DE69734205D1 - Reinigung von kohlenhydraten mittels umkehrosmose und nanofiltration - Google Patents

Reinigung von kohlenhydraten mittels umkehrosmose und nanofiltration

Info

Publication number
DE69734205D1
DE69734205D1 DE69734205T DE69734205T DE69734205D1 DE 69734205 D1 DE69734205 D1 DE 69734205D1 DE 69734205 T DE69734205 T DE 69734205T DE 69734205 T DE69734205 T DE 69734205T DE 69734205 D1 DE69734205 D1 DE 69734205D1
Authority
DE
Germany
Prior art keywords
carbohydrates
nanofiltration
reverse osmosis
cleaning
oligosaccharides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69734205T
Other languages
English (en)
Other versions
DE69734205T2 (de
Inventor
Shawn Defrees
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neose Technologies Inc
Original Assignee
Neose Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neose Technologies Inc filed Critical Neose Technologies Inc
Application granted granted Critical
Publication of DE69734205D1 publication Critical patent/DE69734205D1/de
Publication of DE69734205T2 publication Critical patent/DE69734205T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B30/00Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
    • CCHEMISTRY; METALLURGY
    • C13SUGAR INDUSTRY
    • C13BPRODUCTION OF SUCROSE; APPARATUS SPECIALLY ADAPTED THEREFOR
    • C13B20/00Purification of sugar juices
    • C13B20/16Purification of sugar juices by physical means, e.g. osmosis or filtration
    • C13B20/165Purification of sugar juices by physical means, e.g. osmosis or filtration using membranes, e.g. osmosis, ultrafiltration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B01D61/025Reverse osmosis; Hyperfiltration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B01D61/027Nanofiltration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B01D61/029Multistep processes comprising different kinds of membrane processes selected from reverse osmosis, hyperfiltration or nanofiltration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B01D61/04Feed pretreatment
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0003General processes for their isolation or fractionation, e.g. purification or extraction from biomass
    • CCHEMISTRY; METALLURGY
    • C13SUGAR INDUSTRY
    • C13KSACCHARIDES OBTAINED FROM NATURAL SOURCES OR BY HYDROLYSIS OF NATURALLY OCCURRING DISACCHARIDES, OLIGOSACCHARIDES OR POLYSACCHARIDES
    • C13K13/00Sugars not otherwise provided for in this class
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2311/00Details relating to membrane separation process operations and control
    • B01D2311/04Specific process operations in the feed stream; Feed pretreatment
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Nanotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • External Artificial Organs (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DE69734205T 1996-10-10 1997-10-09 Reinigung von kohlenhydraten mittels umkehrosmose und nanofiltration Expired - Fee Related DE69734205T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2822696P 1996-10-10 1996-10-10
US28226P 1996-10-10
PCT/US1997/018801 WO1998015581A1 (en) 1996-10-10 1997-10-09 Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration

Publications (2)

Publication Number Publication Date
DE69734205D1 true DE69734205D1 (de) 2005-10-20
DE69734205T2 DE69734205T2 (de) 2006-07-06

Family

ID=21842245

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69734205T Expired - Fee Related DE69734205T2 (de) 1996-10-10 1997-10-09 Reinigung von kohlenhydraten mittels umkehrosmose und nanofiltration

Country Status (13)

Country Link
US (4) US6454946B1 (de)
EP (1) EP0931097B1 (de)
JP (1) JP2001502005A (de)
KR (1) KR100490507B1 (de)
AT (1) ATE304546T1 (de)
AU (1) AU735695B2 (de)
CA (1) CA2268168C (de)
DE (1) DE69734205T2 (de)
DK (1) DK0931097T3 (de)
HU (1) HUP0001634A2 (de)
IL (2) IL129363A (de)
NZ (1) NZ335203A (de)
WO (1) WO1998015581A1 (de)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6454946B1 (en) * 1996-10-10 2002-09-24 Neose Technologies, Inc. Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration
EP1903114A3 (de) 1997-12-01 2008-07-23 Neose Technologies, Inc. Enzymatische Synthese von Gangliosiden
CN1086391C (zh) * 1998-12-12 2002-06-19 中国科学院新疆化学研究所 低聚糖纯化方法
US6942754B2 (en) 1999-03-23 2005-09-13 Oji Paper Co., Ltd. Process for producing xylooligosaccharide from lignocellulose pulp
US6824646B2 (en) 1999-03-23 2004-11-30 Oji Paper Co., Ltd. Process for oxygen bleaching and enzyme treating lignocellulosic pulp with liquid treatment and recovery
CA2627846C (en) * 1999-03-23 2011-01-04 Oji Paper Co., Ltd. Process for bleaching lignocellulose pulp
WO2001078881A1 (en) * 2000-04-14 2001-10-25 Bryan Richard Tudhope Apparatus and method for isolating and/or eliminating solutes from a solution
US7465398B1 (en) 2000-09-29 2008-12-16 Delta-T Corporation Method for filtering and recovering solids from potato process water
CA2431399C (fr) * 2000-12-13 2009-04-28 Institut D'optique Theorique Et Appliquee Procede de caracterisation d'une surface, et dispositif pour sa mise en oeuvre
US6736903B2 (en) * 2001-04-23 2004-05-18 Sunshine Raisin Corporation Method and apparatus for producing a work product
KR20020085699A (ko) * 2001-05-09 2002-11-16 박영규 단백질의 회전식 평판형 막분리방법 및 장치
US7214660B2 (en) * 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US8008252B2 (en) 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
EP2292273A3 (de) 2001-10-10 2011-11-23 BioGeneriX AG Remodellierung und Glycokonjugation von Peptiden
CN101724075B (zh) 2001-10-10 2014-04-30 诺和诺德公司 肽的重构和糖缀合
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7795210B2 (en) 2001-10-10 2010-09-14 Novo Nordisk A/S Protein remodeling methods and proteins/peptides produced by the methods
WO2004099231A2 (en) 2003-04-09 2004-11-18 Neose Technologies, Inc. Glycopegylation methods and proteins/peptides produced by the methods
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
US6648978B2 (en) * 2001-10-15 2003-11-18 A. E. Staley Manufacturing Co. Membrane filtration for thickening and starch washing in corn wet milling
MXPA04012496A (es) 2002-06-21 2005-09-12 Novo Nordisk Healthcare Ag Glicoformos del factor vii pegilados.
GB0229423D0 (en) 2002-12-18 2003-01-22 Avecia Ltd Process
MXPA05009480A (es) 2003-03-06 2006-02-22 Neose Technologies Inc Metodos y composiciones para la sintesis enzimatica de gangliosidos.
CA2519092C (en) 2003-03-14 2014-08-05 Neose Technologies, Inc. Branched water-soluble polymers and their conjugates
US8791070B2 (en) 2003-04-09 2014-07-29 Novo Nordisk A/S Glycopegylated factor IX
AU2004240553A1 (en) 2003-05-09 2004-12-02 Neose Technologies, Inc. Compositions and methods for the preparation of human growth hormone glycosylation mutants
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
JP2005147788A (ja) * 2003-11-13 2005-06-09 Inst Nuclear Energy Research Rocaec 逆浸透分離法を用いたほう酸純化及び再利用システム及び方法
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
US7842661B2 (en) 2003-11-24 2010-11-30 Novo Nordisk A/S Glycopegylated erythropoietin formulations
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US8075780B2 (en) * 2003-11-24 2011-12-13 Millipore Corporation Purification and concentration of synthetic biological molecules
US7956032B2 (en) 2003-12-03 2011-06-07 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
US20060040856A1 (en) 2003-12-03 2006-02-23 Neose Technologies, Inc. Glycopegylated factor IX
US7404926B2 (en) * 2003-12-30 2008-07-29 Rhoades Frank G Water treatment system
NZ548123A (en) 2004-01-08 2010-05-28 Novo Nordisk As O-linked glycosylation of peptides
FR2848877B1 (fr) * 2004-01-28 2012-04-20 Applexion Ste Nouvelle De Rech S Et D Applic Ind D Echangeurs D Ions Applexion Procede de purification par nanofiltration d'une solution aqueuse sucree contenant des anions et cations monovalents et polyvalents
AU2005222782B2 (en) 2004-02-04 2010-06-17 Ratiopharm Gmbh Methods of refolding mammalian glycosyltransferases
US20050287515A1 (en) * 2004-06-24 2005-12-29 Reinhold Deppisch Removal of bacterial DNA from therapeutic fluid formulations
EP1771066A2 (de) 2004-07-13 2007-04-11 Neose Technologies, Inc. Remodellierung von verzweigtem peg und klykolysierung von glucagonähnlichem peptide-1 glp-1
ITMI20041627A1 (it) * 2004-08-06 2004-11-06 Lachifarma S R L Lab Chimi Co Processo per il recupero di tirosolo idrossitirosolo e altri componenti fenolici da acque di vegetazione e metodo di ossidazione catalitica di tirosolo a idrossitirosolo
EP1799249A2 (de) 2004-09-10 2007-06-27 Neose Technologies, Inc. Glycopegyliertes interferon alpha
US20080176790A1 (en) 2004-10-29 2008-07-24 Defrees Shawn Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf)
US9029331B2 (en) 2005-01-10 2015-05-12 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
EP1871795A4 (de) 2005-04-08 2010-03-31 Biogenerix Ag Zusammensetzungen und verfahren zur herstellung von glycosylierungsmutanten eines proteaseresistenten menschlichen wachstumshormons
ATE526412T1 (de) 2005-04-11 2011-10-15 Ca Nat Research Council Identifizierung einer beta-1,3-n- acetylgalactosaminyltransferase (cgte) aus campylobacter jejuni lio87
JP5216580B2 (ja) * 2005-05-25 2013-06-19 ノヴォ ノルディスク アー/エス グリコペグ化第ix因子
US8771991B2 (en) 2005-08-11 2014-07-08 National Research Council Of Canada SOAT polypeptide reaction mixture
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
FI120590B (fi) * 2005-10-28 2009-12-15 Danisco Sweeteners Oy Erotusmenetelmä
WO2007056191A2 (en) * 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
AU2006310880B2 (en) * 2005-11-04 2012-06-28 Arla Foods Amba A concentrate derived from a milk product enriched in naturally occurring sialyllactose and a process for preparation thereof
US20080242607A1 (en) 2006-07-21 2008-10-02 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
US20100075375A1 (en) 2006-10-03 2010-03-25 Novo Nordisk A/S Methods for the purification of polypeptide conjugates
JP5457185B2 (ja) 2006-10-04 2014-04-02 ノヴォ ノルディスク アー/エス グリセロール連結のpeg化された糖および糖ペプチド
KR100888513B1 (ko) * 2006-12-15 2009-03-12 주식회사 진켐 신규 n―아세틸글루코사민―2―에피머라아제 및 이를이용한 cmp―n―아세틸뉴라민산의 제조방법
DK2144923T3 (da) 2007-04-03 2013-05-13 Biogenerix Ag Behandlingsfremgangsmåder under anvendelse af glycopegyleret g-csf
WO2008154639A2 (en) * 2007-06-12 2008-12-18 Neose Technologies, Inc. Improved process for the production of nucleotide sugars
US8207112B2 (en) 2007-08-29 2012-06-26 Biogenerix Ag Liquid formulation of G-CSF conjugate
DK176760B1 (da) 2007-10-03 2009-06-29 Arla Foods Amba Process for producing lactose-free milk
CA2715465C (en) 2008-02-27 2017-03-21 Novo Nordisk A/S Conjugated factor viii molecules
US8147735B2 (en) * 2008-07-09 2012-04-03 Eltron Research & Development, Inc. Semipermeable polymers and method for producing same
WO2010067785A1 (ja) * 2008-12-09 2010-06-17 東レ株式会社 糖液の製造方法
WO2010111530A1 (en) 2009-03-25 2010-09-30 Seneb Biosciences, Inc. Glycolipids as treatment for disease
JP5641598B2 (ja) * 2009-09-29 2014-12-17 雪印メグミルク株式会社 シアリルラクトース素材の分離方法
DE102010053749B4 (de) * 2010-12-08 2015-02-19 Airbus Defence and Space GmbH Vorrichtung zum Identifizieren biotischer Partikel
CN103889555B (zh) * 2011-09-01 2018-10-26 中外制药株式会社 通过超滤制备包含高度浓缩的抗体的组合物的方法
EP2596852A1 (de) * 2011-11-28 2013-05-29 Annikki GmbH Verfahren zur Aufarbeitung einer wässerigen, Lignin-enthaltenden Lösung mittels Nanofiltration
CN102532208B (zh) * 2012-01-06 2014-10-29 南京工业大学 一种连续分离唾液酸的方法
ITMI20121184A1 (it) * 2012-07-05 2014-01-06 Altergon Italia Srl Processo per la produzione industriale di ialuronato di sodio (hana) altamente purificato a peso molecolare controllato
EP2857410A1 (de) 2013-10-04 2015-04-08 Jennewein Biotechnologie GmbH Verfahren zur Reinigung von 2´-Fucosyllactose unter Verwendung simulierter Wanderbettchromatografie
PL2896628T3 (pl) 2014-01-20 2019-03-29 Jennewein Biotechnologie Gmbh Sposób wydajnego oczyszczania obojętnych oligosacharydów ludzkiego mleka (HMO) z fermentacji mikrobiologicznej
BR112017000805B1 (pt) 2014-07-18 2023-04-11 Corbion Biotech, Inc Método para preparar um isolado proteico da biomassa de microalgas do gênero chlorella
GB201414213D0 (en) * 2014-08-11 2014-09-24 Imp Innovations Ltd Filtration process
MY186792A (en) 2016-02-04 2021-08-20 Ind Tech Res Inst Method for separating hydrolysis product of biomass
US10899782B2 (en) 2016-03-07 2021-01-26 Glycom A/S Separation of oligosaccharides from fermentation broth
US11312741B2 (en) 2016-04-19 2022-04-26 Glycom A/S Separation of oligosaccharides from fermentation broth
US11160298B1 (en) * 2016-05-20 2021-11-02 Thermolife International, Llc Methods of producing decolorized beet products and compositions produced therefrom
JP2019523278A (ja) 2016-07-28 2019-08-22 フォンテラ コ−オペレイティブ グループ リミティド 乳製品およびプロセス
US11206851B2 (en) * 2017-01-17 2021-12-28 Zea 10, LLC Process for producing protein concentrate or isolate and cellulosic thermochemical feedstock from brewers spent grains
US12065462B2 (en) 2017-06-30 2024-08-20 Glycom A/S Purification of oligosaccharides
EP3450443A1 (de) * 2017-08-29 2019-03-06 Jennewein Biotechnologie GmbH Verfahren zur reinigung sialylierter oligosaccharide
US11180740B2 (en) 2018-04-23 2021-11-23 Danisco Us Inc Synthesis of glucan comprising beta-1,3 glycosidic linkages with beta-1,3-glucan phosphorylase enzymes
EP3790413A1 (de) 2018-05-07 2021-03-17 Jennewein Biotechnologie GmbH Einfaches verfahren zur reinigung von lacto-n-neotetraose (lnnt) aus durch mikrobielle fermentation erhaltenen kohlenhydraten
FI3801037T3 (fi) * 2018-06-01 2023-01-13 Yksinkertainen menetelmä sialylaktooinin puhdistamiseen
EP3686210A1 (de) * 2019-01-24 2020-07-29 DuPont Nutrition Biosciences ApS Verfahren zur reinigung eines muttermilch-oligosaccharids und zugehörige zusammensetzungen
KR20230151745A (ko) 2022-04-26 2023-11-02 (주)에코샤인 연속 생산이 가능한 한외여과 분리정제 장비

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4230463A (en) 1977-09-13 1980-10-28 Monsanto Company Multicomponent membranes for gas separations
US4259183A (en) 1978-11-07 1981-03-31 Midwest Research Institute Reverse osmosis membrane
CA1229530A (fr) 1983-09-06 1987-11-24 Jean-Andre Alary Procede de fabrication d'un element de microfiltration, d'ultrafiltration ou d'osmose inverse
DE3623796A1 (de) 1986-07-15 1988-01-28 Dow Chemical Rheinwerk Gmbh Vorrichtung und adsorptionsverfahren zur selektiven entfernung von ionen aus fluessigkeiten
US4692354A (en) 1986-08-12 1987-09-08 Masashi Asaeda Method for preparing ceramic membrane for separation of condensed component
US4741823A (en) 1986-12-23 1988-05-03 Osmonics, Inc. Flow control manifold for cross-flow membrane system
US4839037A (en) 1987-03-09 1989-06-13 Osmonics, Inc. Tapered, spirally wound filter cartridge and method of making same
US4956458A (en) 1988-05-13 1990-09-11 Warner-Lambert Company Purification of polydextrose by reverse osmosis
JP2805490B2 (ja) 1989-02-07 1998-09-30 雪印乳業株式会社 細菌毒素中和剤
DK165769C (da) * 1989-09-22 1993-06-14 Danisco Fremgangsmaade til fremstilling af en blanding af sakkarider og anvendelse af blandingen ved fremstilling af et kaloriefattigt levnedsmiddel
JPH03133387A (ja) * 1989-10-19 1991-06-06 Nichiden Kagaku Kk マルトオリゴ糖の製造方法
JP2802654B2 (ja) * 1989-10-30 1998-09-24 雪印乳業株式会社 ホエーの脱塩時に生ずる陰イオン交換樹脂のアルカリ洗浄廃液からのオリゴ糖結合型シアル酸類の回収方法
CA2038485A1 (en) 1990-03-23 1991-09-24 Donald K. Hadden Nanofiltration process for making dextrose
JPH04108395A (ja) * 1990-08-28 1992-04-09 Higeta Shoyu Kk ガラクトサミノオリゴ糖の製造方法
IL99245A0 (en) * 1990-09-04 1992-07-15 Taiyo Kagaku Kk Method for production of sialic acid
AU635352B2 (en) 1990-11-09 1993-03-18 Applied Membrane Systems Pty Ltd A method and apparatus for fractionation of sugar containing solution
US5164374A (en) 1990-12-17 1992-11-17 Monsanto Company Use of oligosaccharides for treatment of arthritis
US5352670A (en) 1991-06-10 1994-10-04 Alberta Research Council Methods for the enzymatic synthesis of alpha-sialylated oligosaccharide glycosides
CA2097318A1 (en) * 1991-10-15 1993-04-16 Ronald George Bray Sugar separation from juices
JPH05168490A (ja) * 1991-12-20 1993-07-02 Fushimi Seiyakushiyo:Kk 生理活性ペクチンオリゴマーの製造方法及び使用方法
JPH0686684A (ja) 1992-05-26 1994-03-29 Monsanto Co シアロ抱合体の合成
EP2192131A1 (de) * 1992-08-21 2010-06-02 Vrije Universiteit Brussel Immunglobuline ohne Leichtkette
US5374541A (en) 1993-05-04 1994-12-20 The Scripps Research Institute Combined use of β-galactosidase and sialyltransferase coupled with in situ regeneration of CMP-sialic acid for one pot synthesis of oligosaccharides
WO1995002683A1 (en) 1993-07-15 1995-01-26 Neose Pharmaceuticals Method of synthesizing saccharide compositions
BE1007425A3 (nl) 1993-08-30 1995-06-13 Holland Sweetener Co Werkwijze en inrichting voor de terugwinning van grondstoffen in het aspartaambereidingsproces.
EP0727073A4 (de) 1993-10-28 1998-08-26 Valeriy S Maisotsenko Verfahren zur bestimmung von arbeitsmittelbewegung und zum entwerfen von strömungsstrukturen dafür
ES2173976T3 (es) 1994-09-12 2002-11-01 Aeci Ltd Procedimiento para recuperar acido citrico.
US5728554A (en) * 1995-04-11 1998-03-17 Cytel Corporation Enzymatic synthesis of glycosidic linkages
US6030815A (en) * 1995-04-11 2000-02-29 Neose Technologies, Inc. Enzymatic synthesis of oligosaccharides
US5876980A (en) 1995-04-11 1999-03-02 Cytel Corporation Enzymatic synthesis of oligosaccharides
US5676980A (en) * 1995-09-29 1997-10-14 Continental General Tire, Inc. Center split segmented mold for curing pneumatic tires
US6454946B1 (en) * 1996-10-10 2002-09-24 Neose Technologies, Inc. Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration
US6288222B1 (en) * 2000-02-16 2001-09-11 Neose Technologies, Inc. Method of filtration of a dairy stream

Also Published As

Publication number Publication date
CA2268168A1 (en) 1998-04-16
AU5081698A (en) 1998-05-05
DE69734205T2 (de) 2006-07-06
EP0931097B1 (de) 2005-09-14
US6936173B2 (en) 2005-08-30
IL149275A (en) 2007-07-04
US20030029799A1 (en) 2003-02-13
US20050269265A1 (en) 2005-12-08
IL129363A (en) 2003-02-12
US6454946B1 (en) 2002-09-24
KR100490507B1 (ko) 2005-05-19
IL129363A0 (en) 2000-02-17
HUP0001634A2 (hu) 2000-09-28
JP2001502005A (ja) 2001-02-13
EP0931097A4 (de) 2000-01-12
KR20000049057A (ko) 2000-07-25
CA2268168C (en) 2008-04-29
ATE304546T1 (de) 2005-09-15
NZ335203A (en) 2000-10-27
DK0931097T3 (da) 2006-01-16
AU735695B2 (en) 2001-07-12
EP0931097A1 (de) 1999-07-28
WO1998015581A1 (en) 1998-04-16
US20020148791A1 (en) 2002-10-17

Similar Documents

Publication Publication Date Title
DE69734205D1 (de) Reinigung von kohlenhydraten mittels umkehrosmose und nanofiltration
NO985427L (no) Modulatorer for vevsregenerering
PT1169370E (pt) Solucoes de poliuretano contendo unidades estruturais de alcoxissilano.
NO954168D0 (no) Indolderivater som 5-HT1-lignende agonister for anvendelse mot migrene
ATE484587T1 (de) Ldcam genannte moleküle
ATE291427T1 (de) Verwendung von optisch reinem (+)-norcisapride für die behandlung des reizdarmsyndroms
GB0216001D0 (en) Process and composition
DE50208601D1 (de) Verfahren zur aufreinigung von bakterienzellen und zellbestandteilen
DE69103875D1 (de) Reinigung von Sole für Chlor-Alkali-Membranzellen.
DE69704189D1 (de) Verfahren zur Reinigung von Wasserstoffperoxid
BR9908872A (pt) Método de purificação de água
DE69942200D1 (de) Parvovirus NS1 Varianten
AU2001276629A1 (en) Modulation of tetraspanin function
AU1263799A (en) A method for purifying water, in particular ground water, under anaerobic conditions, using a membrane filtration unit, a device for purifying water, as well asdrinking water obtained by using such a method
HUP0101830A2 (hu) Karboxaldehidek tisztítása
ATE496939T1 (de) Methode zur reinigung von keratinozyten- wachstumfaktoren
SE9702993D0 (sv) Anti-mikrobial komposition
TR199902914T2 (xx) �zole sistolik hipertansiyonu tedavi y�ntemi.
IT1298303B1 (it) Procedimento biologico per la depurazione di acque inquinate, in particolare mediante fermentazione
IT248265Y1 (it) Cassa acustica per altoparlanti applicabile ai lati del vano portabagagli di autoveicoli.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee