BR112022010924A2 - Tetra-hidrofuranos substituídos como moduladores de canais de sódio - Google Patents

Tetra-hidrofuranos substituídos como moduladores de canais de sódio

Info

Publication number
BR112022010924A2
BR112022010924A2 BR112022010924A BR112022010924A BR112022010924A2 BR 112022010924 A2 BR112022010924 A2 BR 112022010924A2 BR 112022010924 A BR112022010924 A BR 112022010924A BR 112022010924 A BR112022010924 A BR 112022010924A BR 112022010924 A2 BR112022010924 A2 BR 112022010924A2
Authority
BR
Brazil
Prior art keywords
sodium channel
channel modulation
compounds
pharmaceutically acceptable
acceptable salts
Prior art date
Application number
BR112022010924A
Other languages
English (en)
Inventor
John Durrant Steven
Ahmad Nadia
Mary Beck Elizabeth
Carvalho Meireles Lidio
Iwona Chudyk Ewa
Etxebarria Jardi Gorka
Galan Bhairavi
S Hadida Ruah Sara
James Hurley Dennis
Marcellus Knegtel Ronald
Donald Neubert Timothy
Louise Pinder Joanne
Pontillo Joseph
Pullin Robert
Schmidt Yvonne
Skerratt Sarah
Matthew SHAW David
Andrew Thomson Stephen
Stamos Dean
Wray Christopher
Nizarali Virani Anisa
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of BR112022010924A2 publication Critical patent/BR112022010924A2/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Liquid Crystal Substances (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Amplitude Modulation (AREA)
  • Amplifiers (AREA)
  • Details Of Television Scanning (AREA)

Abstract

TETRA-HIDROFURANOS SUBSTITUÍDOS COMO MODULADORES DE CANAIS DE SÓDIO. A presente invenção refere-se a compostos, e sais farmaceuticamente aceitáveis dos mesmos, úteis como inibidores de canais de sódio. A invenção também se refere a composições farmacêuticas que compreendem os compostos ou sais farmaceuticamente aceitáveis e métodos de uso dos compostos, sais farmaceuticamente aceitáveis e composições farmacêuticas no tratamento de vários transtornos, incluindo dor.
BR112022010924A 2019-12-06 2020-12-04 Tetra-hidrofuranos substituídos como moduladores de canais de sódio BR112022010924A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962944869P 2019-12-06 2019-12-06
PCT/US2020/063290 WO2021113627A1 (en) 2019-12-06 2020-12-04 Substituted tetrahydrofurans as modulators of sodium channels

Publications (1)

Publication Number Publication Date
BR112022010924A2 true BR112022010924A2 (pt) 2022-09-06

Family

ID=73854989

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112022010924A BR112022010924A2 (pt) 2019-12-06 2020-12-04 Tetra-hidrofuranos substituídos como moduladores de canais de sódio

Country Status (21)

Country Link
US (2) US11834441B2 (pt)
EP (1) EP4069691B1 (pt)
JP (1) JP2023504546A (pt)
KR (1) KR20220124176A (pt)
CN (1) CN114945566A (pt)
AR (1) AR120680A1 (pt)
AU (1) AU2020397059A1 (pt)
BR (1) BR112022010924A2 (pt)
CA (1) CA3164134A1 (pt)
CL (1) CL2022001489A1 (pt)
CO (1) CO2022008969A2 (pt)
CR (1) CR20220316A (pt)
DO (1) DOP2022000115A (pt)
EC (1) ECSP22052564A (pt)
IL (1) IL293592A (pt)
JO (1) JOP20220130A1 (pt)
MX (1) MX2022006865A (pt)
PE (1) PE20230300A1 (pt)
TW (1) TW202128675A (pt)
UY (1) UY38979A (pt)
WO (1) WO2021113627A1 (pt)

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AR126073A1 (es) 2021-06-04 2023-09-06 Vertex Pharma N-(hidroxialquil(hetero)aril)tetrahidrofuran carboxamidas como moduladores de canales de sodio
BR112023025264A2 (pt) 2021-06-04 2024-02-20 Vertex Pharma Formas farmacêuticas sólidas e regimes posológicos compreendendo (2r,3s,4s,5r)-4-[[3- (3,4-difluoro-2-metóxi-fenil)-4,5-dimetil-5-(trifluorometil) tetra-hidrofuran-2-carbonil]amino ]piridina-2-carboxamida
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WO2024046409A1 (zh) * 2022-08-31 2024-03-07 江苏恒瑞医药股份有限公司 杂环类化合物、其制备方法及其在医药上的应用
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