BR112018070903A2 - métodos para detecção de câncer de pulmão - Google Patents

métodos para detecção de câncer de pulmão

Info

Publication number
BR112018070903A2
BR112018070903A2 BR112018070903A BR112018070903A BR112018070903A2 BR 112018070903 A2 BR112018070903 A2 BR 112018070903A2 BR 112018070903 A BR112018070903 A BR 112018070903A BR 112018070903 A BR112018070903 A BR 112018070903A BR 112018070903 A2 BR112018070903 A2 BR 112018070903A2
Authority
BR
Brazil
Prior art keywords
methods
lung cancer
cancer detection
lung
compositions
Prior art date
Application number
BR112018070903A
Other languages
English (en)
Inventor
Zimmermann Bernhard
Abbosh Christopher
Wilson Gareth
Eser Kirkizlar Huseyin
Jamal-Hanjani Mariam
Salari Raheleh
Charles Swanton Robert
Pompiliu Constantin Tudor
Original Assignee
Natera Inc
Ucl Business Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natera Inc, Ucl Business Plc filed Critical Natera Inc
Publication of BR112018070903A2 publication Critical patent/BR112018070903A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Abstract

a invenção fornece métodos para detectar variantes de nucleotídeo único em câncer de pulmão, especialmente no adenocarcinoma de pulmão de estágio 3a e no carcinoma de pulmão de células escamosas. são fornecidos métodos e composições adicionais, tais como misturas de reação e suportes sólidos compreendendo populações clonais de ácidos nucleicos.
BR112018070903A 2016-04-15 2017-04-17 métodos para detecção de câncer de pulmão BR112018070903A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662323589P 2016-04-15 2016-04-15
PCT/US2017/028013 WO2017181202A2 (en) 2016-04-15 2017-04-17 Methods for lung cancer detection

Publications (1)

Publication Number Publication Date
BR112018070903A2 true BR112018070903A2 (pt) 2019-01-29

Family

ID=59215913

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018070903A BR112018070903A2 (pt) 2016-04-15 2017-04-17 métodos para detecção de câncer de pulmão

Country Status (11)

Country Link
US (1) US20190106751A1 (pt)
EP (1) EP3443119B8 (pt)
JP (1) JP7280044B2 (pt)
CN (1) CN109477138A (pt)
AU (1) AU2017249594B2 (pt)
BR (1) BR112018070903A2 (pt)
CA (1) CA3016360A1 (pt)
DK (1) DK3443119T3 (pt)
ES (1) ES2913468T3 (pt)
RU (1) RU2760913C2 (pt)
WO (1) WO2017181202A2 (pt)

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US10081839B2 (en) 2005-07-29 2018-09-25 Natera, Inc System and method for cleaning noisy genetic data and determining chromosome copy number
US11111543B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US11111544B2 (en) 2005-07-29 2021-09-07 Natera, Inc. System and method for cleaning noisy genetic data and determining chromosome copy number
US8825412B2 (en) 2010-05-18 2014-09-02 Natera, Inc. Methods for non-invasive prenatal ploidy calling
EP2473638B1 (en) 2009-09-30 2017-08-09 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11408031B2 (en) 2010-05-18 2022-08-09 Natera, Inc. Methods for non-invasive prenatal paternity testing
US10316362B2 (en) 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
US11332793B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for simultaneous amplification of target loci
US11339429B2 (en) 2010-05-18 2022-05-24 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US20190010543A1 (en) 2010-05-18 2019-01-10 Natera, Inc. Methods for simultaneous amplification of target loci
US9677118B2 (en) 2014-04-21 2017-06-13 Natera, Inc. Methods for simultaneous amplification of target loci
US11322224B2 (en) 2010-05-18 2022-05-03 Natera, Inc. Methods for non-invasive prenatal ploidy calling
US11939634B2 (en) 2010-05-18 2024-03-26 Natera, Inc. Methods for simultaneous amplification of target loci
US11326208B2 (en) 2010-05-18 2022-05-10 Natera, Inc. Methods for nested PCR amplification of cell-free DNA
US11332785B2 (en) 2010-05-18 2022-05-17 Natera, Inc. Methods for non-invasive prenatal ploidy calling
EP2656263B1 (en) 2010-12-22 2019-11-06 Natera, Inc. Methods for non-invasive prenatal paternity testing
ES2625288T3 (es) 2011-04-15 2017-07-19 The Johns Hopkins University Sistema de secuenciación segura
ES2701742T3 (es) 2012-10-29 2019-02-25 Univ Johns Hopkins Prueba de Papanicolaou para cánceres de ovario y de endometrio
US10577655B2 (en) 2013-09-27 2020-03-03 Natera, Inc. Cell free DNA diagnostic testing standards
RU2717641C2 (ru) 2014-04-21 2020-03-24 Натера, Инк. Обнаружение мутаций и плоидности в хромосомных сегментах
US11479812B2 (en) 2015-05-11 2022-10-25 Natera, Inc. Methods and compositions for determining ploidy
US11286531B2 (en) 2015-08-11 2022-03-29 The Johns Hopkins University Assaying ovarian cyst fluid
US20190085406A1 (en) 2016-04-14 2019-03-21 Guardant Health, Inc. Methods for early detection of cancer
US11485996B2 (en) 2016-10-04 2022-11-01 Natera, Inc. Methods for characterizing copy number variation using proximity-litigation sequencing
US10011870B2 (en) 2016-12-07 2018-07-03 Natera, Inc. Compositions and methods for identifying nucleic acid molecules
CA3049139A1 (en) 2017-02-21 2018-08-30 Natera, Inc. Compositions, methods, and kits for isolating nucleic acids
WO2019200228A1 (en) * 2018-04-14 2019-10-17 Natera, Inc. Methods for cancer detection and monitoring by means of personalized detection of circulating tumor dna
AU2019277698A1 (en) 2018-06-01 2020-11-19 Grail, Llc Convolutional neural network systems and methods for data classification
US11211148B2 (en) * 2018-06-28 2021-12-28 International Business Machines Corporation Time-series phylogenetic tumor evolution trees
US11189361B2 (en) 2018-06-28 2021-11-30 International Business Machines Corporation Functional analysis of time-series phylogenetic tumor evolution tree
US11525159B2 (en) 2018-07-03 2022-12-13 Natera, Inc. Methods for detection of donor-derived cell-free DNA
EP3856903A4 (en) 2018-09-27 2022-07-27 Grail, LLC METHYLATION MARKER AND TARGETED METHYLATION PROBE PANEL
US11581062B2 (en) 2018-12-10 2023-02-14 Grail, Llc Systems and methods for classifying patients with respect to multiple cancer classes
US11211144B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Methods and systems for refining copy number variation in a liquid biopsy assay
US11211147B2 (en) 2020-02-18 2021-12-28 Tempus Labs, Inc. Estimation of circulating tumor fraction using off-target reads of targeted-panel sequencing
US11475981B2 (en) 2020-02-18 2022-10-18 Tempus Labs, Inc. Methods and systems for dynamic variant thresholding in a liquid biopsy assay
JP2023528777A (ja) 2020-05-29 2023-07-06 ナテラ，インク． ドナー由来無細胞ｄｎａの検出方法
WO2022182878A1 (en) 2021-02-25 2022-09-01 Natera, Inc. Methods for detection of donor-derived cell-free dna in transplant recipients of multiple organs
AU2022237538A1 (en) 2021-03-18 2023-09-21 Natera, Inc. Methods for determination of transplant rejection
US20240003888A1 (en) 2022-05-17 2024-01-04 Guardant Health, Inc. Methods for identifying druggable targets and treating cancer
WO2023244735A2 (en) 2022-06-15 2023-12-21 Natera, Inc. Methods for determination and monitoring of transplant rejection by measuring rna

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Publication number Priority date Publication date Assignee Title
US8822153B2 (en) * 2007-06-01 2014-09-02 The University Of North Carolina At Chapel Hill Molecular diagnosis and typing of lung cancer variants
US10316362B2 (en) * 2010-05-18 2019-06-11 Natera, Inc. Methods for simultaneous amplification of target loci
KR101890466B1 (ko) * 2012-07-24 2018-08-21 내테라, 인코포레이티드 고도의 다중 ｐｃｒ 방법 및 조성물
WO2014151117A1 (en) * 2013-03-15 2014-09-25 The Board Of Trustees Of The Leland Stanford Junior University Identification and use of circulating nucleic acid tumor markers
WO2015006668A1 (en) * 2013-07-12 2015-01-15 The University Of North Carolina At Chapel Hill Methods for identification of individuals
RU2717641C2 (ru) * 2014-04-21 2020-03-24 Натера, Инк. Обнаружение мутаций и плоидности в хромосомных сегментах
WO2015164432A1 (en) * 2014-04-21 2015-10-29 Natera, Inc. Detecting mutations and ploidy in chromosomal segments
GB201412834D0 (en) * 2014-07-18 2014-09-03 Cancer Rec Tech Ltd A method for detecting a genetic variant

Also Published As

Publication number Publication date
JP7280044B2 (ja) 2023-05-23
EP3443119A2 (en) 2019-02-20
WO2017181202A2 (en) 2017-10-19
RU2760913C2 (ru) 2021-12-01
ES2913468T3 (es) 2022-06-02
RU2018138508A (ru) 2020-05-15
RU2018138508A3 (pt) 2021-02-15
CA3016360A1 (en) 2017-10-19
AU2017249594A1 (en) 2018-09-20
EP3443119B1 (en) 2022-02-23
CN109477138A (zh) 2019-03-15
EP3443119B8 (en) 2022-04-06
JP2019517781A (ja) 2019-06-27
WO2017181202A3 (en) 2018-01-04
DK3443119T3 (da) 2022-05-23
US20190106751A1 (en) 2019-04-11
AU2017249594B2 (en) 2023-08-24

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Legal Events

Date Code Title Description
B25D Requested change of name of applicant approved

Owner name: NATERA, INC. (US) ; UCL BUSINESS LTD (GB)

B350 Update of information on the portal [chapter 15.35 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]