 | 2013-08-14 | 独立行政法人理化学研究所 | 新規多型検出法 |
| ITTO20070307A1 (it) | 2007-05-04 | 2008-11-05 | Silicon Biosystems Spa | Metodo e dispositivo per la diagnosi prenatale non-invasiva |
| US20080293589A1 (en) | 2007-05-24 | 2008-11-27 | Affymetrix, Inc. | Multiplex locus specific amplification |
| CN101849185A (zh) | 2007-05-31 | 2010-09-29 | 加利福尼亚大学董事会 | 基于空间位阻和酶相关信号放大的高特异性和高灵敏度检测 |
| WO2008151110A2 (en) * | 2007-06-01 | 2008-12-11 | The University Of North Carolina At Chapel Hill | Molecular diagnosis and typing of lung cancer variants |
| WO2008157264A2 (en) | 2007-06-15 | 2008-12-24 | Sequenom, Inc. | Combined methods for the detection of chromosomal aneuploidy |
| WO2008155599A1 (en) | 2007-06-20 | 2008-12-24 | Taag-Genetics Sa | Nested multiplex amplification method for identification of multiple biological entities |
| US20090023190A1 (en) | 2007-06-20 | 2009-01-22 | Kai Qin Lao | Sequence amplification with loopable primers |
| ES2647237T3 (es) | 2007-07-03 | 2017-12-20 | Genaphora Ltd. | Cebadores quiméricos para reacciones de amplificación de ácidos nucleicos mejoradas |
| WO2009009769A2 (en) | 2007-07-11 | 2009-01-15 | Artemis Health, Inc. | Diagnosis of fetal abnormalities using nucleated red blood cells |
| EP3892736A1 (en) | 2007-07-23 | 2021-10-13 | The Chinese University of Hong Kong | Determining a nucleic acid sequence imbalance |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| WO2009017784A2 (en) | 2007-08-01 | 2009-02-05 | Dana-Farber Cancer Institute | Enrichment of a target sequence |
| US20090053719A1 (en) | 2007-08-03 | 2009-02-26 | The Chinese University Of Hong Kong | Analysis of nucleic acids by digital pcr |
| WO2009019215A1 (en) | 2007-08-03 | 2009-02-12 | Dkfz Deutsches Krebsforschungszentrum | Method for prenatal diagnosis using exosomes and cd24 as a marker |
| WO2009032779A2 (en) | 2007-08-29 | 2009-03-12 | Sequenom, Inc. | Methods and compositions for the size-specific seperation of nucleic acid from a sample |
| EP2195452B1 (en) | 2007-08-29 | 2012-03-14 | Sequenom, Inc. | Methods and compositions for universal size-specific polymerase chain reaction |
| US8748100B2 (en) | 2007-08-30 | 2014-06-10 | The Chinese University Of Hong Kong | Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences |
| CN101821619B (zh) | 2007-09-07 | 2015-02-11 | 弗卢丁公司 | 拷贝数变化确定、方法和系统 |
| US20110300608A1 (en) | 2007-09-21 | 2011-12-08 | Streck, Inc. | Nucleic acid isolation in preserved whole blood |
| CA2697640C (en) | 2007-09-21 | 2016-06-21 | Katholieke Universiteit Leuven | Tools and methods for genetic tests using next generation sequencing |
| US20100326218A1 (en) | 2007-09-27 | 2010-12-30 | Michael Boeckh | Identifying a subject with an increased risk of invasive mold infection |
| US20100086914A1 (en) | 2008-10-03 | 2010-04-08 | Roche Molecular Systems, Inc. | High resolution, high throughput hla genotyping by clonal sequencing |
| JP2011500041A (ja) | 2007-10-16 | 2011-01-06 | エフ．ホフマン−ラ ロシュ アーゲー | クローナルシークエンシングによる高分解能かつ高効率のｈｌａ遺伝子型決定法 |
| US8415099B2 (en) | 2007-11-05 | 2013-04-09 | Complete Genomics, Inc. | Efficient base determination in sequencing reactions |
| WO2009064897A2 (en) | 2007-11-14 | 2009-05-22 | Chronix Biomedical | Detection of nucleic acid sequence variations in circulating nucleic acid in bovine spongiform encephalopathy |
| WO2009064789A2 (en) | 2007-11-15 | 2009-05-22 | The Johns Hopkins University | Methods for detecting and monitoring circulating cancer stem cells |
| JP5726529B2 (ja) | 2007-11-30 | 2015-06-03 | ジーイー・ヘルスケア・バイオサイエンス・コーポレイション | 単一試料からのゲノムｄｎａ、ｒｎａおよびタンパク質の単離方法 |
| WO2009074983A2 (en) | 2007-12-10 | 2009-06-18 | Ben Gurion University Of The Negev Research And Development Authority | Assay for detecting circulating free nucleic acids |
| FR2925480B1 (fr) | 2007-12-21 | 2011-07-01 | Gervais Danone Sa | Procede d'enrichissement d'une eau en oxygene par voie electrolytique, eau ou boisson enrichie en oxygene et utilisations |
| EP2077337A1 (en) | 2007-12-26 | 2009-07-08 | Eppendorf Array Technologies SA | Amplification and detection composition, method and kit |
| US8852864B2 (en) | 2008-01-17 | 2014-10-07 | Sequenom Inc. | Methods and compositions for the analysis of nucleic acids |
| WO2009091934A1 (en) | 2008-01-17 | 2009-07-23 | Sequenom, Inc. | Single molecule nucleic acid sequence analysis processes and compositions |
| EP2604704B1 (en) | 2008-02-01 | 2018-10-03 | The General Hospital Corporation | Use of microvesicles in diagnosis and prognosis of brain tumor |
| WO2009099602A1 (en) | 2008-02-04 | 2009-08-13 | Massachusetts Institute Of Technology | Selection of nucleic acids by solution hybridization to oligonucleotide baits |
| WO2009105531A1 (en) | 2008-02-19 | 2009-08-27 | Gene Security Network, Inc. | Methods for cell genotyping |
| US20090221620A1 (en) | 2008-02-20 | 2009-09-03 | Celera Corporation | Gentic polymorphisms associated with stroke, methods of detection and uses thereof |
| EP2271772B1 (en) | 2008-03-11 | 2014-07-16 | Sequenom, Inc. | Nucleic acid-based tests for prenatal gender determination |
| EP2227780A4 (en) | 2008-03-19 | 2011-08-03 | Existence Genetics Llc | GENETIC ANALYSIS |
| CA2718137A1 (en) | 2008-03-26 | 2009-10-01 | Sequenom, Inc. | Restriction endonuclease enhanced polymorphic sequence detection |
| WO2009145828A2 (en) | 2008-03-31 | 2009-12-03 | Pacific Biosciences Of California, Inc. | Two slow-step polymerase enzyme systems and methods |
| CN107385040B (zh) | 2008-04-03 | 2022-02-15 | 艾瑞普特公司 | 用于扩增多个靶标的扩增子拯救多重聚合酶链式反应 |
| US20110092763A1 (en) | 2008-05-27 | 2011-04-21 | Gene Security Network, Inc. | Methods for Embryo Characterization and Comparison |
| EP2128169A1 (de) | 2008-05-30 | 2009-12-02 | Qiagen GmbH | Verfahren zur Isolierung von kurzkettigen Nukleinsäuren |
| US9333445B2 (en) | 2008-07-21 | 2016-05-10 | Becton, Dickinson And Company | Density phase separation device |
| US20100041048A1 (en) | 2008-07-31 | 2010-02-18 | The Johns Hopkins University | Circulating Mutant DNA to Assess Tumor Dynamics |
| ES2620431T3 (es) | 2008-08-04 | 2017-06-28 | Natera, Inc. | Métodos para la determinación de alelos y de ploidía |
| EP2326732A4 (en) | 2008-08-26 | 2012-11-14 | Fluidigm Corp | TEST METHODS FOR INCREASED SURPLUS OF SAMPLES AND / OR TARGETS |
| DE102008045705A1 (de) | 2008-09-04 | 2010-04-22 | Macherey, Nagel Gmbh & Co. Kg Handelsgesellschaft | Verfahren zur Gewinnung von kurzer RNA sowie Kit hierfür |
| US8586310B2 (en) | 2008-09-05 | 2013-11-19 | Washington University | Method for multiplexed nucleic acid patch polymerase chain reaction |
| US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| AU2009293232B2 (en) | 2008-09-16 | 2015-05-14 | Sequenom Center For Molecular Medicine | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
| EP2324131A4 (en) | 2008-09-17 | 2013-02-27 | Ge Healthcare Bio Sciences | PROCESS FOR ISOLATING SMALL RNA |
| HUE031848T2 (en) | 2008-09-20 | 2017-08-28 | Univ Leland Stanford Junior | Non-invasive diagnosis of fetal aneuploidy by sequencing |
| US9156010B2 (en) | 2008-09-23 | 2015-10-13 | Bio-Rad Laboratories, Inc. | Droplet-based assay system |
| US20110301221A1 (en) | 2008-10-10 | 2011-12-08 | Swedish Health Services | Diagnosis, prognosis and treatment of glioblastoma multiforme |
| WO2010045617A2 (en) | 2008-10-17 | 2010-04-22 | University Of Louisville Research Foundation | Detecting genetic abnormalities |
| US9506119B2 (en) | 2008-11-07 | 2016-11-29 | Adaptive Biotechnologies Corp. | Method of sequence determination using sequence tags |
| US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
| GB2483810B (en) | 2008-11-07 | 2012-09-05 | Sequenta Inc | Methods for correlating clonotypes with diseases in a population |
| CA2748030A1 (en) | 2008-12-22 | 2010-07-01 | Arnold R. Oliphant | Methods and genotyping panels for detecting alleles, genomes, and transcriptomes |
| US11634747B2 (en) | 2009-01-21 | 2023-04-25 | Streck Llc | Preservation of fetal nucleic acids in maternal plasma |
| WO2010087985A2 (en) | 2009-01-28 | 2010-08-05 | Yale University | Novel markers for detection of complications resulting from in utero encounters |
| US8450063B2 (en) | 2009-01-28 | 2013-05-28 | Fluidigm Corporation | Determination of copy number differences by amplification |
| EP3290530B1 (en) | 2009-02-18 | 2020-09-02 | Streck Inc. | Preservation of cell-free nucleic acids |
| EP3249053A1 (en) | 2009-03-27 | 2017-11-29 | Life Technologies Corporation | Methods, compositions, and kits for detecting allelic variants |
| WO2010115044A2 (en) | 2009-04-02 | 2010-10-07 | Fluidigm Corporation | Selective tagging of short nucleic acid fragments and selective protection of target sequences from degradation |
| EP2414547B1 (en) | 2009-04-02 | 2014-03-12 | Fluidigm Corporation | Multi-primer amplification method for barcoding of target nucleic acids |
| EP3211095B1 (en) | 2009-04-03 | 2019-01-02 | Sequenom, Inc. | Nucleic acid preparation compositions and methods |
| EP3327139A1 (en) | 2009-04-06 | 2018-05-30 | The Johns Hopkins University | Digital quantification of dna methylation |
| US20120115140A1 (en) | 2009-04-29 | 2012-05-10 | Js Genetics Inc. | Molecular Diagnosis of Fragile X Syndrome Associated with FMR1 Gene |
| US9085798B2 (en) | 2009-04-30 | 2015-07-21 | Prognosys Biosciences, Inc. | Nucleic acid constructs and methods of use |
| US8481699B2 (en) | 2009-07-14 | 2013-07-09 | Academia Sinica | Multiplex barcoded Paired-End ditag (mbPED) library construction for ultra high throughput sequencing |
| WO2011015944A2 (en) | 2009-08-06 | 2011-02-10 | Cedars-Sinai Medical Center | Use of free dna as an early predictor of severity in acute pancreatitis |
| US8563242B2 (en) | 2009-08-11 | 2013-10-22 | The Chinese University Of Hong Kong | Method for detecting chromosomal aneuploidy |
| CN101643904B (zh) | 2009-08-27 | 2011-04-27 | 北京北方微电子基地设备工艺研究中心有限责任公司 | 深硅刻蚀装置和深硅刻蚀设备的进气系统 |
| WO2011032078A1 (en) | 2009-09-11 | 2011-03-17 | Health Reseach Inc. | Detection of x4 strains of hiv-1 by heteroduplex tracking assay |
| EP2480683B1 (en) | 2009-09-22 | 2017-11-29 | Roche Diagnostics GmbH | Determination of kir haplotypes by amplification of exons |
| EP2480666B1 (en) | 2009-09-24 | 2017-03-08 | QIAGEN Gaithersburg, Inc. | Compositions, methods, and kits for isolating and analyzing nucleic acids using an anion exchange material |
| WO2011041485A1 (en) | 2009-09-30 | 2011-04-07 | Gene Security Network, Inc. | Methods for non-invasive prenatal ploidy calling |
| AU2010311535B2 (en) | 2009-10-26 | 2015-05-21 | Lifecodexx Ag | Means and methods for non-invasive diagnosis of chromosomal aneuploidy |
| HUE061110T2 (hu) | 2009-11-05 | 2023-05-28 | Univ Hong Kong Chinese | Magzati genomelemzés anyai biológiai mintából |
| JP2013509883A (ja) | 2009-11-06 | 2013-03-21 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 臓器移植患者における移植片拒絶反応の非侵襲的診断方法 |
| WO2011057184A1 (en) | 2009-11-09 | 2011-05-12 | Streck, Inc. | Stabilization of rna in and extracting from intact cells within a blood sample |
| WO2011066476A1 (en) | 2009-11-25 | 2011-06-03 | Quantalife, Inc. | Methods and compositions for detecting genetic material |
| KR101289535B1 (ko) | 2009-12-07 | 2013-07-24 | 전민용 | 원심분리관 |
| CN102802412A (zh) | 2009-12-08 | 2012-11-28 | 海玛奎斯特医药公司 | 用于治疗红细胞病症的方法及低剂量方案 |
| US9315857B2 (en) | 2009-12-15 | 2016-04-19 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse label-tags |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US8574842B2 (en) | 2009-12-22 | 2013-11-05 | The Board Of Trustees Of The Leland Stanford Junior University | Direct molecular diagnosis of fetal aneuploidy |
| EP2516680B1 (en) | 2009-12-22 | 2016-04-06 | Sequenom, Inc. | Processes and kits for identifying aneuploidy |
| EP2524056A4 (en) | 2010-01-15 | 2013-08-14 | Univ British Columbia | MULTIPLEX REINFORCEMENT FOR DETECTING NUCLEIC ACID VARIATIONS |
| US10662474B2 (en) | 2010-01-19 | 2020-05-26 | Verinata Health, Inc. | Identification of polymorphic sequences in mixtures of genomic DNA by whole genome sequencing |
| WO2011090556A1 (en) | 2010-01-19 | 2011-07-28 | Verinata Health, Inc. | Methods for determining fraction of fetal nucleic acid in maternal samples |
| US10388403B2 (en) | 2010-01-19 | 2019-08-20 | Verinata Health, Inc. | Analyzing copy number variation in the detection of cancer |
| US20120270739A1 (en) | 2010-01-19 | 2012-10-25 | Verinata Health, Inc. | Method for sample analysis of aneuploidies in maternal samples |
| US9323888B2 (en) | 2010-01-19 | 2016-04-26 | Verinata Health, Inc. | Detecting and classifying copy number variation |
| EP4074838A1 (en) | 2010-01-19 | 2022-10-19 | Verinata Health, Inc. | Novel protocol for preparing sequencing libraries |
| US20110312503A1 (en) | 2010-01-23 | 2011-12-22 | Artemis Health, Inc. | Methods of fetal abnormality detection |
| WO2011094646A1 (en) | 2010-01-28 | 2011-08-04 | Medical College Of Wisconsin, Inc. | Methods and compositions for high yield, specific amplification |
| US8574832B2 (en) | 2010-02-03 | 2013-11-05 | Massachusetts Institute Of Technology | Methods for preparing sequencing libraries |
| US8940487B2 (en) | 2010-02-09 | 2015-01-27 | UmiTaq Bio | Methods and compositions for universal detection of nucleic acids |
| ES2544288T3 (es) | 2010-02-26 | 2015-08-28 | Life Technologies Corporation | Fast PCR para la genotipificación de STR |
| CN103237901B (zh) | 2010-03-01 | 2016-08-03 | 卡里斯生命科学瑞士控股有限责任公司 | 用于治疗诊断的生物标志物 |
| US20130071844A1 (en) | 2010-03-24 | 2013-03-21 | Toppan Printing Co., Ltd. | Method for detecting target base sequence using competitive primer |
| PL2558854T3 (pl) | 2010-04-16 | 2019-04-30 | Chronix Biomedical | Biomarkery będące krążącymi kwasami nukleinowymi związanymi z rakiem piersi |
| WO2011140510A2 (en) | 2010-05-06 | 2011-11-10 | Bioo Scientific Corporation | Oligonucleotide ligation, barcoding and methods and compositions for improving data quality and throughput using massively parallel sequencing |
| CA2796822C (en) | 2010-05-07 | 2021-10-05 | The Board Of Trustees Of The Leland Standford Junior University | Measurement and comparison of immune diversity by high-throughput sequencing |
| WO2011143659A2 (en) | 2010-05-14 | 2011-11-17 | Fluidigm Corporation | Nucleic acid isolation methods |
| EP2569447A4 (en) | 2010-05-14 | 2013-11-27 | Fluidigm Corp | ASSAYS FOR THE DETECTION OF GENOTYPES, MUTATIONS OR ANEUPLOIDY |
| US11332793B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| CA3207599A1 (en) | 2010-05-18 | 2011-11-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20130196862A1 (en) | 2010-05-18 | 2013-08-01 | Natera, Inc. | Informatics Enhanced Analysis of Fetal Samples Subject to Maternal Contamination |
| US12152275B2 (en) | 2010-05-18 | 2024-11-26 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US12221653B2 (en) | 2010-05-18 | 2025-02-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11408031B2 (en) | 2010-05-18 | 2022-08-09 | Natera, Inc. | Methods for non-invasive prenatal paternity testing |
| US20140206552A1 (en) | 2010-05-18 | 2014-07-24 | Natera, Inc. | Methods for preimplantation genetic diagnosis by sequencing |
| US10316362B2 (en) | 2010-05-18 | 2019-06-11 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20130123120A1 (en) | 2010-05-18 | 2013-05-16 | Natera, Inc. | Highly Multiplex PCR Methods and Compositions |
| US20190309358A1 (en) | 2010-05-18 | 2019-10-10 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| WO2013052557A2 (en) | 2011-10-03 | 2013-04-11 | Natera, Inc. | Methods for preimplantation genetic diagnosis by sequencing |
| US20220356526A1 (en) | 2010-05-18 | 2022-11-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US20190010543A1 (en) | 2010-05-18 | 2019-01-10 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11322224B2 (en) | 2010-05-18 | 2022-05-03 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US9677118B2 (en) | 2014-04-21 | 2017-06-13 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11939634B2 (en) | 2010-05-18 | 2024-03-26 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US11339429B2 (en) | 2010-05-18 | 2022-05-24 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US20190284623A1 (en) | 2010-05-18 | 2019-09-19 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US11326208B2 (en) | 2010-05-18 | 2022-05-10 | Natera, Inc. | Methods for nested PCR amplification of cell-free DNA |
| US11332785B2 (en) | 2010-05-18 | 2022-05-17 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| WO2011146942A1 (en) | 2010-05-21 | 2011-11-24 | The Translational Genomics Research Institute | Methods and kits to analyze microrna by nucleic acid sequencing |
| ES2647612T3 (es) | 2010-06-04 | 2017-12-22 | Chronix Biomedical | Biomarcadores de ácidos nucleicos en circulación asociados al cáncer de próstata |
| US20110301854A1 (en) | 2010-06-08 | 2011-12-08 | Curry Bo U | Method of Determining Allele-Specific Copy Number of a SNP |
| US20120034603A1 (en) | 2010-08-06 | 2012-02-09 | Tandem Diagnostics, Inc. | Ligation-based detection of genetic variants |
| US20130040375A1 (en) | 2011-08-08 | 2013-02-14 | Tandem Diagnotics, Inc. | Assay systems for genetic analysis |
| US8700338B2 (en) | 2011-01-25 | 2014-04-15 | Ariosa Diagnosis, Inc. | Risk calculation for evaluation of fetal aneuploidy |
| US20120190557A1 (en) | 2011-01-25 | 2012-07-26 | Aria Diagnostics, Inc. | Risk calculation for evaluation of fetal aneuploidy |
| EP2426217A1 (en) | 2010-09-03 | 2012-03-07 | Centre National de la Recherche Scientifique (CNRS) | Analytical methods for cell free nucleic acids and applications |
| WO2012042374A2 (en) | 2010-10-01 | 2012-04-05 | Anssi Jussi Nikolai Taipale | Method of determining number or concentration of molecules |
| JP2012085556A (ja) | 2010-10-18 | 2012-05-10 | Shinya Watanabe | 乳がんの診断方法 |
| EP2633311A4 (en) | 2010-10-26 | 2014-05-07 | Univ Stanford | NONINVASIVE FETAL GENETIC SCREENING THROUGH SEQUENCING ANALYSIS |
| DK2633071T3 (en) | 2010-10-27 | 2017-01-30 | Harvard College | COMPOSITIONS OF "MAINTENANCE" PRIMER DUPLEXES AND METHODS OF USE |
| US9163329B2 (en) | 2010-11-12 | 2015-10-20 | Agilent Technologies, Inc. | RNA labeling method |
| SG190344A1 (en) | 2010-11-30 | 2013-06-28 | Univ Hong Kong Chinese | Detection of genetic or molecular aberrations associated with cancer |
| WO2012078792A2 (en) | 2010-12-07 | 2012-06-14 | Stanford University | Non-invasive determination of fetal inheritance of parental haplotypes at the genome-wide scale |
| US20150064695A1 (en) | 2010-12-17 | 2015-03-05 | Celula Inc. | Methods for screening and diagnosing genetic conditions |
| CN110079588B (zh) | 2010-12-17 | 2024-03-15 | 生命技术公司 | 用于核酸扩增的方法、组合物、系统、仪器和试剂盒 |
| BR112013016193B1 (pt) | 2010-12-22 | 2019-10-22 | Natera Inc | método ex vivo para determinar se um suposto pai é o pai biológico de um feto que está em gestação em uma gestante e relatório |
| KR20190002733A (ko) | 2010-12-30 | 2019-01-08 | 파운데이션 메디신 인코포레이티드 | 종양 샘플의 다유전자 분석의 최적화 |
| WO2012103031A2 (en) | 2011-01-25 | 2012-08-02 | Ariosa Diagnostics, Inc. | Detection of genetic abnormalities |
| US10131947B2 (en) | 2011-01-25 | 2018-11-20 | Ariosa Diagnostics, Inc. | Noninvasive detection of fetal aneuploidy in egg donor pregnancies |
| BR112013020220B1 (pt) | 2011-02-09 | 2020-03-17 | Natera, Inc. | Método para determinar o estado de ploidia de um cromossomo em um feto em gestação |
| EP3760732A1 (en) | 2011-02-09 | 2021-01-06 | Natera, Inc. | Methods for non-invasive prenatal ploidy calling |
| US9290815B2 (en) | 2011-02-21 | 2016-03-22 | Qiagen Gmbh | Method for quantifying human DNA |
| GB2488358A (en) | 2011-02-25 | 2012-08-29 | Univ Plymouth | Enrichment of foetal DNA in maternal plasma |
| US20140199781A1 (en) | 2011-03-08 | 2014-07-17 | Beth Israel Deaconess Medical Center, Inc. | Non-invasive methods for diagnosing chronic organ transplant rejection |
| US9260753B2 (en) | 2011-03-24 | 2016-02-16 | President And Fellows Of Harvard College | Single cell nucleic acid detection and analysis |
| LT3567124T (lt) | 2011-04-12 | 2022-04-11 | Verinata Health, Inc. | Genominių frakcijų paskirstymas, naudojant polimorfizmo skaičiavimo rezultatus |
| JP2014516514A (ja) | 2011-04-14 | 2014-07-17 | コンプリート・ジェノミックス・インコーポレイテッド | 複合核酸配列データの処理および解析 |
| WO2014014498A1 (en) | 2012-07-20 | 2014-01-23 | Verinata Health, Inc. | Detecting and classifying copy number variation in a fetal genome |
| US9411937B2 (en) | 2011-04-15 | 2016-08-09 | Verinata Health, Inc. | Detecting and classifying copy number variation |
| DK3246416T3 (da) | 2011-04-15 | 2024-09-02 | Univ Johns Hopkins | Sikkert sekventeringssystem |
| EP3072977B1 (en) | 2011-04-28 | 2018-09-19 | Life Technologies Corporation | Methods and compositions for multiplex pcr |
| US8460872B2 (en) | 2011-04-29 | 2013-06-11 | Sequenom, Inc. | Quantification of a minority nucleic acid species |
| EP2546361B1 (en) | 2011-07-11 | 2015-06-03 | Samsung Electronics Co., Ltd. | Method of amplifying target nucleic acid with reduced amplification bias and method for determining relative amount of target nucleic acid in sample |
| US20130024127A1 (en) | 2011-07-19 | 2013-01-24 | John Stuelpnagel | Determination of source contributions using binomial probability calculations |
| GB201115095D0 (en) | 2011-09-01 | 2011-10-19 | Singapore Volition Pte Ltd | Method for detecting nucleosomes containing nucleotides |
| US8712697B2 (en) | 2011-09-07 | 2014-04-29 | Ariosa Diagnostics, Inc. | Determination of copy number variations using binomial probability calculations |
| US9249460B2 (en) | 2011-09-09 | 2016-02-02 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for obtaining a sequence |
| JP5536729B2 (ja) | 2011-09-20 | 2014-07-02 | 株式会社ソニー・コンピュータエンタテインメント | 情報処理装置、アプリケーション提供システム、アプリケーション提供サーバ、アプリケーション提供方法、および情報処理方法 |
| ES2693672T3 (es) | 2011-09-26 | 2018-12-13 | Qiagen Gmbh | Método rápido para aislar ácidos nucleicos extracelulares |
| CA2850785C (en) | 2011-10-06 | 2022-12-13 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9367663B2 (en) | 2011-10-06 | 2016-06-14 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9984198B2 (en) | 2011-10-06 | 2018-05-29 | Sequenom, Inc. | Reducing sequence read count error in assessment of complex genetic variations |
| EP2764124B1 (en) | 2011-10-07 | 2017-08-02 | Murdoch Childrens Research Institute | Diagnostic assay for tissue transplantation status |
| WO2013078470A2 (en) | 2011-11-22 | 2013-05-30 | MOTIF, Active | Multiplex isolation of protein-associated nucleic acids |
| US10214775B2 (en) | 2011-12-07 | 2019-02-26 | Chronix Biomedical | Prostate cancer associated circulating nucleic acid biomarkers |
| WO2013086464A1 (en) | 2011-12-07 | 2013-06-13 | The Broad Institute, Inc. | Markers associated with chronic lymphocytic leukemia prognosis and progression |
| UA115321C2 (uk) | 2011-12-16 | 2017-10-25 | Басф Агрокемікал Продактс Б.В. | Спосіб та комплект для аналізу ahasl генів у рослин |
| US20130190653A1 (en) | 2012-01-25 | 2013-07-25 | Angel Gabriel Alvarez Ramos | Device for blood collection from the placenta and the umbilical cord |
| SG11201404899VA (en) | 2012-02-14 | 2014-10-30 | Univ Cornell | Method for relative quantification of nucleic acid sequence, expression, or copy changes, using combined nuclease, ligation, and polymerase reactions |
| WO2013128281A1 (en) | 2012-02-28 | 2013-09-06 | Population Genetics Technologies Ltd | Method for attaching a counter sequence to a nucleic acid sample |
| WO2013130848A1 (en) | 2012-02-29 | 2013-09-06 | Natera, Inc. | Informatics enhanced analysis of fetal samples subject to maternal contamination |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| WO2013138510A1 (en) | 2012-03-13 | 2013-09-19 | Patel Abhijit Ajit | Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing |
| WO2013159035A2 (en) | 2012-04-19 | 2013-10-24 | Medical College Of Wisconsin, Inc. | Highly sensitive surveillance using detection of cell free dna |
| EP2653562A1 (en) | 2012-04-20 | 2013-10-23 | Institut Pasteur | Anellovirus genome quantification as a biomarker of immune suppression |
| JP6445426B2 (ja) | 2012-05-10 | 2018-12-26 | ザ ジェネラル ホスピタル コーポレイション | ヌクレオチド配列を決定する方法 |
| US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
| WO2013177220A1 (en) | 2012-05-21 | 2013-11-28 | The Scripps Research Institute | Methods of sample preparation |
| US10077474B2 (en) | 2012-05-29 | 2018-09-18 | Abbott Molecular, Inc. | Method of designing primers, method of detecting single nucleotide polymorphisms (SNPs), method of distinguishing SNPs, and related primers, detectable oligonucleotides, and kits |
| CN104350152B (zh) | 2012-06-01 | 2017-08-11 | 欧米伽生物技术公司 | 选择性核酸片段回收 |
| US11261494B2 (en) | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| WO2014004726A1 (en) | 2012-06-26 | 2014-01-03 | Caifu Chen | Methods, compositions and kits for the diagnosis, prognosis and monitoring of cancer |
| US20150011396A1 (en) | 2012-07-09 | 2015-01-08 | Benjamin G. Schroeder | Methods for creating directional bisulfite-converted nucleic acid libraries for next generation sequencing |
| KR101890466B1 (ko) * | 2012-07-24 | 2018-08-21 | 내테라, 인코포레이티드 | 고도의 다중 ｐｃｒ 방법 및 조성물 |
| NZ704039A (en) | 2012-08-03 | 2018-04-27 | Ferring Bv | Cell-free dna as a therapeutic target for female infertility and diagnostic marker |
| US10993418B2 (en) | 2012-08-13 | 2021-05-04 | Life Genetics Lab, Llc | Method for measuring tumor burden in patient derived xenograft (PDX) mice |
| US20140051585A1 (en) | 2012-08-15 | 2014-02-20 | Natera, Inc. | Methods and compositions for reducing genetic library contamination |
| JP2015528443A (ja) | 2012-08-15 | 2015-09-28 | ユニヴェルシテ・ドゥ・モントリオール | 新規マイナー組織適合抗原を同定するための方法 |
| US20140100126A1 (en) | 2012-08-17 | 2014-04-10 | Natera, Inc. | Method for Non-Invasive Prenatal Testing Using Parental Mosaicism Data |
| CA2883463A1 (en) | 2012-08-28 | 2014-03-06 | Akonni Biosystems Inc. | Method and kit for purifying nucleic acids |
| US20140066317A1 (en) | 2012-09-04 | 2014-03-06 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US20140065621A1 (en) | 2012-09-04 | 2014-03-06 | Natera, Inc. | Methods for increasing fetal fraction in maternal blood |
| WO2014149134A2 (en) | 2013-03-15 | 2014-09-25 | Guardant Health Inc. | Systems and methods to detect rare mutations and copy number variation |
| KR102393608B1 (ko) | 2012-09-04 | 2022-05-03 | 가던트 헬쓰, 인크. | 희귀 돌연변이 및 카피수 변이를 검출하기 위한 시스템 및 방법 |
| US10876152B2 (en) | 2012-09-04 | 2020-12-29 | Guardant Health, Inc. | Systems and methods to detect rare mutations and copy number variation |
| US20220411875A1 (en) | 2012-10-03 | 2022-12-29 | Natera, Inc. | Methods for simultaneous amplification of target loci |
| US9669405B2 (en) | 2012-10-22 | 2017-06-06 | The Regents Of The University Of California | Sterilizable photopolymer serum separator |
| EP3026124A1 (en) | 2012-10-31 | 2016-06-01 | Genesupport SA | Non-invasive method for detecting a fetal chromosomal aneuploidy |
| JP2014118334A (ja) | 2012-12-18 | 2014-06-30 | Sumitomo Electric Ind Ltd | 光ファイバ製造方法 |
| AU2014205110A1 (en) | 2013-01-13 | 2015-08-27 | Unitaq Bio | Methods and compositions for PCR using blocked and universal primers |
| EP2954054B1 (en) | 2013-02-08 | 2018-12-05 | Qiagen GmbH | Method for separating dna by size |
| US9982255B2 (en) | 2013-03-11 | 2018-05-29 | Kailos Genetics, Inc. | Capture methodologies for circulating cell free DNA |
| US10385394B2 (en) | 2013-03-15 | 2019-08-20 | The Translational Genomics Research Institute | Processes of identifying and characterizing X-linked disorders |
| WO2014143989A1 (en) | 2013-03-15 | 2014-09-18 | Medical College Of Wisconsin, Inc. | Fetal well being surveillance using fetal specific cell free dna |
| GB201304810D0 (en) | 2013-03-15 | 2013-05-01 | Isis Innovation | Assay |
| EP3409791B1 (en) | 2013-03-15 | 2021-06-30 | Verinata Health, Inc. | Generating cell-free dna libraries directly from blood |
| EP4253558B1 (en) * | 2013-03-15 | 2025-07-02 | The Board of Trustees of the Leland Stanford Junior University | Identification and use of circulating nucleic acid tumor markers |
| WO2014150300A2 (en) | 2013-03-15 | 2014-09-25 | Abbott Molecular Inc. | Method for amplification and assay of rna fusion gene variants, method of distinguishing same and related primers, probes, and kits |
| KR20160004265A (ko) | 2013-03-15 | 2016-01-12 | 이뮤코 쥐티아이 다이아그노스틱스, 아이엔씨. | 무세포 dna를 이용하는 신장 상태의 평가를 위한 방법 및 조성물 |
| US10072298B2 (en) | 2013-04-17 | 2018-09-11 | Life Technologies Corporation | Gene fusions and gene variants associated with cancer |
| SI3004388T2 (sl) | 2013-05-29 | 2023-11-30 | Chronix Biomedical | Odkrivanje in kvantifikacija donorjeve brezcelične DNK v cirkulaciji prejemnikov presajenih organov |
| WO2015006668A1 (en) * | 2013-07-12 | 2015-01-15 | The University Of North Carolina At Chapel Hill | Methods for identification of individuals |
| EP3968023B1 (en) | 2013-08-19 | 2025-10-08 | Invitae Corporation | Assays for single molecule detection and use thereof |
| US20160376652A1 (en) | 2013-09-06 | 2016-12-29 | Immucor Gti Diagnostics, Inc. | Compositions and methods for diagnosis and prediction of solid organ graft rejection |
| WO2015048535A1 (en) | 2013-09-27 | 2015-04-02 | Natera, Inc. | Prenatal diagnostic resting standards |
| US11694764B2 (en) | 2013-09-27 | 2023-07-04 | University Of Washington | Method for large scale scaffolding of genome assemblies |
| US10577655B2 (en) | 2013-09-27 | 2020-03-03 | Natera, Inc. | Cell free DNA diagnostic testing standards |
| WO2015069933A1 (en) | 2013-11-06 | 2015-05-14 | The Board Of Trustees Of The Leland Stanford Junior University | Circulating cell-free dna for diagnosis of transplant rejection |
| KR20240038168A (ko) | 2013-11-07 | 2024-03-22 | 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 | 인간 마이크로바이옴 및 그의 성분의 분석을 위한 무세포 핵산 |
| US10927408B2 (en) | 2013-12-02 | 2021-02-23 | Personal Genome Diagnostics, Inc. | Method for evaluating minority variants in a sample |
| EP3378952B1 (en) | 2013-12-28 | 2020-02-05 | Guardant Health, Inc. | Methods and systems for detecting genetic variants |
| ES2912183T3 (es) | 2013-12-30 | 2022-05-24 | Atreca Inc | Análisis de ácidos nucleicos asociados a células individuales utilizando códigos de barras de ácidos nucleicos |
| CA2938080A1 (en) | 2014-01-27 | 2015-07-30 | The General Hospital Corporation | Methods of preparing nucleic acids for sequencing |
| JP6494045B2 (ja) | 2014-02-11 | 2019-04-03 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | 標的シーケンシングおよびｕｉｄフィルタリング |
| WO2015178978A2 (en) | 2014-02-14 | 2015-11-26 | The Board Of Regents Of The University Of Texas System | Strand exchange hairpin primers that give high allelic discrimination |
| EP3114231B1 (en) * | 2014-03-03 | 2019-01-02 | Swift Biosciences, Inc. | Enhanced adaptor ligation |
| HUE043288T2 (hu) | 2014-03-14 | 2019-08-28 | Caredx Inc | Eljárások immunszuppresszív terápiák monitorozására transzplantátum recipiensben |
| EP3825421B1 (en) | 2014-03-25 | 2022-06-22 | Quest Diagnostics Investments Incorporated | Detection of gene fusions by intragenic differential expression (ide) using average cycle thresholds |
| EP3134541B1 (en) | 2014-04-21 | 2020-08-19 | Natera, Inc. | Detecting copy number variations (cnv) of chromosomal segments in cancer |
| EP3521454A1 (en) | 2014-05-09 | 2019-08-07 | LifeCodexx AG | Detection of dna that originates from a specific cell-type and related methods |
| US20180173846A1 (en) | 2014-06-05 | 2018-06-21 | Natera, Inc. | Systems and Methods for Detection of Aneuploidy |
| EP3161149B1 (en) | 2014-06-27 | 2020-06-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods employing circulating dna and mirna as biomarkers for female infertility |
| US10435750B2 (en) | 2014-07-03 | 2019-10-08 | Multiplicom N.V. | Methods for non-invasive detection of transplant health or rejection |
| US10619163B2 (en) | 2014-07-03 | 2020-04-14 | Rhodx, Inc. | Tagging and assessing a target sequence |
| AU2015289027B2 (en) | 2014-07-17 | 2021-08-19 | Qiagen Gmbh | Method for isolating RNA with high yield |
| US10119167B2 (en) | 2014-07-18 | 2018-11-06 | Illumina, Inc. | Non-invasive prenatal diagnosis of fetal genetic condition using cellular DNA and cell free DNA |
| DK3194612T3 (da) | 2014-08-22 | 2024-10-14 | Resolution Bioscience Inc | Fremgangsmåder til kvantitativ genetisk analyse af cellefrit dna |
| DK3204520T3 (da) | 2014-10-08 | 2020-04-20 | Univ Cornell | Fremgangsmåde til identificering og kvantificering af nukleinsyreekspression, splejsningsvariant, translokation, kopiantal eller methyleringsændringer |
| ES2708030T3 (es) | 2014-10-20 | 2019-04-08 | Inst Nat Sante Rech Med | Métodos para explorar a un individuo en busca de un cáncer |
| US9783799B2 (en) | 2014-10-24 | 2017-10-10 | Abbott Molecular Inc. | Enrichment of small nucleic acids |
| CN107002130B (zh) | 2014-11-11 | 2022-02-01 | 深圳华大基因研究院 | 多程测序 |
| WO2016085876A1 (en) | 2014-11-25 | 2016-06-02 | The Broad Institute Inc. | Clonal haematopoiesis |
| WO2016089920A1 (en) | 2014-12-01 | 2016-06-09 | The Broad Institute, Inc. | Method for in situ determination of nucleic acid proximity |
| WO2016109604A2 (en) | 2014-12-29 | 2016-07-07 | InnoGenomics Technologies, LLC | Multiplexed assay for quantitating and assessing integrity of cell-free dna in biological fluids for cancer diagnosis, prognosis, and surveillance |
| GB201501907D0 (en) | 2015-02-05 | 2015-03-25 | Technion Res & Dev Foundation | System and method for single cell genetic analysis |
| WO2016123698A1 (en) | 2015-02-06 | 2016-08-11 | Uti Limited Partnership | Diagnostic assay for post-transplant assessment of potential rejection of donor organs |
| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| WO2016138080A1 (en) | 2015-02-24 | 2016-09-01 | Trustees Of Boston University | Protection of barcodes during dna amplification using molecular hairpins |
| EP3262189B1 (en) | 2015-02-27 | 2021-12-08 | Becton, Dickinson and Company | Methods for barcoding nucleic acids for sequencing |
| WO2016160844A2 (en) | 2015-03-30 | 2016-10-06 | Cellular Research, Inc. | Methods and compositions for combinatorial barcoding |
| KR101850437B1 (ko) | 2015-04-14 | 2018-04-20 | 이원다이애그노믹스(주) | 차세대 염기서열 분석기법을 이용한 장기 이식 거부 반응 예측 방법 |
| WO2016172373A1 (en) | 2015-04-23 | 2016-10-27 | Cellular Research, Inc. | Methods and compositions for whole transcriptome amplification |
| US10844428B2 (en) | 2015-04-28 | 2020-11-24 | Illumina, Inc. | Error suppression in sequenced DNA fragments using redundant reads with unique molecular indices (UMIS) |
| HK1252152A1 (zh) | 2015-04-30 | 2019-05-17 | Medical College Of Wisconsin, Inc. | 用於評估無細胞dna的多重優化錯配擴增(moma)實時pcr |
| US11479812B2 (en) | 2015-05-11 | 2022-10-25 | Natera, Inc. | Methods and compositions for determining ploidy |
| ES2961818T3 (es) | 2015-06-01 | 2024-03-14 | Gea Food Solutions Weert Bv | Método para recubrir una piruleta |
| WO2016193490A1 (en) | 2015-06-05 | 2016-12-08 | Qiagen Gmbh | Method for separating dna by size |
| US20160371428A1 (en) | 2015-06-19 | 2016-12-22 | Natera, Inc. | Systems and methods for determining aneuploidy risk using sample fetal fraction |
| EP3317420B1 (en) | 2015-07-02 | 2021-10-20 | Arima Genomics, Inc. | Accurate molecular deconvolution of mixtures samples |
| CN108291330A (zh) | 2015-07-10 | 2018-07-17 | 西弗吉尼亚大学 | 卒中和卒中严重性的标志物 |
| CN108027827B (zh) | 2015-07-16 | 2022-06-10 | 彭冯有限公司 | 基于图像分析的协调通信和/或存储 |
| GB201516047D0 (en) | 2015-09-10 | 2015-10-28 | Cancer Rec Tech Ltd | Method |
| CN106544407B (zh) | 2015-09-18 | 2019-11-08 | 广州华大基因医学检验所有限公司 | 确定受体cfDNA样本中供体来源cfDNA比例的方法 |
| EP3356559A4 (en) | 2015-09-29 | 2019-03-06 | Ludwig Institute for Cancer Research Ltd | TYPING AND COMPOSITION OF DISCONTINUOUS GENOMIC ELEMENTS |
| EP3365445B1 (en) | 2015-10-19 | 2023-05-31 | Dovetail Genomics, LLC | Methods for genome assembly, haplotype phasing, and target independent nucleic acid detection |
| CA3001698C (en) | 2015-10-22 | 2025-01-07 | Cytosorbents Corp | Sorbant in the form of porous, blood-compatible polymer beads, multifunctional for the elimination of protein-based toxins and potassium from biological fluids |
| KR20180097536A (ko) | 2015-11-04 | 2018-08-31 | 아트레카, 인크. | 단일 세포와 연관된 핵산의 분석을 위한 핵산 바코드의 조합 세트 |
| CA3005101A1 (en) | 2015-11-16 | 2017-05-26 | Progenity, Inc. | Nucleic acids and methods for detecting methylation status |
| US20170145475A1 (en) | 2015-11-20 | 2017-05-25 | Streck, Inc. | Single spin process for blood plasma separation and plasma composition including preservative |
| CA3007426A1 (en) | 2015-12-03 | 2017-06-08 | Alfred Health | Monitoring treatment or progression of myeloma |
| CN105986030A (zh) | 2016-02-03 | 2016-10-05 | 广州市基准医疗有限责任公司 | 甲基化dna检测方法 |
| US10597717B2 (en) | 2016-03-22 | 2020-03-24 | Myriad Women's Health, Inc. | Combinatorial DNA screening |
| US10781439B2 (en) | 2016-03-30 | 2020-09-22 | Covaris, Inc. | Extraction of cfDNA from biological samples |
| WO2017165982A1 (en) | 2016-04-01 | 2017-10-05 | Uti Limited Partnership | Plasma derived cell-free mitochondrial deoxyribonucleic acid |
| WO2017176852A1 (en) | 2016-04-07 | 2017-10-12 | Rutgers, The State University Of New Jersey | Multiplex nucleic acid assay methods capable of detecting closely related alleles, and reagents therefor |
| EP4488686A3 (en) | 2016-04-14 | 2025-04-30 | Guardant Health, Inc. | Methods for early detection of cancer |
| RU2760913C2 (ru) | 2016-04-15 | 2021-12-01 | Натера, Инк. | Способы выявления рака легкого |
| AU2017258799A1 (en) | 2016-04-29 | 2018-12-20 | The Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-real time pcr for assessing cancer |
| AU2017258800A1 (en) | 2016-04-29 | 2018-12-20 | The Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (MOMA)-real time PCR for assessing fetal well being |
| EA201892489A1 (ru) | 2016-04-29 | 2019-05-31 | Дзе Медикал Колледж Оф Висконсин, Инк. | Число мишеней для мультиплексной оптимизированной амплификации с несоответствиями (moma) |
| US12043856B2 (en) | 2016-05-24 | 2024-07-23 | The Translational Genomics Research Institute | Molecular tagging methods and sequencing libraries |
| EP4043581A1 (en) | 2016-05-27 | 2022-08-17 | Sequenom, Inc. | Method for generating a paralog assay system |
| CA3025956A1 (en) | 2016-07-01 | 2018-01-04 | Natera, Inc. | Compositions and methods for detection of nucleic acid mutations |
| JP7448310B2 (ja) | 2016-07-06 | 2024-03-12 | ガーダント ヘルス， インコーポレイテッド | セルフリー核酸のフラグメントームプロファイリングのための方法 |
| JP7109424B2 (ja) | 2016-08-17 | 2022-07-29 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 体液に基づくセルフリーＤＮＡ（ｃｆＤＮＡ）アッセイを通して臓器損傷状態を査定するための新規のイムノプローブに基づく方法 |
| WO2018067517A1 (en) | 2016-10-04 | 2018-04-12 | Natera, Inc. | Methods for characterizing copy number variation using proximity-litigation sequencing |
| IL265769B2 (en) | 2016-10-19 | 2023-12-01 | Univ Hong Kong Chinese | Estimation of gestational age using methylation and size profile of maternal plasma DNA |
| GB201618485D0 (en) | 2016-11-02 | 2016-12-14 | Ucl Business Plc | Method of detecting tumour recurrence |
| EP4488383A3 (en) | 2016-11-02 | 2025-04-09 | The Medical College of Wisconsin, Inc. | Methods for assessing risk using total and specific cell-free dna |
| CA3042722A1 (en) | 2016-11-02 | 2018-05-11 | The Medical College Of Wisconsin, Inc. | Methods for assessing risk using mismatch amplification and statistical methods |
| CN109906274B (zh) | 2016-11-08 | 2023-08-25 | 贝克顿迪金森公司 | 用于细胞标记分类的方法 |
| US10011870B2 (en) | 2016-12-07 | 2018-07-03 | Natera, Inc. | Compositions and methods for identifying nucleic acid molecules |
| WO2018119422A1 (en) | 2016-12-22 | 2018-06-28 | Duke University | Polycationic microfibers and methods of using the same |
| WO2018136562A2 (en) | 2017-01-17 | 2018-07-26 | Life Technologies Corporation | Compositions and methods for immune repertoire sequencing |
| CA3049139A1 (en) | 2017-02-21 | 2018-08-30 | Natera, Inc. | Compositions, methods, and kits for isolating nucleic acids |
| CN111094593A (zh) | 2017-06-20 | 2020-05-01 | 威斯康星州立大学医学院 | 使用供体特异性无细胞dna来评估移植对象中的病症 |
| CA3067637A1 (en) | 2017-06-20 | 2018-12-27 | The Medical College Of Wisconsin, Inc. | Assessing transplant complication risk with total cell-free dna |
| CA3067635A1 (en) | 2017-06-20 | 2018-12-27 | The Medical College Of Wisconsin, Inc. | Transplant patient monitoring with cell-free dna |
| WO2019008408A1 (en) | 2017-07-07 | 2019-01-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | METHODS FOR DETERMINING WHETHER A PATIENT SUFFERING FROM MYELOPROLIFERATIVE NEOPLASM IS AT RISK OF THROMBOSIS |
| WO2019006561A1 (en) | 2017-07-07 | 2019-01-10 | Mcmaster University | RISK ASSESSMENT TOOL FOR PATIENTS WITH SEPSIS |
| CN107365769B (zh) | 2017-07-25 | 2021-05-04 | 深圳华大智造科技股份有限公司 | 一种鼓泡状引物及其组成的试剂盒和应用 |
| CN111868260B (zh) | 2017-08-07 | 2025-02-21 | 约翰斯霍普金斯大学 | 用于评估和治疗癌症的方法和材料 |
| US20210032692A1 (en) | 2017-08-17 | 2021-02-04 | Tai Diagnostics, Inc. | Methods of determining donor cell-free dna without donor genotype |
| WO2019046817A1 (en) | 2017-09-01 | 2019-03-07 | Life Technologies Corporation | COMPOSITIONS AND METHODS FOR IMMUNOLOGICAL REPERTOIRE SEQUENCING |
| AU2018332326B2 (en) | 2017-09-18 | 2025-04-03 | Santersus Ag | Method and device for purification of blood from circulating cell free DNA |
| US11091800B2 (en) | 2017-09-20 | 2021-08-17 | University Of Utah Research Foundation | Size-selection of cell-free DNA for increasing family size during next-generation sequencing |
| WO2019109053A1 (en) | 2017-12-01 | 2019-06-06 | Juno Therapeutics, Inc. | Methods for dosing and for modulation of genetically engineered cells |
| US12084720B2 (en) | 2017-12-14 | 2024-09-10 | Natera, Inc. | Assessing graft suitability for transplantation |
| AU2018383191B2 (en) | 2017-12-15 | 2023-02-16 | Acrannolife Genomics Pvt. Ltd. | A non-invasive method for monitoring transplanted organ status in organ-transplant recipients |
| JP7322063B2 (ja) | 2018-01-12 | 2023-08-07 | ナテラ， インコーポレイテッド | 新規なプライマーおよびその使用 |
| WO2019161244A1 (en) | 2018-02-15 | 2019-08-22 | Natera, Inc. | Methods for isolating nucleic acids with size selection |
| GB201819134D0 (en) | 2018-11-23 | 2019-01-09 | Cancer Research Tech Ltd | Improvements in variant detection |
| US12024738B2 (en) | 2018-04-14 | 2024-07-02 | Natera, Inc. | Methods for cancer detection and monitoring |
| WO2019217918A1 (en) | 2018-05-10 | 2019-11-14 | The Medical College Of Wisconsin, Inc. | Multiplexed optimized mismatch amplification (moma)-cancer risk assessment with non-cancer associated targets |
| US20210257048A1 (en) | 2018-06-12 | 2021-08-19 | Natera, Inc. | Methods and systems for calling mutations |
| US12234509B2 (en) | 2018-07-03 | 2025-02-25 | Natera, Inc. | Methods for detection of donor-derived cell-free DNA |
| US20230287497A1 (en) | 2018-07-03 | 2023-09-14 | Natera, Inc. | Methods for detection of donor-derived cell-free dna |
| WO2020018522A1 (en) | 2018-07-17 | 2020-01-23 | Natera, Inc. | Methods and systems for calling ploidy states using a neural network |
| CN120193081A (zh) | 2018-07-23 | 2025-06-24 | 夸登特健康公司 | 用于通过肿瘤分数和覆盖率调整肿瘤突变负荷的方法和系统 |
| WO2020041449A1 (en) | 2018-08-21 | 2020-02-27 | Zymo Research Corporation | Methods and compositions for tracking sample quality |
| US20200109449A1 (en) | 2018-10-09 | 2020-04-09 | Tai Diagnostics, Inc. | Cell lysis assay for cell-free dna analysis |
| WO2020106987A1 (en) | 2018-11-21 | 2020-05-28 | Karius, Inc. | Detection and prediction of infectious disease |
| CA3123847A1 (en) | 2018-12-17 | 2020-06-25 | Natera, Inc. | Methods for analysis of circulating cells |
| WO2020131955A1 (en) | 2018-12-17 | 2020-06-25 | The Medical College Of Wisconsin, Inc. | Assessing risk with total cell-free dna |
| WO2020206290A1 (en) | 2019-04-03 | 2020-10-08 | The Medical College Of Wisconsin, Inc. | Methods for assessing risk using total cell-free dna |
| WO2020206292A2 (en) | 2019-04-03 | 2020-10-08 | The Medical College Of Wisconsin, Inc. | Assessing conditions in transplant subjects using donor-specific cell-free dna |
| WO2020206269A1 (en) | 2019-04-03 | 2020-10-08 | The Medical College Of Wisconsin, Inc. | Transplant patient monitoring with cell-free dna |
| US11931674B2 (en) | 2019-04-04 | 2024-03-19 | Natera, Inc. | Materials and methods for processing blood samples |
| EP3956466A1 (en) | 2019-04-15 | 2022-02-23 | Natera, Inc. | Improved liquid biopsy using size selection |
| WO2020247263A1 (en) | 2019-06-06 | 2020-12-10 | Natera, Inc. | Methods for detecting immune cell dna and monitoring immune system |
| WO2021055968A1 (en) | 2019-09-20 | 2021-03-25 | Natera Inc. | Methods for assessing graft suitability for transplantation |
| WO2021243045A1 (en) | 2020-05-29 | 2021-12-02 | Natera, Inc. | Methods for detection of donor-derived cell-free dna |
| US20230257816A1 (en) | 2020-07-13 | 2023-08-17 | Aoy Tomita Mitchell | Methods for making treatment management decisions in transplant subjects and assessing transplant risks with threshold values |
| AU2022226186A1 (en) | 2021-02-25 | 2023-09-07 | Natera, Inc. | Methods for detection of donor-derived cell-free dna in transplant recipients of multiple organs |
| US20240309472A1 (en) | 2021-03-18 | 2024-09-19 | Natera, Inc. | Methods for determination of transplant rejection |
| AU2022261868A1 (en) | 2021-04-22 | 2023-10-26 | Natera, Inc. | Methods for determining velocity of tumor growth |
| US20240336973A1 (en) | 2021-08-02 | 2024-10-10 | Natera, Inc. | Methods for detecting neoplasm in pregnant women |
| AU2022339791A1 (en) | 2021-09-01 | 2024-03-14 | Natera, Inc. | Methods for non-invasive prenatal testing |
| CN119032182A (zh) | 2022-01-04 | 2024-11-26 | 纳特拉公司 | 用于癌症检测和监测的方法 |
| WO2023192224A1 (en) | 2022-03-28 | 2023-10-05 | Natera, Inc. | Predictive machine learning models for preeclampsia using artificial neural networks |
-
2017
- 2017-04-17 RU RU2018138508A patent/RU2760913C2/ru active
- 2017-04-17 CN CN201780022721.4A patent/CN109477138A/zh active Pending
- 2017-04-17 WO PCT/US2017/028013 patent/WO2017181202A2/en not_active Ceased
- 2017-04-17 AU AU2017249594A patent/AU2017249594B2/en active Active
- 2017-04-17 EP EP17733137.8A patent/EP3443119B8/en active Active
- 2017-04-17 JP JP2018553958A patent/JP7280044B2/ja active Active
- 2017-04-17 US US16/092,436 patent/US12146195B2/en active Active
- 2017-04-17 DK DK17733137.8T patent/DK3443119T3/da active
- 2017-04-17 CA CA3016360A patent/CA3016360A1/en active Pending
- 2017-04-17 ES ES17733137T patent/ES2913468T3/es active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015164432A1 (en) | 2014-04-21 | 2015-10-29 | Natera, Inc. | Detecting mutations and ploidy in chromosomal segments |
| WO2016009224A1 (en) | 2014-07-18 | 2016-01-21 | Cancer Research Technology Limited | A method for detecting a genetic variant |
Non-Patent Citations (2)
| Title |
|---|
| Ann. Oncol.，2016年，Vol. 27, No. 5，pp. 862-867 |
| Cancer Res.，2012年，Vol. 72, No. 14，p. 3492-3498 |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2018138508A3 (enExample) | 2021-02-15 |
| AU2017249594A1 (en) | 2018-09-20 |
| ES2913468T3 (es) | 2022-06-02 |
| DK3443119T3 (da) | 2022-05-23 |
| US20190106751A1 (en) | 2019-04-11 |
| RU2760913C2 (ru) | 2021-12-01 |
| EP3443119B1 (en) | 2022-02-23 |
| WO2017181202A3 (en) | 2018-01-04 |
| BR112018070903A2 (pt) | 2019-01-29 |
| CA3016360A1 (en) | 2017-10-19 |
| AU2017249594B2 (en) | 2023-08-24 |
| RU2018138508A (ru) | 2020-05-15 |
| EP3443119B8 (en) | 2022-04-06 |
| EP3443119A2 (en) | 2019-02-20 |
| CN109477138A (zh) | 2019-03-15 |
| US12146195B2 (en) | 2024-11-19 |
| WO2017181202A2 (en) | 2017-10-19 |
| JP2019517781A (ja) | 2019-06-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7280044B2 (ja) | 肺癌の検出方法 | |
| Chan et al. | Clinical significance of clonal hematopoiesis in the interpretation of blood liquid biopsy | |
| US20210363597A1 (en) | Identification and use of circulating nucleic acids | |
| AU2024202146A1 (en) | Methods of identifying somatic mutational signatures for early cancer detection | |
| US20140296081A1 (en) | Identification and use of circulating tumor markers | |
| JP2019526230A (ja) | 核酸突然変異検出のための組成物及び方法 | |
| JP7763764B2 (ja) | 標的バリアントがクローンレベルで存在しないことの有意性モデリング | |
| CN112779338A (zh) | 用于食管癌预后评估的基因标志物 | |
| KR20250019610A (ko) | 치료 모니터링을 위한 메틸화된 세포 유리 dna의 분자 계수 | |
| JP2022548993A (ja) | Ｄｎａメチル化異常を用いた免疫抗癌治療反応性予測方法 | |
| HK1260066B (en) | Methods for lung cancer detection | |
| US20250101522A1 (en) | Brca1 promoter methylation in sporadic breast cancer patients detected by liquid biopsy | |
| BR112018070903B1 (pt) | Método para determinar variantes de nucleotídeo único presentes em um carcinoma de células escamosas de pulmão | |
| US20250243550A1 (en) | Minimum residual disease (mrd) detection in early stage cancer using urine | |
| Craig | Low Frequency Airway Epithelial Cell Mutation Pattern Associated with Lung Cancer Risk | |
| US20240392385A1 (en) | Method for predicting response to cancer immunotherapy by using dna methylation aberration in line-1 | |
| WO2024252401A1 (en) | Markers | |
| HK1262837A1 (en) | Methods for lung cancer detection | |
| Luna Santamaria | Ultrasensitive nucleic acids analysis using digital sequencing | |
| JP2025535077A (ja) | 癌の多数の分析物検出のためのシステムおよび方法 | |
| KR20250175126A (ko) | 변이체 대립유전자 빈도 분석을 통한 암 진단 방법 | |
| McGregor | A Tale of Two Validations: Molecular Diagnostic Assays for the Detection of Clinically Significant Alterations | |
| WO2025106837A1 (en) | Tumor fraction and outcome association in a real-world non-small cell lung cancer (nsclc) cohort using a methylation-based circulating tumor dna (ctdna) assay | |
| Kachuri | Investigation of Genetic Profiles in Chromosome 5p15. 33 and Telomere Length in Lung Cancer Risk and Clinical Outcomes | |
| Trapani | DNA hypomethylation and hypermethylation in colorectal cancer initiation. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200402 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20200402 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200902 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20210219 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20210406 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20210705 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210914 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220201 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220426 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220830 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20221129 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230224 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20230411 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20230511 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7280044 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |