|
US6395888B1
(en)
*
|
1996-02-01 |
2002-05-28 |
Gilead Sciences, Inc. |
High affinity nucleic acid ligands of complement system proteins
|
|
US5681811A
(en)
*
|
1993-05-10 |
1997-10-28 |
Protein Delivery, Inc. |
Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
|
|
KR100361933B1
(ko)
*
|
1993-09-08 |
2003-02-14 |
라 졸라 파마슈티칼 컴파니 |
화학적으로정의된비중합성결합가플랫폼분자및그것의콘주게이트
|
|
US5919455A
(en)
*
|
1993-10-27 |
1999-07-06 |
Enzon, Inc. |
Non-antigenic branched polymer conjugates
|
|
USRE38827E1
(en)
|
1994-07-27 |
2005-10-11 |
3M Innovative Properties Company |
Adhesive sealant composition
|
|
US5583114A
(en)
|
1994-07-27 |
1996-12-10 |
Minnesota Mining And Manufacturing Company |
Adhesive sealant composition
|
|
GB9425138D0
(en)
|
1994-12-12 |
1995-02-08 |
Dynal As |
Isolation of nucleic acid
|
|
US5932462A
(en)
|
1995-01-10 |
1999-08-03 |
Shearwater Polymers, Inc. |
Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
|
|
TW517067B
(en)
*
|
1996-05-31 |
2003-01-11 |
Hoffmann La Roche |
Interferon conjugates
|
|
KR19990029749A
(ko)
*
|
1997-09-17 |
1999-04-26 |
미우라 아끼라 |
2가 반응성 수용성 고분자 유도체 및 이들을 함유하는 복합체
|
|
TR200000728T2
(tr)
*
|
1997-09-18 |
2000-09-21 |
F.Hoffmann-La Roche Ag |
Kronik hepatit C' nin tedavisinde IFN-alfa ve amantadin kullanımı.
|
|
US6251382B1
(en)
|
1998-04-17 |
2001-06-26 |
Enzon, Inc. |
Biodegradable high molecular weight polymeric linkers and their conjugates
|
|
CZ298681B6
(cs)
*
|
1998-06-08 |
2007-12-19 |
F. Hoffmann-La Roche Ag |
Lécivo pro lécení infekcí chronické hepatitis C
|
|
JP2002524053A
(ja)
|
1998-08-06 |
2002-08-06 |
デューク・ユニバーシティー |
尿酸オキシダーゼ
|
|
US20060188971A1
(en)
*
|
1998-08-06 |
2006-08-24 |
Duke University |
Urate oxidase
|
|
ES2245114T3
(es)
|
1998-08-06 |
2005-12-16 |
Mountain View Pharmaceuticals, Inc. |
Conjugados de peg-oxidasa de urato y su uso.
|
|
US6783965B1
(en)
|
2000-02-10 |
2004-08-31 |
Mountain View Pharmaceuticals, Inc. |
Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
|
|
US6458953B1
(en)
*
|
1998-12-09 |
2002-10-01 |
La Jolla Pharmaceutical Company |
Valency platform molecules comprising carbamate linkages
|
|
KR20020022691A
(ko)
*
|
1999-06-08 |
2002-03-27 |
와이즈먼 앤드루 |
아미노옥시기를 포함하는 원자가 플랫폼 분자
|
|
US7169889B1
(en)
*
|
1999-06-19 |
2007-01-30 |
Biocon Limited |
Insulin prodrugs hydrolyzable in vivo to yield peglylated insulin
|
|
CZ299516B6
(cs)
*
|
1999-07-02 |
2008-08-20 |
F. Hoffmann-La Roche Ag |
Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem
|
|
JO2291B1
(en)
|
1999-07-02 |
2005-09-12 |
اف . هوفمان لاروش ايه جي |
Erythropoietin derivatives
|
|
WO2001017568A2
(en)
*
|
1999-09-07 |
2001-03-15 |
Conjuchem, Inc. |
Bioconjugation in vivo to pulmonary or blood components
|
|
US6723788B1
(en)
|
1999-09-10 |
2004-04-20 |
The Procter & Gamble Company |
Enzyme inhibitors
|
|
EP1212097B1
(en)
|
1999-09-10 |
2005-11-16 |
The Procter & Gamble Company |
Enzyme inhibitors
|
|
US6713454B1
(en)
|
1999-09-13 |
2004-03-30 |
Nobex Corporation |
Prodrugs of etoposide and etoposide analogs
|
|
AU775373B2
(en)
|
1999-10-01 |
2004-07-29 |
Immunogen, Inc. |
Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
|
|
SK11672002A3
(sk)
|
2000-01-10 |
2002-12-03 |
Maxygen Holdings Ltd. |
Polypeptidový konjugát, spôsob jeho výroby, farmaceutický prostriedok s jeho obsahom a jeho použitie
|
|
DE60138364D1
(de)
|
2000-02-11 |
2009-05-28 |
Bayer Healthcare Llc |
Gerinnungsfaktor vii oder viia konjugate
|
|
US6756037B2
(en)
|
2000-03-31 |
2004-06-29 |
Enzon, Inc. |
Polymer conjugates of biologically active agents and extension moieties for facilitating conjugation of biologically active agents to polymeric terminal groups
|
|
US6777387B2
(en)
|
2000-03-31 |
2004-08-17 |
Enzon Pharmaceuticals, Inc. |
Terminally-branched polymeric linkers containing extension moieties and polymeric conjugates containing the same
|
|
US6586398B1
(en)
*
|
2000-04-07 |
2003-07-01 |
Amgen, Inc. |
Chemically modified novel erythropoietin stimulating protein compositions and methods
|
|
CN1434726A
(zh)
|
2000-06-08 |
2003-08-06 |
拉卓拉药物公司 |
包含高分子量聚环氧乙烷的多价平台分子
|
|
MXPA03000311A
(es)
*
|
2000-07-12 |
2004-12-13 |
Gryphon Therapeutics Inc |
Produccion y uso de moduladores de receptor de quimiocina.
|
|
KR100396983B1
(ko)
*
|
2000-07-29 |
2003-09-02 |
이강춘 |
고반응성의 가지 달린 고분자 유도체 및 고분자와 단백질또는 펩타이드의 접합체
|
|
US7118737B2
(en)
*
|
2000-09-08 |
2006-10-10 |
Amylin Pharmaceuticals, Inc. |
Polymer-modified synthetic proteins
|
|
EE200300089A
(et)
*
|
2000-09-08 |
2005-02-15 |
Gryphon Therapeutics, Inc. |
Sünteetilised erütropoeesi stimuleerivad valgud, nende valmistamismeetodid ning kasutamine
|
|
US7052686B2
(en)
|
2000-09-29 |
2006-05-30 |
Schering Corporation |
Pegylated interleukin-10
|
|
ES2382636T3
(es)
|
2000-10-31 |
2012-06-12 |
Surmodics Pharmaceuticals, Inc. |
Método para producir composiciones para la administración mejorada de moléculas bioactivas
|
|
WO2002039951A2
(en)
*
|
2000-11-15 |
2002-05-23 |
Globe Immune, Inc. |
Yeast-dentritic cell vaccines and uses thereof
|
|
US20030054015A1
(en)
*
|
2000-12-25 |
2003-03-20 |
Shinichiro Haze |
Sympathetic-activating perfume composition
|
|
US6350756B1
(en)
|
2001-01-18 |
2002-02-26 |
California Pacific Medical Center |
Camptothecin derivatives
|
|
WO2002060978A1
(en)
*
|
2001-01-30 |
2002-08-08 |
Kyowa Hakko Kogyo Co., Ltd. |
Branched polyalkylene glycols
|
|
US7060675B2
(en)
|
2001-02-15 |
2006-06-13 |
Nobex Corporation |
Methods of treating diabetes mellitus
|
|
US6867183B2
(en)
|
2001-02-15 |
2005-03-15 |
Nobex Corporation |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
AU2002251988A1
(en)
*
|
2001-02-20 |
2002-09-04 |
Enzon, Inc. |
Terminally-branched polymeric linkers and polymeric conjugates containing the same
|
|
EP2080771A3
(en)
|
2001-02-27 |
2010-01-06 |
Maxygen Aps |
New interferon beta-like molecules
|
|
US6855720B2
(en)
|
2001-03-01 |
2005-02-15 |
California Pacific Medical Center |
Nitrogen-based camptothecin derivatives
|
|
US6403604B1
(en)
|
2001-03-01 |
2002-06-11 |
California Pacific Medical Center |
Nitrogen-based camptothecin derivatives
|
|
ES2331562T3
(es)
*
|
2001-03-23 |
2010-01-08 |
Enzon, Inc. |
Profarmacos de agentes anticancerigenos que emplean acidos aromaticos sustituidos.
|
|
EP1392339A4
(en)
*
|
2001-05-04 |
2009-05-27 |
Univ North Carolina State |
POLYMER CONJUGATES OF INSECTICIDES, PEPTIDES OR NUCLEIC ACIDS AND METHOD OF USE THEREOF
|
|
US20030108585A1
(en)
*
|
2001-05-04 |
2003-06-12 |
Roe R. Michael |
Polymer conjugates of insecticidal peptides or nucleic acids or insecticides and methods of use thereof
|
|
US6713452B2
(en)
|
2001-06-04 |
2004-03-30 |
Nobex Corporation |
Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6828305B2
(en)
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of growth hormone drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US7713932B2
(en)
|
2001-06-04 |
2010-05-11 |
Biocon Limited |
Calcitonin drug-oligomer conjugates, and uses thereof
|
|
US6828297B2
(en)
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6835802B2
(en)
|
2001-06-04 |
2004-12-28 |
Nobex Corporation |
Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
|
|
US6858580B2
(en)
|
2001-06-04 |
2005-02-22 |
Nobex Corporation |
Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US20040077835A1
(en)
*
|
2001-07-12 |
2004-04-22 |
Robin Offord |
Chemokine receptor modulators, production and use
|
|
KR100761652B1
(ko)
*
|
2001-08-25 |
2007-10-04 |
동아제약주식회사 |
단백질 또는 펩타이드에 결합되는 다가지의 고분자유도체와 접합체
|
|
US6913903B2
(en)
*
|
2001-09-07 |
2005-07-05 |
Nobex Corporation |
Methods of synthesizing insulin polypeptide-oligomer conjugates, and proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
|
US7166571B2
(en)
|
2001-09-07 |
2007-01-23 |
Biocon Limited |
Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
|
US7030082B2
(en)
*
|
2001-09-07 |
2006-04-18 |
Nobex Corporation |
Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
|
|
US7196059B2
(en)
|
2001-09-07 |
2007-03-27 |
Biocon Limited |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US6770625B2
(en)
|
2001-09-07 |
2004-08-03 |
Nobex Corporation |
Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
|
|
US7312192B2
(en)
*
|
2001-09-07 |
2007-12-25 |
Biocon Limited |
Insulin polypeptide-oligomer conjugates, proinsulin polypeptide-oligomer conjugates and methods of synthesizing same
|
|
US7157277B2
(en)
|
2001-11-28 |
2007-01-02 |
Neose Technologies, Inc. |
Factor VIII remodeling and glycoconjugation of Factor VIII
|
|
US8008252B2
(en)
|
2001-10-10 |
2011-08-30 |
Novo Nordisk A/S |
Factor VII: remodeling and glycoconjugation of Factor VII
|
|
US7173003B2
(en)
|
2001-10-10 |
2007-02-06 |
Neose Technologies, Inc. |
Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
|
|
US7214660B2
(en)
|
2001-10-10 |
2007-05-08 |
Neose Technologies, Inc. |
Erythropoietin: remodeling and glycoconjugation of erythropoietin
|
|
WO2003037915A1
(en)
*
|
2001-10-31 |
2003-05-08 |
Biopolymed Inc. |
Biocompatible polymers including peptide spacer
|
|
AU2002352524B2
(en)
|
2001-11-07 |
2007-10-04 |
Nektar Therapeutics |
Branched polymers and their conjugates
|
|
DE60234858D1
(de)
*
|
2001-11-09 |
2010-02-04 |
Enzon Inc |
Polyalkylenoxid-Konjugate von thiolhaltigen Arzneistoffen
|
|
US20030171285A1
(en)
*
|
2001-11-20 |
2003-09-11 |
Finn Rory F. |
Chemically-modified human growth hormone conjugates
|
|
AU2002357322A1
(en)
*
|
2001-12-19 |
2003-07-09 |
The University Of Chicago |
Rapidly maturing fluorescent proteins and methods for using the same
|
|
ATE371680T1
(de)
|
2002-01-16 |
2007-09-15 |
Biocompatibles Uk Ltd |
Polymerkonjugate
|
|
JP2005538929A
(ja)
|
2002-01-16 |
2005-12-22 |
ダイナル バイオテック エイエスエイ |
単一サンプルからの核酸及びタンパク質の単離方法
|
|
KR100888371B1
(ko)
|
2002-01-17 |
2009-03-13 |
동아제약주식회사 |
가지 달린 고분자 유도체와 인터페론 결합체를 포함하는 항바이러스제
|
|
ES2291620T3
(es)
*
|
2002-03-13 |
2008-03-01 |
Beijing Jiankai Technology Co., Ltd. |
Derivado de polimeros hidrfilicos con rama tipo y y metodo de preparacion de compuesto metodo que comprende el compuesto anterior.
|
|
WO2003079980A2
(en)
*
|
2002-03-19 |
2003-10-02 |
A & D Bioscience, Inc. |
Caboxylic acid glycuronides, glycosamides and glycosides of quinolones, penicillins, analogs, and uses thereof
|
|
US7557195B2
(en)
*
|
2002-03-20 |
2009-07-07 |
Biopolymed, Inc. |
Stoichiometric conjugates of biocompatible polymers at the unpaired cysteine residue of the wild-type G-CSF
|
|
WO2003082926A2
(en)
*
|
2002-03-26 |
2003-10-09 |
Biosynexus Incorporated |
Antimicrobial polymer conjugates
|
|
US20050233949A1
(en)
*
|
2002-04-12 |
2005-10-20 |
Holick Michael F |
Conjugates comprising cancer cell specific ligands, a sugar and cancer chemotherapeutic agents/boron neutron capture therapy agents, and uses thereof
|
|
US20030215395A1
(en)
*
|
2002-05-14 |
2003-11-20 |
Lei Yu |
Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier
|
|
ATE518885T1
(de)
*
|
2002-05-28 |
2011-08-15 |
Ucb Pharma Sa |
Peg-positionsisomer von einem antikorper gegen tnfalpha (cdp870)
|
|
US6933302B2
(en)
*
|
2002-06-03 |
2005-08-23 |
California Pacific Medical Center |
Nitrogen-based homo-camptothecin derivatives
|
|
AU2003243397A1
(en)
*
|
2002-06-03 |
2003-12-19 |
California Pacific Medical Center |
Homo-camptothecin derivatives
|
|
AU2003236521A1
(en)
|
2002-06-13 |
2003-12-31 |
Nobex Corporation |
Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
|
|
RU2362807C2
(ru)
|
2002-06-21 |
2009-07-27 |
Ново Нордиск Хелт Кэр Аг |
Конъюгат полипептида фактора vii, способ его получения, его применение и содержащая его фармацевтическая композиция
|
|
MXPA04012496A
(es)
|
2002-06-21 |
2005-09-12 |
Novo Nordisk Healthcare Ag |
Glicoformos del factor vii pegilados.
|
|
US7413738B2
(en)
*
|
2002-08-13 |
2008-08-19 |
Enzon Pharmaceuticals, Inc. |
Releasable polymeric conjugates based on biodegradable linkers
|
|
US7122189B2
(en)
*
|
2002-08-13 |
2006-10-17 |
Enzon, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
US7087229B2
(en)
*
|
2003-05-30 |
2006-08-08 |
Enzon Pharmaceuticals, Inc. |
Releasable polymeric conjugates based on aliphatic biodegradable linkers
|
|
US20040247588A1
(en)
*
|
2002-08-28 |
2004-12-09 |
Johnson Robert E. |
Formulations of modified antibodies and methods of making the same
|
|
WO2004019861A2
(en)
*
|
2002-08-28 |
2004-03-11 |
Pharmacia Corporation |
Stable ph optimized formulation of a modified antibody
|
|
EP1591467A1
(en)
*
|
2002-09-09 |
2005-11-02 |
Nektar Therapeutics Al, Corporation |
Conjugate between a polyethylene glycol having a terminal alkanal group and a human growth hormone
|
|
NZ540490A
(en)
|
2002-09-09 |
2007-10-26 |
Nektar Therapeutics Al Corp |
Water-soluble polymer alkanal conjugates with human growth hormone
|
|
US7556813B2
(en)
*
|
2002-09-27 |
2009-07-07 |
Trimeris, Inc. |
Antiviral peptide-polymer conjugate comprising a polymer covalently attached to two or more synthetic HIV gp41 HR1 and/or HR2 peptides
|
|
US8129330B2
(en)
*
|
2002-09-30 |
2012-03-06 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
US20040062748A1
(en)
|
2002-09-30 |
2004-04-01 |
Mountain View Pharmaceuticals, Inc. |
Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof
|
|
TWI281864B
(en)
*
|
2002-11-20 |
2007-06-01 |
Pharmacia Corp |
N-terminally monopegylated human growth hormone conjugates and process for their preparation
|
|
GB0229287D0
(en)
*
|
2002-12-16 |
2003-01-22 |
Dna Res Innovations Ltd |
Polyfunctional reagents
|
|
NZ541122A
(en)
*
|
2002-12-26 |
2008-09-26 |
Mountain View Pharmaceuticals |
Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity
|
|
EA008866B1
(ru)
*
|
2002-12-26 |
2007-08-31 |
Маунтин Вью Фамэсьютикэлс, Инк. |
ПОЛИМЕРНЫЙ КОНЪЮГАТ МОДИФИКАЦИЙ ИНТЕРФЕРОНА-β, ФАРМАЦЕВТИЧЕСКИЕ ПРОДУКТЫ НА ЕГО ОСНОВЕ И СПОСОБ ИХ ПОЛУЧЕНИЯ
|
|
US8034900B2
(en)
*
|
2002-12-30 |
2011-10-11 |
Amylin Pharmaceuticals, Inc. |
Water-soluble thioester and selenoester compounds and methods for making and using the same
|
|
US20060014248A1
(en)
*
|
2003-01-06 |
2006-01-19 |
Xencor, Inc. |
TNF super family members with altered immunogenicity
|
|
US20050130892A1
(en)
*
|
2003-03-07 |
2005-06-16 |
Xencor, Inc. |
BAFF variants and methods thereof
|
|
US20050221443A1
(en)
*
|
2003-01-06 |
2005-10-06 |
Xencor, Inc. |
Tumor necrosis factor super family agonists
|
|
US7553930B2
(en)
*
|
2003-01-06 |
2009-06-30 |
Xencor, Inc. |
BAFF variants and methods thereof
|
|
US20070269891A9
(en)
*
|
2003-01-13 |
2007-11-22 |
Yasunobu Tanaka |
Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells
|
|
US20040138154A1
(en)
*
|
2003-01-13 |
2004-07-15 |
Lei Yu |
Solid surface for biomolecule delivery and high-throughput assay
|
|
GB0301014D0
(en)
*
|
2003-01-16 |
2003-02-19 |
Biocompatibles Ltd |
Conjugation reactions
|
|
ES2532399T3
(es)
*
|
2003-03-05 |
2015-03-26 |
Halozyme, Inc. |
Glicoproteína hialuronidasa soluble (sHASEGP), proceso para prepararla, usos y composiciones farmacéuticas que la comprenden
|
|
US20090123367A1
(en)
*
|
2003-03-05 |
2009-05-14 |
Delfmems |
Soluble Glycosaminoglycanases and Methods of Preparing and Using Soluble Glycosaminoglycanases
|
|
US20060104968A1
(en)
|
2003-03-05 |
2006-05-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases
|
|
US7871607B2
(en)
*
|
2003-03-05 |
2011-01-18 |
Halozyme, Inc. |
Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases
|
|
KR20060003862A
(ko)
|
2003-03-14 |
2006-01-11 |
네오스 테크놀로지스, 인크. |
수용성분기폴리머 및 그 접합체
|
|
US7332164B2
(en)
*
|
2003-03-21 |
2008-02-19 |
Enzon Pharmaceuticals, Inc. |
Heterobifunctional polymeric bioconjugates
|
|
EP1610825A2
(en)
*
|
2003-03-31 |
2006-01-04 |
Xencor, Inc. |
Methods for rational pegylation of proteins
|
|
US7642340B2
(en)
|
2003-03-31 |
2010-01-05 |
Xencor, Inc. |
PEGylated TNF-α variant proteins
|
|
US7610156B2
(en)
|
2003-03-31 |
2009-10-27 |
Xencor, Inc. |
Methods for rational pegylation of proteins
|
|
EP2055189A1
(en)
|
2003-04-09 |
2009-05-06 |
Neose Technologies, Inc. |
Glycopegylation methods and proteins/peptides produced by the methods
|
|
US8791070B2
(en)
|
2003-04-09 |
2014-07-29 |
Novo Nordisk A/S |
Glycopegylated factor IX
|
|
CA2521381C
(en)
|
2003-04-11 |
2020-05-26 |
Rezolute, Inc. |
Method for preparation of site-specific protein conjugates
|
|
ATE459647T1
(de)
|
2003-04-15 |
2010-03-15 |
Glaxosmithkline Llc |
Humane il-18 substitutionsmutanten und deren konjugate
|
|
US7189694B2
(en)
*
|
2003-04-18 |
2007-03-13 |
University Of Florida Research Foundation, Inc. |
Inhibitors of autophosphorylation protein kinases
|
|
AU2004240553A1
(en)
|
2003-05-09 |
2004-12-02 |
Neose Technologies, Inc. |
Compositions and methods for the preparation of human growth hormone glycosylation mutants
|
|
WO2004100997A2
(en)
*
|
2003-05-12 |
2004-11-25 |
Affymax, Inc. |
Spacer moiety for poly(ethylene glycol) -modified peptides
|
|
JP4266028B2
(ja)
|
2003-05-12 |
2009-05-20 |
アフィーマックス・インコーポレイテッド |
エリスロポエチン受容体に結合する新規ペプチド
|
|
JP2007530440A
(ja)
*
|
2003-05-12 |
2007-11-01 |
アフィーマックス・インコーポレイテッド |
新規ポリ(エチレングリコール)修飾化合物およびその用途
|
|
SI1625156T1
(sl)
*
|
2003-05-12 |
2013-02-28 |
Affymax, Inc. |
Peptidi, ki se veĹľejo k eritropoetinskemu receptorju
|
|
TR201907313T4
(tr)
*
|
2003-05-23 |
2019-06-21 |
Nektar Therapeutics |
İki PEG zinciri içeren PEG türevleri.
|
|
US7947261B2
(en)
*
|
2003-05-23 |
2011-05-24 |
Nektar Therapeutics |
Conjugates formed from polymer derivatives having particular atom arrangements
|
|
JP5628467B2
(ja)
|
2003-06-26 |
2014-11-19 |
シヴィダ・ユーエス・インコーポレイテッドPsivida Us, Inc. |
生体分解性徐放性ドラッグデリバリーシステム
|
|
JP5229768B2
(ja)
|
2003-06-26 |
2013-07-03 |
シヴィダ・ユーエス・インコーポレイテッド |
In−Situゲル化薬物輸送システム
|
|
WO2005012484A2
(en)
|
2003-07-25 |
2005-02-10 |
Neose Technologies, Inc. |
Antibody-toxin conjugates
|
|
KR101152470B1
(ko)
|
2003-08-13 |
2012-06-01 |
바이오콘 리미티드 |
치료제용 마이크로-입자 지방산 염 고형 투약 제형
|
|
NZ592039A
(en)
*
|
2003-08-27 |
2013-03-28 |
Ophthotech Corp |
Combination therapy for the treatment of ocular neovascular disorders
|
|
ES2629696T3
(es)
*
|
2003-09-17 |
2017-08-14 |
Nektar Therapeutics |
Profármacos poliméricos multibrazo
|
|
US8394365B2
(en)
|
2003-09-17 |
2013-03-12 |
Nektar Therapeutics |
Multi-arm polymer prodrugs
|
|
DE602004029173D1
(de)
|
2003-10-10 |
2010-10-28 |
Novo Nordisk As |
Il-21-derivate
|
|
EP1675871A2
(en)
|
2003-10-10 |
2006-07-05 |
Xencor Inc. |
Protein based tnf-alpha variants for the treatment of tnf-alpha related disorders
|
|
EP2633866A3
(en)
|
2003-10-17 |
2013-12-18 |
Novo Nordisk A/S |
Combination therapy
|
|
US20050214250A1
(en)
|
2003-11-06 |
2005-09-29 |
Harris J M |
Method of preparing carboxylic acid functionalized polymers
|
|
US8633157B2
(en)
|
2003-11-24 |
2014-01-21 |
Novo Nordisk A/S |
Glycopegylated erythropoietin
|
|
ES2445948T3
(es)
*
|
2003-11-24 |
2014-03-06 |
Ratiopharm Gmbh |
Eritropoyetina glicopegilada
|
|
US20080305992A1
(en)
|
2003-11-24 |
2008-12-11 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin
|
|
US7956032B2
(en)
|
2003-12-03 |
2011-06-07 |
Novo Nordisk A/S |
Glycopegylated granulocyte colony stimulating factor
|
|
US20060040856A1
(en)
|
2003-12-03 |
2006-02-23 |
Neose Technologies, Inc. |
Glycopegylated factor IX
|
|
US20080015142A1
(en)
*
|
2003-12-03 |
2008-01-17 |
Defrees Shawn |
Glycopegylated Follicle Stimulating Hormone
|
|
US20050153371A1
(en)
*
|
2004-01-07 |
2005-07-14 |
Ambit Biosciences Corporation |
Conjugated small molecules
|
|
US7338933B2
(en)
|
2004-01-08 |
2008-03-04 |
Neose Technologies, Inc. |
O-linked glycosylation of peptides
|
|
US20070105770A1
(en)
*
|
2004-01-21 |
2007-05-10 |
Novo Nordisk A/S |
Transglutaminase mediated conjugation of peptides
|
|
AU2005208897B2
(en)
*
|
2004-01-26 |
2011-05-19 |
Ratiopharm Gmbh |
Branched polymeric sugars and nucleotides thereof
|
|
CN1925871A
(zh)
*
|
2004-01-27 |
2007-03-07 |
南加州大学 |
聚合物结合的抗体癌症治疗剂
|
|
EP2327724A3
(en)
|
2004-02-02 |
2011-07-27 |
Ambrx, Inc. |
Modified human growth hormone polypeptides and their uses
|
|
US7803931B2
(en)
|
2004-02-12 |
2010-09-28 |
Archemix Corp. |
Aptamer therapeutics useful in the treatment of complement-related disorders
|
|
WO2005084303A2
(en)
*
|
2004-03-01 |
2005-09-15 |
Enzon Pharmaceuticals, Inc. |
Interferon-beta polymer conjugates
|
|
WO2005107815A2
(en)
*
|
2004-05-03 |
2005-11-17 |
Nektar Therapeutics Al, Corporation |
Polymer derivatives comprising an imide branching point
|
|
KR101699142B1
(ko)
|
2004-06-18 |
2017-01-23 |
암브룩스, 인코포레이티드 |
신규 항원-결합 폴리펩티드 및 이의 용도
|
|
AU2014280936B2
(en)
*
|
2004-06-30 |
2016-12-15 |
Nektar Therapeutics |
Polymer-factor ix moiety conjugates
|
|
KR101146160B1
(ko)
*
|
2004-06-30 |
2012-07-16 |
넥타르 테라퓨틱스 |
중합체인자 ix 부분의 접합체
|
|
WO2006010143A2
(en)
|
2004-07-13 |
2006-01-26 |
Neose Technologies, Inc. |
Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
|
|
BRPI0513508B1
(pt)
|
2004-07-19 |
2021-06-01 |
Biocon Limited |
Conjugados de insulina-oligômero, formulações e usos desses
|
|
JP2008507280A
(ja)
|
2004-07-21 |
2008-03-13 |
アンブレツクス・インコーポレイテツド |
非天然コードアミノ酸を用いた生合成ポリペプチド
|
|
US7618615B2
(en)
|
2004-08-13 |
2009-11-17 |
Healthpartners Research Foundation |
Methods for providing neuroprotection for the animal central nervous system against neurodegeneration caused by ischemia
|
|
US9216161B2
(en)
|
2004-08-13 |
2015-12-22 |
Healthpartners Research Foundation |
Methods of treating Huntington's disease comprising administering metal chelators to the upper one-third of the nasal cavity
|
|
WO2006031811A2
(en)
|
2004-09-10 |
2006-03-23 |
Neose Technologies, Inc. |
Glycopegylated interferon alpha
|
|
US7358223B2
(en)
*
|
2004-10-04 |
2008-04-15 |
Nitto Denko Corporation |
Biodegradable cationic polymers
|
|
US20080176790A1
(en)
|
2004-10-29 |
2008-07-24 |
Defrees Shawn |
Remodeling and Glycopegylation of Fibroblast Growth Factor (Fgf)
|
|
WO2006062685A2
(en)
*
|
2004-11-11 |
2006-06-15 |
Affymax, Inc. |
Novel peptides that bind to the erythropoietin receptor
|
|
EA200700990A1
(ru)
*
|
2004-11-11 |
2008-04-28 |
Афимакс, Инк. |
Новые пептиды, которые связывают рецептор эритропоэтина
|
|
JP2008525473A
(ja)
|
2004-12-22 |
2008-07-17 |
アンブレツクス・インコーポレイテツド |
修飾されたヒト成長ホルモン
|
|
US7816320B2
(en)
|
2004-12-22 |
2010-10-19 |
Ambrx, Inc. |
Formulations of human growth hormone comprising a non-naturally encoded amino acid at position 35
|
|
GB2438760A
(en)
|
2004-12-22 |
2007-12-05 |
Ambrx Inc |
Methods for expression and purification of recombinant human growth hormone
|
|
CN102732588B
(zh)
|
2004-12-22 |
2015-01-07 |
Ambrx公司 |
氨酰基-tRNA合成酶的组合物及其用途
|
|
CA2591852A1
(en)
|
2004-12-27 |
2006-07-06 |
Baxter International Inc. |
Polymer-von willebrand factor-conjugates
|
|
US9029331B2
(en)
|
2005-01-10 |
2015-05-12 |
Novo Nordisk A/S |
Glycopegylated granulocyte colony stimulating factor
|
|
US7365127B2
(en)
*
|
2005-02-04 |
2008-04-29 |
Enzon Pharmaceuticals, Inc. |
Process for the preparation of polymer conjugates
|
|
US20080268013A1
(en)
*
|
2005-02-10 |
2008-10-30 |
Emory University |
Polyethylene Oxide Polymers Including Anti-Inflammatory Glycodendrons
|
|
WO2006102659A2
(en)
*
|
2005-03-23 |
2006-09-28 |
Nektar Therapeutics Al, Corporation |
CONJUGATES OF AN hGH MOIETY AND A POLYMER
|
|
CA2602654A1
(en)
|
2005-04-05 |
2006-10-12 |
Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa |
Method for shielding functional sites or epitopes on proteins
|
|
US20070154992A1
(en)
|
2005-04-08 |
2007-07-05 |
Neose Technologies, Inc. |
Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
|
|
US8148123B2
(en)
*
|
2005-04-11 |
2012-04-03 |
Savient Pharmaceuticals, Inc. |
Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
|
|
WO2006110761A2
(en)
|
2005-04-11 |
2006-10-19 |
Savient Pharmaceuticals, Inc. |
A variant form of urate oxidase and use thereof
|
|
HUE052976T2
(hu)
|
2005-04-11 |
2021-06-28 |
Horizon Pharma Rheumatology Llc |
Urát-oxidáz variáns formái és azok alkalmazása
|
|
US20080159976A1
(en)
*
|
2005-04-11 |
2008-07-03 |
Jacob Hartman |
Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase
|
|
US7833979B2
(en)
*
|
2005-04-22 |
2010-11-16 |
Amgen Inc. |
Toxin peptide therapeutic agents
|
|
WO2006125452A1
(en)
*
|
2005-05-23 |
2006-11-30 |
Universite De Geneve |
Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant
|
|
EP1888098A2
(en)
|
2005-05-25 |
2008-02-20 |
Neose Technologies, Inc. |
Glycopegylated erythropoietin formulations
|
|
US8324159B2
(en)
*
|
2005-06-03 |
2012-12-04 |
Affymax, Inc. |
Erythropoietin receptor peptide formulations and uses
|
|
WO2006133089A2
(en)
|
2005-06-03 |
2006-12-14 |
Ambrx, Inc. |
Improved human interferon molecules and their uses
|
|
US7919461B2
(en)
|
2005-06-03 |
2011-04-05 |
Affymax, Inc. |
Erythropoietin receptor peptide formulations and uses
|
|
US7550433B2
(en)
*
|
2005-06-03 |
2009-06-23 |
Affymax, Inc. |
Erythropoietin receptor peptide formulations and uses
|
|
US20090042790A1
(en)
*
|
2005-06-13 |
2009-02-12 |
Nastech Pharmaceutical Company Inc. |
Transmucosal delivery of peptide derivatives
|
|
EP1893632B1
(en)
|
2005-06-17 |
2015-08-12 |
Novo Nordisk Health Care AG |
Selective reduction and derivatization of engineered factor vii proteins comprising at least one non-native cysteine
|
|
KR20080037656A
(ko)
*
|
2005-06-20 |
2008-04-30 |
펩젠 코포레이션 |
저독성의 장시간 순환하는 사람 인터페론-알파 유사체 및인터페론 타우의 키메라
|
|
US7695710B2
(en)
*
|
2005-06-20 |
2010-04-13 |
Pepgen Corporation |
Antitumor and antiviral combination therapies using low-toxicity, long-circulating human interferon-alpha analogs
|
|
EP2412744B1
(en)
*
|
2005-07-18 |
2014-01-22 |
Nektar Therapeutics |
Method for preparing branched functionalised polymers using branched polyol cores
|
|
KR100735784B1
(ko)
*
|
2005-07-20 |
2007-07-06 |
재단법인 목암생명공학연구소 |
인간 과립구콜로니자극인자 변이체 및 이의 화학적 접합물
|
|
US8008453B2
(en)
|
2005-08-12 |
2011-08-30 |
Amgen Inc. |
Modified Fc molecules
|
|
MX2008002149A
(es)
|
2005-08-18 |
2008-04-22 |
Ambrx Inc |
Composiciones de arnt y sus usos.
|
|
US20070105755A1
(en)
|
2005-10-26 |
2007-05-10 |
Neose Technologies, Inc. |
One pot desialylation and glycopegylation of therapeutic peptides
|
|
JP4808453B2
(ja)
*
|
2005-08-26 |
2011-11-02 |
株式会社荏原製作所 |
研磨方法及び研磨装置
|
|
CN101268098A
(zh)
*
|
2005-08-30 |
2008-09-17 |
诺沃-诺迪斯克保健股份有限公司 |
聚乙二醇化生长激素的液体制剂
|
|
US7875602B2
(en)
*
|
2005-10-21 |
2011-01-25 |
Sutter West Bay Hospitals |
Camptothecin derivatives as chemoradiosensitizing agents
|
|
WO2007056191A2
(en)
|
2005-11-03 |
2007-05-18 |
Neose Technologies, Inc. |
Nucleotide sugar purification using membranes
|
|
EP1951890A4
(en)
|
2005-11-16 |
2009-06-24 |
Ambrx Inc |
PROCESSES AND COMPOSITIONS WITH NON-NATURAL AMINO ACIDS
|
|
US7811555B2
(en)
*
|
2005-12-30 |
2010-10-12 |
Cordis Corporation |
Tri-branched biologically active copolymer
|
|
US8133707B2
(en)
*
|
2006-01-17 |
2012-03-13 |
Enzon Pharmaceuticals, Inc. |
Methods of preparing activated polymers having alpha nitrogen groups
|
|
MX2008009125A
(es)
*
|
2006-01-18 |
2008-10-23 |
Qps Llc |
Composiciones farmaceuticas con estabilidad mejorada.
|
|
US8946155B2
(en)
|
2006-02-03 |
2015-02-03 |
Opko Biologics Ltd. |
Long-acting polypeptides and methods of producing and administering same
|
|
US8048849B2
(en)
|
2006-02-03 |
2011-11-01 |
Modigene, Inc. |
Long-acting polypeptides and methods of producing same
|
|
US9249407B2
(en)
|
2006-02-03 |
2016-02-02 |
Opko Biologics Ltd. |
Long-acting coagulation factors and methods of producing same
|
|
US10351615B2
(en)
|
2006-02-03 |
2019-07-16 |
Opko Biologics Ltd. |
Methods of treatment with long-acting growth hormone
|
|
US10221228B2
(en)
|
2006-02-03 |
2019-03-05 |
Opko Biologics Ltd. |
Long-acting polypeptides and methods of producing and administering same
|
|
US20140113860A1
(en)
|
2006-02-03 |
2014-04-24 |
Prolor Biotech Ltd. |
Long-acting polypeptides and methods of producing and administering same
|
|
US20150038413A1
(en)
|
2006-02-03 |
2015-02-05 |
Opko Biologics Ltd. |
Long-acting polypeptides and methods of producing and administering same
|
|
US9458444B2
(en)
|
2006-02-03 |
2016-10-04 |
Opko Biologics Ltd. |
Long-acting coagulation factors and methods of producing same
|
|
US7671067B2
(en)
|
2006-02-09 |
2010-03-02 |
Enzon Pharmaceuticals, Inc. |
Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
|
|
US7462627B2
(en)
|
2006-02-09 |
2008-12-09 |
Enzon Pharmaceuticals, Inc. |
Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
|
|
EP1996237B1
(en)
*
|
2006-02-28 |
2010-07-28 |
Dr. Reddy's Laboratories (EU) Limited |
Method for making polyethylene glycol carbonates
|
|
KR101584468B1
(ko)
|
2006-03-08 |
2016-01-13 |
아케믹스 엘엘씨 |
안질환의 치료에 유용한 보체 결합 앱타머 및 항-c5 제제
|
|
CA2647314A1
(en)
|
2006-03-31 |
2007-11-08 |
Baxter International Inc. |
Pegylated factor viii
|
|
US7645860B2
(en)
|
2006-03-31 |
2010-01-12 |
Baxter Healthcare S.A. |
Factor VIII polymer conjugates
|
|
US7700541B2
(en)
*
|
2006-04-06 |
2010-04-20 |
Nitto Denko Corporation |
Biodegradable cationic polymers
|
|
CN101622270B
(zh)
*
|
2006-04-12 |
2014-01-01 |
萨文特医药公司 |
用阳离子表面活性剂纯化蛋白质的方法
|
|
EP2444499A3
(en)
|
2006-05-02 |
2012-05-09 |
Allozyne, Inc. |
Amino acid substituted molecules
|
|
US20080096819A1
(en)
*
|
2006-05-02 |
2008-04-24 |
Allozyne, Inc. |
Amino acid substituted molecules
|
|
KR20090013816A
(ko)
|
2006-05-24 |
2009-02-05 |
노보 노르디스크 헬스 케어 악티엔게젤샤프트 |
연장된 생체내 반감기를 갖는 인자 ⅸ 유사체
|
|
US20090156629A1
(en)
*
|
2006-06-09 |
2009-06-18 |
Enzon Pharmaceuticals, Inc. |
Indenoisoquinoline-releasable polymer conjugates
|
|
MX2009000284A
(es)
*
|
2006-06-30 |
2009-01-26 |
Enzon Pharmaceuticals Inc |
Hospedero recombinante para produccion de l-asparaginasa ii.
|
|
BRPI0713963A2
(pt)
*
|
2006-07-07 |
2012-11-27 |
Novo Nordisk Healthcare Ag |
conjugados de proteìna e métodos para sua preparação
|
|
ES2516694T3
(es)
|
2006-07-21 |
2014-10-31 |
Ratiopharm Gmbh |
Glicosilación de péptidos a través de secuencias de glicosilación con unión en O
|
|
CN106008699A
(zh)
|
2006-09-08 |
2016-10-12 |
Ambrx公司 |
经修饰的人类血浆多肽或Fc骨架和其用途
|
|
MX2009002460A
(es)
|
2006-09-08 |
2009-03-20 |
Ambrx Inc |
Arnt supresor hibrido para celulas de vertebrados.
|
|
EP2064333B1
(en)
|
2006-09-08 |
2014-02-26 |
Ambrx, Inc. |
Suppressor trna transcription in vertebrate cells
|
|
US7985783B2
(en)
|
2006-09-21 |
2011-07-26 |
The Regents Of The University Of California |
Aldehyde tags, uses thereof in site-specific protein modification
|
|
CA2664304C
(en)
|
2006-09-28 |
2017-08-22 |
Schering Corporation |
Use of pegylated il-10 to treat cancer
|
|
US8969532B2
(en)
|
2006-10-03 |
2015-03-03 |
Novo Nordisk A/S |
Methods for the purification of polypeptide conjugates comprising polyalkylene oxide using hydrophobic interaction chromatography
|
|
US20100041872A1
(en)
|
2006-10-04 |
2010-02-18 |
Defrees Shawn |
Glycerol linked pegylated sugars and glycopeptides
|
|
WO2008051383A2
(en)
*
|
2006-10-19 |
2008-05-02 |
Amgen Inc. |
Use of alcohol co-solvents to improve pegylation reaction yields
|
|
PE20081140A1
(es)
*
|
2006-10-25 |
2008-09-22 |
Amgen Inc |
Agentes terapeuticos a base de peptidos derivados de toxinas
|
|
JP5541594B2
(ja)
*
|
2006-11-07 |
2014-07-09 |
ディーエスエム アイピー アセッツ ビー.ブイ. |
生体分子部分を含むカルバメート、チオカルバメートまたはカルバミド
|
|
CN101125207B
(zh)
*
|
2006-11-14 |
2012-09-05 |
上海华谊生物技术有限公司 |
带有聚乙二醇基团的艾塞丁或其类似物及其制剂和用途
|
|
CN101583380B
(zh)
|
2006-11-30 |
2013-07-10 |
尼克塔治疗公司 |
用于制备聚合物轭合物的方法
|
|
MX2009007145A
(es)
|
2006-12-27 |
2009-08-27 |
Nektar Therapeutics Al Corp |
Conjugados de polimero con factor viii y factor de von willebrand que tienen una ligadura liberable.
|
|
KR101442867B1
(ko)
*
|
2006-12-27 |
2014-09-25 |
넥타르 테라퓨틱스 |
제거될 수 있는 결합을 지니는 인자 ⅸ 부분중합체 컨주게이트
|
|
CA2671209A1
(en)
*
|
2006-12-29 |
2008-07-10 |
Enzon Pharmaceuticals, Inc. |
Use of adenosine deaminase for treating pulmonary disease
|
|
WO2008089185A2
(en)
*
|
2007-01-16 |
2008-07-24 |
Enzon Pharmaceuticals, Inc. |
Posaconazole polymer conjugates and methods of treatment using posaconazole and polymer conjugates thereof
|
|
US8106154B2
(en)
*
|
2007-01-31 |
2012-01-31 |
Affymax, Inc. |
Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules
|
|
US20080254188A1
(en)
*
|
2007-02-01 |
2008-10-16 |
National Research Council Of Canada |
Formulations of lipophilic bioactive molecules
|
|
WO2008098178A2
(en)
|
2007-02-09 |
2008-08-14 |
Enzon Pharmaceuticals, Inc. |
Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
|
|
CA2682147C
(en)
|
2007-03-30 |
2017-08-08 |
Ambrx, Inc. |
Modified fgf-21 polypeptides and their uses
|
|
KR20100016160A
(ko)
|
2007-04-03 |
2010-02-12 |
바이오제너릭스 에이지 |
글리코페길화 g―csf를 이용하는 치료 방법
|
|
HUE027603T2
(en)
*
|
2007-04-20 |
2016-10-28 |
Sigma-Tau Rare Disease Ltd |
Stable, recombinant adenosine deaminase
|
|
EP2147122B1
(en)
*
|
2007-04-20 |
2014-07-16 |
Sigma-Tau Rare Diseases S.A. |
Enzymatic anticancer therapy
|
|
MX2009011870A
(es)
|
2007-05-02 |
2009-11-12 |
Ambrx Inc |
Polipeptidos de interferon beta modificados y usos de los mismos.
|
|
EP2162540A2
(en)
|
2007-05-22 |
2010-03-17 |
Amgen Inc. |
Compositions and methods for producing bioactive fusion proteins
|
|
US20080312174A1
(en)
*
|
2007-06-05 |
2008-12-18 |
Nitto Denko Corporation |
Water soluble crosslinked polymers
|
|
US9707274B2
(en)
|
2007-06-08 |
2017-07-18 |
Healthpartners Research & Education |
Methods for preventing and treating post-traumatic stress disorder (PTSD)
|
|
WO2008154639A2
(en)
|
2007-06-12 |
2008-12-18 |
Neose Technologies, Inc. |
Improved process for the production of nucleotide sugars
|
|
TW200922624A
(en)
*
|
2007-07-11 |
2009-06-01 |
Enzon Pharmaceuticals Inc |
Polymeric drug delivery system containing a multi-substituted aromatic moiety
|
|
CL2008002399A1
(es)
*
|
2007-08-16 |
2009-01-02 |
Pharmaessentia Corp |
Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c.
|
|
CA2707840A1
(en)
*
|
2007-08-20 |
2009-02-26 |
Allozyne, Inc. |
Amino acid substituted molecules
|
|
US8207112B2
(en)
|
2007-08-29 |
2012-06-26 |
Biogenerix Ag |
Liquid formulation of G-CSF conjugate
|
|
JP5868594B2
(ja)
|
2007-10-16 |
2016-02-24 |
バイオコン・リミテッドBiocon Limited |
経口投与可能な固形医薬組成物及びそのプロセス
|
|
MX2010005317A
(es)
|
2007-11-20 |
2010-06-02 |
Ambrx Inc |
Polipeptidos de insulina modificados y sus usos.
|
|
NZ586947A
(en)
|
2008-02-08 |
2012-11-30 |
Ambrx Inc |
Modified leptin polypeptides and their uses
|
|
TWI395593B
(zh)
|
2008-03-06 |
2013-05-11 |
Halozyme Inc |
可活化的基質降解酵素之活體內暫時性控制
|
|
KR20100135291A
(ko)
|
2008-04-14 |
2010-12-24 |
할로자임, 아이엔씨 |
히알루로난 관련 질환 및 상태 치료용 변형된 히알루로니다제 및 그 용도
|
|
TWI394580B
(zh)
|
2008-04-28 |
2013-05-01 |
Halozyme Inc |
超快起作用胰島素組成物
|
|
US8476404B1
(en)
*
|
2008-07-04 |
2013-07-02 |
Bhalchandra Shripad Lele |
Selectively functionalized polyhydric compounds
|
|
NZ590372A
(en)
|
2008-07-08 |
2012-09-28 |
Univ Texas |
Novel inhibitors of proliferation and activation of signal transducer and activator of transcription (stats)
|
|
PT2318029T
(pt)
|
2008-07-23 |
2018-01-10 |
Ambrx Inc |
Polipéptidos de g-csf bovino modificados e suas utilizações
|
|
MY156568A
(en)
*
|
2008-07-31 |
2016-03-15 |
Pharmaessentia Corp |
Peptide-polymer conjugates
|
|
KR101671537B1
(ko)
|
2008-08-11 |
2016-11-01 |
넥타르 테라퓨틱스 |
다분지형 중합체 알카노에이트 컨쥬게이트
|
|
EP2157432A1
(en)
*
|
2008-08-15 |
2010-02-24 |
Qiagen GmbH |
Method for analysing a complex sample by mass spectrometry
|
|
HUE047352T2
(hu)
|
2008-09-23 |
2020-04-28 |
Nektar Therapeutics |
Eljárás ütemezett beadásra kamptotecin elõgyógyszerekkel (például PEG-ironotekánnal)
|
|
MX2011003272A
(es)
|
2008-09-26 |
2011-04-28 |
Ambrx Inc |
Polipeptidos de eritropoyetina animal modificados y sus usos.
|
|
PE20110480A1
(es)
|
2008-09-26 |
2011-07-01 |
Ambrx Inc |
Microorganismos y vacunas dependientes de replicacion de aminoacidos no naturales
|
|
CN103205407B
(zh)
|
2008-12-09 |
2016-03-16 |
哈洛齐梅公司 |
延长的可溶性ph20多肽及其用途
|
|
EP3348281B1
(en)
|
2008-12-17 |
2023-07-05 |
Merck Sharp & Dohme Corp. |
Mono- and di-peg il-10 production; and uses
|
|
CN101870728A
(zh)
|
2009-04-23 |
2010-10-27 |
派格生物医药(苏州)有限公司 |
新型Exendin变体及其缀合物
|
|
KR102170375B1
(ko)
|
2009-06-09 |
2020-10-27 |
프로롱 파마슈티컬스, 엘엘씨 |
헤모글로빈 조성물
|
|
HUP1200205A3
(en)
|
2009-06-25 |
2012-09-28 |
Savient Pharmaceuticals |
Method and kits for perdicting infusion reaction risk and antibody-mediated low of response by monitoring serum uric acid during pegylated uricare therapy
|
|
WO2011003633A1
(en)
|
2009-07-06 |
2011-01-13 |
Alize Pharma Ii |
Pegylated l-asparaginase
|
|
US9663778B2
(en)
|
2009-07-09 |
2017-05-30 |
OPKO Biologies Ltd. |
Long-acting coagulation factors and methods of producing same
|
|
US12203113B2
(en)
|
2009-07-09 |
2025-01-21 |
Opko Biologics Ltd. |
Long-acting coagulation factors and methods of producing same
|
|
JP2013501033A
(ja)
|
2009-08-05 |
2013-01-10 |
ピエリス アーゲー |
リポカリン突然変異タンパク質の制御放出製剤
|
|
MX2012003282A
(es)
|
2009-09-17 |
2012-04-30 |
Baxter Healthcare Sa |
Co-formulacion estable de hialuronidasa e inmunoglobulina, y metodos de su uso.
|
|
US20110081398A1
(en)
*
|
2009-10-01 |
2011-04-07 |
Tyco Healthcare Group Lp |
Multi-mechanism surgical compositions
|
|
US8968785B2
(en)
*
|
2009-10-02 |
2015-03-03 |
Covidien Lp |
Surgical compositions
|
|
US20110081701A1
(en)
*
|
2009-10-02 |
2011-04-07 |
Timothy Sargeant |
Surgical compositions
|
|
JP2013515081A
(ja)
|
2009-12-21 |
2013-05-02 |
アンブルックス,インコーポレイテッド |
修飾されているブタのソマトトロピンポリペプチドおよびそれらの使用
|
|
NZ600361A
(en)
|
2009-12-21 |
2014-06-27 |
Ambrx Inc |
Modified bovine somatotropin polypeptides and their uses
|
|
CA2791841C
(en)
|
2010-03-05 |
2023-01-03 |
Rigshospitalet |
Chimeric inhibitor molecules of complement activation
|
|
EP2569331A1
(en)
|
2010-05-10 |
2013-03-20 |
Perseid Therapeutics LLC |
Polypeptide inhibitors of vla4
|
|
WO2011162831A2
(en)
*
|
2010-06-24 |
2011-12-29 |
Vasculogics, Inc. |
Compositions and methods for treatment of thrombosis and prolonging survival of stored platelets
|
|
JP5825507B2
(ja)
*
|
2010-06-25 |
2015-12-02 |
日油株式会社 |
分岐型ヘテロポリエチレングリコール
|
|
US10040761B2
(en)
*
|
2010-06-25 |
2018-08-07 |
Nof Corporation |
Branched hetero polyethylene glycol and intermediate
|
|
MX348420B
(es)
|
2010-07-20 |
2017-06-12 |
Halozyme Inc |
Efectos secundarios adversos asociados con la administracion de agentes anti-hialuronano y metodos para mejorar o prevenir los efectos secundarios.
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
MA34521B1
(fr)
|
2010-08-17 |
2013-09-02 |
Ambrx Inc |
Polypeptides de relaxine modifiés et leurs utilisations
|
|
TWI480288B
(zh)
|
2010-09-23 |
2015-04-11 |
Lilly Co Eli |
牛顆粒細胞群落刺激因子及其變體之調配物
|
|
WO2012088422A1
(en)
|
2010-12-22 |
2012-06-28 |
Nektar Therapeutics |
Multi-arm polymeric prodrug conjugates of taxane-based compounds
|
|
US10894087B2
(en)
|
2010-12-22 |
2021-01-19 |
Nektar Therapeutics |
Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
|
|
IT1403458B1
(it)
|
2010-12-28 |
2013-10-17 |
Scarpa Calzaturificio Spa |
Scarpone da sci
|
|
EP2907504B1
(en)
|
2011-02-08 |
2017-06-28 |
Halozyme, Inc. |
Composition and lipid formulation of a hyaluronan-degrading enzyme and the use thereof for treatment of benign prostatic hyperplasia
|
|
CA2830065A1
(en)
|
2011-03-16 |
2012-09-20 |
Amgen Inc. |
Potent and selective inhibitors of nav1.3 and nav1.7
|
|
US10166295B2
(en)
|
2011-06-02 |
2019-01-01 |
Opko Biologics Ltd. |
Pegylated OXM variants
|
|
JP5890516B2
(ja)
|
2011-06-17 |
2016-03-22 |
ハロザイム インコーポレイテッド |
ヒアルロナン分解酵素を用いる連続的皮下インスリン注入方法
|
|
US9993529B2
(en)
|
2011-06-17 |
2018-06-12 |
Halozyme, Inc. |
Stable formulations of a hyaluronan-degrading enzyme
|
|
RU2654231C2
(ru)
|
2011-06-28 |
2018-05-17 |
Алтернатив Инновейтив Текнолоджиз, Ллц |
Способ применения белков теплового шока-70 (бтш70) для повышения выносливости и лечения бтш70-зависимых заболеваний (варианты)
|
|
JP5252036B2
(ja)
*
|
2011-06-28 |
2013-07-31 |
大日本印刷株式会社 |
親水性層を有する基材
|
|
EP2726502A1
(en)
|
2011-07-01 |
2014-05-07 |
Bayer Intellectual Property GmbH |
Relaxin fusion polypeptides and uses thereof
|
|
ES2582869T3
(es)
|
2011-07-05 |
2016-09-15 |
Bioasis Technologies Inc |
Conjugados de P97-anticuerpo
|
|
US9034318B2
(en)
|
2011-08-30 |
2015-05-19 |
The Regents Of The University Of Colorado, A Body Corporate |
Chemically modified cystathionine beta-synthase enzyme for treatment of homocystinuria
|
|
WO2013040501A1
(en)
|
2011-09-16 |
2013-03-21 |
Pharmathene, Inc. |
Compositions and combinations of organophosphorus bioscavengers and hyaluronan-degrading enzymes, and uses thereof
|
|
WO2013056197A1
(en)
|
2011-10-14 |
2013-04-18 |
Alternative Innovative Technologies Llc |
Degradation resistant hsp70 formulations and uses thereof
|
|
AU2012328880B2
(en)
|
2011-10-24 |
2017-02-23 |
Halozyme, Inc. |
Companion diagnostic for anti-hyaluronan agent therapy and methods of use thereof
|
|
WO2013101509A2
(en)
|
2011-12-15 |
2013-07-04 |
Alternative Innovative Technologies Llc |
Hsp70 fusion protein conjugates and uses thereof
|
|
EP3130347B1
(en)
|
2011-12-30 |
2019-09-18 |
Halozyme, Inc. |
Ph20 polypeptide variants, formulations and uses thereof
|
|
HRP20181187T1
(hr)
|
2012-04-04 |
2018-09-21 |
Halozyme, Inc. |
Kombinirana terapija s hijaluronidazom i taksanom koji ciljano djeluje na tumor
|
|
BR112014025951A2
(pt)
|
2012-04-19 |
2017-07-11 |
Opko Biologics Ltd |
variantes de oxintomodulina de longa ação e métodos de produção do mesmo
|
|
MX362432B
(es)
|
2012-06-04 |
2019-01-17 |
Opko Biologics Ltd |
Variantes de oxm pegilada.
|
|
PL2859017T3
(pl)
|
2012-06-08 |
2019-07-31 |
Sutro Biopharma, Inc. |
Przeciwciała zawierające swoiste dla miejsca, niewystępujące naturalnie reszty aminokwasowe, sposoby ich wytwarzania i sposoby ich zastosowania
|
|
WO2014004639A1
(en)
|
2012-06-26 |
2014-01-03 |
Sutro Biopharma, Inc. |
Modified fc proteins comprising site-specific non-natural amino acid residues, conjugates of the same, methods of their preparation and methods of their use
|
|
ES2647082T3
(es)
|
2012-07-31 |
2017-12-19 |
Bioasis Technologies Inc |
Proteínas desfosforiladas de la enfermedad de depósito lisosómico y métodos de uso de las mismas
|
|
HRP20220455T1
(hr)
|
2012-08-31 |
2022-05-27 |
Sutro Biopharma, Inc. |
Modificirane aminokiseline koje sadrže azid grupu
|
|
WO2014062856A1
(en)
|
2012-10-16 |
2014-04-24 |
Halozyme, Inc. |
Hypoxia and hyaluronan and markers thereof for diagnosis and monitoring of diseases and conditions and related methods
|
|
AU2013341711A1
(en)
|
2012-11-12 |
2015-05-21 |
Redwood Bioscience, Inc. |
Compounds and methods for producing a conjugate
|
|
CN104870423A
(zh)
|
2012-11-16 |
2015-08-26 |
加利福尼亚大学董事会 |
用于蛋白质化学修饰的pictet-spengler连接反应
|
|
US9310374B2
(en)
|
2012-11-16 |
2016-04-12 |
Redwood Bioscience, Inc. |
Hydrazinyl-indole compounds and methods for producing a conjugate
|
|
EA033788B1
(ru)
|
2012-11-20 |
2019-11-26 |
Opko Biologics Ltd |
Способ увеличения гидродинамического объема полипептида путем присоединения карбоксиконцевого пептида гонадотропина
|
|
ES2875957T3
(es)
|
2012-12-20 |
2021-11-11 |
Amgen Inc |
Agonistas del receptor APJ y usos de los mismos
|
|
DK2947111T3
(en)
*
|
2013-01-17 |
2018-05-07 |
Xiamen Sinopeg Biotech Co Ltd |
MONOFUNCTIONAL BRANCHED POLYETHYLENE LYCOL AND BIORELATED SUBSTANCE MODIFIED BY SAME
|
|
US9700633B2
(en)
|
2013-01-28 |
2017-07-11 |
Jenkem Technology Co., Ltd., Tianjin Branch |
Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
|
|
WO2014114262A1
(zh)
*
|
2013-01-28 |
2014-07-31 |
天津键凯科技有限公司 |
水溶性聚合物-氨基酸寡肽-药物结合物及其制备方法和用途
|
|
US9675678B2
(en)
|
2013-01-29 |
2017-06-13 |
The Regents Of The University Of Colorado, A Body Corporate |
Compositions and methods for treatment of homocystinuria
|
|
US10279012B2
(en)
|
2013-03-11 |
2019-05-07 |
Healthpartners Research & Education |
Methods of treating and preventing social communication disorder in patients by intranasal administration of insulin
|
|
US10344060B2
(en)
|
2013-03-12 |
2019-07-09 |
Amgen Inc. |
Potent and selective inhibitors of Nav1.7
|
|
JP6586412B2
(ja)
|
2013-03-13 |
2019-10-02 |
バイオアシス テクノロジーズ インコーポレイテッド |
p97のフラグメントおよびその使用
|
|
EP2986306A4
(en)
|
2013-04-18 |
2016-12-07 |
Armo Biosciences Inc |
METHOD FOR USE OF INTERLEUKIN-10 FOR THE TREATMENT OF ILLNESSES AND SUFFERING
|
|
US10392611B2
(en)
|
2013-05-30 |
2019-08-27 |
Duke University |
Polymer conjugates having reduced antigenicity and methods of using the same
|
|
US10364451B2
(en)
|
2013-05-30 |
2019-07-30 |
Duke University |
Polymer conjugates having reduced antigenicity and methods of using the same
|
|
ES2688206T3
(es)
|
2013-06-17 |
2018-10-31 |
Armo Biosciences, Inc. |
Procedimiento de evaluación de la identidad y la estabilidad de proteínas
|
|
TW201534726A
(zh)
|
2013-07-03 |
2015-09-16 |
Halozyme Inc |
熱穩定ph20玻尿酸酶變異體及其用途
|
|
ES2865473T3
(es)
|
2013-07-10 |
2021-10-15 |
Sutro Biopharma Inc |
Anticuerpos que comprenden múltiples residuos de aminoácidos no naturales sitio-específicos, métodos para su preparación y métodos de uso
|
|
AU2014286996A1
(en)
|
2013-07-12 |
2016-01-07 |
Iveric Bio, Inc. |
Methods for treating or preventing ophthalmological conditions
|
|
US20150093399A1
(en)
|
2013-08-28 |
2015-04-02 |
Bioasis Technologies, Inc. |
Cns-targeted conjugates having modified fc regions and methods of use thereof
|
|
CN105658232A
(zh)
|
2013-08-30 |
2016-06-08 |
阿尔莫生物科技股份有限公司 |
使用白细胞介素-10治疗疾病和病症的方法
|
|
EP3055298B1
(en)
|
2013-10-11 |
2020-04-29 |
Sutro Biopharma, Inc. |
Modified amino acids comprising tetrazine functional groups, methods of preparation, and methods of their use
|
|
ES2826398T3
(es)
|
2013-10-15 |
2021-05-18 |
Seagen Inc |
Enlazadores-fármacos pegilados para una mejor farmacocinética de los conjugados ligando-fármaco
|
|
US20150158926A1
(en)
|
2013-10-21 |
2015-06-11 |
Opko Biologics, Ltd. |
Long-acting polypeptides and methods of producing and administering same
|
|
EP3068425B1
(en)
|
2013-11-11 |
2021-01-27 |
Armo Biosciences, Inc. |
Methods of using interleukin-10 for treating diseases and disorders
|
|
WO2015081282A1
(en)
|
2013-11-27 |
2015-06-04 |
Redwood Bioscience, Inc. |
Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
|
|
ITTV20130205A1
(it)
|
2013-12-06 |
2015-06-07 |
Scarpa Calzaturificio Spa |
Scarpone da sci
|
|
ITTV20130204A1
(it)
|
2013-12-06 |
2015-06-07 |
Scarpa Calzaturificio Spa |
Scarpone da sci
|
|
US10314911B2
(en)
|
2014-04-08 |
2019-06-11 |
Healthpartners Research & Education |
Methods for protecting and treating traumatic brain injury, concussion and brain inflammation with intranasal insulin
|
|
WO2015187295A2
(en)
|
2014-06-02 |
2015-12-10 |
Armo Biosciences, Inc. |
Methods of lowering serum cholesterol
|
|
JP6803236B2
(ja)
|
2014-06-10 |
2020-12-23 |
アムジェン インコーポレイテッド |
アペリンポリペプチド
|
|
HRP20190881T1
(hr)
|
2014-08-28 |
2019-07-12 |
Halozyme, Inc. |
Kombinacijska terapija s hijaluronan-razgrađujućim enzimom i inhibitorom imunološke kontrolne točke
|
|
ES2753391T3
(es)
|
2014-10-14 |
2020-04-08 |
Halozyme Inc |
Composiciones de adenosina desaminasa 2 (ADA2), variantes de la misma y métodos de uso de las mismas
|
|
WO2016060996A2
(en)
|
2014-10-14 |
2016-04-21 |
Armo Biosciences, Inc. |
Interleukin-15 compositions and uses thereof
|
|
AU2015336101A1
(en)
|
2014-10-22 |
2017-04-20 |
Armo Biosciences, Inc. |
Methods of using interleukin-10 for treating diseases and disorders
|
|
CN114129709A
(zh)
|
2014-10-23 |
2022-03-04 |
恩格姆生物制药公司 |
包含肽变异体的药物组合物及其使用方法
|
|
SMT202100388T1
(it)
|
2014-10-24 |
2021-09-14 |
Bristol Myers Squibb Co |
Polipeptidi fgf-21 modificati e loro usi
|
|
US11559567B2
(en)
|
2014-11-06 |
2023-01-24 |
Pharmaessentia Corporation |
Dosage regimen for pegylated interferon
|
|
HRP20230405T8
(hr)
|
2014-12-10 |
2023-09-29 |
Opko Biologics Ltd. |
Metode proizvodnje dugo djelujućih ctp-modificiranih polipeptida hormona rasta
|
|
US10618970B2
(en)
|
2015-02-03 |
2020-04-14 |
Armo Biosciences, Inc. |
Method of treating cancer with IL-10 and antibodies that induce ADCC
|
|
US10385115B2
(en)
|
2015-03-26 |
2019-08-20 |
Duke University |
Fibronectin type III domain-based fusion proteins
|
|
CA2986755A1
(en)
|
2015-05-28 |
2016-12-01 |
Armo Biosciences, Inc. |
Pegylated interleukin-10 for use in treating cancer
|
|
CA2986774A1
(en)
|
2015-05-29 |
2016-12-08 |
Armo Biosciences, Inc. |
Methods of using interleukin-10 for treating diseases and disorders
|
|
JP2018517697A
(ja)
|
2015-05-29 |
2018-07-05 |
オプコ バイオロジクス リミテッド |
ペグ化オキシントモジュリン変異体
|
|
KR20240025721A
(ko)
|
2015-06-15 |
2024-02-27 |
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 |
노화와 연관된 질환을 치료하기 위한 방법 및 조성물
|
|
ES2893616T3
(es)
|
2015-06-19 |
2022-02-09 |
Opko Biologics Ltd |
Factores de coagulación de acción prolongada y métodos para la producción de los mismos
|
|
JP6882782B2
(ja)
|
2015-08-04 |
2021-06-02 |
デューク ユニバーシティ |
遺伝子コードされた本質的に無秩序な送達用ステルスポリマーおよびその使用方法
|
|
US10398761B2
(en)
|
2015-08-25 |
2019-09-03 |
Armo Biosciences, Inc. |
Methods of using combinations of PEG-IL-10 and IL-15 for treating cancers
|
|
JP6728352B2
(ja)
|
2015-11-09 |
2020-07-22 |
エヌジーエム バイオファーマシューティカルス,インコーポレーテッド |
胆汁酸に関係した障害の治療方法
|
|
KR102783230B1
(ko)
|
2015-11-09 |
2025-03-19 |
알.피.쉐러 테크놀러지즈 엘엘씨 |
항-cd22 항체-메이탄신 콘쥬게이트 및 그것의 사용 방법
|
|
EP3373922B1
(en)
|
2015-11-09 |
2022-01-05 |
The Regents of The University of Colorado, A Body Corporate |
Compositions and methods for use in the treatment of homocystinuria
|
|
US11793880B2
(en)
|
2015-12-04 |
2023-10-24 |
Seagen Inc. |
Conjugates of quaternized tubulysin compounds
|
|
CN108367043A
(zh)
|
2015-12-04 |
2018-08-03 |
西雅图基因公司 |
季铵化的微管溶素化合物的缀合物
|
|
US11752213B2
(en)
|
2015-12-21 |
2023-09-12 |
Duke University |
Surfaces having reduced non-specific binding and antigenicity
|
|
WO2017112825A2
(en)
*
|
2015-12-21 |
2017-06-29 |
Duke University |
Polymer conjugates having reduced antigenicity and methods of using the same
|
|
ITUB20160158A1
(it)
|
2016-01-15 |
2017-07-15 |
Scarpa Calzaturificio Spa |
Scarpone da sci
|
|
WO2017160599A1
(en)
|
2016-03-14 |
2017-09-21 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Use of cd300b antagonists to treat sepsis and septic shock
|
|
KR20180134351A
(ko)
|
2016-03-25 |
2018-12-18 |
시애틀 지네틱스, 인크. |
페길화된 약물-링커 및 그의 중간체의 제조를 위한 공정
|
|
US10421785B2
(en)
|
2016-04-11 |
2019-09-24 |
Bar-Ilan University |
Delta receptor agonist peptides and use thereof
|
|
EP4610656A3
(en)
|
2016-04-15 |
2025-11-19 |
Beckman Coulter, Inc. |
Photoactive macromolecules and uses thereof
|
|
WO2017210476A1
(en)
|
2016-06-01 |
2017-12-07 |
Duke University |
Nonfouling biosensors
|
|
EP3468610A1
(en)
|
2016-06-09 |
2019-04-17 |
OPKO Biologics Ltd. |
Long-acting oxyntomodulin formulation and methods of producing and administering same
|
|
MY206271A
(en)
|
2016-07-11 |
2024-12-06 |
Opko Biologics Ltd |
Long-acting coagulation factor vii and methods of producing same
|
|
RU2019110848A
(ru)
|
2016-09-14 |
2020-10-15 |
Дьюк Юниверсити |
Наночастицы на основе триблочных полипептидов для доставки гидрофильных лекарственных средств
|
|
EP3515928B1
(en)
|
2016-09-23 |
2026-01-28 |
Duke University |
Unstructured non-repetitive polypeptides having lcst behavior
|
|
WO2018066692A1
(ja)
|
2016-10-07 |
2018-04-12 |
国立大学法人東京工業大学 |
分岐型ヘテロ単分散ポリエチレングリコール、その製造方法、及びその結合体
|
|
EP3535386A4
(en)
|
2016-11-04 |
2020-04-15 |
Georgia State University Research Foundation, Inc. |
ENDOTOXIN-FREE ASPARAGINASE
|
|
CN110234340A
(zh)
|
2016-11-11 |
2019-09-13 |
好利恩风湿病制药有限责任公司 |
泼尼松和尿酸酶分子的组合疗法及其用途
|
|
US20200237881A1
(en)
|
2019-01-30 |
2020-07-30 |
Horizon Pharma Rheumatology Llc |
Reducing immunogenicity to pegloticase
|
|
CA3042442C
(en)
|
2016-11-14 |
2024-01-02 |
Hangzhou Dac Biotech Co., Ltd |
Conjugation linkers, cell binding molecule-drug conjugates containing the linkers, methods of making and uses of such conjugates with the linkers
|
|
US11135307B2
(en)
|
2016-11-23 |
2021-10-05 |
Mersana Therapeutics, Inc. |
Peptide-containing linkers for antibody-drug conjugates
|
|
KR20230159629A
(ko)
|
2016-12-12 |
2023-11-21 |
벡톤 디킨슨 앤드 컴퍼니 |
수용성 중합체 염료
|
|
WO2018132732A1
(en)
|
2017-01-12 |
2018-07-19 |
Duke University |
Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
|
|
CN110637027B
(zh)
|
2017-02-08 |
2024-08-30 |
百时美施贵宝公司 |
包含药代动力学增强子的修饰的松弛素多肽及其用途
|
|
AU2018237683A1
(en)
|
2017-03-24 |
2019-10-31 |
Seagen Inc. |
Process for the preparation of glucuronide drug-linkers and intermediates thereof
|
|
TWI911136B
(zh)
|
2017-03-29 |
2026-01-11 |
開曼群島商北極星藥業集團股份有限公司 |
蛋白質結合物
|
|
JP6935059B2
(ja)
|
2017-03-30 |
2021-09-15 |
日油株式会社 |
カルボキシル基を一つ有するポリエチレングリコールの精製方法
|
|
EP3612214A4
(en)
|
2017-04-17 |
2021-01-20 |
The Regents of the University of Colorado, A Body Corporate |
ENZYME REPLACEMENT THERAPY OPTIMIZATION FOR THE TREATMENT OF HOMOCYSTINURIA
|
|
WO2018213320A1
(en)
|
2017-05-15 |
2018-11-22 |
Duke University |
Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
|
|
SG10202110492YA
(en)
|
2017-06-22 |
2021-11-29 |
Catalyst Biosciences Inc |
Modified membrane type serine protease 1 (mtsp-1) polypeptides and methods of use
|
|
WO2019006374A1
(en)
|
2017-06-30 |
2019-01-03 |
Duke University |
ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
|
|
CA3079844A1
(en)
|
2017-11-10 |
2019-05-16 |
Armo Biosciences, Inc. |
Compositions and methods of use of interleukin-10 in combination with immune checkpoint pathway inhibitors
|
|
CN119286279A
(zh)
|
2017-12-26 |
2025-01-10 |
贝克顿·迪金森公司 |
深紫外线可激发的水溶剂化聚合物染料
|
|
US12296018B2
(en)
|
2018-01-26 |
2025-05-13 |
Duke University |
Albumin binding peptide-drug (AlBiPeD) conjugates and methods of making and using same
|
|
CN119220109A
(zh)
|
2018-03-30 |
2024-12-31 |
贝克顿·迪金森公司 |
含侧基发色团的水溶性聚合染料
|
|
EP3788343B1
(en)
|
2018-04-30 |
2024-03-27 |
Duke University |
Stimuli-responsive peg-like polymer-based drug delivery platform
|
|
WO2019211842A1
(en)
|
2018-04-30 |
2019-11-07 |
Opko Biologics Ltd. |
Long-acting human growth hormone-antagonists and methods of producing the same
|
|
US20190351031A1
(en)
|
2018-05-16 |
2019-11-21 |
Halozyme, Inc. |
Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20
|
|
CN112533629A
(zh)
|
2018-06-19 |
2021-03-19 |
阿尔莫生物科技股份有限公司 |
结合使用il-10药剂与嵌合抗原受体细胞疗法的组合物和方法
|
|
US20220162336A1
(en)
|
2018-07-22 |
2022-05-26 |
Bioasis Technologies, Inc. |
Treatment of lymphatic metastases
|
|
EP3829622A4
(en)
|
2018-08-02 |
2022-05-11 |
Duke University |
DOUBLE AGONIST FUSION PROTEINS
|
|
WO2020051541A1
(en)
|
2018-09-07 |
2020-03-12 |
Duke University |
Nanoparticulate drug delivery systems
|
|
HRP20240016T1
(hr)
|
2018-09-11 |
2024-03-29 |
Ambrx, Inc. |
Konjugati polipeptida interleukina-2 i njihove uporabe
|
|
CN110964116A
(zh)
|
2018-09-26 |
2020-04-07 |
北京辅仁瑞辉生物医药研究院有限公司 |
GLP1-Fc融合蛋白及其缀合物
|
|
WO2020082057A1
(en)
|
2018-10-19 |
2020-04-23 |
Ambrx, Inc. |
Interleukin-10 polypeptide conjugates, dimers thereof, and their uses
|
|
US12441776B2
(en)
|
2018-11-30 |
2025-10-14 |
Eirgen Pharma Ltd. |
Oxyntomodulin peptide analog formulations
|
|
CA3176021A1
(en)
|
2018-12-28 |
2020-07-02 |
Catalyst Biosciences, Inc. |
Modified urokinase-type plasminogen activator polypeptides and methods of use
|
|
US11613744B2
(en)
|
2018-12-28 |
2023-03-28 |
Vertex Pharmaceuticals Incorporated |
Modified urokinase-type plasminogen activator polypeptides and methods of use
|
|
US12121566B2
(en)
|
2019-01-30 |
2024-10-22 |
Horizon Therapeutics Usa, Inc. |
Methods for treating gout
|
|
EP3924369A1
(en)
|
2019-02-11 |
2021-12-22 |
OPKO Biologics Ltd. |
Long-acting glp-2 analogs
|
|
JP7695885B2
(ja)
|
2019-02-12 |
2025-06-19 |
アンブルックス,インコーポレイテッド |
抗体-tlrアゴニストコンジュゲートを含有する組成物、その方法、及び使用
|
|
US10882954B2
(en)
|
2019-04-11 |
2021-01-05 |
Sunbio Inc. |
Tertiary alkoxy polyethylene glycol and derivatives thereof
|
|
CN112175088B
(zh)
|
2019-07-02 |
2023-03-28 |
江苏晟斯生物制药有限公司 |
改进的fix融合蛋白、缀合物及其应用
|
|
US11512314B2
(en)
|
2019-07-12 |
2022-11-29 |
Duke University |
Amphiphilic polynucleotides
|
|
WO2021038296A2
(en)
|
2019-08-27 |
2021-03-04 |
Tonix Pharma Holdings Limited |
Modified tff2 polypeptides
|
|
WO2021183832A1
(en)
|
2020-03-11 |
2021-09-16 |
Ambrx, Inc. |
Interleukin-2 polypeptide conjugates and methods of use thereof
|
|
US20210355468A1
(en)
|
2020-05-18 |
2021-11-18 |
Bioasis Technologies, Inc. |
Compositions and methods for treating lewy body dementia
|
|
US20210393787A1
(en)
|
2020-06-17 |
2021-12-23 |
Bioasis Technologies, Inc. |
Compositions and methods for treating frontotemporal dementia
|
|
EP3954393A1
(en)
|
2020-08-13 |
2022-02-16 |
Bioasis Technologies Inc. |
Combination therapies for delivery across the blood brain barrier
|
|
EP4199968A1
(en)
|
2020-08-20 |
2023-06-28 |
Ambrx, Inc. |
Antibody-tlr agonist conjugates, methods and uses thereof
|
|
US11952461B2
(en)
|
2021-03-22 |
2024-04-09 |
Sunbio, Inc. |
Siloxy polyethylene glycol and derivatives thereof
|
|
WO2022211829A1
(en)
|
2021-03-30 |
2022-10-06 |
Jazz Pharmaceuticals Ireland Ltd. |
Dosing of recombinant l-asparaginase
|
|
US20250161471A1
(en)
|
2021-04-03 |
2025-05-22 |
Feng Tian |
Anti-her2 antibody-drug conjugates and uses thereof
|
|
EP4155349A1
(en)
|
2021-09-24 |
2023-03-29 |
Becton, Dickinson and Company |
Water-soluble yellow green absorbing dyes
|
|
CN117980327A
(zh)
|
2021-11-03 |
2024-05-03 |
杭州多禧生物科技有限公司 |
抗体的特异性偶联
|
|
EP4547759A2
(en)
|
2022-07-01 |
2025-05-07 |
Beckman Coulter, Inc. |
Novel fluorescent dyes and polymers from dihydrophenanthrene derivatives
|
|
WO2024015529A2
(en)
|
2022-07-14 |
2024-01-18 |
Jazz Pharmaceuticals Ireland Ltd. |
Combination therapies involving l-asparaginase
|
|
WO2024044327A1
(en)
|
2022-08-26 |
2024-02-29 |
Beckman Coulter, Inc. |
Dhnt monomers and polymer dyes with modified photophysical properties
|
|
CN120936679A
(zh)
|
2023-03-17 |
2025-11-11 |
贝克曼库尔特有限公司 |
苯并噻吩并吡咯花菁染料
|
|
US12269875B2
(en)
|
2023-08-03 |
2025-04-08 |
Jeff R. Peterson |
Gout flare prevention methods using IL-1BETA blockers
|
|
WO2025064842A1
(en)
|
2023-09-21 |
2025-03-27 |
Beckman Coulter, Inc. |
Dihydrophenanthrene (dhp) bridged dyes for use in flow cytometry
|
|
WO2025227129A2
(en)
|
2024-04-25 |
2025-10-30 |
Starrock Pharma Llc |
Delivery vehicles comprising proglucagon derived polypeptides and anabolic polypeptides and uses thereof
|
|
WO2025230756A1
(en)
|
2024-05-01 |
2025-11-06 |
BioLegend, Inc. |
Compositions for use with multiple fluorophores and methods of using
|
|
WO2026043823A2
(en)
|
2024-08-19 |
2026-02-26 |
Sutro Biopharma, Inc. |
Antibodies comprising site-specific non-natural amino acid residues, methods of preparation and uses thereof
|