CA3221259A1 - N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels - Google Patents

N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels Download PDF

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Publication number
CA3221259A1
CA3221259A1 CA3221259A CA3221259A CA3221259A1 CA 3221259 A1 CA3221259 A1 CA 3221259A1 CA 3221259 A CA3221259 A CA 3221259A CA 3221259 A CA3221259 A CA 3221259A CA 3221259 A1 CA3221259 A1 CA 3221259A1
Authority
CA
Canada
Prior art keywords
pain
compound
pharmaceutically acceptable
acceptable salt
carboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3221259A
Other languages
English (en)
French (fr)
Inventor
Elizabeth Mary BECK
Robert PULLIN
Gorka ETXEBARRIA JARDI
Dean Stamos
Yvonne Schmidt
Joseph Pontillo
Stephen Andrew Thomson
David Matthew Shaw
Nadia M. Ahmad
Lidio Marx Carvalho Meireles
Sarah Skerratt
Sara S. Hadida Ruah
Timothy Donald Neubert
Dennis James Hurley
Jinglan Zhou
Steven John Durrant
Christopher Wray
Anisa Nizarali Virani
Kiri NORTH
James Dodd
Michael Edward O'donnell
Bhairavi GALAN
Ronald Marcellus KNEGTEL
Ewa Iwona CHUDYK
Joanne Louise Pinder
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of CA3221259A1 publication Critical patent/CA3221259A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
CA3221259A 2021-06-04 2022-06-03 N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels Pending CA3221259A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163196946P 2021-06-04 2021-06-04
US63/196,946 2021-06-04
PCT/US2022/032116 WO2022256622A1 (en) 2021-06-04 2022-06-03 N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels

Publications (1)

Publication Number Publication Date
CA3221259A1 true CA3221259A1 (en) 2022-12-08

Family

ID=82483401

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3221259A Pending CA3221259A1 (en) 2021-06-04 2022-06-03 N-(hydroxyalkyl (hetero)aryl) tetrahydrofuran carboxamides as modulators of sodium channels

Country Status (33)

Country Link
US (3) US11827627B2 (https=)
EP (2) EP4699607A2 (https=)
JP (1) JP2024522292A (https=)
KR (1) KR20240031300A (https=)
CN (1) CN117794920A (https=)
AR (1) AR126073A1 (https=)
AU (1) AU2022284886A1 (https=)
CA (1) CA3221259A1 (https=)
CL (1) CL2023003625A1 (https=)
CO (1) CO2023017899A2 (https=)
CR (1) CR20230586A (https=)
DK (1) DK4347031T3 (https=)
DO (1) DOP2023000267A (https=)
EC (1) ECSP23095485A (https=)
ES (1) ES3058787T3 (https=)
FI (1) FI4347031T3 (https=)
GE (1) GEAP202416430A (https=)
HR (1) HRP20251504T1 (https=)
IL (1) IL308953A (https=)
JO (1) JOP20230316B1 (https=)
LT (1) LT4347031T (https=)
MA (1) MA64853B1 (https=)
MD (1) MD4347031T2 (https=)
MX (1) MX2023014378A (https=)
PE (1) PE20241335A1 (https=)
PL (1) PL4347031T3 (https=)
PT (1) PT4347031T (https=)
RS (1) RS67577B1 (https=)
SI (1) SI4347031T1 (https=)
SM (1) SMT202500481T1 (https=)
TW (1) TW202313593A (https=)
UY (1) UY39800A (https=)
WO (1) WO2022256622A1 (https=)

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CN115397821B (zh) 2019-10-17 2024-09-03 阿尔维纳斯运营股份有限公司 含有与bcl6靶向部分连接的e3泛素连接酶结合部分的双官能分子
CA3164134A1 (en) 2019-12-06 2021-06-10 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels
SI4347031T1 (sl) 2021-06-04 2026-01-30 Vertex Pharmaceuticals Incorporated N-(hidroksialkil (hetero)aril) tetrahidrofuran karboksamidi kot modulatorji natrijevih kanalčkov
UY40234A (es) 2022-04-22 2023-11-15 Vertex Pharma Compuestos heteroarilo para el tratamiento del dolor
CN119585260A (zh) * 2022-08-24 2025-03-07 江苏恒瑞医药股份有限公司 杂环类化合物、其制备方法及其在医药上的应用
JP2025529931A (ja) * 2022-08-28 2025-09-09 シャンハイ ホイルン ファーマシューティカル カンパニー リミテッド ナトリウムチャネル調節剤及びその応用
AU2023391870A1 (en) * 2022-12-06 2025-06-05 Vertex Pharmaceuticals Incorporated Process for the synthesis of substituted tetrahydrofuran modulators of sodium channels
CN120569377A (zh) * 2023-01-06 2025-08-29 海思科医药集团股份有限公司 一种四氢噻吩衍生物及其在医药上的应用
WO2024188367A1 (zh) * 2023-03-10 2024-09-19 西藏海思科制药有限公司 一种四氢呋喃衍生物及其在医药上的应用
WO2024217528A1 (zh) * 2023-04-20 2024-10-24 西藏海思科制药有限公司 一种杂环化合物及其在医药上的应用
CN119371405A (zh) 2023-07-26 2025-01-28 上海闻耐医药科技有限公司 多取代吡咯烷类衍生物、其制备方法及用途
TW202535352A (zh) * 2023-11-02 2025-09-16 大陸商陽光安津（南京）生物醫藥科技有限公司 化合物、組合物及其方法
WO2025108234A1 (zh) * 2023-11-20 2025-05-30 四川科伦药物研究院有限公司 化合物、其制备方法及用途
WO2025131098A1 (zh) * 2023-12-21 2025-06-26 武汉熙瑞医药科技有限公司 一种含苯环的多环化合物、其药物组合物及其应用
WO2025162194A1 (zh) * 2024-01-31 2025-08-07 上海汇伦医药股份有限公司 钠通道调节剂新化合物及其应用
WO2025168043A1 (zh) * 2024-02-08 2025-08-14 上海枢境生物科技有限公司 并环类衍生物、制备方法及其用途
CN120040431A (zh) * 2024-02-23 2025-05-27 山东盛迪医药有限公司 一种取代四氢呋喃衍生物的可药用盐、其结晶形式及用途
CN120040429B (zh) * 2024-02-23 2026-03-31 山东盛迪医药有限公司 一种取代四氢呋喃衍生物的结晶形式及其用途
CN117902972B (zh) * 2024-03-19 2024-06-11 深圳创元生物医药科技有限公司 一种2,4-二羟基苯乙酸的制备方法
CN120774914A (zh) * 2024-04-03 2025-10-14 武汉人福创新药物研发中心有限公司 作为Nav1.8抑制剂的四氢呋喃吡啶酮类化合物
CN118388466A (zh) * 2024-04-23 2024-07-26 安润医药科技（苏州）有限公司 作钠通道调节剂的酰胺衍生物及其用途
WO2025252109A1 (zh) * 2024-06-04 2025-12-11 成都苑东生物制药股份有限公司 一种取代四氢呋喃类衍生物、其制备方法及用途
WO2026012382A1 (zh) * 2024-07-10 2026-01-15 海思科医药集团股份有限公司 一种硫杂环戊基衍生物的药物制剂及其在医药上的应用
WO2026030525A1 (en) 2024-07-31 2026-02-05 Vertex Pharmaceuticals Incorporated Zilvetrigine dosage forms and dosing regimens for treating pain
CN119285621B (zh) * 2024-12-13 2025-07-18 嘉兴安帝康生物科技有限公司 作为钠通道调节剂的四氢呋喃甲酰胺类化合物及其在医药上的应用

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