IT1254134B - Oligonucleotidi antisenso chimicamente modificati. - Google Patents
Oligonucleotidi antisenso chimicamente modificati.Info
- Publication number
- IT1254134B IT1254134B ITRM920025A ITRM920025A IT1254134B IT 1254134 B IT1254134 B IT 1254134B IT RM920025 A ITRM920025 A IT RM920025A IT RM920025 A ITRM920025 A IT RM920025A IT 1254134 B IT1254134 B IT 1254134B
- Authority
- IT
- Italy
- Prior art keywords
- chemically modified
- antisense oligonucleotides
- modified antisense
- residues
- hydrogen
- Prior art date
Links
- 108020000948 Antisense Oligonucleotides Proteins 0.000 title abstract 2
- 239000000074 antisense oligonucleotide Substances 0.000 title abstract 2
- 238000012230 antisense oligonucleotides Methods 0.000 title abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 3
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000001424 substituent group Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Oligonucleotidi antisenso chimicamente modificati, caratterizzati dal fatto di avere la seguente formula generale (1): (FORMULA I) in cui n è un numero intero da 0 a 200;R1-5 rappresenta una serie di sostituenti, per conferire alla sostituzione una struttura simmetrica nel suo insieme, scelti indipendentemente l'uno dall'altro dal gruppo comprendente idrogeno, eteroatomi, residui con eteroatomi, e residui idrocarbile;R rappresenta idrogeno, sostituenti con eteroatomi oppure residui idrocarbile; e B rappresenta un residuo eterociclico a uno o più anelli, e caratterizzati dal fatto che nella loro molecola sono presenti gruppi fosfato non-ionici e non-chirali.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM920025A IT1254134B (it) | 1992-01-16 | 1992-01-16 | Oligonucleotidi antisenso chimicamente modificati. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITRM920025A IT1254134B (it) | 1992-01-16 | 1992-01-16 | Oligonucleotidi antisenso chimicamente modificati. |
Publications (3)
Publication Number | Publication Date |
---|---|
ITRM920025A0 ITRM920025A0 (it) | 1992-01-16 |
ITRM920025A1 ITRM920025A1 (it) | 1993-07-16 |
IT1254134B true IT1254134B (it) | 1995-09-08 |
Family
ID=11400569
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ITRM920025A IT1254134B (it) | 1992-01-16 | 1992-01-16 | Oligonucleotidi antisenso chimicamente modificati. |
Country Status (1)
Country | Link |
---|---|
IT (1) | IT1254134B (it) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL293592A (en) | 2019-12-06 | 2022-08-01 | Vertex Pharma | Transduced tetrahydrofurans as sodium channel modulators |
AU2022284886A1 (en) | 2021-06-04 | 2023-11-30 | Vertex Pharmaceuticals Incorporated | N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels |
-
1992
- 1992-01-16 IT ITRM920025A patent/IT1254134B/it active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
ITRM920025A1 (it) | 1993-07-16 |
ITRM920025A0 (it) | 1992-01-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NZ210627A (en) | 11-beta-arylestradienes and pharmaceutical compositions | |
PT98710A (pt) | Processo de preparacao de compostos de indolilo substituidos e de composicoes farmaceuticas que os contem | |
DE69520880T2 (de) | 9-deoxotaxan verbindungen | |
ES2104593T3 (es) | Nuevas lipopoliaminas, su preparacion y su empleo. | |
ES8106136A1 (es) | Procedimiento para la preparacion de bis-(n-(3,5-bis-(hidro-xialcohilaminocarbonil)-2,4,6-triyodofenil)-n-(a-hidroxia- cil)-amino)-alcanos | |
FI935701A (fi) | Fluoralkoxibensylaminoderivat av kvaeve-innehaollande heterocykliska foereningar | |
EP0594578A4 (en) | OLIGORIBONUCLEOSIDES AND OLIGODEOXYRIBONUCLEOSIDES BORANOPHOSPHATES. | |
ES8105338A1 (es) | Procedimiento para preparar derivados de di fosfonatos. | |
ES8800338A1 (es) | Procedimiento mejorado de lavado y desinfeccion. | |
IL76456A0 (en) | 1-substituted tetralin derivatives,their preparation and pharmaceutical compositions containing them | |
IT1254134B (it) | Oligonucleotidi antisenso chimicamente modificati. | |
TW252979B (it) | ||
DE59403966D1 (de) | Hydroxymethylfurazancarbonsäurederivate und ihre verwendung in der behandlung von kardiovaskulären erkrankungen | |
DE3268699D1 (en) | Derivatives of 4-phenyl-quinazoline active on the central nervous system | |
ZA88208B (en) | Sweetening agents derived from guanidinoacetic and ethanamidinoacetic acids,process for sweetening various products,and compositions containing such sweetening agents | |
HUT76272A (en) | Pharmaceutical compositions containing heterocyclic benzenesulfonylimine derivatives and their use | |
IT8568064A0 (it) | Procedimento per la rimozione dai tessuti di contaminanti vegetali edi altri contaminanti cellulosici | |
ES8501607A1 (es) | Procedimiento para la obtencion de heterociclos nitrogenosos de 5 miembros | |
FI855132A0 (fi) | 2,3-diamino-2,3 -didesoxyhexosderivat, foerfarande foer deras framstaellning och deras anvaendning. | |
HUT54675A (en) | Process for producing 1-methoxy-pyrimidinyl-1h-1,2,4-triazole-3-sulfonic acid-nitro-anilide derivatives and herbicide preparatives containing these compounds as active substance | |
AU565187B2 (en) | 2-n-cycloalkylmethyl-3-oxo-5,6-diaryl-as-triazines | |
IT8119119A0 (it) | Procedimento perfezionato per la tesatura di linee elettriche di alta tensione, ed attrezzatura perl'attuazione dello stesso. | |
PL312966A1 (en) | Derivatives of thiocarbamoil | |
DE3824939A1 (de) | Neue 2,2-dihalogencyclopropylhydroxyethyltriazole enthaltende antimykotische mittel | |
ES2009283A6 (es) | Procedimiento para preparar nuevos aminoacilatos de glicerol-acetal. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
0001 | Granted | ||
TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19950126 |