ATE291427T1 - Verwendung von optisch reinem (+)-norcisapride für die behandlung des reizdarmsyndroms - Google Patents

Verwendung von optisch reinem (+)-norcisapride für die behandlung des reizdarmsyndroms

Info

Publication number
ATE291427T1
ATE291427T1 AT99927431T AT99927431T ATE291427T1 AT E291427 T1 ATE291427 T1 AT E291427T1 AT 99927431 T AT99927431 T AT 99927431T AT 99927431 T AT99927431 T AT 99927431T AT E291427 T1 ATE291427 T1 AT E291427T1
Authority
AT
Austria
Prior art keywords
irgitable
norcisapride
treatment
bowel syndrome
optically pure
Prior art date
Application number
AT99927431T
Other languages
English (en)
Inventor
Paul D Rubin
Timothy J Barberich
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Application granted granted Critical
Publication of ATE291427T1 publication Critical patent/ATE291427T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT99927431T 1998-06-15 1999-06-10 Verwendung von optisch reinem (+)-norcisapride für die behandlung des reizdarmsyndroms ATE291427T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8922498P 1998-06-15 1998-06-15
US12227599P 1999-03-01 1999-03-01
PCT/US1999/013099 WO1999065571A2 (en) 1998-06-15 1999-06-10 Use of optically pure (+)-norcisapride for treating apnea, bulimia and other disorders

Publications (1)

Publication Number Publication Date
ATE291427T1 true ATE291427T1 (de) 2005-04-15

Family

ID=26780365

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99927431T ATE291427T1 (de) 1998-06-15 1999-06-10 Verwendung von optisch reinem (+)-norcisapride für die behandlung des reizdarmsyndroms

Country Status (26)

Country Link
US (4) US6048879A (de)
EP (1) EP1089733B1 (de)
JP (1) JP2002518352A (de)
KR (3) KR20060017570A (de)
CN (1) CN1312717A (de)
AR (1) AR019671A1 (de)
AT (1) ATE291427T1 (de)
AU (1) AU4433399A (de)
BG (1) BG105096A (de)
BR (1) BR9911299A (de)
CA (1) CA2333666A1 (de)
CZ (1) CZ20004737A3 (de)
DE (1) DE69924375T2 (de)
ES (1) ES2237110T3 (de)
HK (1) HK1040058A1 (de)
HU (1) HUP0102203A3 (de)
IL (1) IL140118A0 (de)
IS (1) IS5756A (de)
NO (1) NO20006357L (de)
NZ (3) NZ526943A (de)
PL (1) PL345275A1 (de)
PT (1) PT1089733E (de)
SI (1) SI1089733T1 (de)
SK (1) SK19052000A3 (de)
TR (7) TR200003708T2 (de)
WO (1) WO1999065571A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060241164A1 (en) * 1998-02-27 2006-10-26 The Board Of Trustees Of The University Of Illinoi Pharmacological treatment for sleep apnea
US7160898B2 (en) 2001-12-14 2007-01-09 Board Of Trustees Of The University Of Illinois Pharmacological treatment for sleep apnea
TR200103757T2 (tr) 1998-06-15 2002-06-21 Sepracor Inc. Apne, bulimi ve başka bozuklukların tedavi edilmesi için optik açıdan saf (-) norsisapridin kullanımı
JP2002538102A (ja) * 1999-03-01 2002-11-12 セプラコア インコーポレーテッド 光学的に純粋なｒ（＋）オンダンセトロンを使用する無呼吸および無呼吸障害の治療方法
EP1435238A1 (de) * 1999-03-01 2004-07-07 Sepracor Inc. Verfahren zur Behandlung von Apnoe und Apnoe-Erkrankungen mit optisch reinem R(+)Ondansetron
US6353005B1 (en) * 1999-03-02 2002-03-05 Sepracor, Inc. Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist
CA2868614A1 (en) 2001-06-08 2002-12-08 Abbott Laboratories (Bermuda) Ltd. Methods of administering anti-tnf.alpha. antibodies
US20040220153A1 (en) * 2002-09-24 2004-11-04 Jost-Price Edward Roydon Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
US20040172084A1 (en) * 2003-02-03 2004-09-02 Knudson Mark B. Method and apparatus for treatment of gastro-esophageal reflux disease (GERD)
US7444183B2 (en) * 2003-02-03 2008-10-28 Enteromedics, Inc. Intraluminal electrode apparatus and method
US7613515B2 (en) * 2003-02-03 2009-11-03 Enteromedics Inc. High frequency vagal blockage therapy
US7844338B2 (en) * 2003-02-03 2010-11-30 Enteromedics Inc. High frequency obesity treatment
US20050070974A1 (en) * 2003-09-29 2005-03-31 Knudson Mark B. Obesity and eating disorder stimulation treatment with neural block
US20050070970A1 (en) * 2003-09-29 2005-03-31 Knudson Mark B. Movement disorder stimulation with neural block
US7803195B2 (en) * 2004-06-03 2010-09-28 Mayo Foundation For Medical Education And Research Obesity treatment and device
US20060020277A1 (en) * 2004-07-20 2006-01-26 Gostout Christopher J Gastric reshaping devices and methods
US20060020298A1 (en) * 2004-07-20 2006-01-26 Camilleri Michael L Systems and methods for curbing appetite
US7833279B2 (en) * 2004-11-12 2010-11-16 Enteromedics Inc. Pancreatic exocrine secretion diversion apparatus and method
CA2590802A1 (en) 2004-12-20 2006-06-29 Collegium Pharmaceutical, Inc. Pharmaceutical compositions for sleep disorders
US7822486B2 (en) * 2005-08-17 2010-10-26 Enteromedics Inc. Custom sized neural electrodes
US7672727B2 (en) * 2005-08-17 2010-03-02 Enteromedics Inc. Neural electrode treatment
GB0524668D0 (en) * 2005-12-02 2006-01-11 Novartis Ag Organic compounds
US20070233204A1 (en) 2006-02-16 2007-10-04 Lima Marcelo G RFID-based apparatus, system, and method for therapeutic treatment of a patient
US20100198103A1 (en) 2007-10-09 2010-08-05 Imthera Medical, Inc. System and method for neural stimulation
US8428725B2 (en) 2008-10-09 2013-04-23 Imthera Medical, Inc. Method of stimulating a Hypoglossal nerve for controlling the position of a patient's tongue
AU2010318651A1 (en) 2009-11-10 2012-05-03 Imthera Medical, Inc. System for stimulating a hypoglossal nerve for controlling the position of a patient's tongue
US8825164B2 (en) 2010-06-11 2014-09-02 Enteromedics Inc. Neural modulation devices and methods
US10123896B2 (en) 2014-03-06 2018-11-13 Mayo Foundation For Medical Education And Research Apparatus and methods of inducing weight loss using blood flow control

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR748807A (fr) * 1932-03-10 1933-07-10 Gulf Refining Co Perfectionnements à la fabrication d'hydrocarbures
US3536809A (en) * 1969-02-17 1970-10-27 Alza Corp Medication method
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) * 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) * 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US5057525A (en) * 1981-10-01 1991-10-15 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl) benzamide derivatives
US4962115A (en) * 1981-10-01 1990-10-09 Janssen Pharmaceutica N.V. Novel N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US5137896A (en) * 1981-10-01 1992-08-11 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US4598123A (en) * 1983-07-14 1986-07-01 Unites States Steel Corporation Impact modified methyl methacrylate polymer
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US4800162A (en) * 1987-04-01 1989-01-24 Sepracor, Inc. Method for resolution of steroisomers in multiphase and extractive membrane reactors
US5057427A (en) * 1988-04-07 1991-10-15 Sepracor, Inc. Method for resolution of stereoisomers
US5073543A (en) * 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
GB8823980D0 (en) * 1988-10-13 1988-11-23 Glaxo Group Ltd Chemical compounds
JPH02188523A (ja) * 1989-01-13 1990-07-24 M S C:Kk 睡眠時無呼吸症治療薬
IT1229203B (it) * 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5075290A (en) * 1989-06-28 1991-12-24 University Of Virginia Alumni Patents Foundation Use of adenosine, adenosine analogs or nucleoside uptake blockers, e.g. dipyridamole, as drug treatments for obstructive sleep apnea and snoring
US5120548A (en) * 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5356934A (en) * 1990-03-29 1994-10-18 Eli Lilly And Company Selected serotonin subtype receptor agonist to treat sleep apnea
US5733566A (en) * 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
WO1993012785A1 (en) * 1991-12-21 1993-07-08 Smithkline Beecham Plc Use of 5-ht4 modulators for the manufacture of a medicament for the treatment of the bladder diseases
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5591767A (en) * 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
GB9310756D0 (en) * 1993-05-25 1993-07-14 Glaxo Lab Sa Compositions
US5502067A (en) * 1994-02-04 1996-03-26 Morgan; Julia A. Treating apneahypopnea/snoring in humans
US5407953A (en) * 1994-02-04 1995-04-18 Morgan; Julia A. Treating apnea/hypopnea/snoring in humans
IT1270594B (it) * 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
FR2735475B1 (fr) * 1995-06-13 1997-07-11 Synthelabo Derives de n-((1,4-diazabicyclo(2.2.2)oct-2-yl)methyl) benzamide, leur preparation et leur application en therapeutique
US5739151A (en) * 1996-07-19 1998-04-14 Sepracor Inc. Method for treating emesis and central nervous system disorders using optically pure (+) norcisapride
DK1000029T3 (da) * 1997-07-11 2004-02-23 Janssen Pharmaceutica Nv Norcisaprid nyttig med hensyn til 5-HT3- og 5-HT4- medierede lidelser

Also Published As

Publication number Publication date
NZ508824A (en) 2003-10-31
TR200103058T2 (tr) 2002-06-21
PT1089733E (pt) 2005-08-31
CZ20004737A3 (cs) 2001-10-17
HUP0102203A2 (hu) 2001-11-28
TR200103059T2 (tr) 2002-06-21
KR20060067986A (ko) 2006-06-20
TR200103057T2 (tr) 2002-06-21
KR20010052739A (ko) 2001-06-25
TR200103056T2 (tr) 2002-06-21
US6048879A (en) 2000-04-11
WO1999065571A2 (en) 1999-12-23
EP1089733A2 (de) 2001-04-11
US6835740B2 (en) 2004-12-28
ES2237110T3 (es) 2005-07-16
NZ526943A (en) 2004-11-26
NZ535135A (en) 2006-04-28
BR9911299A (pt) 2001-03-13
US20020147220A1 (en) 2002-10-10
CA2333666A1 (en) 1999-12-23
AU4433399A (en) 2000-01-05
KR20060017570A (ko) 2006-02-23
PL345275A1 (en) 2001-12-03
WO1999065571A3 (en) 2000-04-20
IL140118A0 (en) 2002-02-10
HUP0102203A3 (en) 2001-12-28
DE69924375T2 (de) 2005-08-11
NO20006357L (no) 2001-02-13
TR200103055T2 (tr) 2002-06-21
TR200003708T2 (tr) 2001-06-21
SI1089733T1 (en) 2005-06-30
CN1312717A (zh) 2001-09-12
JP2002518352A (ja) 2002-06-25
IS5756A (is) 2000-12-08
TR200103054T2 (tr) 2002-06-21
AR019671A1 (es) 2002-03-13
HK1040058A1 (zh) 2002-05-24
EP1089733B1 (de) 2005-03-23
DE69924375D1 (de) 2005-04-28
US6369079B1 (en) 2002-04-09
US20050154018A1 (en) 2005-07-14
SK19052000A3 (sk) 2001-06-11
BG105096A (en) 2002-02-28
NO20006357D0 (no) 2000-12-13

Similar Documents

Publication Publication Date Title
ATE291427T1 (de) Verwendung von optisch reinem (+)-norcisapride für die behandlung des reizdarmsyndroms
ATE241977T1 (de) Verwendung von anti-mikrotubuli mitteln zur behandlung von entzündlichen darmerkrankungen
DE59608738D1 (de) Verwendung von epinastin für die behandlung von schmerzen
DE69925306D1 (de) Behandlung von kohlenwasserstoffgas
DE69927823T2 (de) Hydrogel für die therapeutische behandlung von aneurysmas
DE69528109D1 (de) Thieno -1,5- benzodiazepin zur Behandlung gastrointestinaler Beschwerden
ATE247987T1 (de) Behandlung zur beseitigung von gerüchen
DE69924750D1 (de) Gerät zur thermischen behandlung von gewebe
DE69718731D1 (de) Kombinationstherapie für die Behandlung von Psychosen
DE50009504D1 (de) Verwendung von retigabin zur behandlung von neuropathischen schmerzen
DE69715631D1 (de) Antikonvulsive sulfamatderivate zur behandlung von fettleibigkeit
DE69817446D1 (de) Behandlung von diabetes
DE60019556D1 (de) 2-amino-benzoxazinonderivate zur behandlung von fettleibigkeit
DE10082139T1 (de) Zusammensetzung zur Behandlung von Reibungspaaren
DE60019555D1 (de) 2-oxy-benzoxazinonderivate zur behandlung von fettleibigkeit
ATE279386T1 (de) Retinoide zur behandlung von emphysem
ATE344661T1 (de) Rar-gamma selektive retinoid-agonisten zur behandlung von emphysemen
ATE221763T1 (de) Die verwendung von glyceryltriacetat zur behandlung von onychomykosen
DE69943089D1 (de) Methode zur behandlung von staphylokokkeninfektionen
DE69916073D1 (de) Triazolopyridine für behandlung von thrombosen
DE69931487D1 (de) Verwendung von apomorphin zur behandlung der vorzeitigen ejakulation
DE60021252D1 (de) Antikonvulsiva zur behandlung von autismus
ATE291916T1 (de) Verwendung von optisch reinem (-) norcisapride in der behandlung des reizdarmsyndroms
DE69913380D1 (de) Zusammensetzung zur behandlung von periodontalen erkrankungen
DE69918541D1 (de) Verwendung von nmda antagonisten zur behandlung des reizkolons

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1089733

Country of ref document: EP

REN Ceased due to non-payment of the annual fee