TWI370819B - Lewis acid mediated synthesis of cyclic esters - Google Patents

Lewis acid mediated synthesis of cyclic esters

Info

Publication number
TWI370819B
TWI370819B TW094118835A TW94118835A TWI370819B TW I370819 B TWI370819 B TW I370819B TW 094118835 A TW094118835 A TW 094118835A TW 94118835 A TW94118835 A TW 94118835A TW I370819 B TWI370819 B TW I370819B
Authority
TW
Taiwan
Prior art keywords
lewis acid
cyclic esters
acid mediated
mediated synthesis
synthesis
Prior art date
Application number
TW094118835A
Other languages
English (en)
Other versions
TW200617008A (en
Inventor
Kevin Martin
Original Assignee
Metabasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabasis Therapeutics Inc filed Critical Metabasis Therapeutics Inc
Publication of TW200617008A publication Critical patent/TW200617008A/zh
Application granted granted Critical
Publication of TWI370819B publication Critical patent/TWI370819B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
TW094118835A 2004-06-08 2005-06-08 Lewis acid mediated synthesis of cyclic esters TWI370819B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57846704P 2004-06-08 2004-06-08

Publications (2)

Publication Number Publication Date
TW200617008A TW200617008A (en) 2006-06-01
TWI370819B true TWI370819B (en) 2012-08-21

Family

ID=35509614

Family Applications (1)

Application Number Title Priority Date Filing Date
TW094118835A TWI370819B (en) 2004-06-08 2005-06-08 Lewis acid mediated synthesis of cyclic esters

Country Status (13)

Country Link
US (1) US7582758B2 (zh)
EP (1) EP1753762B1 (zh)
JP (1) JP5142716B2 (zh)
KR (1) KR20070029196A (zh)
CN (2) CN103374041B (zh)
AU (1) AU2005254940A1 (zh)
BR (1) BRPI0511948A (zh)
CA (1) CA2565966A1 (zh)
MX (1) MXPA06014013A (zh)
RU (1) RU2006138907A (zh)
TW (1) TWI370819B (zh)
WO (1) WO2005123729A1 (zh)
ZA (1) ZA200609429B (zh)

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EP1504014B1 (en) * 2002-05-13 2015-12-02 Metabasis Therapeutics, Inc. Process for preparation of cyclic prodrugs of pmea and pmpa
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EP2487160B1 (en) 2006-10-11 2016-02-03 President and Fellows of Harvard College Synthesis of Enone Intermediate
US7635773B2 (en) 2008-04-28 2009-12-22 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions
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WO2010126607A2 (en) 2009-04-30 2010-11-04 President And Fellows Of Harvard College Synthesis of tetracyclines and intermediates thereto
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CA2865950C (en) 2012-02-28 2016-12-20 Cydex Pharmaceuticals, Inc. Alkylated cyclodextrin compositions and processes for preparing and using the same
CN103665043B (zh) 2012-08-30 2017-11-10 江苏豪森药业集团有限公司 一种替诺福韦前药及其在医药上的应用
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WO2016029179A1 (en) 2014-08-22 2016-02-25 Cydex Pharmaceuticals, Inc. Fractionated alkylated cyclodextrin compositions and processes for preparing and using the same
JP2020500199A (ja) 2016-11-21 2020-01-09 バイキング・セラピューティクス・インコーポレイテッド グリコーゲン蓄積症の治療方法
EP3634426A4 (en) 2017-06-05 2021-04-07 Viking Therapeutics, Inc. COMPOSITIONS FOR THE TREATMENT OF FIBROSIS
AU2019207625A1 (en) 2018-01-09 2020-07-30 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
US11787828B2 (en) * 2018-03-22 2023-10-17 Viking Therapeutics, Inc. Crystalline forms and methods of producing crystalline forms of a compound
CN114901657A (zh) 2019-10-17 2022-08-12 人工智能生物制药公司 抗病毒和肝靶向药物
CN113336792B (zh) 2020-02-18 2024-07-16 甘莱制药有限公司 一种环状膦酸酯化合物的制备方法
US11752161B2 (en) 2020-03-27 2023-09-12 Gannex Pharma Co., Ltd. Pharmaceutical compositions, method of making and method of using thereof
WO2021223398A1 (zh) * 2020-05-07 2021-11-11 西安新通药物研究股份有限公司 治疗肝病的晶型及其应用
CN113620993A (zh) * 2020-05-07 2021-11-09 西安新通药物研究股份有限公司 甲磺酸帕拉德福韦d晶型及其应用
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Also Published As

Publication number Publication date
CN103374041A (zh) 2013-10-30
US20050282782A1 (en) 2005-12-22
TW200617008A (en) 2006-06-01
EP1753762B1 (en) 2014-03-19
KR20070029196A (ko) 2007-03-13
JP5142716B2 (ja) 2013-02-13
CA2565966A1 (en) 2005-12-29
EP1753762A4 (en) 2011-05-04
AU2005254940A1 (en) 2005-12-29
EP1753762A1 (en) 2007-02-21
BRPI0511948A (pt) 2008-01-29
JP2008501799A (ja) 2008-01-24
CN1964967A (zh) 2007-05-16
RU2006138907A (ru) 2008-07-20
WO2005123729A1 (en) 2005-12-29
CN103374041B (zh) 2017-05-10
MXPA06014013A (es) 2007-03-15
CN1964967B (zh) 2014-04-16
ZA200609429B (en) 2008-07-30
US7582758B2 (en) 2009-09-01

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