PL2991683T3 - Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem - Google Patents

Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem

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Publication number
PL2991683T3
PL2991683T3 PL14725209T PL14725209T PL2991683T3 PL 2991683 T3 PL2991683 T3 PL 2991683T3 PL 14725209 T PL14725209 T PL 14725209T PL 14725209 T PL14725209 T PL 14725209T PL 2991683 T3 PL2991683 T3 PL 2991683T3
Authority
PL
Poland
Prior art keywords
glycan
glycoprotein
conjugates
toxic payload
payload
Prior art date
Application number
PL14725209T
Other languages
English (en)
Inventor
Tero Satomaa
Jari Helin
Filip S. EKHOLM
Original Assignee
Glykos Finland Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glykos Finland Oy filed Critical Glykos Finland Oy
Publication of PL2991683T3 publication Critical patent/PL2991683T3/pl

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    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
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    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014052713A2 (en) 2012-09-27 2014-04-03 Massachusetts Institute Of Technology Her2-and vegf-a-binding proteins with enhanced stability
PL2991683T3 (pl) * 2013-05-02 2020-03-31 Glykos Finland Oy Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem
EP3016980B1 (en) * 2013-07-05 2020-05-06 Formation Biologics Inc. Egfr antibody conjugates
CA2931547A1 (en) 2013-12-09 2015-06-18 Durect Corporation Pharmaceutically active agent complexes, polymer complexes, and compositions and methods involving the same
CA2944539A1 (en) 2014-04-08 2015-10-15 University Of Georgia Research Foundation, Inc. Site-specific antibody-drug glycoconjugates and methods
AU2015273353B2 (en) * 2014-06-13 2020-09-10 Tenboron Oy Conjugates comprising an anti-EGFR1 antibody
WO2015197919A1 (en) * 2014-06-25 2015-12-30 Glykos Finland Oy Antibody drug conjugates binding to high-mannose n-glycan
DK3160513T3 (da) 2014-06-30 2020-04-06 Glykos Finland Oy Saccharidderivat af en toksisk payload og antistofkonjugater deraf
EP3240797A4 (en) * 2014-12-31 2018-08-01 Development Center for Biotechnology Site-specific conjugation through glycoproteins linkage and method thereof
CN105820248A (zh) * 2015-01-07 2016-08-03 上海张江生物技术有限公司 一种新型抗egfr单克隆抗体的制备方法及应用
JP6932649B2 (ja) 2015-02-16 2021-09-08 ロンザ リミテッドLonza Limited Cl及び/又はch1が突然変異された薬剤コンジュゲーションのための抗体
US20170114127A1 (en) * 2015-10-22 2017-04-27 Massachusetts Institute Of Technology Vegf-a-binding proteins and her2-binding proteins with enhanced stability against aggregation
US10874746B2 (en) 2016-02-08 2020-12-29 Synaffix B.V. Sulfamide linkers for use in bioconjugates
CN108883191B (zh) * 2016-02-08 2022-10-14 西纳福克斯股份有限公司 用于靶向cd30肿瘤的具有改善的治疗指数的抗体-缀合物以及用于改善抗体-缀合物的治疗指数的方法
CN109069658B (zh) * 2016-02-08 2022-10-14 西纳福克斯股份有限公司 用于靶向her2肿瘤的具有改善的治疗指数的抗体-缀合物以及用于改善抗体-缀合物的治疗指数的方法
EP3413920A1 (en) 2016-02-08 2018-12-19 Synaffix B.V. Bioconjugates containing sulfamide linkers for use in treatment
WO2017137457A1 (en) * 2016-02-08 2017-08-17 Synaffix B.V. Antibody-conjugates with improved therapeutic index for targeting cd30 tumours and method for improving therapeutic index of antibody-conjugates
EP3423105B1 (en) 2016-03-02 2021-05-05 Eisai R&D Management Co., Ltd. Eribulin-based antibody-drug conjugates and methods of use
MY199937A (en) 2016-11-08 2023-11-29 Regeneron Pharma Steroids and protein-conjugates thereof
EP3538098A4 (en) * 2016-11-14 2020-07-29 Cho Pharma Inc ANTIBODY-ACTIVE SUBSTANCE CONJUGATES
TWI673363B (zh) * 2016-12-29 2019-10-01 財團法人生物技術開發中心 製備醣蛋白-藥物共軛物之方法
WO2018146506A1 (en) * 2017-02-10 2018-08-16 Universitat Politècnica De València Therapeutic derivatives
CN119367549A (zh) 2017-06-21 2025-01-28 芬兰吉利科斯有限公司 亲水性接头及其共轭物
CN111655290A (zh) * 2017-11-02 2020-09-11 展马博联合股份有限公司 抗组织因子抗体-药物偶联物及其在癌症治疗中的应用
AU2018395417B2 (en) 2017-12-29 2023-07-13 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
TWI841554B (zh) 2018-03-21 2024-05-11 丹麥商珍美寶股份有限公司 以鉑為主之劑與抗組織因子抗體-藥物共軛物的組合治療癌症之方法
CN112739716B (zh) 2018-05-07 2025-05-27 展马博联合股份有限公司 使用抗pd-1抗体与抗组织因子抗体-药物偶联物的组合治疗癌症的方法
TWI844571B (zh) 2018-10-30 2024-06-11 丹麥商珍美寶股份有限公司 使用抗血管內皮生長因子(vegf)抗體與抗組織因子(tf)抗體-藥物共軛體之組合以治療癌症之方法
AR117735A1 (es) * 2018-12-25 2021-08-25 Joint Stock Company “Biocad” ANTICUERPOS MONOCLONALES QUE SE UNEN ESPECÍFICAMENTE A LA REGIÓN b DE LA FAMILIA TRBV-9 DEL RECEPTOR DE CÉLULAS T HUMANO, Y LOS MÉTODOS PARA SU USO
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
WO2020139960A1 (en) 2018-12-27 2020-07-02 Glycomimetics, Inc Galectin-3 inhibiting c-glycosides
US20230038373A1 (en) * 2019-12-18 2023-02-09 Glykos Biomedical Oy Stabile conjugate
KR20230021018A (ko) * 2020-06-05 2023-02-13 재단법인 생물기술개발중심 항-메조텔린 항체를 함유하는 항체-약물 컨쥬게이트 및 이의 용도
IL303447A (en) 2020-12-23 2023-08-01 Univ Muenchen Ludwig Maximilians Improved cd30 targeting antibody drug conjugates and uses thereof
WO2022175595A1 (en) 2021-02-16 2022-08-25 Glykos Finland Oy Linker-payloads and conjugates thereof
JP2024509282A (ja) * 2021-03-10 2024-02-29 バイオヘイブン・セラピューティクス・リミテッド ガラクトース欠損免疫グロブリンの二官能性分解剤
FI131754B1 (en) 2023-03-13 2025-11-11 Glykos Finland Oy Antibody-exatecan conjugates
US20240376212A1 (en) * 2023-04-25 2024-11-14 Targetthera Llc Alpha v-integrin targeted small molecule drug conjugates

Family Cites Families (112)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0606925B1 (en) * 1986-12-11 1998-10-07 Genzyme Corporation A method for derivatizing a 1-amino-1-deoxyoligosaccharide
US5461143A (en) 1991-03-18 1995-10-24 The Scripps Research Institute Oligosaccharide enzyme substrates and inhibitors: methods and compositions
JP3476455B2 (ja) 1991-03-18 2003-12-10 ザ スクリップス リサーチ インスティテュート NeuAcα2、6Galβ1、4GlcNAc及びシアリルLexの合成法
US5278299A (en) 1991-03-18 1994-01-11 Scripps Clinic And Research Foundation Method and composition for synthesizing sialylated glycosyl compounds
EP0524143B1 (de) 1991-07-17 1997-12-10 Novartis AG Verfahren zur Herstellung aktivierter Sialinsäuren
US5635483A (en) 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides
US5443953A (en) 1993-12-08 1995-08-22 Immunomedics, Inc. Preparation and use of immunoconjugates
DE69729283T2 (de) 1996-03-20 2005-05-25 Immunomedics, Inc. GLYKOSYLIERTE IgG ANTIKÖRPER
AU2001235285A1 (en) 2000-02-24 2001-09-03 University Of Guelph Method of modulating glycosylation pathways
US20060034828A1 (en) 2000-06-28 2006-02-16 Gerngross Tillman U Immunoglobulins comprising predominantly a GlcNAcMAN5GLCNAC2 glycoform
WO2002026262A2 (en) 2000-09-25 2002-04-04 Pro-Pharmaceuticals, Inc. Compositions for reducing side effects in chemotherapeutic treatments
CN100491389C (zh) 2001-06-19 2009-05-27 偌格·凯姆 唾液酸结合性免疫球蛋白样凝集素抑制剂
ES2411007T3 (es) * 2001-10-10 2013-07-04 Novo Nordisk A/S Remodelación y glicoconjugación de péptidos
US7265085B2 (en) 2001-10-10 2007-09-04 Neose Technologies, Inc. Glycoconjugation methods and proteins/peptides produced by the methods
US7696163B2 (en) * 2001-10-10 2010-04-13 Novo Nordisk A/S Erythropoietin: remodeling and glycoconjugation of erythropoietin
US8008252B2 (en) 2001-10-10 2011-08-30 Novo Nordisk A/S Factor VII: remodeling and glycoconjugation of Factor VII
US20050233949A1 (en) 2002-04-12 2005-10-20 Holick Michael F Conjugates comprising cancer cell specific ligands, a sugar and cancer chemotherapeutic agents/boron neutron capture therapy agents, and uses thereof
CA2487815A1 (en) * 2002-05-29 2003-12-11 Symbiontics, Inc. Targeted therapeutic proteins
SI2357006T1 (sl) 2002-07-31 2016-01-29 Seattle Genetics, Inc. Konjugati zdravil in njihova uporaba za zdravljenje raka, avtoimunske bolezni ali infekcijske bolezni
US20060166929A1 (en) * 2002-12-26 2006-07-27 Yasuhiro Kajihara Sugar-chain asparagine derivatives and processes for the preparation thereof
EP1587919A4 (en) 2003-01-10 2006-10-11 Us Gov Health & Human Serv CATALYTIC DOMAINS OF BETA / 1,4) -GALACTOSYLTRANSFERASE I WITH CHANGED DONOR AND ACCEPTOR SPECIFICATIONS, THE IN-VITRO-PROTEIN FILLING PROMOTING DOMAINS, AND METHODS FOR THEIR USE
WO2005012484A2 (en) * 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
US7332355B2 (en) 2003-11-18 2008-02-19 California Institute Of Technology Method and compositions for the detection of protein glycosylation
WO2005051429A2 (en) 2003-11-19 2005-06-09 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Targeted conjugates with a modified saccharide linker
US8703459B2 (en) 2003-12-05 2014-04-22 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Catalytic domains of beta(1,4)-galactosyltransferase I having altered metal ion specificity
AU2005216251B2 (en) 2004-02-23 2011-03-10 Genentech, Inc. Heterocyclic self-immolative linkers and conjugates
RU2402548C2 (ru) 2004-05-19 2010-10-27 Медарекс, Инк. Химические линкеры и их конъюгаты
JP4193771B2 (ja) 2004-07-27 2008-12-10 セイコーエプソン株式会社 階調電圧発生回路及び駆動回路
US7807619B2 (en) 2004-11-01 2010-10-05 The Regents Of The University Of California Compositions and methods for modification of biomolecules
US8431558B2 (en) 2004-11-01 2013-04-30 The Regents Of The University Of California Compositions and methods for modification of biomolecules
KR20080021590A (ko) 2005-03-24 2008-03-07 네오스 테크놀로지스, 인크. 가용성이고 활성인 진핵생물 글리코실트랜스퍼라제의원핵생물 유기체 내에서의 발현
SI3248613T1 (sl) * 2005-07-18 2022-04-29 Seagen Inc. Konjugati beta-glukuronidni linker-zdravilo
KR101507027B1 (ko) 2005-10-21 2015-03-31 엘에프비 유에스에이, 인크. 항체 의존성 세포 독성 활성이 증강된 항체, 그 생산 및 사용 방법
AU2006306355A1 (en) 2005-10-27 2007-05-03 Merck & Co., Inc. HIV integrase inhibitors
US8357671B2 (en) 2005-11-10 2013-01-22 James Paulson High affinity Siglec ligands
EP2623610B1 (en) 2006-02-10 2015-04-29 Life Technologies Corporation Labeling and detection of post translationally modified proteins
CA2647632C (en) 2006-03-27 2017-06-27 University Of Maryland Biotechnology Institute Glycoprotein synthesis and remodeling by enzymatic transglycosylation
HRP20140172T1 (hr) 2006-05-30 2014-03-28 Genentech, Inc. Protutijela i imunokonjugati kao i njihove uporabe
CA2654000A1 (en) 2006-06-06 2008-05-22 Genentech, Inc. Anti-dll4 antibodies and methods using same
TWI412367B (zh) 2006-12-28 2013-10-21 Medarex Llc 化學鏈接劑與可裂解基質以及其之綴合物
US8398956B2 (en) 2007-01-11 2013-03-19 Immunomedics, Inc. In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
EP2125848B1 (en) * 2007-01-23 2014-09-10 Therapicon Srl Antiviral compounds
JP5967861B2 (ja) 2007-04-03 2016-08-10 オキシレイン ユーケー リミテッド 分子のグリコシル化
WO2008143944A2 (en) 2007-05-14 2008-11-27 Government Of The Usa, As Represented By The Secretary, Department Of Health And Human Services Methods of glycosylation and bioconjugation
WO2009006620A1 (en) * 2007-07-03 2009-01-08 Children's Hospital & Research Center At Oakland Oligosialic acid derivatives, methods of manufacture, and immunological uses
WO2009013359A2 (en) 2007-07-25 2009-01-29 Fraunhofer Gesellschaft Zur Förderung Der Angewandten Forschung E. V. Self coupling recombinant antibody fusion proteins
US8512991B2 (en) 2007-08-22 2013-08-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Beta 1,4-galactosyltransferases with altered donor and acceptor specificities, compositions and methods of use
US8425901B2 (en) 2007-08-22 2013-04-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Alpha 1-3 N-galactosyltransferase with altered donor specificities
EP2190984B1 (en) 2007-09-14 2013-09-04 Genovis Ab Methods and kits for purification and detection of glycosylated IgG
US8133515B2 (en) 2007-11-21 2012-03-13 University Of Georgia Research Foundation, Inc. Alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds
JP5647899B2 (ja) 2008-01-08 2015-01-07 ラツィオファルム ゲーエムベーハーratiopharm GmbH オリゴサッカリルトランスフェラーゼを使用するポリペプチドの複合糖質化
WO2009102820A2 (en) 2008-02-11 2009-08-20 Government Of The U.S A., As Represented By The Secretary, Department Of Health And Human Services Modified sugar substrates and methods of use
EP2331701B1 (en) 2008-08-08 2013-03-20 Vib Vzw Cells producing glycoproteins having altered glycosylation patterns and methods and use thereof
EP2414399A1 (en) 2009-04-01 2012-02-08 F. Hoffmann-La Roche AG Anti-fcrh5 antibodies and immunoconjugates and methods of use
EP2253635B1 (en) 2009-04-28 2014-03-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Novel hydrophilic and lipophilic rhodamines for labelling and imaging
EP2470535A4 (en) 2009-08-24 2014-01-01 Univ Duke COMPOSITIONS, METHODS, AND KITS FOR DETERMINING AN ALKYL TRANSFERASE
JP2013507378A (ja) 2009-10-09 2013-03-04 メルク・シャープ・エンド・ドーム・コーポレイション 抗her3抗体の製造、特徴づけ及びその用途
GB0919070D0 (en) 2009-10-30 2009-12-16 Univ East Anglia Compounds and their uses in glycosyltransferase binding assays
GB0919423D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
BR112012011980A2 (pt) 2009-11-19 2021-09-08 Oxyrane Uk Limited Métodos de produzir células transformadas de yarrowia lipolytica e proteínas-alvocompreendendo n-glicanos, células transformadas de yarrowia lipolytica e suas culturas, bem como composição compreendendo glicoproteínas
IT1396620B1 (it) * 2009-11-25 2012-12-14 Therapicon Srl Analoghi chimerici
EP2515914A4 (en) 2009-12-23 2013-09-11 Scripps Research Inst BIOCONJUGATION OF TYROSINE BY EYE REACTIONS IN AQUEOUS MEDIA
US8519122B2 (en) 2010-02-12 2013-08-27 The Regents Of The University Of California Compositions and methods for modification of biomolecules
PL2563753T6 (pl) 2010-04-27 2016-05-31 Synaffix Bv Stopione związki cyklooktynu i ich zastosowanie w reakcjach typu "click" bez udziału metalu
DK2566335T3 (en) 2010-05-05 2016-10-03 Prolynx Llc Controlled release of active ingredients from macromolecular CONJUGATES
US8912322B2 (en) 2010-07-29 2014-12-16 University Of Georgia Research Foundation, Inc. Aza-dibenzocyclooctynes and methods of making and using same
EP2618817B1 (en) 2010-07-31 2018-06-13 The Scripps Research Institute Liposome targeting compounds and related uses
RU2584597C2 (ru) 2010-08-13 2016-05-20 Рош Гликарт Аг Антитела против а2 тенасцина с и способы их применения
EP2621532A1 (en) 2010-09-30 2013-08-07 Merck Sharp & Dohme Corp. Generation, characterization and uses thereof of anti-her3 antibodies
US9676871B2 (en) 2010-11-05 2017-06-13 Pfizer Inc. Engineered polypeptide conjugates and methods for making thereof using transglutaminase
JP6014596B2 (ja) 2010-11-09 2016-10-25 メディミューン,エルエルシー 均一コンジュゲーションのための抗体足場
AU2011336396B2 (en) 2010-12-02 2016-02-04 Immunomedics, Inc. In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
US20150072396A1 (en) 2011-03-04 2015-03-12 Life Technologies Corporation Compounds and Methods for Conjugation of Biomolecules
CN103534233B (zh) 2011-03-25 2016-08-24 生命科技公司 用于标记靶分子的杂双官能酯
PL2694111T3 (pl) 2011-04-01 2017-01-31 Wyeth Llc Koniugaty przeciwciało-lek
JP6177231B2 (ja) 2011-04-20 2017-08-09 ゲンマブ エー/エス Her2に対する二重特異性抗体
PT2707031T (pt) 2011-05-08 2019-09-05 Legochem Biosciences Inc Conjugados de proteína e agente ativo e processo para a sua preparação
US8852599B2 (en) 2011-05-26 2014-10-07 Bristol-Myers Squibb Company Immunoconjugates, compositions for making them, and methods of making and use
KR102356286B1 (ko) * 2011-05-27 2022-02-08 암브룩스, 인코포레이티드 비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
KR20140037105A (ko) * 2011-05-27 2014-03-26 암브룩스, 인코포레이티드 비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
AU2012264696A1 (en) * 2011-05-31 2013-12-12 Probiogen Ag Methods for preparation of fucose-linked site specific conjugates of proteins with toxins, adjuvants, detection labels and pharmacokinetic half life extenders
WO2012170938A1 (en) 2011-06-08 2012-12-13 Acceleron Pharma Inc. Compositions and methods for increasing serum half-life
CN103764665A (zh) 2011-06-28 2014-04-30 怀特黑德生物医学研究所 使用分选酶安装用于蛋白质连接的点击化学柄
WO2013012961A2 (en) 2011-07-19 2013-01-24 Cellmosaic, Llc Novel crosslinking reagents, macromolecules, therapeutic conjugates, and synthetic methods thereof
WO2013036748A1 (en) 2011-09-09 2013-03-14 Berry, Lana, L. Bicyclo[6.1.0]non-4-yne reagents for chemical modification of oligonucleotides
GB201115841D0 (en) 2011-09-13 2011-10-26 Genovis Ab Protein and method
US9464137B2 (en) 2011-12-13 2016-10-11 Glykos Finland Oy Glycoprotein
US20150210777A1 (en) 2011-12-13 2015-07-30 Glykos Finland Oy Glycoprotein
EP2610263A1 (de) 2011-12-30 2013-07-03 Brossmer, Reinhard Sialinsäure-Dimere
BR112014019825B1 (pt) 2012-02-10 2021-08-24 University Of Maryland, Baltimore Glicoengenharia quimioenzimática de anticorpos e fragmentos fc dos mesmos
US9545449B2 (en) 2012-05-11 2017-01-17 Advanced Proteone Therapeutics Inc. Site-specific labeling and targeted delivery of proteins for the treatment of cancer
CA2875989A1 (en) 2012-06-08 2013-12-12 Sutro Biopharma, Inc. Antibodies comprising site-specific non-natural amino acid residues, methods of their preparation and methods of their use
EP2863925B1 (de) 2012-06-21 2016-09-14 Reinhard Brossmer Sialinsäurederivate
US9732161B2 (en) 2012-06-26 2017-08-15 Sutro Biopharma, Inc. Modified Fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
US9682934B2 (en) 2012-08-31 2017-06-20 Sutro Biopharma, Inc. Modified amino acids
HRP20230690T1 (hr) * 2012-10-23 2023-10-13 Synaffix B.V. Modificirano antitijelo, konjugat antitijela i postupak za njihovo pripremanje
WO2014066733A2 (en) 2012-10-25 2014-05-01 Life Technologies Corporation Methods and compositions for enzyme-mediated site-specific radiolabeling of glycoproteins
US20150314007A1 (en) * 2012-12-21 2015-11-05 Glykos Finland Oy Linker-payload molecule conjugates
HUE033626T2 (en) 2013-02-14 2017-12-28 Bristol Myers Squibb Co Tubulysin compounds, methods of preparation and use
GB2511137A (en) 2013-02-26 2014-08-27 Glykos Finland Oy Chelator Molecule
WO2014143241A1 (en) 2013-03-15 2014-09-18 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
PL2991683T3 (pl) * 2013-05-02 2020-03-31 Glykos Finland Oy Koniugaty glikoproteiny lub glikanu z toksycznym ładunkiem
WO2014189370A1 (en) 2013-05-24 2014-11-27 Stichting Katholieke Universiteit Substituted azadibenzocyclooctyne compounds and their use in metal-free click reactions
CA2914189C (en) 2013-06-21 2023-03-14 Innate Pharma Enzymatic conjugation of polypeptides
JP2016538878A (ja) 2013-10-14 2016-12-15 シンアフィックス ビー.ブイ. 糖鎖工学的に操作された抗体、抗体コンジュゲート、及びそれらの調製方法
WO2015057065A1 (en) 2013-10-14 2015-04-23 Synaffix B.V. Glycoengineered antibody, antibody-conjugate and methods for their preparation
US9987373B2 (en) 2013-10-14 2018-06-05 Synaffix B.V. Modified glycoprotein, protein-conjugate and process for the preparation thereof
JP2016538877A (ja) 2013-10-14 2016-12-15 シンアフィックス ビー.ブイ. 修飾糖タンパク質、タンパク質コンジュゲート及びそれらの調製方法
EP2910561A1 (de) 2014-02-25 2015-08-26 Reinhard Brossmer Sialinsäurederivate
CN108883191B (zh) 2016-02-08 2022-10-14 西纳福克斯股份有限公司 用于靶向cd30肿瘤的具有改善的治疗指数的抗体-缀合物以及用于改善抗体-缀合物的治疗指数的方法
US10874746B2 (en) 2016-02-08 2020-12-29 Synaffix B.V. Sulfamide linkers for use in bioconjugates
US10858641B2 (en) 2016-02-08 2020-12-08 Synaffix B.V. Enzymes for trimming of glycoproteins

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LT2991683T (lt) 2019-12-27
US20180256732A1 (en) 2018-09-13
US11723983B2 (en) 2023-08-15
US20160106860A1 (en) 2016-04-21
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