JP2015531773A5 - - Google Patents
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- JP2015531773A5 JP2015531773A5 JP2015529005A JP2015529005A JP2015531773A5 JP 2015531773 A5 JP2015531773 A5 JP 2015531773A5 JP 2015529005 A JP2015529005 A JP 2015529005A JP 2015529005 A JP2015529005 A JP 2015529005A JP 2015531773 A5 JP2015531773 A5 JP 2015531773A5
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- 229910052739 hydrogen Inorganic materials 0.000 claims description 54
- 125000000217 alkyl group Chemical group 0.000 claims description 31
- 150000001875 compounds Chemical class 0.000 claims description 31
- 125000001424 substituent group Chemical group 0.000 claims description 24
- 229910052757 nitrogen Inorganic materials 0.000 claims description 23
- 125000005842 heteroatom Chemical group 0.000 claims description 22
- 239000001257 hydrogen Substances 0.000 claims description 21
- 150000003839 salts Chemical class 0.000 claims description 19
- 125000005843 halogen group Chemical group 0.000 claims description 18
- 229910052760 oxygen Inorganic materials 0.000 claims description 18
- 229910052717 sulfur Inorganic materials 0.000 claims description 17
- 239000012453 solvate Substances 0.000 claims description 16
- 125000003545 alkoxy group Chemical group 0.000 claims description 12
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical group C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims description 10
- 125000003118 aryl group Chemical group 0.000 claims description 5
- 208000015181 infectious disease Diseases 0.000 claims description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
- 229930192474 thiophene Chemical group 0.000 claims description 5
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- 241000124008 Mammalia Species 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 125000002950 monocyclic group Chemical group 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 239000003112 inhibitor Substances 0.000 claims description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 2
- 230000002265 prevention Effects 0.000 claims description 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 19
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 230000001548 androgenic effect Effects 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000003003 spiro group Chemical group 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 description 18
- 125000004435 hydrogen atom Chemical class [H]* 0.000 description 14
- 125000004432 carbon atom Chemical group C* 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018207904A JP6895938B2 (ja) | 2012-08-28 | 2018-11-05 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12182076.5 | 2012-08-28 | ||
| EP12182076 | 2012-08-28 | ||
| EP12185055 | 2012-09-19 | ||
| EP12185055.6 | 2012-09-19 | ||
| EP12190837.0 | 2012-10-31 | ||
| EP12190837 | 2012-10-31 | ||
| EP13157230 | 2013-02-28 | ||
| EP13157230.7 | 2013-02-28 | ||
| EP13169574 | 2013-05-28 | ||
| EP13169574.4 | 2013-05-28 | ||
| PCT/EP2013/067821 WO2014033170A1 (en) | 2012-08-28 | 2013-08-28 | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018207904A Division JP6895938B2 (ja) | 2012-08-28 | 2018-11-05 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015531773A JP2015531773A (ja) | 2015-11-05 |
| JP2015531773A5 true JP2015531773A5 (https=) | 2018-03-01 |
| JP6505013B2 JP6505013B2 (ja) | 2019-04-24 |
Family
ID=49085019
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015529007A Withdrawn JP2015533782A (ja) | 2012-08-28 | 2013-08-28 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
| JP2015529005A Expired - Fee Related JP6505013B2 (ja) | 2012-08-28 | 2013-08-28 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
| JP2018208063A Expired - Fee Related JP6907173B2 (ja) | 2012-08-28 | 2018-11-05 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
| JP2018207904A Expired - Fee Related JP6895938B2 (ja) | 2012-08-28 | 2018-11-05 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
| JP2021095380A Withdrawn JP2021176846A (ja) | 2012-08-28 | 2021-06-07 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015529007A Withdrawn JP2015533782A (ja) | 2012-08-28 | 2013-08-28 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018208063A Expired - Fee Related JP6907173B2 (ja) | 2012-08-28 | 2018-11-05 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
| JP2018207904A Expired - Fee Related JP6895938B2 (ja) | 2012-08-28 | 2018-11-05 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
| JP2021095380A Withdrawn JP2021176846A (ja) | 2012-08-28 | 2021-06-07 | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 |
Country Status (27)
| Country | Link |
|---|---|
| US (5) | US20150274653A1 (https=) |
| EP (2) | EP2890375B1 (https=) |
| JP (5) | JP2015533782A (https=) |
| KR (4) | KR102271574B1 (https=) |
| CN (4) | CN104812743A (https=) |
| AP (2) | AP2015008249A0 (https=) |
| AR (2) | AR092270A1 (https=) |
| AU (5) | AU2013307337B2 (https=) |
| BR (2) | BR112015004192B1 (https=) |
| CA (2) | CA2880699A1 (https=) |
| CL (2) | CL2015000487A1 (https=) |
| CR (2) | CR20210079A (https=) |
| EA (2) | EA038942B1 (https=) |
| EC (2) | ECSP15007335A (https=) |
| GT (2) | GT201500021A (https=) |
| HK (2) | HK1208465A1 (https=) |
| IL (3) | IL236967A0 (https=) |
| JO (1) | JOP20130256B1 (https=) |
| MX (2) | MX375789B (https=) |
| NI (2) | NI201500030A (https=) |
| NZ (4) | NZ704752A (https=) |
| PH (3) | PH12015500317A1 (https=) |
| SG (4) | SG10201605291WA (https=) |
| TW (4) | TW201900607A (https=) |
| UA (2) | UA122385C2 (https=) |
| UY (2) | UY34993A (https=) |
| WO (2) | WO2014033176A1 (https=) |
Families Citing this family (164)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112014015197A8 (pt) | 2011-12-21 | 2017-06-13 | Novira Therapeutics Inc | agentes antivirais de hepatite b |
| KR102271574B1 (ko) | 2012-08-28 | 2021-07-01 | 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 | 설파모일-아릴아미드 및 b형 간염 치료제로서의 그 용도 |
| BR112015015584A2 (pt) | 2012-12-27 | 2017-12-12 | Baruch S Blumberg Inst | novos agentes antivirais contra infecção por hbv |
| WO2014131847A1 (en) * | 2013-02-28 | 2014-09-04 | Janssen R&D Ireland | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
| US8993771B2 (en) | 2013-03-12 | 2015-03-31 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
| MX353412B (es) | 2013-04-03 | 2018-01-10 | Janssen Sciences Ireland Uc | Derivados de n-fenil-carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
| DK2997019T3 (en) | 2013-05-17 | 2018-12-03 | Janssen Sciences Ireland Uc | SULFAMOYLTHIOPHENAMIDE DERIVATIVES AND USE THEREOF AS MEDICINES FOR TREATING HEPATITIS B |
| TWI733288B (zh) * | 2013-05-17 | 2021-07-11 | 愛爾蘭商健生科學愛爾蘭無限公司 | 胺磺醯基吡咯醯胺衍生物及其作為用於治療ｂ型肝炎藥物的用途 |
| HRP20180791T1 (hr) | 2013-07-25 | 2018-09-07 | Janssen Sciences Ireland Uc | Glioksamid supstituirani derivati pirolamida i njihova uporaba kao lijekova za liječenje hepatitisa b |
| CA2923712C (en) | 2013-10-23 | 2021-11-02 | Janssen Sciences Ireland Uc | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US9181288B2 (en) | 2014-01-16 | 2015-11-10 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| CA2936947A1 (en) | 2014-02-05 | 2015-08-13 | Novira Therapeutics, Inc. | Combination therapy for treatment of hbv infections |
| TW201620893A (zh) | 2014-02-06 | 2016-06-16 | 健生科學愛爾蘭無限公司 | 磺醯胺基吡咯醯胺衍生物及其用作治療ｂ型肝炎之醫藥品的用途 |
| ES2748029T3 (es) | 2014-03-13 | 2020-03-12 | Univ Indiana Res & Tech Corp | Moduladores alostéricos de proteína núcleo de hepatitis B |
| US9400280B2 (en) | 2014-03-27 | 2016-07-26 | Novira Therapeutics, Inc. | Piperidine derivatives and methods of treating hepatitis B infections |
| BR112017002001B1 (pt) * | 2014-07-31 | 2022-10-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Compostos e composição farmacêutica |
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| MA41338B1 (fr) | 2015-01-16 | 2019-07-31 | Hoffmann La Roche | Composés de pyrazine pour le traitement de maladies infectieuses |
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| US10442788B2 (en) | 2015-04-01 | 2019-10-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
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| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| US10179131B2 (en) | 2015-07-13 | 2019-01-15 | Enanta Pharmaceuticals, Inc. | Hepatitis B antiviral agents |
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