MA46762A - Procédé amélioré de préparation de nanoparticules lipidiques chargées d'arnm - Google Patents
Procédé amélioré de préparation de nanoparticules lipidiques chargées d'arnmInfo
- Publication number
- MA46762A MA46762A MA046762A MA46762A MA46762A MA 46762 A MA46762 A MA 46762A MA 046762 A MA046762 A MA 046762A MA 46762 A MA46762 A MA 46762A MA 46762 A MA46762 A MA 46762A
- Authority
- MA
- Morocco
- Prior art keywords
- rna
- improved process
- lipid nanoparticles
- nanoparticles loaded
- preparing lipid
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/44—Oxidoreductases (1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/53—Ligases (6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/5123—Organic compounds, e.g. fats, sugars
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
- C12Y114/16—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with reduced pteridine as one donor, and incorporation of one atom of oxygen (1.14.16)
- C12Y114/16001—Phenylalanine 4-monooxygenase (1.14.16.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y201/00—Transferases transferring one-carbon groups (2.1)
- C12Y201/03—Carboxy- and carbamoyltransferases (2.1.3)
- C12Y201/03003—Ornithine carbamoyltransferase (2.1.3.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
- C12Y603/04—Other carbon-nitrogen ligases (6.3.4)
- C12Y603/04005—Argininosuccinate synthase (6.3.4.5)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Optics & Photonics (AREA)
- Nanotechnology (AREA)
- Cell Biology (AREA)
- Dispersion Chemistry (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662420413P | 2016-11-10 | 2016-11-10 | |
| US201762580155P | 2017-11-01 | 2017-11-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA46762A true MA46762A (fr) | 2019-09-18 |
Family
ID=60782328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA046762A MA46762A (fr) | 2016-11-10 | 2017-11-10 | Procédé amélioré de préparation de nanoparticules lipidiques chargées d'arnm |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20180153822A1 (fr) |
| EP (1) | EP3538073A1 (fr) |
| JP (2) | JP2019533707A (fr) |
| AU (1) | AU2017357758B2 (fr) |
| CA (1) | CA3041345A1 (fr) |
| MA (1) | MA46762A (fr) |
| WO (1) | WO2018089801A1 (fr) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3336082B1 (fr) | 2011-06-08 | 2020-04-15 | Translate Bio, Inc. | Lipides clivables |
| WO2016004318A1 (fr) * | 2014-07-02 | 2016-01-07 | Shire Human Genetic Therapies, Inc. | Encapsulation d'arn messager |
| WO2018157154A2 (fr) * | 2017-02-27 | 2018-08-30 | Translate Bio, Inc. | Nouvel arnm cftr à codons optimisés |
| WO2018170245A1 (fr) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Vaccin à large spectre contre le virus de la grippe |
| EP3595713A4 (fr) | 2017-03-15 | 2021-01-13 | ModernaTX, Inc. | Vaccin contre le virus respiratoire syncytial |
| US11786607B2 (en) | 2017-06-15 | 2023-10-17 | Modernatx, Inc. | RNA formulations |
| WO2019046809A1 (fr) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | Procédés de fabrication de nanoparticules lipidiques |
| JP7423521B2 (ja) | 2017-11-22 | 2024-01-29 | モダーナティエックス・インコーポレイテッド | フェニルケトン尿症の治療用のフェニルアラニンヒドロキシラーゼをコードするポリヌクレオチド |
| WO2019148101A1 (fr) | 2018-01-29 | 2019-08-01 | Modernatx, Inc. | Vaccins à base d'arn contre le vrs |
| US20210220449A1 (en) * | 2018-05-15 | 2021-07-22 | Translate Bio, Inc. | Subcutaneous Delivery of Messenger RNA |
| CN112384523A (zh) | 2018-05-16 | 2021-02-19 | 川斯勒佰尔公司 | 核糖阳离子脂质 |
| US12076439B2 (en) | 2018-05-24 | 2024-09-03 | Translate Bio, Inc. | Thioester cationic lipids |
| AU2019277361A1 (en) * | 2018-05-30 | 2020-12-17 | Translate Bio, Inc. | Messenger RNA vaccines and uses thereof |
| WO2019232097A1 (fr) | 2018-05-30 | 2019-12-05 | Translate Bio, Inc. | Lipides cationiques de phosphoesters |
| CA3100214A1 (fr) | 2018-05-30 | 2019-12-05 | Translate Bio, Inc. | Lipides cationiques comprenant une fraction steroidienne |
| AU2019278985A1 (en) | 2018-05-30 | 2020-12-17 | Translate Bio, Inc. | Vitamin cationic lipids |
| JP7422977B2 (ja) | 2018-07-23 | 2024-01-29 | トランスレイト バイオ， インコーポレイテッド | メッセンジャーｒｎａ用乾燥粉末製剤 |
| CA3109548A1 (fr) * | 2018-08-14 | 2020-02-20 | Ethris Gmbh | Formulations a base de lipides contenant des sels pour l'administration d'arn |
| BR112021003311A2 (pt) * | 2018-08-24 | 2021-05-25 | Flagship Pioneering Innovations Vi, Llc | pacotes de mensageiros de plantas modificados e seus usos |
| KR20210091120A (ko) | 2018-08-29 | 2021-07-21 | 트랜슬레이트 바이오 인코포레이티드 | Mrna-로딩된 지질 나노입자를 제조하는 개선된 공정 |
| EP3849617A1 (fr) | 2018-09-14 | 2021-07-21 | Translate Bio, Inc. | Compositions et méthodes de traitement de l'acidémie méthylmalonique |
| US20220047518A1 (en) * | 2018-09-19 | 2022-02-17 | Moderna TX, Inc. | Peg lipids and uses thereof |
| EP3852728B1 (fr) | 2018-09-20 | 2024-09-18 | ModernaTX, Inc. | Préparation de nanoparticules lipidiques et leurs méthodes d'administration |
| WO2020077007A1 (fr) | 2018-10-09 | 2020-04-16 | The University Of British Columbia | Compositions et systèmes comprenant des vésicules compétentes pour la transfection exemptes de solvants organiques et de détergents, et procédés associés |
| KR20210090634A (ko) | 2018-10-19 | 2021-07-20 | 트랜슬레이트 바이오 인코포레이티드 | 전령 rna의 무펌프 캡슐화 |
| WO2020097511A2 (fr) | 2018-11-09 | 2020-05-14 | Translate Bio, Inc. | Thérapie par l'arn messager pour le traitement des maladies oculaires |
| WO2020097384A1 (fr) | 2018-11-09 | 2020-05-14 | Translate Bio, Inc. | Lipides de 2,5-dioxopipérazine à fractions ester, thioester, disulfure et anhydride intercalées |
| EP3880174A2 (fr) | 2018-11-12 | 2021-09-22 | Translate Bio, Inc. | Méthodes pour induire une tolérance immunitaire |
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| KR20210143718A (ko) * | 2019-01-17 | 2021-11-29 | 조지아 테크 리서치 코포레이션 | 산화된 콜레스테롤을 함유하는 약물 전달 시스템 |
| EP4427739A3 (fr) * | 2019-01-31 | 2024-10-16 | ModernaTX, Inc. | Procédés de préparation de nanoparticules lipidiques |
| US20220177423A1 (en) | 2019-04-18 | 2022-06-09 | Translate Bio, Inc. | Cystine cationic lipids |
| ES2972014T3 (es) | 2019-04-22 | 2024-06-10 | Translate Bio Inc | Lípidos catiónicos de tioéster |
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| CN114401942B (zh) | 2019-06-21 | 2024-01-26 | 川斯勒佰尔公司 | 三(羟甲基)甲基甘氨酸和柠檬酸脂质 |
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| WO2021173840A1 (fr) | 2020-02-25 | 2021-09-02 | Translate Bio, Inc. | Procédés améliorés de préparation de nanoparticules lipidiques chargées d'arnm |
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| WO2024126809A1 (fr) | 2022-12-15 | 2024-06-20 | Sanofi | Arnm codant pour une particule de type virus de la grippe |
| WO2024133515A1 (fr) | 2022-12-20 | 2024-06-27 | Sanofi | Vaccin contre l'arnm de rhinovirus |
| WO2024160828A1 (fr) | 2023-01-31 | 2024-08-08 | BioNTech SE | Compositions et procédés |
| US20240299524A1 (en) | 2023-03-02 | 2024-09-12 | Sanofi | Compositions for use in treatment of chlamydia |
| WO2024184500A1 (fr) | 2023-03-08 | 2024-09-12 | CureVac SE | Nouvelles formulations de nanoparticules lipidiques pour l'administration d'acides nucléiques |
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| US7094423B1 (en) * | 1999-07-15 | 2006-08-22 | Inex Pharmaceuticals Corp. | Methods for preparation of lipid-encapsulated therapeutic agents |
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| DK3394030T3 (da) | 2015-12-22 | 2022-03-28 | Modernatx Inc | Forbindelser og sammensætninger til intracellulær afgivelse af midler |
| EP3442590A2 (fr) | 2016-04-13 | 2019-02-20 | Modernatx, Inc. | Compositions lipidiques et leurs utilisations pour l'administration intratumorale de polynucléotides |
-
2017
- 2017-11-10 JP JP2019524194A patent/JP2019533707A/ja active Pending
- 2017-11-10 CA CA3041345A patent/CA3041345A1/fr active Pending
- 2017-11-10 AU AU2017357758A patent/AU2017357758B2/en active Active
- 2017-11-10 US US15/809,680 patent/US20180153822A1/en not_active Abandoned
- 2017-11-10 MA MA046762A patent/MA46762A/fr unknown
- 2017-11-10 EP EP17818338.0A patent/EP3538073A1/fr active Pending
- 2017-11-10 WO PCT/US2017/061113 patent/WO2018089801A1/fr unknown
-
2023
- 2023-06-02 US US18/328,206 patent/US20240041789A1/en active Pending
- 2023-08-31 JP JP2023141009A patent/JP2023166489A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3041345A1 (fr) | 2018-05-17 |
| JP2023166489A (ja) | 2023-11-21 |
| AU2017357758A1 (en) | 2019-05-16 |
| AU2017357758B2 (en) | 2023-11-16 |
| JP2019533707A (ja) | 2019-11-21 |
| EP3538073A1 (fr) | 2019-09-18 |
| US20240041789A1 (en) | 2024-02-08 |
| WO2018089801A1 (fr) | 2018-05-17 |
| US20180153822A1 (en) | 2018-06-07 |
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