JP2005255683A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005255683A5 JP2005255683A5 JP2005080310A JP2005080310A JP2005255683A5 JP 2005255683 A5 JP2005255683 A5 JP 2005255683A5 JP 2005080310 A JP2005080310 A JP 2005080310A JP 2005080310 A JP2005080310 A JP 2005080310A JP 2005255683 A5 JP2005255683 A5 JP 2005255683A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- aryl
- substituted
- optionally
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 89
- 125000001072 heteroaryl group Chemical group 0.000 claims 63
- 125000000623 heterocyclic group Chemical group 0.000 claims 58
- 125000003118 aryl group Chemical group 0.000 claims 53
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 33
- -1 o-hydroxyphenyl Chemical group 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 125000000753 cycloalkyl group Chemical group 0.000 claims 14
- 125000003107 substituted aryl group Chemical group 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 125000005843 halogen group Chemical group 0.000 claims 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 12
- 239000000126 substance Substances 0.000 claims 12
- 125000001424 substituent group Chemical group 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 11
- 125000003710 aryl alkyl group Chemical group 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 9
- 125000001624 naphthyl group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 7
- 125000005549 heteroarylene group Chemical group 0.000 claims 7
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000001544 thienyl group Chemical group 0.000 claims 7
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims 6
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims 6
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 125000000732 arylene group Chemical group 0.000 claims 5
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 125000002947 alkylene group Chemical group 0.000 claims 4
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 229920006395 saturated elastomer Polymers 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000004450 alkenylene group Chemical group 0.000 claims 3
- 125000001153 fluoro group Chemical group F* 0.000 claims 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims 3
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims 3
- 125000002883 imidazolyl group Chemical group 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 claims 3
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 3
- 125000005551 pyridylene group Chemical group 0.000 claims 3
- 125000005493 quinolyl group Chemical group 0.000 claims 3
- 229910052717 sulfur Inorganic materials 0.000 claims 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 3
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- HSMPSHPWCOOUJH-UHFFFAOYSA-N anilinyl Chemical group [NH]C1=CC=CC=C1 HSMPSHPWCOOUJH-UHFFFAOYSA-N 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 2
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 2
- XSCHRSMBECNVNS-UHFFFAOYSA-N quinoxaline Chemical compound N1=CC=NC2=CC=CC=C21 XSCHRSMBECNVNS-UHFFFAOYSA-N 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 2
- CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 claims 2
- IANQTJSKSUMEQM-UHFFFAOYSA-N 1-benzofuran Chemical group C1=CC=C2OC=CC2=C1 IANQTJSKSUMEQM-UHFFFAOYSA-N 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 102000003964 Histone deacetylase Human genes 0.000 claims 1
- 108090000353 Histone deacetylase Proteins 0.000 claims 1
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 1
- 125000004419 alkynylene group Chemical group 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000002576 diazepinyl group Chemical class N1N=C(C=CC=C1)* 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 150000002460 imidazoles Chemical class 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 claims 1
- 125000002950 monocyclic group Chemical group 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 150000003222 pyridines Chemical class 0.000 claims 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims 1
- 125000000147 tetrahydroquinolinyl group Chemical group N1(CCCC2=CC=CC=C12)* 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
- 125000005557 thiazolylene group Chemical group 0.000 claims 1
- VSNHBZFIBVYYTO-UHFFFAOYSA-N Cc(nn1)nc2c1nnc(C)n2 Chemical compound Cc(nn1)nc2c1nnc(C)n2 VSNHBZFIBVYYTO-UHFFFAOYSA-N 0.000 description 1
- WYXCLXOZJLVETF-UHFFFAOYSA-N Cc1nc(C)nnn1 Chemical compound Cc1nc(C)nnn1 WYXCLXOZJLVETF-UHFFFAOYSA-N 0.000 description 1
- DGLYTMLIGRQDPE-UHFFFAOYSA-N Cc1nnc(C)nn1 Chemical compound Cc1nnc(C)nn1 DGLYTMLIGRQDPE-UHFFFAOYSA-N 0.000 description 1
- WMYJUIIOAXHXTA-UHFFFAOYSA-N Cc1nnc2nc(C)nnc2n1 Chemical compound Cc1nnc2nc(C)nnc2n1 WMYJUIIOAXHXTA-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US32240201P | 2001-09-14 | 2001-09-14 | |
| US39172802P | 2002-06-26 | 2002-06-26 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003528544A Division JP3795044B2 (ja) | 2001-09-14 | 2002-09-12 | ヒストンデアセチラーゼの阻害剤 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010013418A Division JP2010168382A (ja) | 2001-09-14 | 2010-01-25 | ヒストンデアセチラーゼの阻害剤 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005255683A JP2005255683A (ja) | 2005-09-22 |
| JP2005255683A5 true JP2005255683A5 (enExample) | 2006-04-20 |
Family
ID=26983397
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003528544A Expired - Fee Related JP3795044B2 (ja) | 2001-09-14 | 2002-09-12 | ヒストンデアセチラーゼの阻害剤 |
| JP2005080310A Pending JP2005255683A (ja) | 2001-09-14 | 2005-03-18 | ヒストンデアセチラーゼの阻害剤 |
| JP2010013418A Abandoned JP2010168382A (ja) | 2001-09-14 | 2010-01-25 | ヒストンデアセチラーゼの阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003528544A Expired - Fee Related JP3795044B2 (ja) | 2001-09-14 | 2002-09-12 | ヒストンデアセチラーゼの阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010013418A Abandoned JP2010168382A (ja) | 2001-09-14 | 2010-01-25 | ヒストンデアセチラーゼの阻害剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7595343B2 (enExample) |
| EP (1) | EP1429765A2 (enExample) |
| JP (3) | JP3795044B2 (enExample) |
| KR (2) | KR20100107509A (enExample) |
| CN (2) | CN1578663B (enExample) |
| AU (1) | AU2002327627B2 (enExample) |
| BR (1) | BR0212510A (enExample) |
| CA (1) | CA2465978C (enExample) |
| MX (1) | MXPA04002397A (enExample) |
| WO (1) | WO2003024448A2 (enExample) |
Families Citing this family (189)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003024448A2 (en) | 2001-09-14 | 2003-03-27 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| US7868204B2 (en) * | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
| US6897220B2 (en) * | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| US7375222B2 (en) | 2002-02-05 | 2008-05-20 | Astellas Pharma Inc. | 2,4,6-Triamino-1,3,5-triazine derivative |
| TWI319387B (en) * | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| GB0209715D0 (en) * | 2002-04-27 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| US7154002B1 (en) | 2002-10-08 | 2006-12-26 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7250514B1 (en) | 2002-10-21 | 2007-07-31 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US7351719B2 (en) | 2002-10-31 | 2008-04-01 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Amide compounds having MCH-antagonistic activity and medicaments comprising these compounds |
| KR20050122210A (ko) | 2003-03-17 | 2005-12-28 | 다케다 샌디에고, 인코포레이티드 | 히스톤 탈아세틸화 효소 억제제 |
| ME00541B (me) | 2003-05-23 | 2011-10-10 | Zentaris Gmbh | NOVI PIRIDOPIRAZINI I NJlUHOVA UPOTREBA KAO MODULATORA KlNAZA |
| DE10323345A1 (de) | 2003-05-23 | 2004-12-16 | Zentaris Gmbh | Neue Pyridopyrazine und deren Verwendung als Kinase-Inhibitoren |
| WO2005012256A1 (en) | 2003-07-22 | 2005-02-10 | Astex Therapeutics Limited | 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators |
| WO2005019188A1 (ja) * | 2003-08-22 | 2005-03-03 | Takeda Pharmaceutical Company Limited | 縮合ピリミジン誘導体およびその用途 |
| CA2539117A1 (en) | 2003-09-24 | 2005-04-07 | Methylgene Inc. | Inhibitors of histone deacetylase |
| GB0322409D0 (en) * | 2003-09-25 | 2003-10-29 | Astrazeneca Ab | Quinazoline derivatives |
| US20050085531A1 (en) * | 2003-10-03 | 2005-04-21 | Hodge Carl N. | Thiophene-based compounds exhibiting ATP-utilizing enzyme inhibitory activity, and compositions, and uses thereof |
| US7432281B2 (en) | 2003-10-07 | 2008-10-07 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
| US7935724B2 (en) * | 2003-10-09 | 2011-05-03 | Merck Hdac Research, Llc | Thiophene and benzothiophene hydroxamic acid derivatives |
| US7691866B2 (en) | 2003-10-16 | 2010-04-06 | Novartis Vaccines And Diagnostics, Inc. | 2,6-disubstituted quinazolines, quinoxalines, quinolines and isoquinolines and methods of their use as inhibitors of Raf kinase |
| WO2005066151A2 (en) * | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| WO2005065681A1 (en) * | 2003-12-19 | 2005-07-21 | Takeda San Diego, Inc. | N- hydroxy-3-(3-(1h-imidazol-2-yl)-phenyl)-acrylamide derivatives and related compounds as histone deacetylase (hdac) inhibitors for the treatment of cancer |
| US7592373B2 (en) | 2003-12-23 | 2009-09-22 | Boehringer Ingelheim International Gmbh | Amide compounds with MCH antagonistic activity and medicaments comprising these compounds |
| AU2005208938A1 (en) * | 2004-01-29 | 2005-08-11 | Elixir Pharmaceuticals, Inc | Anti-viral therapeutics |
| EP1713775A4 (en) * | 2004-01-30 | 2009-08-12 | Smithkline Beecham Corp | CHEMICAL COMPOUNDS |
| DK1725528T3 (da) | 2004-03-11 | 2013-09-02 | 4Sc Ag | Sulfonylpyrroler som hdac-inhibitorer |
| EP1735319B1 (en) * | 2004-03-26 | 2017-05-03 | MethylGene Inc. | Inhibitors of histone deacetylase |
| TWI415606B (zh) * | 2004-03-26 | 2013-11-21 | Methylgene Inc | 組蛋白去乙醯基酶之抑制劑 |
| US7253204B2 (en) * | 2004-03-26 | 2007-08-07 | Methylgene Inc. | Inhibitors of histone deacetylase |
| US7456176B2 (en) | 2004-04-08 | 2008-11-25 | Targegen, Inc. | Benzotriazine inhibitors of kinases |
| AR050926A1 (es) * | 2004-09-03 | 2006-12-06 | Astrazeneca Ab | Derivados de benzamida como inhibidores de la histonadesacetilasa(hdac) |
| US7776869B2 (en) | 2004-10-18 | 2010-08-17 | Amgen Inc. | Heteroaryl-substituted alkyne compounds and method of use |
| JP2008524246A (ja) | 2004-12-16 | 2008-07-10 | タケダ サン ディエゴ インコーポレイテッド | ヒストンデアセチラーゼ阻害剤 |
| GB0501146D0 (en) * | 2005-01-20 | 2005-02-23 | Astrazeneca Ab | Novel benzamide derivatives |
| US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
| AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
| AU2006209216A1 (en) | 2005-01-25 | 2006-08-03 | Galenea Corp | Substituted arylamine compounds and their use as 5-HT6 modulators |
| US7576099B2 (en) | 2005-02-28 | 2009-08-18 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
| PT1861365E (pt) | 2005-03-15 | 2009-09-22 | 4Sc Ag | N-sulfonilpirroles e a sua utilização como inibidores de histona-desacetilase |
| EP1874294A4 (en) | 2005-04-20 | 2010-12-01 | Merck Sharp & Dohme | BENZOTHIOPHENO HYDROXAMIDIC DERIVATIVES WITH CARBAMATE, UREA, AMID AND SULPHONAMIDE SUBSTITUTIONS |
| EP1874295A4 (en) | 2005-04-20 | 2009-08-12 | Merck & Co Inc | benzothiophene |
| CN101163690A (zh) | 2005-04-20 | 2008-04-16 | 默克公司 | 苯并噻吩异羟肟酸衍生物 |
| WO2006122319A2 (en) * | 2005-05-11 | 2006-11-16 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| EP1881835A4 (en) * | 2005-05-19 | 2010-04-07 | Prometic Biosciences Inc | TRIAZINE COMPOUNDS AND COMPOSITIONS THEREOF FOR THE TREATMENT OF CANCER |
| JP5148499B2 (ja) | 2005-05-20 | 2013-02-20 | メチルジーン インコーポレイテッド | Ｖｅｇｆ受容体およびｈｇｆ受容体シグナル伝達の阻害剤 |
| US7417066B2 (en) | 2005-06-08 | 2008-08-26 | Schering Ag | Inhibitors of soluble adenylate cyclase |
| DE102005027274A1 (de) * | 2005-06-08 | 2006-12-14 | Schering Ag | Inhibitoren der löslichen Adenylatzyklase |
| US8193206B2 (en) | 2005-06-14 | 2012-06-05 | Taigen Biotechnology Co., Ltd. | Pyrimidine compounds |
| US20060281712A1 (en) | 2005-06-14 | 2006-12-14 | Chi-Feng Yen | Pyrimidine compounds |
| JP4528918B2 (ja) * | 2005-06-21 | 2010-08-25 | 学校法人 関西大学 | カルボキサミド誘導体 |
| JP2008546793A (ja) | 2005-06-24 | 2008-12-25 | メルク エンド カムパニー インコーポレーテッド | 修飾マロン酸誘導体 |
| ZA200800901B (en) * | 2005-07-14 | 2010-05-26 | Takeda San Diego Inc | Histone deacetylase inhibitors |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス，インコーポレイティド | ムスカリン性受容体調節による神経発生 |
| JP5305909B2 (ja) | 2005-09-21 | 2013-10-02 | フォーエスシー アクチエンゲゼルシャフト | ヒストンデアセチラーゼインヒビターとしてのスルホニルピロール塩酸塩 |
| PT1928872E (pt) | 2005-09-21 | 2012-05-25 | 4Sc Ag | Utilização de novos sulfonilpirroles como inibidores de hdacs |
| GB0521244D0 (en) | 2005-10-19 | 2005-11-30 | Astrazeneca Ab | Benzamide compounds |
| US7985756B2 (en) | 2005-10-21 | 2011-07-26 | Braincells Inc. | Modulation of neurogenesis by PDE inhibition |
| WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US7528143B2 (en) | 2005-11-01 | 2009-05-05 | Targegen, Inc. | Bi-aryl meta-pyrimidine inhibitors of kinases |
| EP1790342A1 (de) | 2005-11-11 | 2007-05-30 | Zentaris GmbH | Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege |
| AU2006313701B2 (en) | 2005-11-11 | 2012-05-31 | Aeterna Zentaris Gmbh | Novel pyridopyrazines and their use as modulators of kinases |
| US8217042B2 (en) | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
| AR057579A1 (es) | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| CA2642813A1 (en) | 2006-02-28 | 2007-09-07 | Merck & Co., Inc. | Inhibitors of histone deacetylase |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| ES2452820T3 (es) | 2006-04-07 | 2014-04-02 | Methylgene, Inc. | Derivados de benzamida como inhibidores de histona desacetilasa |
| CA2649861A1 (en) | 2006-04-26 | 2007-11-08 | Merck & Co., Inc. | Disubstituted aniline compounds |
| WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| JP2009537529A (ja) | 2006-05-18 | 2009-10-29 | メルク エンド カムパニー インコーポレーテッド | アリール縮合スピロ環化合物 |
| JP2009544611A (ja) | 2006-07-20 | 2009-12-17 | メルク エンド カムパニー インコーポレーテッド | ヒストン脱アセチル化酵素阻害剤としてのリン誘導体 |
| EP2068872A1 (en) | 2006-09-08 | 2009-06-17 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| EP2049483A2 (en) | 2006-10-28 | 2009-04-22 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| EP2923703B1 (en) | 2006-12-15 | 2018-09-19 | NantBio, Inc. | Triazine derivatives and their therapeutical applications |
| CA2679198C (en) | 2007-02-26 | 2011-07-12 | Pfizer Products Inc. | Nicotinamide derivatives as inhibitors of h-pgds and their use for treating prostaglandin d2 mediated diseases |
| US8030344B2 (en) | 2007-03-13 | 2011-10-04 | Methylgene Inc. | Inhibitors of histone deacetylase |
| AU2008269154B2 (en) | 2007-06-27 | 2014-06-12 | Merck Sharp & Dohme Llc | 4-carboxybenzylamino derivatives as histone deacetylase inhibitors |
| US8461189B2 (en) | 2007-06-27 | 2013-06-11 | Merck Sharp & Dohme Corp. | Pyridyl derivatives as histone deacetylase inhibitors |
| JP5322477B2 (ja) * | 2007-09-28 | 2013-10-23 | 富士フイルム株式会社 | 新規アセチレン化合物、その塩、その製造方法、それを構成単位として含むポリマー、該ポリマーの製造方法、該ポリマーの組成物、該ポリマー組成物を硬化させてなる硬化物 |
| CA2700058A1 (en) | 2007-09-19 | 2009-03-26 | 4Sc Ag | Novel tetrahydrofusedpyridines |
| CN101808999B (zh) | 2007-09-27 | 2013-02-13 | 弗·哈夫曼-拉罗切有限公司 | 用作5ht5a受体拮抗剂的喹啉衍生物 |
| AU2008309269B2 (en) * | 2007-10-10 | 2012-06-07 | Orchid Research Laboratories Limited | Novel histone deacetylase inhibitors |
| KR20100074288A (ko) * | 2007-10-22 | 2010-07-01 | 오키드 리서치 레버라토리즈 리미티드 | 히스톤 디아세틸라제 억제제 |
| EP2060565A1 (en) * | 2007-11-16 | 2009-05-20 | 4Sc Ag | Novel bifunctional compounds which inhibit protein kinases and histone deacetylases |
| BRPI0906361A2 (pt) * | 2008-01-29 | 2019-04-30 | F. Hoffmann- La Roche Ag | derivados de n-(2-amino-fenil)-amida |
| EP2268635B1 (en) | 2008-04-21 | 2015-06-10 | Taigen Biotechnology Co., Ltd. | Heterocyclic compounds |
| MX2010012297A (es) * | 2008-05-16 | 2010-12-06 | Hoffmann La Roche | Nuevas n-(2-amino-fenil)-acrilamidas. |
| WO2009142321A1 (ja) * | 2008-05-23 | 2009-11-26 | 参天製薬株式会社 | ウレア構造を有する新規チオフェンジアミン誘導体 |
| JP5351254B2 (ja) | 2008-05-23 | 2013-11-27 | ノバルティス アーゲー | キノキサリン−およびキノリン−カルボキシアミド誘導体 |
| AU2009260503B2 (en) | 2008-05-27 | 2014-03-27 | The Board Of Regents Of The University Of Texas System | Wnt protein signalling inhibitors |
| AU2009289649B2 (en) | 2008-09-03 | 2016-05-05 | Biomarin Pharmaceutical Inc. | Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors |
| US8202866B2 (en) * | 2008-09-17 | 2012-06-19 | Hoffmann-La Roche Inc. | Ortho-aminoanilides for the treatment of cancer |
| SMT202000257T1 (it) * | 2008-10-10 | 2020-07-08 | Vm Discovery Inc | Composizioni e metodi per il trattamento dei disturbi da uso di alcol, dolore e altre malattie |
| CA2740746A1 (en) | 2008-10-14 | 2010-04-22 | Ning Xi | Compounds comprising a spiro-ring and and methods of use |
| TW201021855A (en) | 2008-11-13 | 2010-06-16 | Taigen Biotechnology Co Ltd | Lyophilization formulation |
| EP3725775A1 (en) | 2009-02-17 | 2020-10-21 | Syntrix Biosystems, Inc. | Pyridine- and pyrimidinecarboxamides as cxcr2 modulators |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| CN101906076B (zh) * | 2009-06-04 | 2013-03-13 | 深圳微芯生物科技有限责任公司 | 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用 |
| AU2010258974A1 (en) * | 2009-06-09 | 2012-01-12 | California Capital Equity, Llc | Pyridil-triazine inhibitors of hedgehog signaling |
| CA2765030C (en) | 2009-06-09 | 2015-10-27 | California Capital Equity, Llc | Triazine derivatives and their therapeutical applications |
| CN102573484B (zh) | 2009-06-09 | 2015-07-01 | 加利福尼亚资本权益有限责任公司 | 苄基取代的三嗪衍生物及其治疗应用 |
| US8784873B2 (en) * | 2009-07-22 | 2014-07-22 | Naturewise Biotech & Medicals Corporation | Use of histone deacetylase inhibitors in changing MRJP3 protein in royal jelly |
| JP2011057661A (ja) * | 2009-08-14 | 2011-03-24 | Bayer Cropscience Ag | 殺虫性カルボキサミド類 |
| IN2012DN03807A (enExample) | 2009-10-30 | 2015-08-28 | Massachusetts Inst Technology | |
| BR112012029647A2 (pt) | 2010-05-21 | 2016-08-02 | Chemilia Ab | novos derivados de pirimidinas |
| AU2011293612B2 (en) * | 2010-08-23 | 2015-11-26 | Syntrix Biosystems Inc. | Aminopyridine- and aminopyrimidinecarboxamides as CXCR2 modulators |
| WO2012060847A1 (en) | 2010-11-07 | 2012-05-10 | Targegen, Inc. | Compositions and methods for treating myelofibrosis |
| RU2568258C2 (ru) | 2011-02-28 | 2015-11-20 | Саншайн Лейк Фарма Ко., Лтд | Замещенные соединения хинолина и способы их использования |
| US10059723B2 (en) | 2011-02-28 | 2018-08-28 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| JP6250403B2 (ja) | 2011-02-28 | 2017-12-20 | バイオマリン ファーマシューティカル インク | ヒストン脱アセチル化酵素阻害剤 |
| US8957066B2 (en) | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| JP5886411B2 (ja) | 2011-03-24 | 2016-03-16 | ノビガ・リサーチ・エービーＮｏｖｉｇａ Ｒｅｓｅａｒｃｈ ＡＢ | 新規のピリミジン誘導体 |
| EP2508184A1 (en) | 2011-04-06 | 2012-10-10 | Æterna Zentaris GmbH | Pyridopyrazine derivatives and their use |
| CN102775356B (zh) * | 2011-05-13 | 2015-07-22 | 江苏恒谊药业有限公司 | 4-氨基喹唑啉衍生物及其应用 |
| CN102807526B (zh) * | 2011-06-21 | 2015-12-02 | 寿光富康制药有限公司 | 组蛋白去乙酰化酶抑制剂ZYJ-D08a及其差向异构体的制备方法与应用 |
| CN102838625B (zh) * | 2011-06-22 | 2015-04-15 | 中国科学院上海药物研究所 | 四氢吡啶并噻唑类化合物、其制备方法、包含该化合物的药物组合物及其用途 |
| CN102276554B (zh) * | 2011-06-28 | 2013-10-30 | 四川大学 | 4-（（2-氨基-5-巯基-1,3,4-噻二唑）-甲基）-苯甲酰胺衍生物及其制备方法和用途 |
| CN103764635B (zh) * | 2011-07-08 | 2016-01-20 | 诺华股份有限公司 | 新的三氟甲基-噁二唑衍生物及其在疾病治疗中的用途 |
| EP2736883B1 (en) * | 2011-07-29 | 2019-09-04 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| EP2736887B1 (en) | 2011-07-29 | 2017-10-18 | Karyopharm Therapeutics, Inc. | Hydrazide containing nuclear transport modulators and uses thereof |
| EP2785713B1 (en) * | 2011-11-28 | 2016-09-07 | Novartis AG | Novel trifluoromethyl-oxadiazole derivatives and their use in the treatment of disease |
| JP5881460B2 (ja) * | 2012-02-23 | 2016-03-09 | 公立大学法人名古屋市立大学 | 新規アミド化合物及びその用途 |
| JPWO2013137371A1 (ja) * | 2012-03-15 | 2015-08-03 | 興和株式会社 | 新規ピリミジン化合物及びそれらを含有する医薬 |
| IN2014DN09434A (enExample) | 2012-05-09 | 2015-07-17 | Karyopharm Therapeutics Inc | |
| US9499496B2 (en) | 2012-06-05 | 2016-11-22 | University Of Kansas | Inhibitors of respiratory syncytial virus |
| JP6342392B2 (ja) | 2012-07-28 | 2018-06-13 | カリター・サイエンシーズ・エルエルシー | 置換型ピラゾロン化合物及び使用方法 |
| TWI574962B (zh) | 2012-11-14 | 2017-03-21 | 加拓科學公司 | 作爲ｐｉ３激酶調節劑的芳雜環化合物及其使用方法和用途 |
| CA2895808A1 (en) | 2012-12-21 | 2014-06-26 | Quanticel Pharmaceuticals, Inc. | Histone demethylase inhibitors |
| WO2014121062A1 (en) | 2013-02-01 | 2014-08-07 | Acetylon Pharmaceuticals, Inc. | Selective hdac3 inhibitors |
| US9139583B2 (en) | 2013-02-01 | 2015-09-22 | Acetylon Pharmaceuticals, Inc. | Selective HDAC3 inhibitors |
| KR102148681B1 (ko) | 2013-02-21 | 2020-08-27 | 칼리토르 사이언시즈, 엘엘씨 | Pi3 키나제 모듈레이터로서의 헤테로방향족 화합물 |
| WO2014144772A1 (en) | 2013-03-15 | 2014-09-18 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using crm1 inhibitors |
| PT2970139T (pt) | 2013-03-15 | 2018-08-01 | Biomarin Pharm Inc | Inibidores de hdac |
| CN110386919B (zh) | 2013-06-21 | 2023-07-14 | 卡尔约药物治疗公司 | 核转运调节剂及其用途 |
| US8969365B2 (en) | 2013-08-02 | 2015-03-03 | Syntrix Biosystems, Inc. | Thiopyrimidinecarboxamides as CXCR1/2 modulators |
| US10561676B2 (en) | 2013-08-02 | 2020-02-18 | Syntrix Biosystems Inc. | Method for treating cancer using dual antagonists of CXCR1 and CXCR2 |
| US10046002B2 (en) | 2013-08-02 | 2018-08-14 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| EP2853532B1 (en) * | 2013-09-28 | 2020-12-09 | Instytut Farmakologii Polskiej Akademii Nauk | 1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III |
| TWI624467B (zh) | 2013-10-14 | 2018-05-21 | 衛材Ｒ＆Ｄ企管股份有限公司 | 選擇性經取代之喹啉化合物 |
| US9663486B2 (en) | 2013-10-14 | 2017-05-30 | Eisai R&D Management Co., Ltd. | Selectively substituted quinoline compounds |
| EP3062783B1 (en) | 2013-10-18 | 2020-08-12 | The General Hospital Corporation | Imaging histone deacetylases with a radiotracer using positron emission tomography |
| USRE49240E1 (en) * | 2013-11-05 | 2022-10-11 | The General Hospital Corporation | Inhibitors of histone deacetylase |
| US9636298B2 (en) | 2014-01-17 | 2017-05-02 | Methylgene Inc. | Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs |
| MX375219B (es) | 2014-06-25 | 2025-03-06 | Celgene Quanticel Res Inc | Inhibidores de histona demetilasa. |
| KR102494596B1 (ko) * | 2014-07-31 | 2023-01-31 | 재단법인 한국파스퇴르연구소 | 2-아미노-벤즈이미다졸 유도체 및 5-리폭시게나아제 및/또는 프로스타글란딘 e 합성효소 억제제로서의 이들의 용도 |
| CN111484483B (zh) | 2014-08-15 | 2023-05-26 | 卡尔约药物治疗公司 | 赛灵克斯的多晶型物 |
| CA2990660A1 (en) * | 2015-07-02 | 2017-01-05 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| AU2016343517B2 (en) | 2015-10-19 | 2020-04-30 | Sunshine Lake Pharma Co., Ltd. | A salt of EGFR inhibitor, crystalline form and uses thereof |
| EP3397634A1 (en) | 2015-12-31 | 2018-11-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| US10526295B2 (en) | 2015-12-31 | 2020-01-07 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| CN109311825B (zh) * | 2016-05-12 | 2022-03-22 | 南京世其医药科技有限公司 | 2,4,6-三取代均三嗪化合物及其制备方法和应用 |
| CN106242992A (zh) * | 2016-07-25 | 2016-12-21 | 北京化工大学 | 一种苯甲酰胺类化合物及其在制备抑制癌细胞增殖和/或治疗癌症的药物中的应用 |
| CN106496053B (zh) * | 2016-09-22 | 2018-01-05 | 潍坊医学院 | 一种组蛋白去乙酰酶抑制剂n‑(2’‑胺基苯基)‑4‑(双(2‑氯乙基)胺基)苯甲酰胺及其制备方法和应用 |
| US10660909B2 (en) | 2016-11-17 | 2020-05-26 | Syntrix Biosystems Inc. | Method for treating cancer using chemokine antagonists |
| US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
| TW201829381A (zh) * | 2016-12-22 | 2018-08-16 | 美商拜奧馬林製藥公司 | 組蛋白脫乙醯基酶抑制劑 |
| WO2018165520A1 (en) | 2017-03-10 | 2018-09-13 | Vps-3, Inc. | Metalloenzyme inhibitor compounds |
| US20200039938A1 (en) | 2017-03-30 | 2020-02-06 | Albert-Ludwigs-University Freiburg | Kdm4 inhibitors |
| CN107141244B (zh) * | 2017-05-08 | 2019-11-19 | 潍坊医学院 | 吲哚丁酸类组蛋白去乙酰酶抑制剂及其制备方法和应用 |
| EP3624804B1 (en) * | 2017-05-16 | 2022-02-16 | Annji Pharmaceutical Co., Ltd. | Histone deacetylases (hdacs) inhibitors |
| US11230524B2 (en) * | 2017-08-17 | 2022-01-25 | Standard Llc | Myocyte enhancer factor 2 (MEF2) modulators |
| CN107459480A (zh) * | 2017-09-05 | 2017-12-12 | 镇江斯格派医疗器械有限公司 | 一种双芳基脲类组蛋白去乙酰化酶抑制剂 |
| KR101964810B1 (ko) | 2017-10-12 | 2019-04-02 | 충북대학교 산학협력단 | Hdac 억제제로서 신규한 퀴나졸린-4(3h)-원 기반 n-하이드록시벤즈아미드 또는 n-하이드록시프로펜아미드 및 이를 유효성분으로 포함하는 항암제 조성물 |
| EP3710430B9 (en) | 2017-11-15 | 2024-10-30 | Metabomed Ltd | Acss2 inhibitors and methods of use thereof |
| US12133852B2 (en) | 2017-11-15 | 2024-11-05 | Epivario, Inc. | ACSS2 inhibitors and methods of use thereof |
| CN108570012B (zh) * | 2018-05-23 | 2021-11-12 | 中南大学 | 1,3-苯并噁嗪-2,4(3h)-二酮衍生物及其合成方法和用途 |
| CN109020951B (zh) * | 2018-08-24 | 2020-06-02 | 大连理工大学 | 含三取代三聚氯氰的萘酰亚胺类衍生物及其合成方法和应用 |
| CN109336867A (zh) * | 2018-10-31 | 2019-02-15 | 南京先进生物材料与过程装备研究院有限公司 | 咔唑类stat3抑制剂晶型a及其制备方法 |
| CN109369626A (zh) * | 2018-10-31 | 2019-02-22 | 南京先进生物材料与过程装备研究院有限公司 | 咔唑类stat3抑制剂p晶型及其制备方法 |
| CN109180656A (zh) * | 2018-10-31 | 2019-01-11 | 南京先进生物材料与过程装备研究院有限公司 | 一类stat3抑制剂及其应用 |
| CN109336870A (zh) * | 2018-10-31 | 2019-02-15 | 南京先进生物材料与过程装备研究院有限公司 | 咔唑类stat3抑制剂晶型i及其制备方法 |
| CN109336877A (zh) * | 2018-10-31 | 2019-02-15 | 南京先进生物材料与过程装备研究院有限公司 | 二苯并[b,d]噻吩类STAT3抑制剂的甲磺酸盐及其制备方法与用途 |
| CN109336869A (zh) * | 2018-10-31 | 2019-02-15 | 南京先进生物材料与过程装备研究院有限公司 | 一种stat3抑制剂的甲磺酸盐及其制备方法与用途 |
| CN109336876A (zh) * | 2018-10-31 | 2019-02-15 | 南京先进生物材料与过程装备研究院有限公司 | 二苯并[b,d]噻吩类STAT3抑制剂的酒石酸盐及其制备方法与用途 |
| CN110078722A (zh) * | 2018-10-31 | 2019-08-02 | 南京先进生物材料与过程装备研究院有限公司 | 一种噻吨酮类stat3抑制剂马来酸盐晶型a及其应用 |
| CN109336871A (zh) * | 2018-10-31 | 2019-02-15 | 南京先进生物材料与过程装备研究院有限公司 | 一种stat3抑制剂的马来酸盐及其制备方法与用途 |
| CN109293647A (zh) * | 2018-10-31 | 2019-02-01 | 南京先进生物材料与过程装备研究院有限公司 | 二苯并[b,d]噻吩类STAT3抑制剂的M晶型及其制备方法 |
| CN109369628A (zh) * | 2018-10-31 | 2019-02-22 | 南京先进生物材料与过程装备研究院有限公司 | 咔唑类stat3抑制剂晶型ii及其制备方法 |
| AU2020274645A1 (en) * | 2019-05-14 | 2021-12-16 | Metabomed Ltd | ACSS2 inhibitors and methods of use thereof |
| WO2021021979A2 (en) | 2019-07-30 | 2021-02-04 | Eikonizo Therapapeutics, Inc. | Hdac6 inhibitors and uses thereof |
| GB201918404D0 (en) * | 2019-12-13 | 2020-01-29 | Z Factor Ltd | Compounds and their use for the treatment of aplha1-antitrypsin deficiency |
| CN111116469A (zh) * | 2019-12-27 | 2020-05-08 | 北京鑫开元医药科技有限公司 | 一种hdac抑制剂、制备方法、药物组合物及其用途 |
| CN113549057B (zh) * | 2020-04-24 | 2023-01-31 | 中国药科大学 | Snail抑制剂及其衍生物，制备方法、药物组合物和应用 |
| CN115403483B (zh) * | 2021-07-02 | 2024-01-26 | 河南省儿童医院郑州儿童医院 | 含二苯乙烯或二苯甲酮骨架的ca-4衍生物、药物组合物及其制备方法和应用 |
| CN114539180B (zh) * | 2021-12-24 | 2025-02-07 | 贵州大学 | 一种含异噁唑啉的双酰胺类化合物及其制备方法和用途 |
| EP4504190A4 (en) | 2022-04-08 | 2026-03-25 | Eikonizo Therapeutics Inc | OXADIAZOLE HDAC6 INHIBITORS AND THEIR USES |
| CN118745163B (zh) * | 2024-06-06 | 2026-02-17 | 四川省医学科学院·四川省人民医院 | 苯并呋喃类化合物、其制备方法及其应用和pdgfr激酶抑制剂 |
Family Cites Families (107)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE623069C (de) | 1931-11-07 | 1935-12-12 | I G Farbenindustrie Akt Ges | Verfahren zur Herstellung von Aminoacylaminoanthrachinonen |
| US2598587A (en) | 1949-07-22 | 1952-05-27 | Ciba Ltd | Di (1, 4 diamino-2-aryl ketone anthraquinone) amides of aromatic dicarboxylic acids |
| GB680857A (en) | 1949-07-22 | 1952-10-15 | Ciba Ltd | Manufacture of vat dyestuffs of the anthraquinone series |
| US2754286A (en) * | 1951-10-15 | 1956-07-10 | Du Pont | Aldehydes and their acetals |
| FR1071798A (fr) | 1952-04-12 | 1954-09-06 | Basf Ag | Procédé pour la production de dérivés d'acides 1-aminoanthraquinones-2-carboxyliques |
| CH431764A (de) | 1959-05-06 | 1967-03-15 | Sandoz Ag | Verfahren zur Herstellung metallhaltiger Reaktivfarbstoffe |
| DE1164003B (de) | 1961-08-05 | 1964-02-27 | Bayer Ag | Verfahren zur Herstellung von Anthrachinonfarbstoffen |
| US3329700A (en) | 1962-02-15 | 1967-07-04 | Polaroid Corp | (dihydroxy- and dicarbethoxy-phenyl) phenylcarboxamide compounds |
| BE630205A (enExample) | 1963-03-28 | |||
| US3263924A (en) | 1963-09-13 | 1966-08-02 | Dole Valve Co | Heating and cooling zone valve |
| IL22272A (en) | 1963-11-06 | 1969-02-27 | Merck & Co Inc | 2-heteroaryl-5(or 6)-aryl substituted benzazoles |
| US3376268A (en) | 1964-02-26 | 1968-04-02 | Monsanto Co | Amide-heterocyclic polymers |
| US3336286A (en) | 1964-06-25 | 1967-08-15 | Du Pont | 5-nitro-2-thiazole-3'-amino arylcarbonyl and arylsulfonyl anilide azo dyes |
| GB1147769A (en) | 1965-09-30 | 1969-04-10 | Monsanto Co | Polymerization of aromatic primary diamines |
| CH477163A (de) * | 1967-07-26 | 1969-10-15 | Ciba Geigy | Verwendung von Salicylsäure-o-hydroxyphenylamiden zum antimikrobiellen Ausrüsten bzw. zum Schützen von textilem Material gegen schädliche Mikroorganismen |
| FR2036652A5 (en) | 1969-03-06 | 1970-12-24 | Ciba Geigy | Naphthoxazole optical blueing agents |
| US3637534A (en) | 1969-07-09 | 1972-01-25 | Monsanto Co | Polymers from aromatic primary diamines |
| DE2019427A1 (de) | 1970-04-22 | 1971-11-11 | Bayer Ag | 1-Arylamino-2-hydroxy-anthrachinone und Verfahren zu ihrer Herstellung |
| CH554890A (de) | 1970-12-31 | 1974-10-15 | Sandoz Ag | Verfahren zur herstellung von bistriazolverbindungen. |
| FR2128369A1 (en) | 1971-03-03 | 1972-10-20 | Ciba Geigy Ag | Anthraquinone/acridone vat dyes - and pigments contg triazine grps for cellulosic fibres, plastics, paints, etc |
| CH559737A5 (en) | 1971-09-28 | 1975-03-14 | Sandoz Ag | Bis-ar-oxazolyl-para-poly-phenylenes, prodn. - from di-carboxylic acid and ortho-amino-hydroxy cpds. and use as optical brighteners |
| LU76467A1 (enExample) | 1976-12-23 | 1978-07-10 | ||
| DE2846168A1 (de) | 1978-10-24 | 1980-05-08 | Bayer Ag | Verfahren zum faerben und bedrucken von cellulosefasern |
| JPS60126832A (ja) | 1983-12-14 | 1985-07-06 | Hitachi Ltd | ドライエツチング方法および装置 |
| IT1196348B (it) | 1984-11-29 | 1988-11-16 | Italfarmaco Spa | Composti ad attivita'antiinfiammatoria |
| LU86022A1 (fr) | 1985-07-25 | 1987-02-04 | Cird | Derives aromatiques polycyliques,leur procede de preparation et leur application dans les domaines pharmaceutique et cosmetique |
| NZ219974A (en) * | 1986-04-22 | 1989-08-29 | Goedecke Ag | N-(2'-aminophenyl)-benzamide derivatives, process for their preparation and their use in the control of neoplastic diseases |
| JPS63111400A (ja) | 1986-10-28 | 1988-05-16 | Tokyo Gas Co Ltd | 地下式低温貯槽の側壁上部構造 |
| US5149797A (en) * | 1990-02-15 | 1992-09-22 | The Worcester Foundation For Experimental Biology | Method of site-specific alteration of rna and production of encoded polypeptides |
| JPH03258749A (ja) | 1990-03-07 | 1991-11-19 | Ono Pharmaceut Co Ltd | ベンゾフェノン誘導体、それらの製造方法、およびそれらを含有する薬剤 |
| US5149755A (en) | 1991-07-05 | 1992-09-22 | Eastman Kodak Company | Preparation of poly(benz(ox, imid, thi)azole) polymers |
| US5332750A (en) | 1991-09-04 | 1994-07-26 | Merck Patent Gesellschaft Mit Beschrankter Haftung | 1,2-dihydro-2-oxopyridines |
| DK0533268T3 (da) | 1991-09-18 | 2001-12-03 | Glaxo Group Ltd | Benzanilidderivater som 5HT-1D antagonister |
| RU2027701C1 (ru) | 1992-01-03 | 1995-01-27 | Акционерное общество открытого типа "Научно-исследовательский и проектный институт мономеров с опытным заводом" | N,n`-бис-(2,4-диаминофенил)амиды 4,4`-дифенил- или 4,4`-дифенилоксид дикарбоновой кислоты в качестве промежуточных продуктов в синтезе 4,4`-бис [5(6)-аминобензимидазолил-2]-дифенила или -дифенилоксида |
| US5652355A (en) * | 1992-07-23 | 1997-07-29 | Worcester Foundation For Experimental Biology | Hybrid oligonucleotide phosphorothioates |
| JPH06128276A (ja) | 1992-10-20 | 1994-05-10 | Canon Inc | 液晶性化合物、これを含む液晶組成物、それを有する液晶素子、それらを用いた表示方法および表示装置 |
| DE4339868A1 (de) | 1993-11-23 | 1995-05-24 | Merck Patent Gmbh | Imidazopyridazine |
| US6162815A (en) * | 1994-04-26 | 2000-12-19 | Centre International De Recherches Dermatologiques Galderma | RXR-agonist polycyclic aromatic compounds, pharmaceutical/cosmetic compositions comprising said compound and uses thereof |
| JP3668494B2 (ja) | 1994-05-31 | 2005-07-06 | 帝人株式会社 | ナフタレン誘導体 |
| DE19510957A1 (de) | 1995-03-25 | 1996-09-26 | Huels Chemische Werke Ag | Eingedickter Bodenverfestiger, sowie diesen enthaltende verpackte Fertigmischung für Bodenbehandlungen |
| FR2733684B1 (fr) | 1995-05-03 | 1997-05-30 | Cird Galderma | Utilisation de retinoides dans une composition cosmetique ou pour la fabrication d'une composition pharmaceutique |
| US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| US6174905B1 (en) * | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
| JP3354090B2 (ja) * | 1996-09-30 | 2002-12-09 | シエーリング アクチエンゲゼルシャフト | 分化誘導剤 |
| US6794392B1 (en) * | 1996-09-30 | 2004-09-21 | Schering Aktiengesellschaft | Cell differentiation inducer |
| JPH10219128A (ja) | 1997-02-06 | 1998-08-18 | Mitsui Chem Inc | 新規アントラキノン化合物及びその用途 |
| AU6422098A (en) * | 1997-03-24 | 1998-10-20 | Kyowa Hakko Kogyo Co. Ltd. | Benzene derivatives |
| FR2761986B1 (fr) | 1997-04-09 | 1999-05-21 | Hoechst Schering Agrevo Sa | Nouveaux amides aromatiques, leur procede de preparation et leur application comme pesticides |
| JP4669590B2 (ja) | 1997-05-14 | 2011-04-13 | 富士フイルム株式会社 | ビスベンゾアゾール化合物 |
| FR2767525B1 (fr) | 1997-08-21 | 1999-11-12 | Cird Galderma | Derives biphenyliques substitues par un radical aromatique ou heteroaromatique et compositions pharmaceutiques et cosmetiques les contenant |
| JP3355292B2 (ja) | 1997-08-25 | 2002-12-09 | 大日精化工業株式会社 | 複写防止記録方法 |
| US6034251A (en) | 1997-11-07 | 2000-03-07 | Schering Corporation | Phenyl-alkyl-imidazoles |
| JPH11318492A (ja) | 1998-03-09 | 1999-11-24 | Aisin Seiki Co Ltd | 蛍光発生性基質を含有する組成物 |
| JPH11269146A (ja) | 1998-03-24 | 1999-10-05 | Mitsui Chem Inc | 分化誘導剤 |
| PL345283A1 (en) | 1998-07-20 | 2001-12-03 | Merck Patent Gmbh | Biphenyl derivatives |
| EP1100484A1 (en) * | 1998-07-20 | 2001-05-23 | SmithKline Beecham Corporation | Macrophage scavenger receptor antagonists |
| JP3753293B2 (ja) | 1998-08-07 | 2006-03-08 | 富士写真フイルム株式会社 | 有機エレクトロルミネッセンス素子 |
| SG104255A1 (en) | 1998-09-29 | 2004-06-21 | Sumitomo Bakelite Co | Polybenzoxazole resin and precursor thereof |
| JP2000178356A (ja) | 1998-12-17 | 2000-06-27 | Sumitomo Bakelite Co Ltd | ポリベンゾオキサゾール前駆体及びポリベンゾオキサゾール樹脂 |
| JP4524808B2 (ja) | 1999-03-30 | 2010-08-18 | 日立化成デュポンマイクロシステムズ株式会社 | 感光性樹脂組成物、レリーフパターンの製造法 |
| JP2000290374A (ja) | 1999-04-09 | 2000-10-17 | Central Glass Co Ltd | 含フッ素ポリベンゾオキサゾール |
| US6653309B1 (en) * | 1999-04-26 | 2003-11-25 | Vertex Pharmaceuticals Incorporated | Inhibitors of IMPDH enzyme technical field of the invention |
| JP4399949B2 (ja) | 1999-06-29 | 2010-01-20 | 日立化成デュポンマイクロシステムズ株式会社 | 感光性樹脂組成物、パターンの製造法及び電子部品 |
| JP2001011181A (ja) | 1999-07-02 | 2001-01-16 | Sumitomo Bakelite Co Ltd | 絶縁材用樹脂組成物及びこれを用いた絶縁材 |
| JP2001035256A (ja) | 1999-07-23 | 2001-02-09 | Sumitomo Bakelite Co Ltd | 絶縁材用組成物及びこれを用いた絶縁材 |
| JP2001081031A (ja) | 1999-08-30 | 2001-03-27 | Schering Ag | 溶解性および経口吸収性を改善したベンズアミド誘導体含有製剤 |
| JP2001139684A (ja) | 1999-08-30 | 2001-05-22 | Sumitomo Bakelite Co Ltd | 多層配線用層間絶縁膜並びにそれに用いる樹脂及びその製造方法 |
| US6632815B2 (en) | 1999-09-17 | 2003-10-14 | Millennium Pharmaceuticals, Inc. | Inhibitors of factor Xa |
| DE60040676D1 (de) | 1999-09-17 | 2008-12-11 | Millennium Pharm Inc | BENZAMIDE UND ÄHNLICHE INHIBITOREN VON FAKTOR Xa |
| JP2001114893A (ja) | 1999-10-15 | 2001-04-24 | Sumitomo Bakelite Co Ltd | ポリベンゾオキサゾール樹脂およびその前駆体 |
| JP4360660B2 (ja) | 1999-11-09 | 2009-11-11 | 三井化学株式会社 | モノアシルフェニレンジアミン誘導体の精製法 |
| CA2391952C (en) * | 1999-11-23 | 2012-01-31 | Methylgene Inc. | Inhibitors of histone deacetylase |
| AU2001234089B2 (en) | 2000-02-15 | 2005-08-11 | Teijin Limited | Cancer remedy comprising anthranilic acid derivative as active ingredient |
| ES2254385T3 (es) | 2000-02-29 | 2006-06-16 | Millennium Pharmaceuticals, Inc. | Benzamidas e inhibidores relacionados del factor xa. |
| AU2001241128A1 (en) * | 2000-03-14 | 2001-09-24 | Fujisawa Pharmaceutical Co. Ltd. | Novel amide compounds |
| EP1438404A2 (en) | 2000-03-24 | 2004-07-21 | Methylgene, Inc. | Inhibition of specific histone deacetylase isoforms |
| AU2001248701A1 (en) | 2000-03-24 | 2001-10-03 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| US7122544B2 (en) * | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| WO2002069947A2 (en) | 2001-01-12 | 2002-09-12 | Methylgene, Inc. | Antisense oligonucleotides and trichostatin analogue histone deacetylase-4 inhibitors against cancer |
| US7067539B2 (en) | 2001-02-08 | 2006-06-27 | Schering Corporation | Cannabinoid receptor ligands |
| US7507767B2 (en) * | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
| US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| WO2003024448A2 (en) * | 2001-09-14 | 2003-03-27 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| US7868204B2 (en) | 2001-09-14 | 2011-01-11 | Methylgene Inc. | Inhibitors of histone deacetylase |
| JP2005509032A (ja) * | 2001-11-14 | 2005-04-07 | シェーリング コーポレイション | カンナビノイドレセプターリガンド |
| JP4169986B2 (ja) | 2001-11-26 | 2008-10-22 | 日本曹達株式会社 | フェノール性化合物及びそれを用いた記録材料 |
| AU2003218737B2 (en) | 2002-03-13 | 2008-04-10 | Janssen Pharmaceutica N.V. | Inhibitors of histone deacetylase |
| ATE395343T1 (de) | 2002-03-13 | 2008-05-15 | Janssen Pharmaceutica Nv | Sulfonylderivate als histone-deacetylase- inhibitoren |
| ES2306880T3 (es) | 2002-03-13 | 2008-11-16 | Janssen Pharmaceutica Nv | Derivados de sulfonilamino como inhibidores novedosos de la histona desacetilasa. |
| EA007270B1 (ru) | 2002-03-13 | 2006-08-25 | Янссен Фармацевтика Н.В. | Пиперазинил-, пиперидинил- и морфолинилпроизводные как новые ингибиторы гистондеацетилазы |
| CA2476067C (en) | 2002-03-13 | 2011-09-20 | Janssen Pharmaceutica N.V. | Carbonylamino-derivatives as novel inhibitors of histone deacetylase |
| US7169737B2 (en) * | 2002-03-14 | 2007-01-30 | Nippon Soda Co., Ltd. | Phenolic compound and recording material using the same |
| TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| GB0209715D0 (en) | 2002-04-27 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| EP1539693B9 (en) * | 2002-06-19 | 2008-10-08 | Schering Corporation | Cannabinoid receptor agonists |
| US20040072770A1 (en) | 2002-07-03 | 2004-04-15 | Besterman Jeffrey M. | Methods for specifically inhibiting histone deacetylase-7 and 8 |
| EP1551795A1 (en) | 2002-10-17 | 2005-07-13 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| CN100349862C (zh) * | 2002-11-25 | 2007-11-21 | 先灵公司 | 大麻素受体配体 |
| EP1641458A2 (en) | 2002-12-27 | 2006-04-05 | Schering Aktiengesellschaft | Pharmaceutical combinations of phthalazine vegf inhibitors and benzamide hdac inhibitors |
| US7208491B2 (en) | 2003-02-07 | 2007-04-24 | Hoffmann-La Roche Inc. | N-monoacylated o-phenylenediamines |
| US7244751B2 (en) | 2003-02-14 | 2007-07-17 | Shenzhen Chipscreen Biosciences Ltd. | Histone deacetylase inhibitors of novel benzamide derivatives with potent differentiation and anti-proliferation activity |
| TW200505902A (en) * | 2003-03-20 | 2005-02-16 | Schering Corp | Cannabinoid receptor ligands |
| CA2539117A1 (en) | 2003-09-24 | 2005-04-07 | Methylgene Inc. | Inhibitors of histone deacetylase |
| EP1735319B1 (en) | 2004-03-26 | 2017-05-03 | MethylGene Inc. | Inhibitors of histone deacetylase |
| US7253204B2 (en) | 2004-03-26 | 2007-08-07 | Methylgene Inc. | Inhibitors of histone deacetylase |
| WO2006122319A2 (en) | 2005-05-11 | 2006-11-16 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| ES2452820T3 (es) | 2006-04-07 | 2014-04-02 | Methylgene, Inc. | Derivados de benzamida como inhibidores de histona desacetilasa |
-
2002
- 2002-09-12 WO PCT/US2002/029017 patent/WO2003024448A2/en not_active Ceased
- 2002-09-12 US US10/242,304 patent/US7595343B2/en not_active Expired - Fee Related
- 2002-09-12 KR KR1020107019027A patent/KR20100107509A/ko not_active Ceased
- 2002-09-12 AU AU2002327627A patent/AU2002327627B2/en not_active Ceased
- 2002-09-12 MX MXPA04002397A patent/MXPA04002397A/es active IP Right Grant
- 2002-09-12 JP JP2003528544A patent/JP3795044B2/ja not_active Expired - Fee Related
- 2002-09-12 CN CN028226909A patent/CN1578663B/zh not_active Expired - Lifetime
- 2002-09-12 BR BR0212510-2A patent/BR0212510A/pt not_active IP Right Cessation
- 2002-09-12 CA CA2465978A patent/CA2465978C/en not_active Expired - Fee Related
- 2002-09-12 EP EP02763627A patent/EP1429765A2/en not_active Withdrawn
- 2002-09-12 KR KR10-2004-7003794A patent/KR20040048411A/ko not_active Ceased
- 2002-09-12 CN CN201010195036A patent/CN101851173A/zh active Pending
-
2005
- 2005-03-18 JP JP2005080310A patent/JP2005255683A/ja active Pending
-
2010
- 2010-01-25 JP JP2010013418A patent/JP2010168382A/ja not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AU2021212669B2 (en) | GLP-1R modulating compounds | |
| KR102915918B1 (ko) | Glp-1r 작용제 및 이의 용도 | |
| CN110637016B (zh) | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 | |
| ES2927860T3 (es) | Compuestos heterocíclicos bicíclicos sustituidos como inhibidores de PRMT5 | |
| KR102534262B1 (ko) | 헤테로환형 유도체 및 이의 용도 | |
| TWI536991B (zh) | 黏著斑激酶之抑制劑 | |
| WO2023045960A1 (zh) | 一种吡啶类衍生物及其用途 | |
| CN114174303B (zh) | 作为sting激动剂的大环化合物及其方法和用途 | |
| JP2020158523A (ja) | 新規ヒストンデアセチラーゼインヒビター | |
| IL285215B2 (en) | Immunomodulators, compositions and methods thereof | |
| KR20180017038A (ko) | Nrf2 조절제 | |
| AU2022273702B2 (en) | Lpa receptor antagonists and uses thereof | |
| SG192439A1 (en) | Organic compounds | |
| CN101014571A (zh) | 用作hiv整合酶抑制剂的n－苄基－3,4－二羟基吡啶－2－羧酰胺类和n－苄基－2,3－二羟基吡啶－4－羧酰胺类化合物 | |
| JP2021504317A (ja) | ハロアリルアミン類のｓｓａｏ／ｖａｐ−１阻害剤とその用途 | |
| TW201617316A (zh) | 人類免疫不全症病毒複製之抑制物 | |
| CN112204023A (zh) | 因子XIIa抑制剂 | |
| AU2019312393A1 (en) | Iminosulfanone compound as bromodomain protein inhibitor and pharmaceutical composition and medical use thereof | |
| JP7357146B2 (ja) | アザヘテロアリール化合物及びその使用 | |
| ES2789449T3 (es) | Moduladores de ROR-gamma | |
| AU2021341258A1 (en) | CD73 inhibitor and application thereof in medicine | |
| ES2805030T3 (es) | Compuestos monocíclicos sustituidos con heteroarilo | |
| JP2022529466A (ja) | 二環式及び三環式化合物 | |
| CN111303147B (zh) | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 | |
| CN109134481B (zh) | 一种取代吡咯色原酮类化合物或其药学上可接受的盐及其制备方法和应用 |