JP5142716B2 - サイクリックエステルのルイス酸介在合成法 - Google Patents
サイクリックエステルのルイス酸介在合成法 Download PDFInfo
- Publication number
- JP5142716B2 JP5142716B2 JP2007527592A JP2007527592A JP5142716B2 JP 5142716 B2 JP5142716 B2 JP 5142716B2 JP 2007527592 A JP2007527592 A JP 2007527592A JP 2007527592 A JP2007527592 A JP 2007527592A JP 5142716 B2 JP5142716 B2 JP 5142716B2
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- JP
- Japan
- Prior art keywords
- lewis acid
- group
- formula
- added
- propanediol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002841 Lewis acid Substances 0.000 title claims description 84
- 150000007517 lewis acids Chemical class 0.000 title claims description 77
- 125000004122 cyclic group Chemical group 0.000 title description 17
- 230000015572 biosynthetic process Effects 0.000 title description 8
- 238000003786 synthesis reaction Methods 0.000 title description 5
- 230000001404 mediated effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims description 61
- 238000000034 method Methods 0.000 claims description 53
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims description 50
- 125000000217 alkyl group Chemical group 0.000 claims description 32
- -1 phenylmethylidene, dimethylaminomethylidene Chemical group 0.000 claims description 30
- 238000006243 chemical reaction Methods 0.000 claims description 28
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims description 18
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 claims description 16
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims description 16
- 229910052739 hydrogen Inorganic materials 0.000 claims description 15
- VJGRFGFLZJIODS-VIFPVBQESA-N (1s)-1-(3-chlorophenyl)propane-1,3-diol Chemical compound OCC[C@H](O)C1=CC=CC(Cl)=C1 VJGRFGFLZJIODS-VIFPVBQESA-N 0.000 claims description 12
- 230000008569 process Effects 0.000 claims description 12
- 150000007529 inorganic bases Chemical class 0.000 claims description 11
- 230000000269 nucleophilic effect Effects 0.000 claims description 10
- 125000001424 substituent group Chemical group 0.000 claims description 9
- 150000003973 alkyl amines Chemical group 0.000 claims description 8
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims description 8
- 239000001257 hydrogen Substances 0.000 claims description 8
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims description 8
- IMFACGCPASFAPR-UHFFFAOYSA-N tributylamine Chemical compound CCCCN(CCCC)CCCC IMFACGCPASFAPR-UHFFFAOYSA-N 0.000 claims description 8
- YPFDHNVEDLHUCE-UHFFFAOYSA-N 1,3-propanediol Substances OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 7
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims description 7
- 229920000166 polytrimethylene carbonate Polymers 0.000 claims description 7
- 125000006242 amine protecting group Chemical group 0.000 claims description 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 6
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 5
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims description 4
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 4
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims description 4
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 58
- 239000000243 solution Substances 0.000 description 50
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 39
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 33
- 229910052757 nitrogen Inorganic materials 0.000 description 28
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 27
- 239000000203 mixture Substances 0.000 description 24
- 125000003118 aryl group Chemical group 0.000 description 23
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 19
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical group OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 18
- 229940002612 prodrug Drugs 0.000 description 17
- 239000000651 prodrug Substances 0.000 description 17
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 16
- 229910052796 boron Inorganic materials 0.000 description 16
- 150000002009 diols Chemical class 0.000 description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 16
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 238000005859 coupling reaction Methods 0.000 description 15
- 239000002244 precipitate Substances 0.000 description 15
- 239000007787 solid Substances 0.000 description 15
- 239000010936 titanium Substances 0.000 description 15
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 14
- 238000004519 manufacturing process Methods 0.000 description 14
- 239000000047 product Substances 0.000 description 13
- 239000010410 layer Substances 0.000 description 12
- CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 12
- 125000003545 alkoxy group Chemical group 0.000 description 11
- 239000008346 aqueous phase Substances 0.000 description 11
- 150000000185 1,3-diols Chemical class 0.000 description 10
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 10
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 10
- 229910052772 Samarium Inorganic materials 0.000 description 10
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 10
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 10
- WOZSCQDILHKSGG-UHFFFAOYSA-N adefovir depivoxil Chemical compound N1=CN=C2N(CCOCP(=O)(OCOC(=O)C(C)(C)C)OCOC(=O)C(C)(C)C)C=NC2=C1N WOZSCQDILHKSGG-UHFFFAOYSA-N 0.000 description 10
- 229910052782 aluminium Inorganic materials 0.000 description 10
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 10
- 230000008878 coupling Effects 0.000 description 10
- 238000010168 coupling process Methods 0.000 description 10
- 150000003254 radicals Chemical class 0.000 description 10
- KZUNJOHGWZRPMI-UHFFFAOYSA-N samarium atom Chemical compound [Sm] KZUNJOHGWZRPMI-UHFFFAOYSA-N 0.000 description 10
- 238000003756 stirring Methods 0.000 description 10
- 229910052718 tin Inorganic materials 0.000 description 10
- 229910052719 titanium Inorganic materials 0.000 description 10
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 description 10
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 9
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 9
- 239000000460 chlorine Substances 0.000 description 9
- 150000003009 phosphonic acids Chemical class 0.000 description 9
- 229940079593 drug Drugs 0.000 description 8
- 239000003814 drug Substances 0.000 description 8
- UEZVMMHDMIWARA-UHFFFAOYSA-M phosphonate Chemical compound [O-]P(=O)=O UEZVMMHDMIWARA-UHFFFAOYSA-M 0.000 description 8
- 239000011541 reaction mixture Substances 0.000 description 8
- 125000006413 ring segment Chemical group 0.000 description 8
- 239000011780 sodium chloride Substances 0.000 description 8
- HDAKKFUBVLXOCP-UHFFFAOYSA-N 3-(3-chlorophenyl)-3-oxopropanoic acid Chemical compound OC(=O)CC(=O)C1=CC=CC(Cl)=C1 HDAKKFUBVLXOCP-UHFFFAOYSA-N 0.000 description 7
- 125000004179 3-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(Cl)=C1[H] 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 7
- BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 7
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 7
- 125000002947 alkylene group Chemical group 0.000 description 7
- 238000001816 cooling Methods 0.000 description 7
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 7
- 238000010992 reflux Methods 0.000 description 7
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 6
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 6
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 6
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 6
- 229910052794 bromium Inorganic materials 0.000 description 6
- 229910052801 chlorine Inorganic materials 0.000 description 6
- 239000011737 fluorine Substances 0.000 description 6
- 229910052731 fluorine Inorganic materials 0.000 description 6
- 229910052736 halogen Inorganic materials 0.000 description 6
- 150000002367 halogens Chemical class 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 238000004128 high performance liquid chromatography Methods 0.000 description 6
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 6
- 239000012074 organic phase Substances 0.000 description 6
- 239000010452 phosphate Substances 0.000 description 6
- 150000003839 salts Chemical class 0.000 description 6
- SUGIWOQOKKWXRH-QMMMGPOBSA-N (3s)-3-(3-chlorophenyl)-3-hydroxypropanoic acid Chemical compound OC(=O)C[C@H](O)C1=CC=CC(Cl)=C1 SUGIWOQOKKWXRH-QMMMGPOBSA-N 0.000 description 5
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 5
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 5
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 5
- SUAKHGWARZSWIH-UHFFFAOYSA-N N,N‐diethylformamide Chemical compound CCN(CC)C=O SUAKHGWARZSWIH-UHFFFAOYSA-N 0.000 description 5
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 5
- 229910052797 bismuth Inorganic materials 0.000 description 5
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 229910017052 cobalt Inorganic materials 0.000 description 5
- 239000010941 cobalt Substances 0.000 description 5
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 5
- 229910052802 copper Inorganic materials 0.000 description 5
- 239000010949 copper Substances 0.000 description 5
- 238000002425 crystallisation Methods 0.000 description 5
- 230000008025 crystallization Effects 0.000 description 5
- 229910052742 iron Inorganic materials 0.000 description 5
- 239000011777 magnesium Substances 0.000 description 5
- 229910052749 magnesium Inorganic materials 0.000 description 5
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 5
- 229910052753 mercury Inorganic materials 0.000 description 5
- 239000012044 organic layer Substances 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 5
- 239000000523 sample Substances 0.000 description 5
- 229910052709 silver Inorganic materials 0.000 description 5
- 239000004332 silver Substances 0.000 description 5
- 239000002002 slurry Substances 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- 229910052717 sulfur Inorganic materials 0.000 description 5
- 229910052725 zinc Inorganic materials 0.000 description 5
- 239000011701 zinc Substances 0.000 description 5
- VJGRFGFLZJIODS-SECBINFHSA-N (1r)-1-(3-chlorophenyl)propane-1,3-diol Chemical compound OCC[C@@H](O)C1=CC=CC(Cl)=C1 VJGRFGFLZJIODS-SECBINFHSA-N 0.000 description 4
- VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 4
- 229930024421 Adenine Natural products 0.000 description 4
- KWYHDKDOAIKMQN-UHFFFAOYSA-N N,N,N',N'-tetramethylethylenediamine Chemical compound CN(C)CCN(C)C KWYHDKDOAIKMQN-UHFFFAOYSA-N 0.000 description 4
- 238000005481 NMR spectroscopy Methods 0.000 description 4
- 229960000643 adenine Drugs 0.000 description 4
- 150000001412 amines Chemical class 0.000 description 4
- UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 239000007789 gas Substances 0.000 description 4
- 125000005842 heteroatom Chemical group 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 4
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Substances [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 4
- 239000012258 stirred mixture Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 4
- 229910052721 tungsten Inorganic materials 0.000 description 4
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 3
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 125000002252 acyl group Chemical group 0.000 description 3
- 125000004429 atom Chemical group 0.000 description 3
- 239000012267 brine Substances 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 238000005660 chlorination reaction Methods 0.000 description 3
- IJOOHPMOJXWVHK-UHFFFAOYSA-N chlorotrimethylsilane Chemical compound C[Si](C)(C)Cl IJOOHPMOJXWVHK-UHFFFAOYSA-N 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 125000004093 cyano group Chemical group *C#N 0.000 description 3
- 150000005690 diesters Chemical class 0.000 description 3
- UAOMVDZJSHZZME-UHFFFAOYSA-N diisopropylamine Chemical compound CC(C)NC(C)C UAOMVDZJSHZZME-UHFFFAOYSA-N 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 125000001072 heteroaryl group Chemical group 0.000 description 3
- 230000014759 maintenance of location Effects 0.000 description 3
- 239000012071 phase Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 3
- 239000011975 tartaric acid Substances 0.000 description 3
- 235000002906 tartaric acid Nutrition 0.000 description 3
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 3
- 238000000825 ultraviolet detection Methods 0.000 description 3
- DNIAPMSPPWPWGF-VKHMYHEASA-N (+)-propylene glycol Chemical compound C[C@H](O)CO DNIAPMSPPWPWGF-VKHMYHEASA-N 0.000 description 2
- 0 *C(C[n]1c(ncnc2*)c2nc1)OCC(C(C1Cl)Cl)C1=O Chemical compound *C(C[n]1c(ncnc2*)c2nc1)OCC(C(C1Cl)Cl)C1=O 0.000 description 2
- VJGRFGFLZJIODS-UHFFFAOYSA-N 1-(3-chlorophenyl)propane-1,3-diol Chemical compound OCCC(O)C1=CC=CC(Cl)=C1 VJGRFGFLZJIODS-UHFFFAOYSA-N 0.000 description 2
- VFSNCDDPONNCST-UHFFFAOYSA-N 2-(2-aminopurin-9-yl)ethoxymethylphosphonic acid Chemical compound NC1=NC=C2N=CN(CCOCP(O)(O)=O)C2=N1 VFSNCDDPONNCST-UHFFFAOYSA-N 0.000 description 2
- RCQMOSJJIVCPJO-UHFFFAOYSA-N 2-(5-methyl-2,4-dioxopyrimidin-1-yl)ethoxymethylphosphonic acid Chemical compound CC1=CN(CCOCP(O)(O)=O)C(=O)NC1=O RCQMOSJJIVCPJO-UHFFFAOYSA-N 0.000 description 2
- RLXJTRMVNXHNQH-UHFFFAOYSA-N 2-(6-oxo-3h-purin-9-yl)ethoxymethylphosphonic acid Chemical compound N1C=NC(=O)C2=C1N(CCOCP(O)(=O)O)C=N2 RLXJTRMVNXHNQH-UHFFFAOYSA-N 0.000 description 2
- ALRHLSYJTWAHJZ-UHFFFAOYSA-N 3-hydroxypropionic acid Chemical compound OCCC(O)=O ALRHLSYJTWAHJZ-UHFFFAOYSA-N 0.000 description 2
- NZVORGQIEFTOQZ-UHFFFAOYSA-N 9-[2-(phosphonomethoxy)ethyl]guanine Chemical compound N1C(N)=NC(=O)C2=C1N(CCOCP(O)(O)=O)C=N2 NZVORGQIEFTOQZ-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
- 239000005909 Kieselgur Substances 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 2
- OVCMMBUTHVUMKS-SLBYMWBJSA-N O=P(COCC[n]1c(ncnc2/N=C\I)c2nc1)(OCC1)O[C@@H]1c1cc(Cl)ccc1 Chemical compound O=P(COCC[n]1c(ncnc2/N=C\I)c2nc1)(OCC1)O[C@@H]1c1cc(Cl)ccc1 OVCMMBUTHVUMKS-SLBYMWBJSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 125000005041 acyloxyalkyl group Chemical group 0.000 description 2
- SUPKOOSCJHTBAH-UHFFFAOYSA-N adefovir Chemical compound NC1=NC=NC2=C1N=CN2CCOCP(O)(O)=O SUPKOOSCJHTBAH-UHFFFAOYSA-N 0.000 description 2
- 125000001931 aliphatic group Chemical group 0.000 description 2
- 125000005205 alkoxycarbonyloxyalkyl group Chemical group 0.000 description 2
- 230000000840 anti-viral effect Effects 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 230000002238 attenuated effect Effects 0.000 description 2
- 229910000085 borane Inorganic materials 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 239000012141 concentrate Substances 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 125000000524 functional group Chemical group 0.000 description 2
- 125000002541 furyl group Chemical group 0.000 description 2
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 description 2
- 150000004820 halides Chemical class 0.000 description 2
- 125000005843 halogen group Chemical group 0.000 description 2
- CESOUITVLYKYSK-UHFFFAOYSA-N iodomethylphosphonic acid Chemical compound OP(O)(=O)CI CESOUITVLYKYSK-UHFFFAOYSA-N 0.000 description 2
- 238000002955 isolation Methods 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000011968 lewis acid catalyst Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 229940098779 methanesulfonic acid Drugs 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 230000035699 permeability Effects 0.000 description 2
- 230000003285 pharmacodynamic effect Effects 0.000 description 2
- ACVYVLVWPXVTIT-UHFFFAOYSA-N phosphinic acid Chemical compound O[PH2]=O ACVYVLVWPXVTIT-UHFFFAOYSA-N 0.000 description 2
- XNQULTQRGBXLIA-UHFFFAOYSA-O phosphonic anhydride Chemical compound O[P+](O)=O XNQULTQRGBXLIA-UHFFFAOYSA-O 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 229910000160 potassium phosphate Inorganic materials 0.000 description 2
- 235000011009 potassium phosphates Nutrition 0.000 description 2
- 125000006239 protecting group Chemical group 0.000 description 2
- 125000004076 pyridyl group Chemical group 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 125000005017 substituted alkenyl group Chemical group 0.000 description 2
- 125000000547 substituted alkyl group Chemical group 0.000 description 2
- 125000004426 substituted alkynyl group Chemical group 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- QSUJAUYJBJRLKV-UHFFFAOYSA-M tetraethylazanium;fluoride Chemical compound [F-].CC[N+](CC)(CC)CC QSUJAUYJBJRLKV-UHFFFAOYSA-M 0.000 description 2
- 125000001544 thienyl group Chemical group 0.000 description 2
- BIDNLKIUORFRQP-XYGFDPSESA-N (2s,4s)-4-cyclohexyl-1-[2-[[(1s)-2-methyl-1-propanoyloxypropoxy]-(4-phenylbutyl)phosphoryl]acetyl]pyrrolidine-2-carboxylic acid Chemical compound C([P@@](=O)(O[C@H](OC(=O)CC)C(C)C)CC(=O)N1[C@@H](C[C@H](C1)C1CCCCC1)C(O)=O)CCCC1=CC=CC=C1 BIDNLKIUORFRQP-XYGFDPSESA-N 0.000 description 1
- OACMINWRAKUBOL-UHFFFAOYSA-N (8-nitroquinolin-3-yl)phosphonic acid Chemical compound [O-][N+](=O)C1=CC=CC2=CC(P(O)(=O)O)=CN=C21 OACMINWRAKUBOL-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- DYLIWHYUXAJDOJ-OWOJBTEDSA-N (e)-4-(6-aminopurin-9-yl)but-2-en-1-ol Chemical compound NC1=NC=NC2=C1N=CN2C\C=C\CO DYLIWHYUXAJDOJ-OWOJBTEDSA-N 0.000 description 1
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical compound ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- LABRPRANVKSMGP-UHFFFAOYSA-N 1,3,2-dioxaphosphinane Chemical compound C1COPOC1 LABRPRANVKSMGP-UHFFFAOYSA-N 0.000 description 1
- AFABGHUZZDYHJO-UHFFFAOYSA-N 2-Methylpentane Chemical compound CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 description 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
- WHIHIKVIWVIIER-UHFFFAOYSA-N 3-chlorobenzoyl chloride Chemical compound ClC(=O)C1=CC=CC(Cl)=C1 WHIHIKVIWVIIER-UHFFFAOYSA-N 0.000 description 1
- 229960000549 4-dimethylaminophenol Drugs 0.000 description 1
- 125000001572 5'-adenylyl group Chemical group C=12N=C([H])N=C(N([H])[H])C=1N=C([H])N2[C@@]1([H])[C@@](O[H])([H])[C@@](O[H])([H])[C@](C(OP(=O)(O[H])[*])([H])[H])([H])O1 0.000 description 1
- 125000001417 5'-guanylyl group Chemical group C=12N=C(N([H])[H])N([H])C(=O)C=1N=C([H])N2[C@@]1([H])[C@@](O[H])([H])[C@@](O[H])([H])[C@](C(OP(=O)(O[H])[*])([H])[H])([H])O1 0.000 description 1
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical group N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 1
- 239000005541 ACE inhibitor Substances 0.000 description 1
- 101000620356 Actinidia deliciosa Pectinesterase inhibitor Proteins 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 101710129690 Angiotensin-converting enzyme inhibitor Proteins 0.000 description 1
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- 101710086378 Bradykinin-potentiating and C-type natriuretic peptides Proteins 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 206010011831 Cytomegalovirus infection Diseases 0.000 description 1
- 229910004373 HOAc Inorganic materials 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- 229910004298 SiO 2 Inorganic materials 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 229940123495 Squalene synthetase inhibitor Drugs 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- LWEKFDHXJHJYGB-RXMQYKEDSA-N [(2r)-1-(2,6-diaminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid Chemical compound N1=C(N)N=C2N(C[C@@H](C)OCP(O)(O)=O)C=NC2=C1N LWEKFDHXJHJYGB-RXMQYKEDSA-N 0.000 description 1
- GFVHBMMZFJJYDN-UHFFFAOYSA-N [1-(2,6-diaminopurin-9-yl)-3-fluoropropan-2-yl]oxymethylphosphonic acid Chemical compound NC1=NC(N)=C2N=CN(CC(CF)OCP(O)(O)=O)C2=N1 GFVHBMMZFJJYDN-UHFFFAOYSA-N 0.000 description 1
- JXBAVRIYDKLCOE-UHFFFAOYSA-N [C].[P] Chemical compound [C].[P] JXBAVRIYDKLCOE-UHFFFAOYSA-N 0.000 description 1
- 125000002015 acyclic group Chemical group 0.000 description 1
- 229960001997 adefovir Drugs 0.000 description 1
- 238000005575 aldol reaction Methods 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- 125000000304 alkynyl group Chemical group 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 125000006295 amino methylene group Chemical group [H]N(*)C([H])([H])* 0.000 description 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 1
- 239000002220 antihypertensive agent Substances 0.000 description 1
- 229940127088 antihypertensive drug Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 239000011260 aqueous acid Substances 0.000 description 1
- 125000003710 aryl alkyl group Chemical group 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 125000005841 biaryl group Chemical group 0.000 description 1
- 230000001588 bifunctional effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
- 125000005586 carbonic acid group Chemical group 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 description 1
- 150000001733 carboxylic acid esters Chemical class 0.000 description 1
- 239000003054 catalyst Substances 0.000 description 1
- 238000004296 chiral HPLC Methods 0.000 description 1
- 239000012320 chlorinating reagent Substances 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
- 238000010511 deprotection reaction Methods 0.000 description 1
- 125000005265 dialkylamine group Chemical group 0.000 description 1
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
- 229940043279 diisopropylamine Drugs 0.000 description 1
- HWSUUGHIDOOOOJ-UHFFFAOYSA-N dioxaphosphinane Chemical compound C1COOPC1 HWSUUGHIDOOOOJ-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000002024 ethyl acetate extract Substances 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000003818 flash chromatography Methods 0.000 description 1
- 229960002490 fosinopril Drugs 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- VNXBKJFUJUWOCW-UHFFFAOYSA-N methylcyclopropane Chemical compound CC1CC1 VNXBKJFUJUWOCW-UHFFFAOYSA-N 0.000 description 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000012038 nucleophile Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 125000005499 phosphonyl group Chemical group 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 239000002952 polymeric resin Substances 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical compound CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 239000012066 reaction slurry Substances 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000010956 selective crystallization Methods 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 239000004059 squalene synthase inhibitor Substances 0.000 description 1
- 230000000707 stereoselective effect Effects 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 230000002277 temperature effect Effects 0.000 description 1
- 229960004556 tenofovir Drugs 0.000 description 1
- VCMJCVGFSROFHV-WZGZYPNHSA-N tenofovir disoproxil fumarate Chemical compound OC(=O)\C=C\C(O)=O.N1=CN=C2N(C[C@@H](C)OCP(=O)(OCOC(=O)OC(C)C)OCOC(=O)OC(C)C)C=NC2=C1N VCMJCVGFSROFHV-WZGZYPNHSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 150000003573 thiols Chemical class 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
- QHUNJMXHQHHWQP-UHFFFAOYSA-N trimethylsilyl acetate Chemical compound CC(=O)O[Si](C)(C)C QHUNJMXHQHHWQP-UHFFFAOYSA-N 0.000 description 1
- 208000019553 vascular disease Diseases 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
- C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
- C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Description
本出願は米国仮出願No.60/578,467(2004年6月8日に出願)に関連し、その利益を主張する(この内容は本明細書の一部を構成する。)
(発明の要約)
R1は、水素、所望により置換されたアリール、所望により置換されたヘテロアリールからなる群から選ばれるか、または
R1は、式:Ar1-G-Ar2で示される基である(ここで、Ar1およびAr2は、低級アルキル、低級アルコキシ、ハロゲン、ヒドロキシ、シアノ、およびアミノにより置換されたアリール基であり、Gは、-O-、-S-、-S(=O)-、-S(=O)2-、-CH2-、-CF2-、-CHF-、-C(O)-、-CH(OH)-、-NH-、および-N(C1-C4アルキル)-である);
alk1およびalk2は、同じかまたは異なり、それぞれ所望により置換された低級アルキレンである;
Yは、-O-、-S-、-NR2-、-C(O)-、-C(O)NR2、および-NR2C(O)-からなる群から選ばれる;
WおよびW'は、H、所望により置換されたアルキル、所望により置換されたアルケニル、所望により置換されたアルキニル、所望により置換された単環式アリール、および所望により置換された単環式ヘテロアリールからなる群から独立して選ばれる;
Zは、ハロゲン、-CN、-COR3、-CONR4 2、-CO2R3、-CHR2OC(O)R3、-CHR2OC(S)R3、-CHR2OC(O)SR3、-CHR2OCO2R3、-OR3、-SR3、-R2、-NR3 2、-OCOR3、-OCO2R3、-SCO2R3、-SCO2R3、-(CH2)p-OR4、および-(CH2)p-SR4からなる群から選ばれる;
R2は水素または低級アルキルである;
R3はアルキルである;
R4はアルキルまたはアシルである;
pは2または3である;
rは0または1である;
sは0または1である。]
で示される化合物の製造方法に関する。
別の局面では、本発明は、式II:
WおよびW'は、H、所望により置換されたアルキル、所望により置換されたアルケニル、所望により置換されたアルキニル、所望により置換された単環式アリール、および所望により置換された単環式ヘテロアリールからなる群から独立して選ばれる;
Zは、ハロゲン、-CN、-COR3、-CONR4 2、-CO2R3、-CHR2OC(O)R3、-CHR2OC(S)R3、-CHR2OC(O)SR3、-CHR2OCO2R3、-OR3、-SR3、-R2、-NR3 2、-OCOR3、-OCO2R3、-SCO2R3、-SCO2R3、-(CH2)p-OR4、および-(CH2)p-SR4からなる群から選ばれる;
Tは、Hおよび低級アルキルからなる群から選ばれる;
R2は水素または低級アルキルである;
R3はアルキルである;
R4はアルキルまたはアシルである;
pは2または3である;
rは0または1である;
sは0または1である;
R5は1価のアミン保護基であり、R6は水素であるか、または
R5とR6が一緒になって二価のアミン保護基である。]
で示される化合物の製造方法に関する。
R5とR6は一緒になってフタリミドイル、フェニルメチリデン、ジメチルアミノメチリデンおよびジエチルアミノメチリデンである;
Tは、Hおよび低級アルキルからなる群から選ばれる。]
で示される化合物の製造方法を提供する。
R5とR6は一緒になってフタリミドイル、フェニルメチリデン、ジメチルアミノメチリデンおよびジエチルアミノメチリデンである;
Tは、Hおよび低級アルキルからなる群から選ばれる。]
で示される化合物の製造方法であって、
ルイス酸の存在下で(R)-1-(3-クロロフェニル)-1,3-プロパンジオールと式III:
で示される化合物の製造方法を提供する。ある局面では、(R)-1-(3-クロロフェニル)-1,3-プロパンジオールは、ルイス酸:
(定義)
[R]-[S]X100=%R-%S
[R]+[S]
[式中、[R]はR異性体の量であり、[S]はS異性体の量である。]
を用いて得られる。この式は、Rが主な異性体である時に%eeをもたらす。
[シス]-[トランス]X100=%[シス]−%[トランス]
[シス]+[トランス]
を用いて得られる。
生物学的に活性な化合物:
BOC;tert-ブトキシカルボニル基
CBz;ベンジルカルバメート
トリチル;トリフェニルメチル基
CH2Cl2;ジクロロメタンまたは塩化メチレン
DCM;ジクロロメタン
-(-)-DIP-Cl;-β-クロロジイソピノカンフェイルボラン
DMAP;4-ジメチルアミノピリジン
DMF;ジメチルホルムアミド
HCl;塩酸
KI;ヨウ化カリウム
MgSO4;硫酸マグネシウム
MTBE;t-ブチルメチルエーテル
NaCl;塩化ナトリウム
NaOH;水酸化ナトリウム
PyBOP;ベンゾトリアゾール-1-イルオキシトリピロリジノホスホニウムヘキサフルオロホスフェート
TEA;トリエチルアミン
THF;テトラヒドロフラン
TMSCl;クロロトリメチルシラン
TMEDA;テトラメチルエチレンジアミン
EDTA;エチレンジアミン四酢酸。
PMEA;9-(2-ホスホニルメトキシエチル)アデニン(Adefovir)
(R)-PMPA;(R)-9-(2-ホスホニルメトキシプロピル)アデニン(Tenofovir)
(R)-PMPDAP;(R)-9-(2-ホスホニルメトキシプロピル)-2,6-ジアミノプリン
FPMPDAP;9-[(2RS)-3-フルオロ-2-ホスホニルメトキシプロピル]-2,6-ジアミノプリン
FPMGP;9-[(2RS)-3-フルオロ-2-ホスホニルメトキシプロピル]グアニン
(S)-HPMPDAP;9-=[2S]-3-ヒドロキシ-2-ホスホニルメトキシルプロピル]-2,6-ジアミノプリン
PMEG;9-(2-ホスホニルメトキシエチル)グアニン
PMEI;2-ホスホニルメトキシエチル-6-オキソプリン
PMEMAP;9-(2-ホスホニルメトキシエチル)2-アミノプリン
PMET;2-ホスホニルメトキシエチル-チミン
(発明の詳細な説明)
(本発明により製造される化合物)
1. N6-保護PMEA-ジクロリデートの合成:
表1
溶液成分、温度、および添加順序の影響
4. シスプロドラッグ塩の結晶化
ジオールは米国公開出願No.20030225277A1に記載のごとく製造した。12L、三首丸底フラスコに機械式スターラーおよび添加漏斗(2L)を取り付けた。フラスコを窒素でフラッシュし、ジイソプロピルアミン(636mL)およびTHF(1.80L)を充填した。撹拌した内容を-20℃に冷却した。n-ブチルリチウム(ヘキサン中の2.5M溶液、1.81L)を撹拌しながら徐々に加え、温度を-20〜-28℃に維持した。添加が完結した後(30分間)、添加漏斗をヘキサン(30mL)でリンスし、次いで撹拌溶液を-62℃に冷却した。トリメチルシリルアセテート(300g)を撹拌しながら徐々に加え、<-60℃の温度に維持した。添加が完結した後(約30分間)、溶液を-60℃で15分間撹拌した。3-クロロベンゾイルクロリド(295mL)を撹拌しながら徐々に加え、<-60℃の温度に維持した。添加が完結した後(約65分間)、冷却槽を除去し、反応溶液を徐々に0℃に温めながら約1.25時間撹拌した。反応フラスコを氷浴で冷却し、次いで撹拌溶液に水(1.8L)を加えた。反応混合物を10分間撹拌し、次で、t-ブチルメチルエーテル(MTBE)(1.0L)で希釈した。下の水性相を分離し、機械式スターラーを取り付けた丸底フラスコに移した。MTBEを加え(1.8L)、撹拌混合物を氷浴中で<10℃に冷却した。濃HCl溶液(12M溶液、300mL)を加え、混合物を勢いよく撹拌した。層を分離し、水性相をさらに濃HCl(30mL)で酸性化し、MTBE(1.0L)で再度抽出した。混合MTBE抽出物を約10%NaCl溶液(1L)で洗浄し、乾燥し(MgSO4、70g)、濾過し、次いで減圧下で濃縮して827gの黄色固体を得た。粗固体をヘキサン(2.2L)中でスラリーとし、機械式スターラーを取り付けた丸底フラスコに移した。混合物を<10℃で1時間撹拌し、次いで濾過し、ヘキサン(4×100mL)で洗浄し、次いで乾燥して一定重量とした(-30 in.Hg、周囲温度、14時間)。
実施例2:(S)-3-(3-クロロフェニル)-3-ヒドロキシプロパン酸(2)の製造
実施例3:(S)-(-)-1-(3-クロロフェニル)-1,3-プロパンジオール(3)の製造
実施例4:9-{2-[2,4-シス-(S)-(+)-4-(3-クロロフェニル)-2-オキソ-1,3,2-ジオキサホスホリナン-2-イル]メトキシエチル}アデニンメタンスルホネート(9)の製造
実施例4.1:ジクロリデート(8)の形成
実施例4.2:カップリング反応
HPLC条件:
YMC-Pack R&D、R-33-5 S-5 120A、250×4.6mm;移動相:溶媒A=20mM燐酸カリウム、pH6.2;溶媒B=アセトニトリル;勾配:10-60%B/15分、60-10%B/2分、10%B/3分;1.4mL/分;inj. vol.=10μL;270nmでUV検出。
保持時間:シス13=12.5分間、トランス14=13.0分間。
HPLC条件:
YMC-PACK R&D、R-33-5 S-5 120A、250×4.6mm;移動相:溶媒A=20mMリン酸カリウム、pH6.2;溶媒B=アセトニトリル;勾配:10-60%B/15分、60-10%B/2分、10%B/3分;1.4mL/分;inj.vol.=10μL;270nmでUV検出。
保持時間:シス15=9.5分間、トランス16=9.8分間。
回収量=9が19.9g(70%)。固体シス:トランス比は97.8:1.7であった。
色:淡黄色固体
実施例5:ヨードメチルホスホン酸と(S)-(-)-1-(3-クロロフェニル)-1,3-プロパンジオールのカップリング
実施例6:4-{4-[2,4-シス-(S)-4-(3-クロロフェニル)-2-オキソ-2λ5-[1,3,2]ジオキサホスフィナン-2-イルメトキシ]-2,6-ジメチルベンジル}-2-イソプロピルフェノール)の製造
実施例7:4-{4-[2,4-シス-(S)-4-(3,5-ジクロロフェニル)-2-オキソ-2λ5-[1,3,2]ジオキサホスフィナン-2-イルメトキシ]-2,6-ジメチルベンジル}-2-イソプロピルフェノールの製造
実施例8:8-ニトロ-3-[2,4-シス-4-(3-クロロフェニル)-2-オキソ-1,3,2-ジオキサホスホリナニル]キノリンの製造
Claims (22)
- 式II:
[式中、Vは、フェニル、および1〜2個の置換基で置換されたフェニルからなる群から選ばれる;
Tは、Hおよび低級アルキルからなる群から選ばれる;
R5は1価のアミン保護基であり、R6は水素であるか、または
R5とR6が一緒になって二価のアミン保護基である。]
で示される化合物のジアステレオ選択的製造方法であって、
塩基、およびTiCl 4 であるルイス酸の存在下で1-(V)-1,3-プロパンジオールと式III:
で示される化合物を混合することを含む、
形成される式IIの化合物のシス-/トランス-ジアステレオマー比が3:1に等しいかまたはそれ以上であり、
該1-(V)-1,3-プロパンジオールを該ルイス酸に加え、次いで該ジオール-ルイス酸複合体を該式IIIの化合物に加えるものである方法。 - 該塩基が、第3アルキルアミン、Nを含有する複素環式芳香族塩基、および非求核性無機塩基からなる群から選ばれる請求項1の方法。
- 該塩基がトリエチルアミン、トリ(n-ブチル)アミン、ピリジン、キノリンおよびジイソプロピルエチルアミンからなる群から選ばれる請求項2記載の方法。
- 反応温度が-78℃〜60℃である請求項1記載の方法。
- 該温度が-20℃〜50℃である請求項4記載の方法。
- 該温度が15℃〜42℃である請求項5記載の方法。
- さらに該1-(V)-1,3-プロパンジオールの1.0当量に該ルイス酸の0.01〜5当量を加えることを含む請求項1記載の方法。
- 該ルイス酸の0.5〜2.0当量を加える請求項7記載の方法。
- 式IV:
R5とR6は一緒になってフタリミドイル、フェニルメチリデン、ジメチルアミノメチリデンおよびジエチルアミノメチリデンである;
Tは、Hおよび低級アルキルからなる群から選ばれる。]
で示される化合物のジアステレオ選択的製造方法であって、
塩基、およびTiCl 4 であるルイス酸の存在下で(S)-(-)-(3-クロロフェニル)-1,3-プロパンジオールと式III:
形成される式IVの化合物のシス-/トランス-ジアステレオマー比が3:1に等しいかまたはそれ以上であり、
該(S)-(-)-(3-クロロフェニル)-1,3-プロパンジオールを該ルイス酸に加え、次いで該ジオール-ルイス酸複合体を該式IIIの化合物に加えるものである方法。 - 該塩基が、第3アルキルアミン、Nを含有する複素環式芳香族塩基および非求核性無機塩基からなる群から選ばれる請求項9記載の方法。
- 該塩基がトリエチルアミン、トリ(n-ブチル)アミン、ピリジン、キノリンおよびジイソプロピルエチルアミンからなる群から選ばれる請求項10記載の方法。
- 反応温度が-78℃〜60℃である請求項9記載の方法。
- 該温度が-20℃〜50℃である請求項12記載の方法。
- 該温度が15℃〜42℃である請求項13記載の方法。
- さらに該(S)-(-)-(3-クロロフェニル)-1,3-プロパンジオールの1.0当量に該ルイス酸の0.01〜5当量を加えることを含む請求項9記載の方法。
- 該ルイス酸の0.5〜2.0当量を加える請求項15記載の方法。
- 該塩基が、第3アルキルアミン、Nを含有する複素環式芳香族塩基および非求核性無機塩基からなる群から選ばれる請求項17の方法。
- 該塩基がトリエチルアミン、トリ(n-ブチル)アミン、ピリジン、キノリンおよびジイソプロピルエチルアミンからなる群から選ばれる請求項18記載の方法。
- 該温度が15℃〜42℃である請求項17記載の方法。
- さらに該(S)-(-)-(3-クロロフェニル)-1,3-プロパンジオール1.0当量に該ルイス酸0.01〜5当量を加えることを含む請求項17の方法。
- 該ルイス酸0.5〜2.0当量を加える請求項21記載の方法。
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2005
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- 2005-06-03 US US11/144,348 patent/US7582758B2/en active Active
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CN103374041A (zh) | 2013-10-30 |
US20050282782A1 (en) | 2005-12-22 |
TW200617008A (en) | 2006-06-01 |
EP1753762B1 (en) | 2014-03-19 |
KR20070029196A (ko) | 2007-03-13 |
CA2565966A1 (en) | 2005-12-29 |
EP1753762A4 (en) | 2011-05-04 |
AU2005254940A1 (en) | 2005-12-29 |
EP1753762A1 (en) | 2007-02-21 |
BRPI0511948A (pt) | 2008-01-29 |
JP2008501799A (ja) | 2008-01-24 |
CN1964967A (zh) | 2007-05-16 |
RU2006138907A (ru) | 2008-07-20 |
WO2005123729A1 (en) | 2005-12-29 |
CN103374041B (zh) | 2017-05-10 |
MXPA06014013A (es) | 2007-03-15 |
TWI370819B (en) | 2012-08-21 |
CN1964967B (zh) | 2014-04-16 |
ZA200609429B (en) | 2008-07-30 |
US7582758B2 (en) | 2009-09-01 |
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