AU8294101A
(en)
*
|
2000-07-21 |
2002-02-05 |
Gilead Sciences Inc |
Prodrugs of phosphonate nucleotide analogues and methods for selecting and making same
|
US7388002B2
(en)
*
|
2001-11-14 |
2008-06-17 |
Biocryst Pharmaceuticals, Inc. |
Nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases
|
WO2003087298A2
(en)
*
|
2001-11-14 |
2003-10-23 |
Biocryst Pharmaceuticals, Inc. |
Nucleosides preparation thereof and use as inhibitors of rna viral polymerases
|
AU2003231766A1
(en)
*
|
2002-04-26 |
2003-11-10 |
Gilead Sciences, Inc. |
Non nucleoside reverse transcriptase inhibitors
|
US20050239054A1
(en)
*
|
2002-04-26 |
2005-10-27 |
Arimilli Murty N |
Method and compositions for identifying anti-HIV therapeutic compounds
|
NZ536328A
(en)
|
2002-05-13 |
2007-11-30 |
Metabasis Therapeutics Inc |
Novel phosphonic acid based prodrugs of PMEA and its analogues
|
AU2004206827A1
(en)
*
|
2003-01-14 |
2004-08-05 |
Gilead Sciences, Inc. |
Compositions and methods for combination antiviral therapy
|
US20050261237A1
(en)
*
|
2003-04-25 |
2005-11-24 |
Boojamra Constantine G |
Nucleoside phosphonate analogs
|
CA2522845A1
(en)
|
2003-04-25 |
2004-11-11 |
Gilead Sciences, Inc. |
Kinase inhibitor phosphonate conjugates
|
EP1628685B1
(en)
*
|
2003-04-25 |
2010-12-08 |
Gilead Sciences, Inc. |
Antiviral phosphonate analogs
|
US7452901B2
(en)
|
2003-04-25 |
2008-11-18 |
Gilead Sciences, Inc. |
Anti-cancer phosphonate analogs
|
US7470724B2
(en)
*
|
2003-04-25 |
2008-12-30 |
Gilead Sciences, Inc. |
Phosphonate compounds having immuno-modulatory activity
|
US20090247488A1
(en)
*
|
2003-04-25 |
2009-10-01 |
Carina Cannizzaro |
Anti-inflammatory phosphonate compounds
|
US7432261B2
(en)
|
2003-04-25 |
2008-10-07 |
Gilead Sciences, Inc. |
Anti-inflammatory phosphonate compounds
|
CN101410120A
(zh)
*
|
2003-04-25 |
2009-04-15 |
吉里德科学公司 |
抗炎的膦酸酯化合物
|
WO2004096285A2
(en)
*
|
2003-04-25 |
2004-11-11 |
Gilead Sciences, Inc. |
Anti-infective phosphonate conjugates
|
US7407965B2
(en)
*
|
2003-04-25 |
2008-08-05 |
Gilead Sciences, Inc. |
Phosphonate analogs for treating metabolic diseases
|
WO2005002626A2
(en)
*
|
2003-04-25 |
2005-01-13 |
Gilead Sciences, Inc. |
Therapeutic phosphonate compounds
|
WO2004096287A2
(en)
|
2003-04-25 |
2004-11-11 |
Gilead Sciences, Inc. |
Inosine monophosphate dehydrogenase inhibitory phosphonate compounds
|
US7432273B2
(en)
|
2003-10-24 |
2008-10-07 |
Gilead Sciences, Inc. |
Phosphonate analogs of antimetabolites
|
AU2004290298A1
(en)
|
2003-10-24 |
2005-05-26 |
Gilead Sciences, Inc. |
Methods and compositions for identifying therapeutic compounds
|
WO2005044279A1
(en)
|
2003-10-24 |
2005-05-19 |
Gilead Sciences, Inc. |
Purine nucleoside phosphonate conjugates
|
BRPI0417988A
(pt)
|
2003-12-22 |
2007-04-27 |
Gilead Sciences Inc |
análogos de fosfonato antivirais
|
US20050153990A1
(en)
*
|
2003-12-22 |
2005-07-14 |
Watkins William J. |
Phosphonate substituted kinase inhibitors
|
US20070281907A1
(en)
*
|
2003-12-22 |
2007-12-06 |
Watkins William J |
Kinase Inhibitor Phosphonate Conjugates
|
NZ548771A
(en)
*
|
2003-12-30 |
2010-05-28 |
Gilead Sciences Inc |
Phosphonates, monophosphonamidates, bisphosphonamidates for the treatment of viral diseases
|
US20070281911A1
(en)
*
|
2004-01-21 |
2007-12-06 |
Gilead Sciences Inc. |
Use of Adefovir or Tenofovir for Inhibiting Mmtv-Like Viruses Involved in Breast Cancer and Primary Biliary Cirrhosis
|
US8416242B1
(en)
|
2004-05-14 |
2013-04-09 |
Nvidia Corporation |
Method and system for interpolating level-of-detail in graphics processors
|
US7079156B1
(en)
|
2004-05-14 |
2006-07-18 |
Nvidia Corporation |
Method and system for implementing multiple high precision and low precision interpolators for a graphics pipeline
|
US8411105B1
(en)
|
2004-05-14 |
2013-04-02 |
Nvidia Corporation |
Method and system for computing pixel parameters
|
US8432394B1
(en)
|
2004-05-14 |
2013-04-30 |
Nvidia Corporation |
Method and system for implementing clamped z value interpolation in a raster stage of a graphics pipeline
|
JP5142716B2
(ja)
|
2004-06-08 |
2013-02-13 |
リガンド・ファーマシューティカルズ・インコーポレイテッド |
サイクリックエステルのルイス酸介在合成法
|
ME03423B
(me)
*
|
2004-07-27 |
2020-01-20 |
Gilead Sciences Inc |
Fosfonatni analozi jedinjenja hiv inhibitora
|
US20070003608A1
(en)
*
|
2005-04-08 |
2007-01-04 |
Almond Merrick R |
Compounds, compositions and methods for the treatment of viral infections and other medical disorders
|
US8642577B2
(en)
|
2005-04-08 |
2014-02-04 |
Chimerix, Inc. |
Compounds, compositions and methods for the treatment of poxvirus infections
|
CN100359315C
(zh)
*
|
2005-05-26 |
2008-01-02 |
林维宣 |
兽药残留能力验证样品及制备方法
|
TWI471145B
(zh)
|
2005-06-13 |
2015-02-01 |
Bristol Myers Squibb & Gilead Sciences Llc |
單一式藥學劑量型
|
TWI375560B
(en)
|
2005-06-13 |
2012-11-01 |
Gilead Sciences Inc |
Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
|
US8076303B2
(en)
|
2005-12-13 |
2011-12-13 |
Spring Bank Pharmaceuticals, Inc. |
Nucleotide and oligonucleotide prodrugs
|
CN100396689C
(zh)
*
|
2006-03-07 |
2008-06-25 |
中国医学科学院医药生物技术研究所 |
一组具有抑制hiv-1/hbv病毒复制活性的替诺福韦单酯化合物
|
SI2020996T1
(sl)
|
2006-05-16 |
2012-03-30 |
Gilead Sciences Inc |
Postopek in sestavki za zdravljenje hematološkihmalignosti
|
EP2046792B1
(en)
*
|
2006-07-12 |
2015-02-25 |
Mylan Laboratories Limited |
Process for the preparation of tenofovir
|
US20080261913A1
(en)
|
2006-12-28 |
2008-10-23 |
Idenix Pharmaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of liver disorders
|
US7964580B2
(en)
|
2007-03-30 |
2011-06-21 |
Pharmasset, Inc. |
Nucleoside phosphoramidate prodrugs
|
AU2008302676B2
(en)
*
|
2007-06-26 |
2013-02-28 |
University Of Wyoming Research Corporation D/B/A Western Research Institute |
Treatment and prevention systems for acid mine drainage and halogenated contaminants
|
US8441497B1
(en)
*
|
2007-08-07 |
2013-05-14 |
Nvidia Corporation |
Interpolation of vertex attributes in a graphics processor
|
US8993542B2
(en)
*
|
2008-01-25 |
2015-03-31 |
Chimerix Inc. |
Methods of treating viral infections
|
TWI444384B
(zh)
|
2008-02-20 |
2014-07-11 |
Gilead Sciences Inc |
核苷酸類似物及其在治療惡性腫瘤上的用途
|
KR20110017863A
(ko)
|
2008-04-25 |
2011-02-22 |
씨아이피엘에이 엘티디. |
테노포비어 디소프록실의 결정형 및 그의 제조방법
|
US8173621B2
(en)
|
2008-06-11 |
2012-05-08 |
Gilead Pharmasset Llc |
Nucleoside cyclicphosphates
|
WO2010014134A1
(en)
*
|
2008-07-02 |
2010-02-04 |
Idenix Pharamaceuticals, Inc. |
Compounds and pharmaceutical compositions for the treatment of viral infections
|
BRPI0915878A2
(pt)
|
2008-07-08 |
2015-11-03 |
Gilead Sciences Inc |
sais ou hidratos de compostos inibidores de hiv, seu uso e composição farmacêutica que os compreende
|
NZ593648A
(en)
|
2008-12-23 |
2013-09-27 |
Gilead Pharmasset Llc |
Nucleoside phosphoramidates
|
CL2009002206A1
(es)
*
|
2008-12-23 |
2011-08-26 |
Gilead Pharmasset Llc |
Compuestos derivados de pirrolo -(2-3-d]-pirimidin-7(6h)-tetrahidrofuran-2-il fosfonamidato, composicion farmaceutica; y su uso en el tratamiento de enfermedades virales.
|
EP2376514A2
(en)
|
2008-12-23 |
2011-10-19 |
Pharmasset, Inc. |
Nucleoside analogs
|
TWI583692B
(zh)
|
2009-05-20 |
2017-05-21 |
基利法瑪席特有限責任公司 |
核苷磷醯胺
|
US8618076B2
(en)
|
2009-05-20 |
2013-12-31 |
Gilead Pharmasset Llc |
Nucleoside phosphoramidates
|
US8614200B2
(en)
|
2009-07-21 |
2013-12-24 |
Chimerix, Inc. |
Compounds, compositions and methods for treating ocular conditions
|
US10023600B2
(en)
|
2009-09-21 |
2018-07-17 |
Gilead Sciences, Inc. |
Processes and intermediates for the preparation of 1′-substituted carba-nucleoside analogs
|
US9006218B2
(en)
|
2010-02-12 |
2015-04-14 |
Chimerix Inc. |
Nucleoside phosphonate salts
|
KR101715981B1
(ko)
|
2010-03-31 |
2017-03-13 |
길리애드 파마셋 엘엘씨 |
뉴클레오사이드 포스포르아미데이트
|
PL3290428T3
(pl)
|
2010-03-31 |
2022-02-07 |
Gilead Pharmasset Llc |
Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
|
MX2012011222A
(es)
|
2010-04-01 |
2013-01-18 |
Centre Nat Rech Scient |
Compuestos y composiciones farmaceuticas para el tratamiento de infecciones virales.
|
AU2011248620B2
(en)
|
2010-04-26 |
2015-11-26 |
Chimerix, Inc. |
Methods of treating retroviral infections and related dosage regimes
|
EP2805960A1
(en)
*
|
2010-07-19 |
2014-11-26 |
Gilead Sciences, Inc. |
Methods for the preparation of diasteromerically pure phosphoramidate prodrugs
|
SG186830A1
(en)
|
2010-07-22 |
2013-02-28 |
Gilead Sciences Inc |
Methods and compounds for treating paramyxoviridae virus infections
|
US8841275B2
(en)
|
2010-11-30 |
2014-09-23 |
Gilead Pharmasset Llc |
2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
|
MX2013006127A
(es)
|
2010-12-10 |
2013-09-26 |
Sigmapharm Lab Llc |
Composiciones sumamente estables de analogos nucleotidicoas oralmente activos o profarmacos analogos nucleotidicos oralmente activos.
|
ZA201103820B
(en)
|
2010-12-13 |
2012-01-25 |
Laurus Labs Private Ltd |
Process for the preparation of tenofovir
|
JP2014514295A
(ja)
|
2011-03-31 |
2014-06-19 |
アイディニックス ファーマシューティカルズ インコーポレイテッド |
ウイルス感染の治療のための化合物および薬学的組成物
|
US9550803B2
(en)
|
2011-05-06 |
2017-01-24 |
University Of Southern California |
Method to improve antiviral activity of nucleotide analogue drugs
|
TWI635093B
(zh)
|
2011-05-19 |
2018-09-11 |
基利科學股份有限公司 |
用於製備抗hiv藥劑的方法與中間物
|
AU2014271320B2
(en)
*
|
2011-08-16 |
2017-02-23 |
Gilead Sciences, Inc. |
Tenofovir alafenamide hemifumarate
|
ES2608871T5
(es)
*
|
2011-08-16 |
2024-04-04 |
Gilead Sciences Inc |
Alafenamide hemifumarate de tenofovir
|
DE202012013074U1
(de)
|
2011-09-16 |
2014-10-29 |
Gilead Pharmasset Lcc |
Zusammensetzungen zur Behandlung von HCV
|
AU2016228317B2
(en)
*
|
2011-10-07 |
2018-07-19 |
Gilead Sciences, Inc. |
Methods for preparing anti-viral nucleotide analogs
|
ES2661705T3
(es)
|
2011-10-07 |
2018-04-03 |
Gilead Sciences, Inc. |
Métodos para la preparación de análogos de nucleótidos antivirales
|
AU2014215976B2
(en)
*
|
2011-10-07 |
2016-06-30 |
Gilead Sciences, Inc. |
Methods for preparing anti-viral nucleotide analogs
|
US8889159B2
(en)
|
2011-11-29 |
2014-11-18 |
Gilead Pharmasset Llc |
Compositions and methods for treating hepatitis C virus
|
DK2794624T3
(da)
|
2011-12-22 |
2019-07-22 |
Geron Corp |
Guanin-analoger som telomerase-substrater og påvirkere af telomer-længde
|
WO2013115916A1
(en)
|
2012-02-03 |
2013-08-08 |
Gilead Sciences, Inc. |
Combination therapy comprising gs-7340 and cobicistat for use in the treatment of viral infections
|
EA026138B1
(ru)
|
2012-02-03 |
2017-03-31 |
Джилид Сайэнс, Инк. |
Комбинированная терапия, включающая тенофовир алафенамида гемифумарат и кобицистат, для применения для лечения вирусных инфекций
|
CN103665043B
(zh)
|
2012-08-30 |
2017-11-10 |
江苏豪森药业集团有限公司 |
一种替诺福韦前药及其在医药上的应用
|
GB201215696D0
(en)
*
|
2012-09-03 |
2012-10-17 |
Ithemba Pharmaceuticals Pty Ltd |
A process for the preparation of (R)-9-[2-(Phosphonometh-Oxy)propyl]adenine (PMPA)
|
WO2014068265A1
(en)
*
|
2012-10-29 |
2014-05-08 |
Cipla Limited |
Antiviral phosphonate analogues and process for preparation thereof
|
CN102899327B
(zh)
*
|
2012-11-06 |
2014-06-11 |
清华大学深圳研究生院 |
一种抗病毒的小核酸及其温度敏感型凝胶制剂与应用
|
AU2013347538B2
(en)
*
|
2012-11-16 |
2017-04-27 |
Merck Sharp & Dohme Corp. |
Purine inhibitors of human phosphatidylinositol 3-kinase delta
|
CN103848868B
(zh)
*
|
2012-12-04 |
2017-04-12 |
蚌埠丰原涂山制药有限公司 |
制备替诺福韦的方法
|
CN103848869B
(zh)
*
|
2012-12-04 |
2016-12-21 |
上海医药工业研究院 |
制备替诺福韦的方法
|
SI2950786T1
(sl)
|
2013-01-31 |
2020-03-31 |
Gilead Pharmasset Llc |
Formulacija kombinacije dveh protivirusnih spojin
|
CN104072539B
(zh)
*
|
2013-03-25 |
2017-03-29 |
安徽贝克联合制药有限公司 |
替诺福韦双(4‑乙酰氨基苯酚氧基)酯及其制备方法和其应用
|
EP3000898B1
(en)
*
|
2013-05-21 |
2020-11-18 |
Hitgen Inc. |
Drug target capturing method
|
CA2914381A1
(en)
|
2013-06-07 |
2014-12-11 |
Cipla Limited |
An efficient process for separation of diastereomers of 9-[(r)-2-[[(r,s)-[[(s)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl] methoxy]propyl]adenine
|
ES2900570T3
(es)
|
2013-08-27 |
2022-03-17 |
Gilead Pharmasset Llc |
Formulación de combinación de dos compuestos antivirales
|
WO2015040640A2
(en)
*
|
2013-09-20 |
2015-03-26 |
Laurus Labs Private Limited |
An improved process for the preparation of tenofovir alafenamide or pharmaceutically acceptable salts thereof
|
EP2860185A1
(en)
|
2013-10-09 |
2015-04-15 |
Zentiva, k.s. |
An improved process for the preparation of Tenofovir disoproxil and pharmaceutically acceptable salts thereof
|
IN2013CH05455A
(ja)
*
|
2013-11-27 |
2015-08-07 |
Laurus Labs Private Ltd |
|
IN2014MU00118A
(ja)
|
2014-01-14 |
2015-08-28 |
Mylan Lab Ltd |
|
TWI660965B
(zh)
|
2014-01-15 |
2019-06-01 |
美商基利科學股份有限公司 |
泰諾福韋之固體形式
|
CN104804042B
(zh)
*
|
2014-01-24 |
2018-01-19 |
齐鲁制药有限公司 |
核苷酸膦酸酯类化合物、其药物组合物、制备方法及用途
|
US9463194B2
(en)
|
2014-02-05 |
2016-10-11 |
Gilead Sciences, Inc. |
Methods of treating patients co-infected with HIV and tuberculosis
|
EP3623364A1
(en)
|
2014-02-13 |
2020-03-18 |
Ligand Pharmaceuticals, Inc. |
Prodrug compounds and their uses
|
WO2015127848A1
(zh)
*
|
2014-02-27 |
2015-09-03 |
四川海思科制药有限公司 |
一种取代的氨基磷酸酯类衍生物、其制备方法及其应用
|
CN105001262B
(zh)
*
|
2014-04-18 |
2017-09-01 |
四川海思科制药有限公司 |
芳基取代的磷酰胺类衍生物及其在医学上的应用
|
WO2015161781A1
(zh)
*
|
2014-04-21 |
2015-10-29 |
四川海思科制药有限公司 |
一种核苷类似物及其中间体的制备方法
|
CN105085571A
(zh)
*
|
2014-05-20 |
2015-11-25 |
四川海思科制药有限公司 |
替诺福韦艾拉酚胺复合物及其制备方法和用途
|
WO2015197006A1
(zh)
*
|
2014-06-25 |
2015-12-30 |
四川海思科制药有限公司 |
一种取代的氨基酸硫酯类化合物、其组合物及应用
|
CN106687118A
(zh)
|
2014-07-02 |
2017-05-17 |
配体药物公司 |
前药化合物及其用途
|
KR101703258B1
(ko)
|
2014-12-30 |
2017-02-06 |
한미정밀화학주식회사 |
고순도의 (r)-9-[2-(포스포노메톡시)프로필]아데닌의 제조방법
|
KR101703257B1
(ko)
|
2014-09-30 |
2017-02-06 |
한미정밀화학주식회사 |
고순도의 (r)-9-[2-(포스포노메톡시)프로필]아데닌의 제조방법
|
JP2017535520A
(ja)
*
|
2014-09-30 |
2017-11-30 |
ハンミ・ファイン・ケミカル・カンパニー・リミテッドHanmi Fine Chemical Co., Ltd. |
高純度の(r)−9−[2−(ホスホノメトキシ)プロピル]アデニンの製造方法
|
EP3203995A4
(en)
|
2014-10-09 |
2019-05-15 |
Board of Regents of the University of Nebraska |
COMPOSITIONS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS
|
TWI698444B
(zh)
|
2014-10-29 |
2020-07-11 |
美商基利科學股份有限公司 |
製備核糖苷的方法
|
CN108148094A
(zh)
*
|
2014-11-12 |
2018-06-12 |
四川海思科制药有限公司 |
一种替诺福韦艾拉酚胺富马酸盐晶型c及其制备方法和用途
|
CN104558036A
(zh)
*
|
2014-12-11 |
2015-04-29 |
杭州和泽医药科技有限公司 |
一种替诺福韦艾拉酚胺半反丁烯二酸盐晶型及其制备方法
|
BR112017014085A2
(pt)
|
2015-01-03 |
2018-01-09 |
Mylan Laboratories Ltd |
processos para a preparação de hemifumarato de tenofovir alafenamida amorfo e uma pré-mistura do mesmo
|
US20180148774A1
(en)
*
|
2015-05-16 |
2018-05-31 |
Godx, Inc |
Point of need testing device and methods of use thereof
|
CN106188139B
(zh)
*
|
2015-05-29 |
2020-02-18 |
江苏天士力帝益药业有限公司 |
替诺福韦单苄酯磷酸酰胺前药、其制备方法及应用
|
CZ2015384A3
(cs)
|
2015-06-05 |
2016-12-14 |
Zentiva, K.S. |
Pevné formy Tenofovir alafenamidu
|
WO2016205141A1
(en)
*
|
2015-06-17 |
2016-12-22 |
Gilead Sciences, Inc. |
Co-crystals, salts and solid forms of tenofovir alafenamide
|
EP3607939B1
(en)
|
2015-06-30 |
2022-06-01 |
Gilead Sciences, Inc. |
Pharmaceutical formulations comprising tenofovir and emtricitabine
|
TWI639598B
(zh)
|
2015-08-10 |
2018-11-01 |
美商默沙東藥廠 |
抗病毒β-胺基酸酯磷酸二醯胺化合物
|
TWI620754B
(zh)
*
|
2015-08-26 |
2018-04-11 |
|
Method for preparing amino phosphate derivative and preparation method thereof
|
TWI616452B
(zh)
*
|
2015-08-26 |
2018-03-01 |
|
Preparation method of nucleoside analog and intermediate thereof
|
TWI616453B
(zh)
*
|
2015-08-27 |
2018-03-01 |
|
Substituted amino acid thioester compounds, compositions and uses thereof
|
WO2017037608A1
(en)
*
|
2015-08-28 |
2017-03-09 |
Laurus Labs Private Limited |
Solid forms of tenofovir alafenamide and salts thereof, processes for its preparation and pharmaceutical compositions thereof
|
BR112018005048B8
(pt)
|
2015-09-16 |
2021-03-23 |
Gilead Sciences Inc |
uso de um composto antiviral ou sal do mesmo para o tratamento de uma infecção por coronaviridae
|
PL3346995T3
(pl)
|
2015-11-09 |
2020-03-31 |
Gilead Sciences, Inc. |
Kompozycje terapeutyczne do leczenia ludzkiego wirusa niedoboru odporności
|
CN106800573B
(zh)
*
|
2015-11-25 |
2020-03-10 |
四川海思科制药有限公司 |
一种核苷酸膦酸酯一水合物及其制备方法和在医药上的应用
|
US10745428B2
(en)
|
2015-12-10 |
2020-08-18 |
Idenix Pharmaceuticals Llc |
Antiviral phosphodiamide prodrugs of tenofovir
|
CN106866737B
(zh)
*
|
2015-12-11 |
2020-11-20 |
南京圣和药物研发有限公司 |
膦酸衍生物及其应用
|
EP3390413B1
(en)
|
2015-12-15 |
2020-08-19 |
Merck Sharp & Dohme Corp. |
Antiviral oxime phosphoramide compounds
|
WO2017118928A1
(en)
|
2016-01-06 |
2017-07-13 |
Lupin Limited |
Process for the separation of diastereomers of tenofovir alafenamide
|
ES2806604T3
(es)
|
2016-02-02 |
2021-02-18 |
Sandoz Ag |
Formas cristalinas de monofumarato de tenofovir alafenamida
|
CN107709288A
(zh)
*
|
2016-02-03 |
2018-02-16 |
四川海思科制药有限公司 |
一种磷酰胺衍生物及制备方法和用途
|
WO2017148290A1
(zh)
*
|
2016-03-01 |
2017-09-08 |
深圳市塔吉瑞生物医药有限公司 |
一种取代的腺嘌呤化合物及其药物组合物
|
CN107179355B
(zh)
*
|
2016-03-11 |
2021-08-10 |
广东东阳光药业有限公司 |
一种分离检测替诺福韦艾拉酚胺及其有关物质的方法
|
CZ2016156A3
(cs)
|
2016-03-17 |
2017-09-27 |
Zentiva, K.S. |
Způsob přípravy diastereomerně čistého Tenofoviru Alafenamidu nebo jeho solí
|
CN107226826A
(zh)
*
|
2016-03-25 |
2017-10-03 |
江苏奥赛康药业股份有限公司 |
替诺福韦艾拉酚胺富马酸盐化合物及其药物组合物
|
WO2017211325A1
(zh)
|
2016-06-05 |
2017-12-14 |
上海诚妙医药科技有限公司 |
富马酸替诺福韦艾拉酚胺盐的新晶型、制备方法及其用途
|
CN107698621A
(zh)
*
|
2016-06-20 |
2018-02-16 |
杭州和泽医药科技有限公司 |
一种腺嘌呤衍生物的膦酸酯前药及其在医药上的应用
|
WO2017221189A1
(en)
*
|
2016-06-22 |
2017-12-28 |
Laurus Labs Limited |
An improved process for the preparation of tenofovir alafenamide or pharmaceutically acceptable salts thereof
|
CN106317116A
(zh)
*
|
2016-08-19 |
2017-01-11 |
张红利 |
磷酰胺核苷类化合物及其药学上可接受的盐与应用、药物组合物
|
KR102180740B1
(ko)
|
2016-08-19 |
2020-11-20 |
길리애드 사이언시즈, 인코포레이티드 |
Hiv 바이러스 감염의 예방적 또는 치유적 치료에 유용한 치료 화합물
|
EP3503895B1
(en)
|
2016-08-25 |
2021-09-15 |
Merck Sharp & Dohme Corp. |
Antiviral prodrugs of tenofovir
|
CN106380484A
(zh)
*
|
2016-08-29 |
2017-02-08 |
杭州百诚医药科技股份有限公司 |
一种替诺福韦艾拉酚胺的新晶型及其制备方法
|
WO2018042331A1
(en)
|
2016-08-31 |
2018-03-08 |
Glaxosmithkline Intellectual Property (No.2) Limited |
Combinations and uses and treatments thereof
|
WO2018051250A1
(en)
|
2016-09-14 |
2018-03-22 |
Viiv Healthcare Company |
Combination comprising tenofovir alafenamide, bictegravir and 3tc
|
EP3532069A4
(en)
|
2016-10-26 |
2020-05-13 |
Merck Sharp & Dohme Corp. |
ARYL-AMIDE PHOSPHODIAMIDE COMPOUNDS ANTIVIRALS
|
CN106565785B
(zh)
*
|
2016-11-09 |
2019-11-12 |
周雨恬 |
一种具有抗hbv/hiv活性的核苷氨基磷酸酯类化合物及其盐和用途
|
CN108129514A
(zh)
*
|
2016-12-01 |
2018-06-08 |
北京美倍他药物研究有限公司 |
磷酸/膦酸衍生物的单一异构体及其医药用途
|
MA47094A
(fr)
|
2016-12-22 |
2021-05-26 |
Idenix Pharmaceuticals Llc |
Promédicaments d'ester aliphatique antiviral de ténofovir
|
MX2019007262A
(es)
*
|
2016-12-22 |
2019-09-05 |
Merck Sharp & Dohme |
Compuestos antivirales de bencilamina fosfodiamida.
|
WO2018115046A1
(en)
|
2016-12-23 |
2018-06-28 |
Sandoz Ag |
Crystalline solid forms of tenofovir alafenamide
|
AR110768A1
(es)
|
2017-01-31 |
2019-05-02 |
Gilead Sciences Inc |
Formas cristalinas de tenofovir alafenamida
|
WO2018153977A1
(en)
|
2017-02-24 |
2018-08-30 |
Hexal Ag |
Stable composition of tenofovir alafenamide
|
RU2659388C1
(ru)
|
2017-02-28 |
2018-07-02 |
Васильевич Иващенко Александр |
Нуклеотиды, включающие N-[(S)-1-циклобутоксикарбонил]фосфорамидатный фрагмент, их аналоги и их применение
|
RU2647576C1
(ru)
*
|
2017-02-28 |
2018-03-16 |
Васильевич Иващенко Александр |
Циклобутил (S)-2-[[[(R)-2-(6-аминопурин-9-ил)-1-метил-этокси]метил-фенокси-фосфорил]амино]-пропаноаты, способ их получения и применения
|
CN106866739B
(zh)
*
|
2017-03-10 |
2018-11-02 |
华东师范大学 |
一种(r)-1-(6-氨基-9h-嘌呤-9-基)2-苯酯的制备方法
|
AU2018235754B2
(en)
|
2017-03-14 |
2021-04-08 |
Gilead Sciences, Inc. |
Methods of treating feline coronavirus infections
|
EP3600332B1
(en)
|
2017-03-20 |
2023-12-13 |
The United States of America, as represented by the Secretary, Department of Health and Human Services |
Hiv post-exposure prophylaxis
|
CN108794530A
(zh)
*
|
2017-04-26 |
2018-11-13 |
上海医药工业研究院 |
一种替诺福韦丙酚酰胺盐晶型及其制备方法和用途
|
ES2938859T3
(es)
|
2017-05-01 |
2023-04-17 |
Gilead Sciences Inc |
Una forma cristalina de (S)-2-etilbutilo 2-(((S)-(((2R,3S,4R,5R)-5-(4-aminopirrolo[2,1-f][1,2,4]triazin-7-il)-5-ciano-3,4-dihidroxitetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato
|
KR102379965B1
(ko)
*
|
2017-05-19 |
2022-03-29 |
주식회사 종근당 |
테노포비르의 효율적인 제조방법
|
CN107266499B
(zh)
*
|
2017-06-05 |
2019-07-02 |
珠海优润医药科技有限公司 |
一种抗病毒化合物及其制备方法
|
WO2019003251A1
(en)
|
2017-06-30 |
2019-01-03 |
Cipla Limited |
PHARMACEUTICAL COMPOSITIONS
|
CN111093627B
(zh)
|
2017-07-11 |
2024-03-08 |
吉利德科学公司 |
用于治疗病毒感染的包含rna聚合酶抑制剂和环糊精的组合物
|
WO2019021319A1
(en)
|
2017-07-27 |
2019-01-31 |
Cipla Limited |
PHARMACEUTICAL COMPOSITIONS
|
EP3661937B1
(en)
|
2017-08-01 |
2021-07-28 |
Gilead Sciences, Inc. |
Crystalline forms of ethyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninate (gs-9131) for treating viral infections
|
AR112412A1
(es)
|
2017-08-17 |
2019-10-23 |
Gilead Sciences Inc |
Formas de sal de colina de un inhibidor de la cápside del vih
|
CN107655987B
(zh)
*
|
2017-09-08 |
2020-11-03 |
厦门蔚扬药业有限公司 |
一种替诺福韦艾拉酚胺及其异构体的hplc检测方法
|
CN107522743A
(zh)
*
|
2017-09-30 |
2017-12-29 |
深圳科兴生物工程有限公司 |
一种半富马酸替诺福韦艾拉酚胺工业化连续生产方法
|
US20190151307A1
(en)
|
2017-10-24 |
2019-05-23 |
Gilead Sciences, Inc. |
Methods of treating patients co-infected with a virus and tuberculosis
|
CN109942633B
(zh)
*
|
2017-12-20 |
2021-08-31 |
上海新礼泰药业有限公司 |
替诺福韦艾拉酚胺中间体的制备方法
|
CN109942632B
(zh)
*
|
2017-12-20 |
2021-08-31 |
上海博志研新药物研究有限公司 |
替诺福韦艾拉酚胺中间体的制备方法
|
US20200407382A1
(en)
|
2017-12-30 |
2020-12-31 |
Cipla Limited |
Polymorphic forms of (9-[(r)-2-[[(s)-[[(s)-1-(isopropoxycarbonyl)ethyl]amino]phenoxy phosphinyl]methoxy]propyl] adenine and pharmaceutically acceptable salts thereof
|
JP2021509907A
(ja)
|
2018-01-09 |
2021-04-08 |
リガンド・ファーマシューティカルズ・インコーポレイテッド |
アセタール化合物およびその治療的使用
|
US12110308B2
(en)
|
2018-01-10 |
2024-10-08 |
Nucorion Pharmaceuticals, Inc. |
Phosphor(n)amidatacetal and phosph(on)atalcetal compounds
|
US11839623B2
(en)
*
|
2018-01-12 |
2023-12-12 |
Board Of Regents Of The University Of Nebraska |
Antiviral prodrugs and formulations thereof
|
JP7083398B2
(ja)
|
2018-02-15 |
2022-06-10 |
ギリアード サイエンシーズ, インコーポレイテッド |
ピリジン誘導体およびhiv感染を処置するためのその使用
|
KR102587504B1
(ko)
|
2018-02-16 |
2023-10-11 |
길리애드 사이언시즈, 인코포레이티드 |
레트로비리다에 바이러스 감염의 치료에 유용한 치료 화합물을 제조하기 위한 방법 및 중간체
|
CN108101943B
(zh)
*
|
2018-02-28 |
2020-11-24 |
顾世海 |
一种替诺福韦前药或可药用盐及其在医药上的应用
|
WO2019199756A1
(en)
|
2018-04-09 |
2019-10-17 |
Board Of Regents Of The University Of Nebraska |
Antiviral prodrugs and formulations thereof
|
TW202425967A
(zh)
|
2018-07-16 |
2024-07-01 |
美商基利科學股份有限公司 |
用於治療hiv之蛋白殼抑制劑
|
EP3823629A4
(en)
|
2018-07-19 |
2022-05-04 |
Merck Sharp & Dohme Corp. |
PHOSPHINAMIDE PRODRUGS OF TENOFOVIR
|
EP3852761A1
(en)
|
2018-09-19 |
2021-07-28 |
Gilead Sciences, Inc. |
Integrase inhibitors for the prevention of hiv
|
US12110311B2
(en)
|
2019-07-17 |
2024-10-08 |
Nucorion Pharmaceuticals, Inc. |
Cyclic deoxyribonucleotide compounds
|
WO2021011891A1
(en)
|
2019-07-18 |
2021-01-21 |
Gilead Sciences, Inc. |
Long-acting formulations of tenofovir alafenamide
|
AU2020318808A1
(en)
|
2019-07-19 |
2022-02-03 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
HIV pre-exposure prophylaxis
|
EP4017476A1
(en)
|
2019-08-19 |
2022-06-29 |
Gilead Sciences, Inc. |
Pharmaceutical formulations of tenofovir alafenamide
|
EP4017499A4
(en)
*
|
2019-08-22 |
2024-01-10 |
Emory University |
NUCLEOSIDE PRODRUGS AND RELATED USES
|
WO2021055808A1
(en)
*
|
2019-09-20 |
2021-03-25 |
Abbott Rapid Diagnostics International Unlimited Company |
Antibodies directed against tenofovir and derivatives thereof
|
JP2023502530A
(ja)
|
2019-11-26 |
2023-01-24 |
ギリアード サイエンシーズ, インコーポレイテッド |
Hiv予防のためのカプシド阻害剤
|
CN118766947A
(zh)
|
2020-01-27 |
2024-10-15 |
吉利德科学公司 |
用于治疗SARS CoV-2感染的方法
|
EP4085062A1
(en)
|
2020-02-20 |
2022-11-09 |
Cipla Limited |
Novel salts and/or co-crystals of tenofovir alafenamide
|
WO2021183750A2
(en)
|
2020-03-12 |
2021-09-16 |
Gilead Sciences, Inc. |
Methods of preparing 1'-cyano nucleosides
|
AU2021237718B2
(en)
|
2020-03-20 |
2023-09-21 |
Gilead Sciences, Inc. |
Prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same
|
WO2021202669A2
(en)
|
2020-04-01 |
2021-10-07 |
Reyoung Corporation |
Nucleoside and nucleotide conjugate compounds and uses thereof
|
KR20220164784A
(ko)
|
2020-04-06 |
2022-12-13 |
길리애드 사이언시즈, 인코포레이티드 |
1'-시아노 치환된 카르바뉴클레오시드 유사체의 흡입 제형
|
KR20210125298A
(ko)
|
2020-04-08 |
2021-10-18 |
주식회사 파마코스텍 |
테노포비어 알라펜아미드 헤미타르트레이트의 신규한 제조방법
|
JP2023523415A
(ja)
|
2020-04-21 |
2023-06-05 |
リガンド・ファーマシューティカルズ・インコーポレイテッド |
ヌクレオチドプロドラッグ化合物
|
CN115666570A
(zh)
|
2020-05-29 |
2023-01-31 |
吉利德科学公司 |
瑞德西韦治疗方法
|
EP4172160A2
(en)
|
2020-06-24 |
2023-05-03 |
Gilead Sciences, Inc. |
1'-cyano nucleoside analogs and uses thereof
|
US11680064B2
(en)
|
2020-06-25 |
2023-06-20 |
Gilead Sciences, Inc. |
Capsid inhibitors for the treatment of HIV
|
CN113970612B
(zh)
*
|
2020-07-22 |
2023-08-01 |
北京四环制药有限公司 |
一种高效液相色谱法测定丙酚替诺福韦有关物质的方法
|
CA3190702A1
(en)
|
2020-08-27 |
2022-03-03 |
Elaine Bunyan |
Compounds and methods for treatment of viral infections
|
CN112336695B
(zh)
*
|
2020-09-28 |
2023-01-03 |
华北制药华坤河北生物技术有限公司 |
一种富马酸丙酚替诺福韦片剂及其制备方法和有关物质的检测方法
|
CN116437958A
(zh)
|
2020-11-11 |
2023-07-14 |
吉利德科学公司 |
鉴定对采用gp120 CD4结合位点导向的抗体的疗法敏感的HIV患者的方法
|
US11667656B2
(en)
|
2021-01-27 |
2023-06-06 |
Apotex Inc. |
Crystalline forms of Tenofovir alafenamide
|
CN113075307A
(zh)
*
|
2021-03-08 |
2021-07-06 |
瑞阳制药股份有限公司 |
富马酸丙酚替诺福韦异构体的检测方法
|
CN113214322B
(zh)
*
|
2021-04-30 |
2022-10-25 |
山东立新制药有限公司 |
替诺福韦绿色环保的制备方法
|
WO2022251594A1
(en)
*
|
2021-05-27 |
2022-12-01 |
Antios Therapeutics, Inc. |
Pharmacokinetics and dose-related improvments in subjects treated with phosphoramidate clevudine prodrugs
|
KR20240117588A
(ko)
|
2021-12-03 |
2024-08-01 |
길리애드 사이언시즈, 인코포레이티드 |
Hiv 바이러스 감염 치료용 화합물
|
CA3235937A1
(en)
|
2021-12-03 |
2023-06-08 |
Gilead Sciences, Inc. |
Therapeutic compounds for hiv virus infection
|
EP4440701A1
(en)
|
2021-12-03 |
2024-10-09 |
Gilead Sciences, Inc. |
Therapeutic compounds for hiv virus infection
|
CN114369120A
(zh)
*
|
2022-01-28 |
2022-04-19 |
石家庄龙泽制药股份有限公司 |
一种丙酚替诺福韦关键中间体的制备方法
|
TW202400185A
(zh)
|
2022-03-02 |
2024-01-01 |
美商基利科學股份有限公司 |
用於治療病毒感染的化合物及方法
|
TWI843506B
(zh)
|
2022-04-06 |
2024-05-21 |
美商基利科學股份有限公司 |
橋聯三環胺甲醯基吡啶酮化合物及其用途
|
TW202402280A
(zh)
|
2022-07-01 |
2024-01-16 |
美商基利科學股份有限公司 |
可用於hiv病毒感染之疾病預防性或治療性治療的治療性化合物
|
WO2024044477A1
(en)
|
2022-08-26 |
2024-02-29 |
Gilead Sciences, Inc. |
Dosing and scheduling regimen for broadly neutralizing antibodies
|
US20240226130A1
(en)
|
2022-10-04 |
2024-07-11 |
Gilead Sciences, Inc. |
4'-thionucleoside analogues and their pharmaceutical use
|
WO2024196814A1
(en)
|
2023-03-17 |
2024-09-26 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Methods for treatment of age-related macular degeneration
|
CN118652277A
(zh)
*
|
2024-08-19 |
2024-09-17 |
成都工业学院 |
一种用于治疗癌症疾病的化合物的制备方法
|