ES2104593T3 - Nuevas lipopoliaminas, su preparacion y su empleo. - Google Patents

Nuevas lipopoliaminas, su preparacion y su empleo.

Info

Publication number
ES2104593T3
ES2104593T3 ES90401020T ES90401020T ES2104593T3 ES 2104593 T3 ES2104593 T3 ES 2104593T3 ES 90401020 T ES90401020 T ES 90401020T ES 90401020 T ES90401020 T ES 90401020T ES 2104593 T3 ES2104593 T3 ES 2104593T3
Authority
ES
Spain
Prior art keywords
lipopoliamins
preparation
new
inclusive
integer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90401020T
Other languages
English (en)
Inventor
Jean-Paul Behr
Jean-Philippe Loeffler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Application granted granted Critical
Publication of ES2104593T3 publication Critical patent/ES2104593T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NUEVAS LIPOPOLIAMINAS DE FORMULA GENERAL (I), SUS SALES, SU OBTENCION Y SU EMPLEO, DONDE N = 1-5, Y M = 2-6; R REPRESENTA UN RADICAL DE FORMULA: (FIG. A), SIENDO R1 Y R2 RADICAL ALFATICO QUE CONTIENE 12-22 ATOMOS DE CARBONO, R ATOMO DE HIDROGENO O RADICAL ALQUILO EVENTUALMENTE SUSTITUIDO POR FENILO; O UN RADICAL DE FORMULA: (FIG. B), SIENDO X = CH2, CO; R3 Y R4 RADICALES ALIFATICOS QUE CONTIENEN 11-21 ATOMOS DE CARBONO, SU OBTENCION Y SU EMPLEO. LAS LIPOPOLIAMINAS DE FORMULA GENERAL (I) SON ESPECIALMENTE UTILES COMO VECTORES DE TRANSFECCION DE CELULAS EUCARIOTES.
ES90401020T 1989-04-17 1990-04-13 Nuevas lipopoliaminas, su preparacion y su empleo. Expired - Lifetime ES2104593T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR898905037A FR2645866B1 (fr) 1989-04-17 1989-04-17 Nouvelles lipopolyamines, leur preparation et leur emploi

Publications (1)

Publication Number Publication Date
ES2104593T3 true ES2104593T3 (es) 1997-10-16

Family

ID=9380787

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90401020T Expired - Lifetime ES2104593T3 (es) 1989-04-17 1990-04-13 Nuevas lipopoliaminas, su preparacion y su empleo.

Country Status (11)

Country Link
US (3) US5171678A (es)
EP (1) EP0394111B1 (es)
JP (1) JP2716565B2 (es)
AT (1) ATE154035T1 (es)
CA (1) CA2014518C (es)
DE (1) DE69030839T2 (es)
DK (1) DK0394111T3 (es)
ES (1) ES2104593T3 (es)
FR (1) FR2645866B1 (es)
GR (1) GR3023691T3 (es)
IL (1) IL94077A (es)

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US5476962A (en) 1995-12-19
DE69030839T2 (de) 1997-11-20
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CA2014518C (fr) 2003-11-18
FR2645866A1 (fr) 1990-10-19
US5616745A (en) 1997-04-01
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FR2645866B1 (fr) 1991-07-05
IL94077A0 (en) 1991-01-31
DK0394111T3 (da) 1997-09-08
JPH02292246A (ja) 1990-12-03
EP0394111B1 (fr) 1997-06-04
IL94077A (en) 1994-12-29
CA2014518A1 (fr) 1990-10-17
US5171678A (en) 1992-12-15
GR3023691T3 (en) 1997-09-30
ATE154035T1 (de) 1997-06-15
JP2716565B2 (ja) 1998-02-18

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