IN2014MU00118A - - Google Patents
Download PDFInfo
- Publication number
- IN2014MU00118A IN2014MU00118A IN118MU2014A IN2014MU00118A IN 2014MU00118 A IN2014MU00118 A IN 2014MU00118A IN 118MU2014 A IN118MU2014 A IN 118MU2014A IN 2014MU00118 A IN2014MU00118 A IN 2014MU00118A
- Authority
- IN
- India
- Prior art keywords
- phenoxyphosphinyl
- isopropoxycarbonyl
- adenine
- methoxy
- propyl
- Prior art date
Links
- 229930024421 Adenine Natural products 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 229960000643 adenine Drugs 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- LDEKQSIMHVQZJK-CAQYMETFSA-N tenofovir alafenamide Chemical compound O([P@@](=O)(CO[C@H](C)CN1C2=NC=NC(N)=C2N=C1)N[C@@H](C)C(=O)OC(C)C)C1=CC=CC=C1 LDEKQSIMHVQZJK-CAQYMETFSA-N 0.000 abstract 1
- 229960004946 tenofovir alafenamide Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES15705378T ES2842123T3 (es) | 2014-01-14 | 2015-01-13 | Purificación de tenofovir alafenamida y sus intermedios |
IN118MU2014 IN2014MU00118A (ja) | 2014-01-14 | 2015-01-13 | |
EP15705378.6A EP3077404B1 (en) | 2014-01-14 | 2015-01-13 | Purification of tenofovir alafenamide and its intermediates |
PCT/IB2015/050239 WO2015107451A2 (en) | 2014-01-14 | 2015-01-13 | Purification of tenofovir alafenamide and its intermediates |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN118MU2014 IN2014MU00118A (ja) | 2014-01-14 | 2015-01-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014MU00118A true IN2014MU00118A (ja) | 2015-08-28 |
Family
ID=52484522
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN118MU2014 IN2014MU00118A (ja) | 2014-01-14 | 2015-01-13 |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP3077404B1 (ja) |
ES (1) | ES2842123T3 (ja) |
IN (1) | IN2014MU00118A (ja) |
WO (1) | WO2015107451A2 (ja) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CZ2015384A3 (cs) * | 2015-06-05 | 2016-12-14 | Zentiva, K.S. | Pevné formy Tenofovir alafenamidu |
US9777028B2 (en) | 2015-06-17 | 2017-10-03 | Gilead Sciences, Inc. | Co-crystals, salts and solid forms of tenofovir alafenamide |
CN106699812A (zh) * | 2015-11-12 | 2017-05-24 | 江苏豪森药业集团有限公司 | 替诺福韦前药的制备和纯化方法 |
WO2017118928A1 (en) | 2016-01-06 | 2017-07-13 | Lupin Limited | Process for the separation of diastereomers of tenofovir alafenamide |
WO2017134089A1 (en) | 2016-02-02 | 2017-08-10 | Sandoz Ag | Crystalline forms of tenofovir alafenamide monofumarate |
CN107179355B (zh) * | 2016-03-11 | 2021-08-10 | 广东东阳光药业有限公司 | 一种分离检测替诺福韦艾拉酚胺及其有关物质的方法 |
CZ2016156A3 (cs) * | 2016-03-17 | 2017-09-27 | Zentiva, K.S. | Způsob přípravy diastereomerně čistého Tenofoviru Alafenamidu nebo jeho solí |
CN107226826A (zh) * | 2016-03-25 | 2017-10-03 | 江苏奥赛康药业股份有限公司 | 替诺福韦艾拉酚胺富马酸盐化合物及其药物组合物 |
CN106478725B (zh) * | 2016-10-14 | 2018-11-09 | 上海礼泰医药科技有限公司 | 高纯度膦丙替诺福韦中间体的制备方法及其应用 |
CN113072583A (zh) * | 2016-11-28 | 2021-07-06 | 正大天晴药业集团股份有限公司 | 一种替诺福韦艾拉酚胺半富马酸盐的结晶及其制备方法 |
CN108341841B (zh) * | 2017-01-22 | 2020-07-17 | 成都倍特药业股份有限公司 | 一种替诺福韦艾拉酚胺与门冬氨酸的盐 |
TWI714820B (zh) | 2017-01-31 | 2021-01-01 | 美商基利科學股份有限公司 | 替諾福韋艾拉酚胺(tenofovir alafenamide)之晶型 |
CN106946935B (zh) * | 2017-04-28 | 2020-01-07 | 福建广生堂药业股份有限公司 | 一种非对映异构体核苷衍生物的制备方法 |
CN109942632B (zh) * | 2017-12-20 | 2021-08-31 | 上海博志研新药物研究有限公司 | 替诺福韦艾拉酚胺中间体的制备方法 |
CN109942633B (zh) * | 2017-12-20 | 2021-08-31 | 上海新礼泰药业有限公司 | 替诺福韦艾拉酚胺中间体的制备方法 |
CN108467410B (zh) * | 2018-04-09 | 2021-04-09 | 重庆三圣实业股份有限公司 | 一种taf中间体的制备方法及产品和应用 |
CN108484672A (zh) * | 2018-05-23 | 2018-09-04 | 中国药科大学制药有限公司 | 磷丙替诺福韦的手性拆分方法 |
CN110283208B (zh) * | 2018-06-22 | 2022-07-08 | 南京济群医药科技股份有限公司 | 一种替诺福韦艾拉酚胺的手性拆分方法 |
CN110105392A (zh) * | 2019-06-04 | 2019-08-09 | 石家庄凯赛医药科技有限公司 | 一种替诺福韦艾拉酚胺的高效合成工艺 |
EP4085062A1 (en) | 2020-02-20 | 2022-11-09 | Cipla Limited | Novel salts and/or co-crystals of tenofovir alafenamide |
US11667656B2 (en) | 2021-01-27 | 2023-06-06 | Apotex Inc. | Crystalline forms of Tenofovir alafenamide |
CN114907409A (zh) * | 2022-06-21 | 2022-08-16 | 辰欣药业股份有限公司 | 一种丙酚替诺福韦的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5798340A (en) * | 1993-09-17 | 1998-08-25 | Gilead Sciences, Inc. | Nucleotide analogs |
EE05366B1 (et) | 2000-07-21 | 2010-12-15 | Gilead Sciences, Inc | Fosfonaatnukleotiidanaloogide eelravimid ja skriinimise meetodid nende identifitseerimiseks |
CN101712692A (zh) * | 2009-12-21 | 2010-05-26 | 巢杰 | 泰诺福韦酯的药用酸加成盐及其制备方法和药物应用 |
TWI709567B (zh) | 2011-10-07 | 2020-11-11 | 美商基利科學股份有限公司 | 抗病毒核苷酸類似物的製備方法 |
WO2013115916A1 (en) * | 2012-02-03 | 2013-08-08 | Gilead Sciences, Inc. | Combination therapy comprising gs-7340 and cobicistat for use in the treatment of viral infections |
EP3004121A1 (en) * | 2013-06-07 | 2016-04-13 | Cipla Limited | An efficient process for separation of diastereomers of 9-[(r)-2-[[(r,s)-[[(s)-1-(isopropoxycarbonyl)ethyl]amino]-phenoxyphosphinyl]methoxy]propyl]adenine |
-
2015
- 2015-01-13 ES ES15705378T patent/ES2842123T3/es active Active
- 2015-01-13 EP EP15705378.6A patent/EP3077404B1/en active Active
- 2015-01-13 WO PCT/IB2015/050239 patent/WO2015107451A2/en active Application Filing
- 2015-01-13 IN IN118MU2014 patent/IN2014MU00118A/en unknown
Also Published As
Publication number | Publication date |
---|---|
EP3077404A2 (en) | 2016-10-12 |
WO2015107451A2 (en) | 2015-07-23 |
WO2015107451A3 (en) | 2015-12-10 |
EP3077404B1 (en) | 2020-10-07 |
ES2842123T3 (es) | 2021-07-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IN2014MU00118A (ja) | ||
IN2013MU01967A (ja) | ||
CR20140204A (es) | Métodos para preparar análogos nucleotídicos antivirales | |
MX2021013118A (es) | Compuestos polifluorados que actuan como inhibidores de la tirosina cinasa de bruton. | |
PH12016501192B1 (en) | Tetrahydropyridopyrazines modulators of gpr6 | |
WO2016130920A3 (en) | Lrrk2 inhibitors and methods of making and using the same | |
AU2015208932A8 (en) | (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides as dipeptidyl peptidase I inhibitors | |
MX2021014663A (es) | Il-23a y tnf-alfa orientados y compuesto y sus usos. | |
IN2014MU00455A (ja) | ||
PH12016502229A1 (en) | Process for preparing phosphorus-containing cyanohydrins | |
RS60533B1 (sr) | Postupak za prečišćavanje hidrolizata biomase | |
MY191352A (en) | Aldosterone synthase inhibitors | |
GEP201706626B (en) | Synthesis of (s)-nifuratel | |
NZ720106A (en) | A process for the preparation of regadenoson | |
EP3187484A4 (en) | Method for producing composition containing purified chlorogenic acids | |
MX346636B (es) | Procedimiento para la produccion a escala comercial de prrsv. | |
MX2019002017A (es) | Derivados de sofosbuvir para el tratamiento de la hepatitis c. | |
PH12014501327A1 (en) | Processes for making magnolol analogs | |
UA103197C2 (uk) | Застосування ніфуртимоксу для лікування хвороб, спричинених трихомонадами | |
MX2017003415A (es) | Un derivado de tetrahidropirrolo [3,4-d] [1,3]tiazina como inhibidor de bace. | |
MX2019006783A (es) | Procedimiento para la preparacion de 4-amino-1-( (1s, 4r, 5s) -2-fluoro-4,5-dihidroxi-3-hidroximetil-ciclopent-2-enil)-1h-pirim idin-2-ona. | |
MX2017012027A (es) | Desaminacion de nucleosidos organofosforados. | |
AU2015221431A8 (en) | Novel 6,7-dihydro-3H-oxazolo[3,4-a]pyrazine-5,8-dione derivative compounds | |
IN2014CH01391A (ja) | ||
MX2017011820A (es) | Reactivos de acilacion de aminoacidos y metodos para usar los mismos. |