JP2016178938A5 - - Google Patents
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- Publication number
- JP2016178938A5 JP2016178938A5 JP2016118316A JP2016118316A JP2016178938A5 JP 2016178938 A5 JP2016178938 A5 JP 2016178938A5 JP 2016118316 A JP2016118316 A JP 2016118316A JP 2016118316 A JP2016118316 A JP 2016118316A JP 2016178938 A5 JP2016178938 A5 JP 2016178938A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- linking group
- soluble polymer
- glycosyl linking
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 238000000034 method Methods 0.000 claims 22
- 108090000765 processed proteins & peptides Proteins 0.000 claims 21
- 125000003147 glycosyl group Chemical group 0.000 claims 18
- 239000000562 conjugate Substances 0.000 claims 16
- 125000005647 linker group Chemical group 0.000 claims 14
- 229920003169 water-soluble polymer Polymers 0.000 claims 12
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- 108010055629 Glucosyltransferases Proteins 0.000 claims 4
- 102000000340 Glucosyltransferases Human genes 0.000 claims 4
- 108700023372 Glycosyltransferases Proteins 0.000 claims 4
- 102000051366 Glycosyltransferases Human genes 0.000 claims 4
- 150000001720 carbohydrates Chemical class 0.000 claims 4
- 239000002773 nucleotide Substances 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 125000005629 sialic acid group Chemical group 0.000 claims 3
- 102100022641 Coagulation factor IX Human genes 0.000 claims 2
- 102000016911 Deoxyribonucleases Human genes 0.000 claims 2
- 108010053770 Deoxyribonucleases Proteins 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 2
- 108090000790 Enzymes Proteins 0.000 claims 2
- 102000003951 Erythropoietin Human genes 0.000 claims 2
- 108090000394 Erythropoietin Proteins 0.000 claims 2
- 108010076282 Factor IX Proteins 0.000 claims 2
- 108010054218 Factor VIII Proteins 0.000 claims 2
- 102000001690 Factor VIII Human genes 0.000 claims 2
- 108010054265 Factor VIIa Proteins 0.000 claims 2
- 102000012673 Follicle Stimulating Hormone Human genes 0.000 claims 2
- 108010079345 Follicle Stimulating Hormone Proteins 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 2
- 101000976075 Homo sapiens Insulin Proteins 0.000 claims 2
- 102000002265 Human Growth Hormone Human genes 0.000 claims 2
- 108010000521 Human Growth Hormone Proteins 0.000 claims 2
- 239000000854 Human Growth Hormone Substances 0.000 claims 2
- 102000006992 Interferon-alpha Human genes 0.000 claims 2
- 108010047761 Interferon-alpha Proteins 0.000 claims 2
- 102000003996 Interferon-beta Human genes 0.000 claims 2
- 108090000467 Interferon-beta Proteins 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 102000008070 Interferon-gamma Human genes 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 102100020873 Interleukin-2 Human genes 0.000 claims 2
- 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 2
- 206010054094 Tumour necrosis Diseases 0.000 claims 2
- LFTYTUAZOPRMMI-UHFFFAOYSA-N UNPD164450 Natural products O1C(CO)C(O)C(O)C(NC(=O)C)C1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 LFTYTUAZOPRMMI-UHFFFAOYSA-N 0.000 claims 2
- HSCJRCZFDFQWRP-UHFFFAOYSA-N Uridindiphosphoglukose Natural products OC1C(O)C(O)C(CO)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-UHFFFAOYSA-N 0.000 claims 2
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 claims 2
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 108010050122 alpha 1-Antitrypsin Proteins 0.000 claims 2
- 102000015395 alpha 1-Antitrypsin Human genes 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 230000003097 anti-respiratory effect Effects 0.000 claims 2
- 230000000259 anti-tumor effect Effects 0.000 claims 2
- 102000006995 beta-Glucosidase Human genes 0.000 claims 2
- 108010047754 beta-Glucosidase Proteins 0.000 claims 2
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940088598 enzyme Drugs 0.000 claims 2
- 229940105423 erythropoietin Drugs 0.000 claims 2
- 229960004222 factor ix Drugs 0.000 claims 2
- 229940012414 factor viia Drugs 0.000 claims 2
- 229960000301 factor viii Drugs 0.000 claims 2
- 229940028334 follicle stimulating hormone Drugs 0.000 claims 2
- 208000002672 hepatitis B Diseases 0.000 claims 2
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 claims 2
- 229960003130 interferon gamma Drugs 0.000 claims 2
- 229960001388 interferon-beta Drugs 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 2
- 229920000570 polyether Polymers 0.000 claims 2
- 238000006116 polymerization reaction Methods 0.000 claims 2
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 229940124597 therapeutic agent Drugs 0.000 claims 2
- 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 2
- 229960005356 urokinase Drugs 0.000 claims 2
- MVMSCBBUIHUTGJ-UHFFFAOYSA-N 10108-97-1 Natural products C1=2NC(N)=NC(=O)C=2N=CN1C(C(C1O)O)OC1COP(O)(=O)OP(O)(=O)OC1OC(CO)C(O)C(O)C1O MVMSCBBUIHUTGJ-UHFFFAOYSA-N 0.000 claims 1
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 1
- TXCIAUNLDRJGJZ-UHFFFAOYSA-N CMP-N-acetyl neuraminic acid Natural products O1C(C(O)C(O)CO)C(NC(=O)C)C(O)CC1(C(O)=O)OP(O)(=O)OCC1C(O)C(O)C(N2C(N=C(N)C=C2)=O)O1 TXCIAUNLDRJGJZ-UHFFFAOYSA-N 0.000 claims 1
- TXCIAUNLDRJGJZ-BILDWYJOSA-N CMP-N-acetyl-beta-neuraminic acid Chemical compound O1[C@@H]([C@H](O)[C@H](O)CO)[C@H](NC(=O)C)[C@@H](O)C[C@]1(C(O)=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N=C(N)C=C2)=O)O1 TXCIAUNLDRJGJZ-BILDWYJOSA-N 0.000 claims 1
- 108010019236 Fucosyltransferases Proteins 0.000 claims 1
- 102000006471 Fucosyltransferases Human genes 0.000 claims 1
- LQEBEXMHBLQMDB-UHFFFAOYSA-N GDP-L-fucose Natural products OC1C(O)C(O)C(C)OC1OP(O)(=O)OP(O)(=O)OCC1C(O)C(O)C(N2C3=C(C(N=C(N)N3)=O)N=C2)O1 LQEBEXMHBLQMDB-UHFFFAOYSA-N 0.000 claims 1
- MVMSCBBUIHUTGJ-GDJBGNAASA-N GDP-alpha-D-mannose Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H]1O)O)N1C=2N=C(NC(=O)C=2N=C1)N)OP(O)(=O)OP(O)(=O)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]1O MVMSCBBUIHUTGJ-GDJBGNAASA-N 0.000 claims 1
- LQEBEXMHBLQMDB-JGQUBWHWSA-N GDP-beta-L-fucose Chemical compound O[C@H]1[C@H](O)[C@H](O)[C@H](C)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C3=C(C(NC(N)=N3)=O)N=C2)O1 LQEBEXMHBLQMDB-JGQUBWHWSA-N 0.000 claims 1
- 108060003306 Galactosyltransferase Proteins 0.000 claims 1
- 102000030902 Galactosyltransferase Human genes 0.000 claims 1
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 1
- 108010087568 Mannosyltransferases Proteins 0.000 claims 1
- 102000006722 Mannosyltransferases Human genes 0.000 claims 1
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical group CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 claims 1
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 claims 1
- SQVRNKJHWKZAKO-LUWBGTNYSA-N N-acetylneuraminic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)CC(O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-LUWBGTNYSA-N 0.000 claims 1
- 108010066816 Polypeptide N-acetylgalactosaminyltransferase Proteins 0.000 claims 1
- 102000003838 Sialyltransferases Human genes 0.000 claims 1
- 108090000141 Sialyltransferases Proteins 0.000 claims 1
- LFTYTUAZOPRMMI-NESSUJCYSA-N UDP-N-acetyl-alpha-D-galactosamine Chemical compound O1[C@H](CO)[C@H](O)[C@H](O)[C@@H](NC(=O)C)[C@H]1O[P@](O)(=O)O[P@](O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 LFTYTUAZOPRMMI-NESSUJCYSA-N 0.000 claims 1
- LFTYTUAZOPRMMI-CFRASDGPSA-N UDP-N-acetyl-alpha-D-glucosamine Chemical compound O1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](NC(=O)C)[C@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 LFTYTUAZOPRMMI-CFRASDGPSA-N 0.000 claims 1
- 108010090473 UDP-N-acetylglucosamine-peptide beta-N-acetylglucosaminyltransferase Proteins 0.000 claims 1
- CYKLRRKFBPBYEI-KBQKSTHMSA-N UDP-alpha-D-galactosamine Chemical compound O1[C@H](CO)[C@H](O)[C@H](O)[C@@H](N)[C@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 CYKLRRKFBPBYEI-KBQKSTHMSA-N 0.000 claims 1
- HSCJRCZFDFQWRP-ABVWGUQPSA-N UDP-alpha-D-galactose Chemical group O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-ABVWGUQPSA-N 0.000 claims 1
- CYKLRRKFBPBYEI-NQQHDEILSA-N UDP-alpha-D-glucosamine Chemical compound O1[C@H](CO)[C@@H](O)[C@H](O)[C@@H](N)[C@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 CYKLRRKFBPBYEI-NQQHDEILSA-N 0.000 claims 1
- HSCJRCZFDFQWRP-JZMIEXBBSA-N UDP-alpha-D-glucose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OP(O)(=O)OP(O)(=O)OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(=O)C=C2)=O)O1 HSCJRCZFDFQWRP-JZMIEXBBSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 229930182830 galactose Natural products 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 238000005374 membrane filtration Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229950006780 n-acetylglucosamine Drugs 0.000 claims 1
- 229940060155 neuac Drugs 0.000 claims 1
- CERZMXAJYMMUDR-UHFFFAOYSA-N neuraminic acid Natural products NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO CERZMXAJYMMUDR-UHFFFAOYSA-N 0.000 claims 1
- 239000000863 peptide conjugate Substances 0.000 claims 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Applications Claiming Priority (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32852301P | 2001-10-10 | 2001-10-10 | |
| US60/328,523 | 2001-10-10 | ||
| US34469201P | 2001-10-19 | 2001-10-19 | |
| US60/344,692 | 2001-10-19 | ||
| US33430101P | 2001-11-28 | 2001-11-28 | |
| US33423301P | 2001-11-28 | 2001-11-28 | |
| US60/334,233 | 2001-11-28 | ||
| US60/334,301 | 2001-11-28 | ||
| US38729202P | 2002-06-07 | 2002-06-07 | |
| US60/387,292 | 2002-06-07 | ||
| US39177702P | 2002-06-25 | 2002-06-25 | |
| US60/391,777 | 2002-06-25 | ||
| US39659402P | 2002-07-17 | 2002-07-17 | |
| US60/396,594 | 2002-07-17 | ||
| US40424902P | 2002-08-16 | 2002-08-16 | |
| US60/404,249 | 2002-08-16 | ||
| US40752702P | 2002-08-28 | 2002-08-28 | |
| US60/407,527 | 2002-08-28 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014013799A Division JP2014087370A (ja) | 2001-10-10 | 2014-01-28 | ペプチドの改造および複合糖質化 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016178938A JP2016178938A (ja) | 2016-10-13 |
| JP2016178938A5 true JP2016178938A5 (enExample) | 2017-04-27 |
| JP6321724B2 JP6321724B2 (ja) | 2018-05-09 |
Family
ID=27578810
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003534446A Expired - Lifetime JP5232352B2 (ja) | 2001-10-10 | 2002-10-09 | ペプチドの改造および複合糖質化 |
| JP2008297209A Expired - Lifetime JP5376912B2 (ja) | 2001-10-10 | 2008-11-20 | ペプチドの改造および複合糖質化 |
| JP2010024516A Expired - Lifetime JP5258809B2 (ja) | 2001-10-10 | 2010-02-05 | ペプチドの改造および複合糖質化 |
| JP2010217733A Expired - Fee Related JP5739632B2 (ja) | 2001-10-10 | 2010-09-28 | ペプチドの改造および複合糖質化 |
| JP2012106130A Pending JP2012143250A (ja) | 2001-10-10 | 2012-05-07 | ペプチドの改造および複合糖質化 |
| JP2014013799A Ceased JP2014087370A (ja) | 2001-10-10 | 2014-01-28 | ペプチドの改造および複合糖質化 |
| JP2015184218A Expired - Lifetime JP6316784B2 (ja) | 2001-10-10 | 2015-09-17 | ペプチドの改造および複合糖質化 |
| JP2016118316A Expired - Lifetime JP6321724B2 (ja) | 2001-10-10 | 2016-06-14 | ペプチドの改造および複合糖質化 |
Family Applications Before (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003534446A Expired - Lifetime JP5232352B2 (ja) | 2001-10-10 | 2002-10-09 | ペプチドの改造および複合糖質化 |
| JP2008297209A Expired - Lifetime JP5376912B2 (ja) | 2001-10-10 | 2008-11-20 | ペプチドの改造および複合糖質化 |
| JP2010024516A Expired - Lifetime JP5258809B2 (ja) | 2001-10-10 | 2010-02-05 | ペプチドの改造および複合糖質化 |
| JP2010217733A Expired - Fee Related JP5739632B2 (ja) | 2001-10-10 | 2010-09-28 | ペプチドの改造および複合糖質化 |
| JP2012106130A Pending JP2012143250A (ja) | 2001-10-10 | 2012-05-07 | ペプチドの改造および複合糖質化 |
| JP2014013799A Ceased JP2014087370A (ja) | 2001-10-10 | 2014-01-28 | ペプチドの改造および複合糖質化 |
| JP2015184218A Expired - Lifetime JP6316784B2 (ja) | 2001-10-10 | 2015-09-17 | ペプチドの改造および複合糖質化 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US7416858B2 (enExample) |
| EP (14) | EP2279753B1 (enExample) |
| JP (8) | JP5232352B2 (enExample) |
| CN (4) | CN101724075B (enExample) |
| AU (2) | AU2002360264B2 (enExample) |
| BE (2) | BE2014C004I2 (enExample) |
| BR (1) | BRPI0213207B1 (enExample) |
| CA (1) | CA2462930C (enExample) |
| DK (4) | DK2322229T3 (enExample) |
| ES (9) | ES2411007T3 (enExample) |
| FR (2) | FR14C0007I2 (enExample) |
| HK (1) | HK1080090B (enExample) |
| IL (3) | IL161251A0 (enExample) |
| LU (1) | LU92359I2 (enExample) |
| MX (1) | MXPA04003333A (enExample) |
| NL (1) | NL300912I2 (enExample) |
| NZ (1) | NZ532027A (enExample) |
| PT (2) | PT2279753E (enExample) |
| SG (2) | SG177002A1 (enExample) |
| WO (1) | WO2003031464A2 (enExample) |
| ZA (2) | ZA200700168B (enExample) |
Families Citing this family (331)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5581476A (en) * | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| US5545553A (en) * | 1994-09-26 | 1996-08-13 | The Rockefeller University | Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them |
| WO2001045746A2 (en) | 1999-12-24 | 2001-06-28 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| AU2001266557A1 (en) * | 2000-04-12 | 2001-10-23 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| US7625756B2 (en) | 2000-06-28 | 2009-12-01 | GycoFi, Inc. | Expression of class 2 mannosidase and class III mannosidase in lower eukaryotic cells |
| US7863020B2 (en) | 2000-06-28 | 2011-01-04 | Glycofi, Inc. | Production of sialylated N-glycans in lower eukaryotes |
| US7449308B2 (en) | 2000-06-28 | 2008-11-11 | Glycofi, Inc. | Combinatorial DNA library for producing modified N-glycans in lower eukaryotes |
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