JP2024522292A5 - - Google Patents

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Publication number
JP2024522292A5
JP2024522292A5 JP2023574395A JP2023574395A JP2024522292A5 JP 2024522292 A5 JP2024522292 A5 JP 2024522292A5 JP 2023574395 A JP2023574395 A JP 2023574395A JP 2023574395 A JP2023574395 A JP 2023574395A JP 2024522292 A5 JP2024522292 A5 JP 2024522292A5
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JP
Japan
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JP2023574395A
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JPWO2022256622A5 (https=
JP2024522292A (ja
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Priority claimed from PCT/US2022/032116 external-priority patent/WO2022256622A1/en
Publication of JP2024522292A publication Critical patent/JP2024522292A/ja
Publication of JPWO2022256622A5 publication Critical patent/JPWO2022256622A5/ja
Publication of JP2024522292A5 publication Critical patent/JP2024522292A5/ja
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JP2023574395A 2021-06-04 2022-06-03 ナトリウムチャネルのモジュレーターとしてのn-(ヒドロキシアルキル(ヘテロ)アリール)テトラヒドロフランカルボキサミド Pending JP2024522292A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163196946P 2021-06-04 2021-06-04
US63/196,946 2021-06-04
PCT/US2022/032116 WO2022256622A1 (en) 2021-06-04 2022-06-03 N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels

Publications (3)

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JP2024522292A JP2024522292A (ja) 2024-06-13
JPWO2022256622A5 JPWO2022256622A5 (https=) 2025-07-01
JP2024522292A5 true JP2024522292A5 (https=) 2025-07-01

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JP2023574395A Pending JP2024522292A (ja) 2021-06-04 2022-06-03 ナトリウムチャネルのモジュレーターとしてのn-(ヒドロキシアルキル(ヘテロ)アリール)テトラヒドロフランカルボキサミド

Country Status (33)

Country Link
US (3) US11827627B2 (https=)
EP (2) EP4699607A2 (https=)
JP (1) JP2024522292A (https=)
KR (1) KR20240031300A (https=)
CN (1) CN117794920A (https=)
AR (1) AR126073A1 (https=)
AU (1) AU2022284886A1 (https=)
CA (1) CA3221259A1 (https=)
CL (1) CL2023003625A1 (https=)
CO (1) CO2023017899A2 (https=)
CR (1) CR20230586A (https=)
DK (1) DK4347031T3 (https=)
DO (1) DOP2023000267A (https=)
EC (1) ECSP23095485A (https=)
ES (1) ES3058787T3 (https=)
FI (1) FI4347031T3 (https=)
GE (1) GEAP202416430A (https=)
HR (1) HRP20251504T1 (https=)
IL (1) IL308953A (https=)
JO (1) JOP20230316B1 (https=)
LT (1) LT4347031T (https=)
MA (1) MA64853B1 (https=)
MD (1) MD4347031T2 (https=)
MX (1) MX2023014378A (https=)
PE (1) PE20241335A1 (https=)
PL (1) PL4347031T3 (https=)
PT (1) PT4347031T (https=)
RS (1) RS67577B1 (https=)
SI (1) SI4347031T1 (https=)
SM (1) SMT202500481T1 (https=)
TW (1) TW202313593A (https=)
UY (1) UY39800A (https=)
WO (1) WO2022256622A1 (https=)

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CN115397821B (zh) 2019-10-17 2024-09-03 阿尔维纳斯运营股份有限公司 含有与bcl6靶向部分连接的e3泛素连接酶结合部分的双官能分子
CA3164134A1 (en) 2019-12-06 2021-06-10 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels
SI4347031T1 (sl) 2021-06-04 2026-01-30 Vertex Pharmaceuticals Incorporated N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov
UY40234A (es) 2022-04-22 2023-11-15 Vertex Pharma Compuestos heteroarilo para el tratamiento del dolor
CN119585260A (zh) * 2022-08-24 2025-03-07 江苏恒瑞医药股份有限公司 杂环类化合物、其制备方法及其在医药上的应用
JP2025529931A (ja) * 2022-08-28 2025-09-09 シャンハイ ホイルン ファーマシューティカル カンパニー リミテッド ナトリウムチャネル調節剤及びその応用
AU2023391870A1 (en) * 2022-12-06 2025-06-05 Vertex Pharmaceuticals Incorporated Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
CN120569377A (zh) * 2023-01-06 2025-08-29 海思科医药集团股份有限公司 一种四氢噻吩衍生物及其在医药上的应用
WO2024188367A1 (zh) * 2023-03-10 2024-09-19 西藏海思科制药有限公司 一种四氢呋喃衍生物及其在医药上的应用
WO2024217528A1 (zh) * 2023-04-20 2024-10-24 西藏海思科制药有限公司 一种杂环化合物及其在医药上的应用
CN119371405A (zh) 2023-07-26 2025-01-28 上海闻耐医药科技有限公司 多取代吡咯烷类衍生物、其制备方法及用途
TW202535352A (zh) * 2023-11-02 2025-09-16 大陸商陽光安津(南京)生物醫藥科技有限公司 化合物、組合物及其方法
WO2025108234A1 (zh) * 2023-11-20 2025-05-30 四川科伦药物研究院有限公司 化合物、其制备方法及用途
WO2025131098A1 (zh) * 2023-12-21 2025-06-26 武汉熙瑞医药科技有限公司 一种含苯环的多环化合物、其药物组合物及其应用
WO2025162194A1 (zh) * 2024-01-31 2025-08-07 上海汇伦医药股份有限公司 钠通道调节剂新化合物及其应用
WO2025168043A1 (zh) * 2024-02-08 2025-08-14 上海枢境生物科技有限公司 并环类衍生物、制备方法及其用途
CN120040431A (zh) * 2024-02-23 2025-05-27 山东盛迪医药有限公司 一种取代四氢呋喃衍生物的可药用盐、其结晶形式及用途
CN120040429B (zh) * 2024-02-23 2026-03-31 山东盛迪医药有限公司 一种取代四氢呋喃衍生物的结晶形式及其用途
CN117902972B (zh) * 2024-03-19 2024-06-11 深圳创元生物医药科技有限公司 一种2,4-二羟基苯乙酸的制备方法
CN120774914A (zh) * 2024-04-03 2025-10-14 武汉人福创新药物研发中心有限公司 作为Nav1.8抑制剂的四氢呋喃吡啶酮类化合物
CN118388466A (zh) * 2024-04-23 2024-07-26 安润医药科技(苏州)有限公司 作钠通道调节剂的酰胺衍生物及其用途
WO2025252109A1 (zh) * 2024-06-04 2025-12-11 成都苑东生物制药股份有限公司 一种取代四氢呋喃类衍生物、其制备方法及用途
WO2026012382A1 (zh) * 2024-07-10 2026-01-15 海思科医药集团股份有限公司 一种硫杂环戊基衍生物的药物制剂及其在医药上的应用
WO2026030525A1 (en) 2024-07-31 2026-02-05 Vertex Pharmaceuticals Incorporated Zilvetrigine dosage forms and dosing regimens for treating pain
CN119285621B (zh) * 2024-12-13 2025-07-18 嘉兴安帝康生物科技有限公司 作为钠通道调节剂的四氢呋喃甲酰胺类化合物及其在医药上的应用

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