ATE304546T1 - Reinigung von kohlenhydraten mittels umkehrosmose und nanofiltration - Google Patents

Reinigung von kohlenhydraten mittels umkehrosmose und nanofiltration

Info

Publication number
ATE304546T1
ATE304546T1 AT97913687T AT97913687T ATE304546T1 AT E304546 T1 ATE304546 T1 AT E304546T1 AT 97913687 T AT97913687 T AT 97913687T AT 97913687 T AT97913687 T AT 97913687T AT E304546 T1 ATE304546 T1 AT E304546T1
Authority
AT
Austria
Prior art keywords
carbohydrates
nanofiltration
reverse osmosis
purification
oligosaccharides
Prior art date
Application number
AT97913687T
Other languages
English (en)
Inventor
Shawn Defrees
Original Assignee
Neose Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neose Technologies Inc filed Critical Neose Technologies Inc
Application granted granted Critical
Publication of ATE304546T1 publication Critical patent/ATE304546T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B30/00Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
    • CCHEMISTRY; METALLURGY
    • C13SUGAR INDUSTRY
    • C13BPRODUCTION OF SUCROSE; APPARATUS SPECIALLY ADAPTED THEREFOR
    • C13B20/00Purification of sugar juices
    • C13B20/16Purification of sugar juices by physical means, e.g. osmosis or filtration
    • C13B20/165Purification of sugar juices by physical means, e.g. osmosis or filtration using membranes, e.g. osmosis, ultrafiltration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B01D61/025Reverse osmosis; Hyperfiltration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B01D61/027Nanofiltration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B01D61/029Multistep processes comprising different kinds of membrane processes selected from reverse osmosis, hyperfiltration or nanofiltration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B01D61/04Feed pretreatment
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003General processes for their isolation or fractionation, e.g. purification or extraction from biomass
    • CCHEMISTRY; METALLURGY
    • C13SUGAR INDUSTRY
    • C13KSACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
    • C13K13/00Sugars not otherwise provided for in this class
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2311/00Details relating to membrane separation process operations and control
    • B01D2311/04Specific process operations in the feed stream; Feed pretreatment
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Saccharide Compounds (AREA)
  • External Artificial Organs (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT97913687T 1996-10-10 1997-10-09 Reinigung von kohlenhydraten mittels umkehrosmose und nanofiltration ATE304546T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2822696P 1996-10-10 1996-10-10
PCT/US1997/018801 WO1998015581A1 (en) 1996-10-10 1997-10-09 Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration

Publications (1)

Publication Number Publication Date
ATE304546T1 true ATE304546T1 (de) 2005-09-15

Family

ID=21842245

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97913687T ATE304546T1 (de) 1996-10-10 1997-10-09 Reinigung von kohlenhydraten mittels umkehrosmose und nanofiltration

Country Status (13)

Country Link
US (4) US6454946B1 (de)
EP (1) EP0931097B1 (de)
JP (1) JP2001502005A (de)
KR (1) KR100490507B1 (de)
AT (1) ATE304546T1 (de)
AU (1) AU735695B2 (de)
CA (1) CA2268168C (de)
DE (1) DE69734205T2 (de)
DK (1) DK0931097T3 (de)
HU (1) HUP0001634A2 (de)
IL (2) IL129363A (de)
NZ (1) NZ335203A (de)
WO (1) WO1998015581A1 (de)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL129363A (en) * 1996-10-10 2003-02-12 Neose Technologies Inc Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration
EP1903114A3 (de) 1997-12-01 2008-07-23 Neose Technologies, Inc. Enzymatische Synthese von Gangliosiden
CN1086391C (zh) * 1998-12-12 2002-06-19 中国科学院新疆化学研究所 低聚糖纯化方法
US6942754B2 (en) 1999-03-23 2005-09-13 Oji Paper Co., Ltd. Process for producing xylooligosaccharide from lignocellulose pulp
US6824646B2 (en) 1999-03-23 2004-11-30 Oji Paper Co., Ltd. Process for oxygen bleaching and enzyme treating lignocellulosic pulp with liquid treatment and recovery
CA2301371C (en) * 1999-03-23 2009-09-01 Oji Paper Co., Ltd. Process for bleaching lignocellulose pulp
WO2001078881A1 (en) * 2000-04-14 2001-10-25 Bryan Richard Tudhope Apparatus and method for isolating and/or eliminating solutes from a solution
US7465398B1 (en) 2000-09-29 2008-12-16 Delta-T Corporation Method for filtering and recovering solids from potato process water
AU2002219304A1 (en) * 2000-12-13 2002-06-24 Institut D'optique Theorique Et Appliquee Method for characterising a surface, and device therefor
US6736903B2 (en) * 2001-04-23 2004-05-18 Sunshine Raisin Corporation Method and apparatus for producing a work product
KR20020085699A (ko) * 2001-05-09 2002-11-16 박영규 단백질의 회전식 평판형 막분리방법 및 장치
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
CA2462930C (en) 2001-10-10 2012-07-10 Shawn De Frees Remodeling and glycoconjugation of peptides
US7214660B2 (en) * 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7795210B2 (en) 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
US8008252B2 (en) 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US6648978B2 (en) 2001-10-15 2003-11-18 A. E. Staley Manufacturing Co. Membrane filtration for thickening and starch washing in corn wet milling
DE60336555D1 (de) 2002-06-21 2011-05-12 Novo Nordisk Healthcare Ag Pegylierte glykoformen von faktor vii
GB0229423D0 (en) 2002-12-18 2003-01-22 Avecia Ltd Process
JP2006519878A (ja) 2003-03-06 2006-08-31 ネオーズ テクノロジーズ, インコーポレイテッド ガングリオシドの酵素合成のための方法および化合物
EP1608688B1 (de) 2003-03-14 2013-02-27 BioGeneriX AG Verzweigte wasserlösliche polymere und konjugate davon
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
US20070026485A1 (en) 2003-04-09 2007-02-01 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
AU2004240553A1 (en) 2003-05-09 2004-12-02 Neose Technologies, Inc. Compositions and methods for the preparation of human growth hormone glycosylation mutants
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
JP2005147788A (ja) * 2003-11-13 2005-06-09 Inst Nuclear Energy Research Rocaec 逆浸透分離法を用いたほう酸純化及び再利用システム及び方法
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US8075780B2 (en) * 2003-11-24 2011-12-13 Millipore Corporation Purification and concentration of synthetic biological molecules
US7956032B2 (en) 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
US7404926B2 (en) * 2003-12-30 2008-07-29 Rhoades Frank G Water treatment system
NZ548123A (en) 2004-01-08 2010-05-28 Novo Nordisk As O-linked glycosylation of peptides
FR2848877B1 (fr) * 2004-01-28 2012-04-20 Applexion Ste Nouvelle De Rech S Et D Applic Ind D Echangeurs D Ions Applexion Procede de purification par nanofiltration d'une solution aqueuse sucree contenant des anions et cations monovalents et polyvalents
ATE516349T1 (de) 2004-02-04 2011-07-15 Novo Nordisk As Verfahren zur rückfaltung von säuger- glycosyltransferasen
US20050287515A1 (en) * 2004-06-24 2005-12-29 Reinhold Deppisch Removal of bacterial DNA from therapeutic fluid formulations
US20080300173A1 (en) 2004-07-13 2008-12-04 Defrees Shawn Branched Peg Remodeling and Glycosylation of Glucagon-Like Peptides-1 [Glp-1]
ITMI20041627A1 (it) * 2004-08-06 2004-11-06 Lachifarma S R L Lab Chimi Co Processo per il recupero di tirosolo idrossitirosolo e altri componenti fenolici da acque di vegetazione e metodo di ossidazione catalitica di tirosolo a idrossitirosolo
WO2006031811A2 (en) 2004-09-10 2006-03-23 Neose Technologies, Inc. Glycopegylated interferon alpha
EP2586456B1 (de) 2004-10-29 2016-01-20 ratiopharm GmbH Umformung und GlycoPEGylierung des Fibroblastenwachstumsfaktors (FGF)
JP4951527B2 (ja) 2005-01-10 2012-06-13 バイオジェネリックス アーゲー 糖peg化顆粒球コロニー刺激因子
US9187546B2 (en) 2005-04-08 2015-11-17 Novo Nordisk A/S Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
WO2006108273A1 (en) 2005-04-11 2006-10-19 National Research Council Of Canada Identification of a beta-1,3-n-acetylgalactosaminyltransferase (cgte) from campylobacter jejuni lio87
WO2006127910A2 (en) 2005-05-25 2006-11-30 Neose Technologies, Inc. Glycopegylated erythropoietin formulations
US20080255026A1 (en) * 2005-05-25 2008-10-16 Glycopegylated Factor 1X Glycopegylated Factor Ix
US8771991B2 (en) 2005-08-11 2014-07-08 National Research Council Of Canada SOAT polypeptide reaction mixture
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
FI120590B (fi) * 2005-10-28 2009-12-15 Danisco Sweeteners Oy Erotusmenetelmä
WO2007056191A2 (en) * 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
CA2628225C (en) 2005-11-04 2014-06-17 Hans Henrik Holst A concentrate derived from a milk product enriched in naturally occurring sialyllactose and a process for preparation thereof
US20080248959A1 (en) 2006-07-21 2008-10-09 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
JP2010505874A (ja) 2006-10-03 2010-02-25 ノヴォ ノルディスク アー/エス ポリペプチドコンジュゲートの精製方法
WO2008060780A2 (en) 2006-10-04 2008-05-22 Novo Nordisk A/S Glycerol linked pegylated sugars and glycopeptides
KR100888513B1 (ko) * 2006-12-15 2009-03-12 주식회사 진켐 신규 n―아세틸글루코사민―2―에피머라아제 및 이를이용한 cmp―n―아세틸뉴라민산의 제조방법
AU2008237411B2 (en) 2007-04-03 2013-10-03 Ratiopharm Gmbh Methods of treatment using glycopegylated G-CSF
WO2008154639A2 (en) * 2007-06-12 2008-12-18 Neose Technologies, Inc. Improved process for the production of nucleotide sugars
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
DK176760B1 (da) 2007-10-03 2009-06-29 Arla Foods Amba Process for producing lactose-free milk
WO2009108806A1 (en) 2008-02-27 2009-09-03 Novo Nordisk A/S Conjugated factor viii molecules
US8147735B2 (en) * 2008-07-09 2012-04-03 Eltron Research & Development, Inc. Semipermeable polymers and method for producing same
DK2371973T3 (en) * 2008-12-09 2015-04-20 Toray Industries A process for preparing a sugar liquid
EP2410846B1 (de) 2009-03-25 2016-09-07 Seneb Biosciences, Inc. Glycolipide zur behandlung von erkrankungen
JP5641598B2 (ja) * 2009-09-29 2014-12-17 雪印メグミルク株式会社 シアリルラクトース素材の分離方法
DE102010053749B4 (de) * 2010-12-08 2015-02-19 Airbus Defence and Space GmbH Vorrichtung zum Identifizieren biotischer Partikel
JP6363017B2 (ja) * 2011-09-01 2018-07-25 中外製薬株式会社 限外ろ過によって高度に濃縮された抗体を含む組成物を調製するための方法
EP2596852A1 (de) * 2011-11-28 2013-05-29 Annikki GmbH Verfahren zur Aufarbeitung einer wässerigen, Lignin-enthaltenden Lösung mittels Nanofiltration
CN102532208B (zh) * 2012-01-06 2014-10-29 南京工业大学 一种连续分离唾液酸的方法
ITMI20121184A1 (it) * 2012-07-05 2014-01-06 Altergon Italia Srl Processo per la produzione industriale di ialuronato di sodio (hana) altamente purificato a peso molecolare controllato
EP2857410A1 (de) 2013-10-04 2015-04-08 Jennewein Biotechnologie GmbH Verfahren zur Reinigung von 2´-Fucosyllactose unter Verwendung simulierter Wanderbettchromatografie
EP2896628B1 (de) 2014-01-20 2018-09-19 Jennewein Biotechnologie GmbH Verfahren zur effizienten Reinigung von neutralen humanen Milch-Oligosacchariden (HMOs) aus mikrobieller Fermentation
WO2016009146A1 (fr) 2014-07-18 2016-01-21 Roquette Freres Procede d'extraction des proteines solubles de biomasses de microalgues
GB201414213D0 (en) * 2014-08-11 2014-09-24 Imp Innovations Ltd Filtration process
MY186792A (en) 2016-02-04 2021-08-20 Ind Tech Res Inst Method for separating hydrolysis product of biomass
US10899782B2 (en) 2016-03-07 2021-01-26 Glycom A/S Separation of oligosaccharides from fermentation broth
EP3445770B1 (de) * 2016-04-19 2025-11-26 Glycom A/S Trennung von oligosacchariden aus fermentationsbrühe
US11160298B1 (en) * 2016-05-20 2021-11-02 Thermolife International, Llc Methods of producing decolorized beet products and compositions produced therefrom
EP3490567A4 (de) 2016-07-28 2020-03-18 Fonterra Co-Operative Group Limited Molkereiprodukt und molkereiverfahren
US11206851B2 (en) * 2017-01-17 2021-12-28 Zea 10, LLC Process for producing protein concentrate or isolate and cellulosic thermochemical feedstock from brewers spent grains
WO2019003136A1 (en) * 2017-06-30 2019-01-03 Glycom A/S SYNTHESIS OF OLIGOSACCHARIDES
EP3450443A1 (de) 2017-08-29 2019-03-06 Jennewein Biotechnologie GmbH Verfahren zur reinigung sialylierter oligosaccharide
US11180740B2 (en) 2018-04-23 2021-11-23 Danisco Us Inc Synthesis of glucan comprising beta-1,3 glycosidic linkages with beta-1,3-glucan phosphorylase enzymes
WO2019215073A1 (en) * 2018-05-07 2019-11-14 Jennewein Biotechnologie Gmbh A SIMPLE METHOD FOR THE PURIFICATION OF LACTO-N-NEOTETRAOSE (LNnT) FROM CARBOHYDRATES OBTAINED BY MICROBIAL FERMENTATION
KR102837674B1 (ko) 2018-06-01 2025-07-23 크리스찬 한센 에이치엠오 게엠베하 시알릴락토스의 정제를 위한 간단한 방법
EP3686210A1 (de) * 2019-01-24 2020-07-29 DuPont Nutrition Biosciences ApS Verfahren zur reinigung eines muttermilch-oligosaccharids und zugehörige zusammensetzungen
EP3925689A1 (de) * 2020-06-16 2021-12-22 Prayon Verfahren zur reinigung einer phosphat enthaltenden sauren lösung, die verunreinigungen enthält, und vorrichtung zu deren anwendung
KR102867966B1 (ko) 2022-04-26 2025-10-13 (주)에코샤인 연속 생산이 가능한 한외여과 분리정제 장비
KR20250157863A (ko) 2024-04-29 2025-11-05 (주)에코샤인 Rna 백신용 lnp 대량 정제를 위한 tff 글라스 멤브레인 필터

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230463A (en) 1977-09-13 1980-10-28 Monsanto Company Multicomponent membranes for gas separations
US4259183A (en) 1978-11-07 1981-03-31 Midwest Research Institute Reverse osmosis membrane
CA1229530A (fr) 1983-09-06 1987-11-24 Jean-Andre Alary Procede de fabrication d'un element de microfiltration, d'ultrafiltration ou d'osmose inverse
DE3623796A1 (de) 1986-07-15 1988-01-28 Dow Chemical Rheinwerk Gmbh Vorrichtung und adsorptionsverfahren zur selektiven entfernung von ionen aus fluessigkeiten
US4692354A (en) 1986-08-12 1987-09-08 Masashi Asaeda Method for preparing ceramic membrane for separation of condensed component
US4741823A (en) 1986-12-23 1988-05-03 Osmonics, Inc. Flow control manifold for cross-flow membrane system
US4839037A (en) 1987-03-09 1989-06-13 Osmonics, Inc. Tapered, spirally wound filter cartridge and method of making same
US4956458A (en) 1988-05-13 1990-09-11 Warner-Lambert Company Purification of polydextrose by reverse osmosis
JP2805490B2 (ja) 1989-02-07 1998-09-30 雪印乳業株式会社 細菌毒素中和剤
DK165769C (da) * 1989-09-22 1993-06-14 Danisco Fremgangsmaade til fremstilling af en blanding af sakkarider og anvendelse af blandingen ved fremstilling af et kaloriefattigt levnedsmiddel
JPH03133387A (ja) * 1989-10-19 1991-06-06 Nichiden Kagaku Kk マルトオリゴ糖の製造方法
JP2802654B2 (ja) * 1989-10-30 1998-09-24 雪印乳業株式会社 ホエーの脱塩時に生ずる陰イオン交換樹脂のアルカリ洗浄廃液からのオリゴ糖結合型シアル酸類の回収方法
CA2038485A1 (en) * 1990-03-23 1991-09-24 Donald K. Hadden Nanofiltration process for making dextrose
JPH04108395A (ja) * 1990-08-28 1992-04-09 Higeta Shoyu Kk ガラクトサミノオリゴ糖の製造方法
IL99245A0 (en) 1990-09-04 1992-07-15 Taiyo Kagaku Kk Method for production of sialic acid
AU635352B2 (en) * 1990-11-09 1993-03-18 Applied Membrane Systems Pty Ltd A method and apparatus for fractionation of sugar containing solution
US5164374A (en) 1990-12-17 1992-11-17 Monsanto Company Use of oligosaccharides for treatment of arthritis
US5352670A (en) 1991-06-10 1994-10-04 Alberta Research Council Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides
DE69215854T2 (de) * 1991-10-15 1997-05-15 Nutrasweet Co Zuckerabtrennung in säften
JPH05168490A (ja) * 1991-12-20 1993-07-02 Fushimi Seiyakushiyo:Kk 生理活性ペクチンオリゴマーの製造方法及び使用方法
JPH0686684A (ja) 1992-05-26 1994-03-29 Monsanto Co シアロ抱合体の合成
ATE427968T1 (de) * 1992-08-21 2009-04-15 Univ Bruxelles Immunoglobuline ohne leichtkette
US5374541A (en) 1993-05-04 1994-12-20 The Scripps Research Institute Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides
AU691510B2 (en) 1993-07-15 1998-05-21 Neose Pharmaceuticals Method of synthesizing saccharide compositions
BE1007425A3 (nl) 1993-08-30 1995-06-13 Holland Sweetener Co Werkwijze en inrichting voor de terugwinning van grondstoffen in het aspartaambereidingsproces.
AU8129394A (en) 1993-10-28 1995-05-22 Valeriy S. Maisotsenko Method of determining working media motion and designing flow structures for same
AU3823195A (en) 1994-09-12 1996-03-29 Aeci Limited Process for recovering citric acid
US6030815A (en) * 1995-04-11 2000-02-29 Neose Technologies, Inc. Enzymatic synthesis of oligosaccharides
US5728554A (en) * 1995-04-11 1998-03-17 Cytel Corporation Enzymatic synthesis of glycosidic linkages
US5876980A (en) 1995-04-11 1999-03-02 Cytel Corporation Enzymatic synthesis of oligosaccharides
US5676980A (en) * 1995-09-29 1997-10-14 Continental General Tire, Inc. Center split segmented mold for curing pneumatic tires
IL129363A (en) * 1996-10-10 2003-02-12 Neose Technologies Inc Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration
US6288222B1 (en) * 2000-02-16 2001-09-11 Neose Technologies, Inc. Method of filtration of a dairy stream

Also Published As

Publication number Publication date
CA2268168A1 (en) 1998-04-16
WO1998015581A1 (en) 1998-04-16
AU735695B2 (en) 2001-07-12
HUP0001634A2 (hu) 2000-09-28
IL149275A (en) 2007-07-04
US20050269265A1 (en) 2005-12-08
DE69734205D1 (de) 2005-10-20
DE69734205T2 (de) 2006-07-06
US6454946B1 (en) 2002-09-24
EP0931097A1 (de) 1999-07-28
NZ335203A (en) 2000-10-27
AU5081698A (en) 1998-05-05
JP2001502005A (ja) 2001-02-13
EP0931097A4 (de) 2000-01-12
IL129363A (en) 2003-02-12
US20030029799A1 (en) 2003-02-13
US6936173B2 (en) 2005-08-30
DK0931097T3 (da) 2006-01-16
KR100490507B1 (ko) 2005-05-19
EP0931097B1 (de) 2005-09-14
CA2268168C (en) 2008-04-29
IL129363A0 (en) 2000-02-17
KR20000049057A (ko) 2000-07-25
US20020148791A1 (en) 2002-10-17

Similar Documents

Publication Publication Date Title
ATE304546T1 (de) Reinigung von kohlenhydraten mittels umkehrosmose und nanofiltration
NO985427L (no) Modulatorer for vevsregenerering
WO2003104418A3 (en) Reconstituted polypeptides
BR9714517A (pt) Cicloalquila, lactama, lactona e compostos correlatos, composições farmacêuticas compreendendo os mesmos e processos para inibir liberação de peptìdeo beta-amilóide e/ou sua sìntese por uso de tais compostos
DE69924375D1 (de) Verwendung von optisch reinem (+)-norcisapride für die behandlung des reizdarmsyndroms
GB0216001D0 (en) Process and composition
DK0891302T3 (da) Fremgangsmåde til biologisk rensning af spildevand
DE50208601D1 (de) Verfahren zur aufreinigung von bakterienzellen und zellbestandteilen
AU7303301A (en) Isolated nucleic acid molecules which encode t cell inducible factors, or interleukin-21, the proteins encoded, and uses thereof
DK1060134T3 (da) Fremgangsmåde og indretning til behandling af vandige strømme i en bioreaktor, en ultrafiltreringsenhed og en membranfiltreringsenhed
ATE432946T1 (de) Abtrennung von fibrinogen von plasmaproteasen
AU2001260077A1 (en) Microfiltration using activated carbon
FI20002866A0 (fi) Menetelmä maltoosin puhdistamiseksi
DK1080040T3 (da) Fremgangsmåde til oprensning af vand
ES2193760T3 (es) Procedimiento de tratamiento de lactamas y procedimiento de purificacionde una lactama.
ZA958609B (en) Method for purifying keratinocyte growth factors
GB0016362D0 (en) Tetraspanin modulation
WO1995017418A3 (en) NOVEL INTERMEDIATES FOR THE SYNTHESIS OF L-ASPARTYL-D-α-AMINOALKANOYL-(S)-N-α-ALKYLBENZYL AMIDES USEFUL AS ARTIFICIAL SWEETENERS
NZ512546A (en) Use of actylcholine esterase inhibitors to treat delirium
SE9702993D0 (sv) Anti-mikrobial komposition
SE9804029D0 (sv) Adsorption av ftalater
WO1999051531A8 (en) Waste treatment system and method
WO2003057852A3 (en) Purification and characterization of hla proteins
IT1298303B1 (it) Procedimento biologico per la depurazione di acque inquinate, in particolare mediante fermentazione
HUT35217A (en) Process for sewage purification

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0931097

Country of ref document: EP

REN Ceased due to non-payment of the annual fee