IL128681A0 - 6-O substituted ketolides having antibacterial activity - Google Patents

6-O substituted ketolides having antibacterial activity

Info

Publication number
IL128681A0
IL128681A0 IL12868197A IL12868197A IL128681A0 IL 128681 A0 IL128681 A0 IL 128681A0 IL 12868197 A IL12868197 A IL 12868197A IL 12868197 A IL12868197 A IL 12868197A IL 128681 A0 IL128681 A0 IL 128681A0
Authority
IL
Israel
Prior art keywords
alkyl
substituted
heteroaryl
aryl
optionally substituted
Prior art date
Application number
IL12868197A
Other languages
English (en)
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27107953&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL128681(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/888,350 external-priority patent/US5866549A/en
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of IL128681A0 publication Critical patent/IL128681A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
IL12868197A 1996-09-04 1997-09-02 6-O substituted ketolides having antibacterial activity IL128681A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70777696A 1996-09-04 1996-09-04
US08/888,350 US5866549A (en) 1996-09-04 1997-07-03 6-O-substituted ketolides having antibacterial activity
PCT/US1997/015506 WO1998009978A1 (en) 1996-09-04 1997-09-02 6-o-substituted ketolides having antibacterial activity

Publications (1)

Publication Number Publication Date
IL128681A0 true IL128681A0 (en) 2000-01-31

Family

ID=27107953

Family Applications (1)

Application Number Title Priority Date Filing Date
IL12868197A IL128681A0 (en) 1996-09-04 1997-09-02 6-O substituted ketolides having antibacterial activity

Country Status (28)

Country Link
US (4) US6028181A (de)
EP (5) EP1291352B1 (de)
JP (1) JP4597274B2 (de)
KR (5) KR100523679B1 (de)
CN (4) CN1273475C (de)
AT (5) ATE296307T1 (de)
BG (1) BG63547B1 (de)
BR (1) BR9711661A (de)
CA (1) CA2263972C (de)
CZ (1) CZ300106B6 (de)
DE (5) DE69733439T2 (de)
DK (5) DK1291351T3 (de)
ES (5) ES2242983T3 (de)
HK (1) HK1021537A1 (de)
HR (5) HRP970473B1 (de)
HU (1) HU230166B1 (de)
ID (1) ID19406A (de)
IL (1) IL128681A0 (de)
NO (1) NO314230B1 (de)
NZ (1) NZ334274A (de)
PL (1) PL188173B1 (de)
PT (5) PT929563E (de)
RO (1) RO121473B1 (de)
RU (1) RU2192427C2 (de)
SI (1) SI20023B (de)
SK (5) SK285535B6 (de)
TR (1) TR199901127T2 (de)
WO (1) WO1998009978A1 (de)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495348B1 (en) 1993-10-07 2002-12-17 Regents Of The University Of Minnesota Mitomycin biosynthetic gene cluster
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
AP1060A (en) * 1998-01-02 2002-04-23 Pfizer Prod Inc Novel erythromycin derivatives.
DK0952157T3 (da) 1998-04-24 2003-10-13 Pfizer Prod Inc 9a, 11b-dehydroderivater af 9-oxim-3-keto-6-0-methylerythromycin
US6265202B1 (en) 1998-06-26 2001-07-24 Regents Of The University Of Minnesota DNA encoding methymycin and pikromycin
JP4573925B2 (ja) * 1998-07-09 2010-11-04 アベンティス・ファーマ・ソシエテ・アノニム 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用
FR2792637B1 (fr) * 1999-04-26 2001-06-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2780977B1 (fr) * 1998-07-09 2000-09-01 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2785612A1 (fr) * 1998-11-10 2000-05-12 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
AU5995299A (en) * 1998-11-03 2000-05-22 Pfizer Products Inc. Novel macrolide antibiotics
CZ20013223A3 (cs) * 1999-03-15 2002-01-16 Abbott Laboratories 6-0-Substituované makrolidy mající antibakteriální aktivitu
ATE340183T1 (de) 1999-04-16 2006-10-15 Kosan Biosciences Inc Antiinfektiöse makrolidderivate
US6939861B2 (en) 1999-04-16 2005-09-06 Kosan Biosciences, Inc. Amido macrolides
US6451768B1 (en) 1999-04-16 2002-09-17 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6514944B2 (en) 1999-04-16 2003-02-04 Kosan Biosciences, Inc. Macrolide antiinfective agents
US6420535B1 (en) * 1999-06-07 2002-07-16 Abbott Laboratories 6-O-carbamate ketolide derivatives
WO2000075156A1 (en) * 1999-06-07 2000-12-14 Abbott Laboratories 6-o-carbamate ketolide derivatives
US6437106B1 (en) 1999-06-24 2002-08-20 Abbott Laboratories Process for preparing 6-o-substituted erythromycin derivatives
US6417366B2 (en) * 1999-06-24 2002-07-09 Abbott Laboratories Preparation of quinoline-substituted carbonate and carbamate derivatives
EP1101769A3 (de) 1999-11-18 2001-10-24 Pfizer Products Inc. Stickstoff-enthaltend Erythromycin-Derivate
US6472372B1 (en) 2000-12-06 2002-10-29 Ortho-Mcneil Pharmaceuticals, Inc. 6-O-Carbamoyl ketolide antibacterials
US6756359B2 (en) * 2001-07-03 2004-06-29 Chiron Corporation C12 modified erythromycin macrolides and ketolides having antibacterial activity
JP2005503416A (ja) 2001-09-17 2005-02-03 オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド ６−ｏ−カルバメート−１１，１２−ラクト−ケトライド抗菌剤
US6673774B2 (en) * 2001-12-03 2004-01-06 Enanta Pharmaceuticals, Inc. 11-O-substituted macrolides and their descladinose derivatives
BR0214748A (pt) 2001-12-05 2004-11-23 Ortho Mcneil Pharm Inc Derivados 6-oacil-cetolidas de eritromicina, úteis como antibacterianos
US20030162729A1 (en) * 2002-02-13 2003-08-28 Zhenkun Ma Macrolides with activity against methicillin-resistant staphylococcus aureus
MXPA04007883A (es) * 2002-02-13 2004-11-26 Abbott Lab Compuestos antimicrobianos de macrolido.
US6831068B2 (en) * 2002-02-13 2004-12-14 Abbott Laboratories Macrolide antibacterial compounds
EP2266590A3 (de) 2002-02-22 2011-04-20 Shire LLC Wirkstoff-Abgabesystem und Verfahren zum Schutz und zur Verabreichung von Wirkstoffen
US6995143B2 (en) 2002-02-28 2006-02-07 Basilea Pharmaceutica Ag Macrolides with antibacterial activity
US6841664B2 (en) * 2002-07-25 2005-01-11 Enanra Pharmaceuticals, Inc. 6,11-4-carbon bridged ketolides
US7910558B2 (en) * 2002-05-13 2011-03-22 Enanta Pharmaceuticals, Inc. Bridged macrocyclic compounds and processes for the preparation thereof
US7273853B2 (en) * 2002-05-13 2007-09-25 Enanta Pharmaceuticals, Inc. 6-11 bicyclic ketolide derivatives
AU2003234650A1 (en) 2002-05-31 2003-12-19 Janssen Pharmaceutica N.V. 3-descladinosyl-6-o-carbamoyl and 6-o-carbonoyl macrolide antibacterial agents
JPWO2004078771A1 (ja) * 2003-03-07 2006-06-08 大正製薬株式会社 ２−フルオロ−６−ｏ−置換ケトライド誘導体
EP1638549A4 (de) 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc Neue antibakterielle mittel
US7163924B2 (en) * 2003-04-25 2007-01-16 Chiron Corporation Ketolide derivatives
US20040254126A1 (en) * 2003-06-05 2004-12-16 Yao-Ling Qiu 11-12 Bicyclic erythromycin derivatives
US6790835B1 (en) * 2003-06-05 2004-09-14 Enanta Pharmaceuticals, Inc. Bicyclic macrolide derivatives
WO2005028493A1 (en) * 2003-09-12 2005-03-31 Chiron Corporation Antimicrobial derivatives
GB0327720D0 (en) * 2003-11-28 2003-12-31 Biotica Tech Ltd Erythromycins and process for their preparation
US7414030B2 (en) * 2004-01-07 2008-08-19 Enanta Pharmaceuticals, Inc. 6-11 Bicyclic erythromycin derivatives
WO2005070113A2 (en) * 2004-01-09 2005-08-04 Enanta Pharmaceuticals, Inc. 9n-substituted 6-11 bicyclic erythromycin derivatives
US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
CA2572442A1 (fr) * 2004-07-30 2006-03-09 Palumed S.A. Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
FR2874922A1 (fr) * 2004-07-30 2006-03-10 Palumed Sa Molecules hybrides qa ou q est une aminoquinoleine et a est un residu antibiotique, leur synthese et leurs utilisations en tant qu'agent antibacterien
TW200635600A (en) * 2004-12-13 2006-10-16 Enanta Pharm Inc Tetracyclic bicyclolides
AU2005317735B2 (en) 2004-12-21 2009-06-04 Pfizer Products Inc. Macrolides
US20060252710A1 (en) * 2005-05-04 2006-11-09 Guoqiang Wang 6-11 Bridged oxime erythromycin derivatives
US7517859B2 (en) * 2005-05-04 2009-04-14 Enanta Pharmaceuticals, Inc. Spirocyclic bicyclolides
US7384922B2 (en) * 2005-05-04 2008-06-10 Enanta Pharmaceuticals, Inc. 6-11 bridged oxime erythromycin derivatives
JP5015016B2 (ja) 2006-02-07 2012-08-29 大正製薬株式会社 １０ａ−アザライド化合物
CN101541331A (zh) 2006-08-24 2009-09-23 沃克哈特研究中心 具有抗微生物活性的新颖大环内酯和酮内酯
EP2177526A4 (de) 2007-08-06 2012-08-22 Taisho Pharmaceutical Co Ltd An position 10a und position 12 vernetzte 10a-azalidverbindung
CN101855219B (zh) * 2007-09-17 2014-06-25 英安塔制药有限公司 6，11-桥联的联芳大环内酯类
US8354383B2 (en) * 2007-09-17 2013-01-15 Enanta Pharmaceuticals, Inc. 6,11-bridged biaryl macrolides
US8273720B2 (en) * 2007-09-17 2012-09-25 Enanta Pharmaceuticals, Inc. 6,11-bicyclolides: bridged biaryl macrolide derivatives
EP2214484A4 (de) * 2007-10-25 2013-01-02 Cempra Pharmaceuticals Inc Verfahren zur herstellung von antibakteriellen makrolid-wirkstoffen
TW200946109A (en) * 2008-05-09 2009-11-16 Enanta Pharm Inc Anti-bacterial activity of 9-hydroxy derivatives 6, 11-bicyclolides
WO2009139181A1 (ja) 2008-05-15 2009-11-19 大正製薬株式会社 ４員環構造を有する１０ａ－アザライド化合物
US8796232B2 (en) * 2008-10-24 2014-08-05 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
MX2011012614A (es) 2009-05-27 2012-02-22 Wockhardt Ltd Compuestos de quetolida que tienen actividad antimicrobiana.
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
AU2010292010B2 (en) 2009-09-10 2016-01-07 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
CN103080122A (zh) 2010-03-22 2013-05-01 森普拉制药公司 大环内脂的结晶形式及其用途
US9051346B2 (en) 2010-05-20 2015-06-09 Cempra Pharmaceuticals, Inc. Process for preparing triazole-containing ketolide antibiotics
US8796474B1 (en) 2010-08-23 2014-08-05 Rutgers, The State University Of New Jersey Macrolide compounds and methods and intermediates useful for their preparation
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
RU2601550C2 (ru) 2010-12-09 2016-11-10 Вокхардт Лимитед Кетолидные соединения
AR085286A1 (es) * 2011-02-21 2013-09-18 Taisho Pharmaceutical Co Ltd Derivado de macrolido sustituido en la posicion c-4
JP5718488B2 (ja) 2011-03-01 2015-05-13 ウォックハート リミテッド ケトライド中間体の調製方法
ES2603227T3 (es) 2011-03-22 2017-02-24 Wockhardt Limited Proceso para la preparación de compuestos cetólidos
CN102766181A (zh) * 2011-05-06 2012-11-07 上海医药工业研究院 6-o-取代的红霉素衍生物的制备方法
CN102766089A (zh) * 2011-05-06 2012-11-07 上海医药工业研究院 3-(3-喹啉基)-2-丙烯-1-卤代物及其制备方法
CN104470527B (zh) * 2012-03-27 2019-05-28 森普拉制药公司 用于施用大环内酯抗生素的肠胃外制剂
JP5857008B2 (ja) * 2012-08-20 2016-02-10 大正製薬株式会社 Ｃ−４”位置換マクロライド誘導体を含有する医薬
GB201217310D0 (en) 2012-09-27 2012-11-14 C10 Pharma As Compounds
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
AR102810A1 (es) 2014-08-18 2017-03-29 Taisho Pharmaceutical Co Ltd Derivado de macrólido sustituido en la posición c-4
JP2019533669A (ja) * 2016-10-04 2019-11-21 バイオファーマティ ソシエテ アノニム 抗菌活性を有するケトライド
EP3589327A4 (de) * 2017-03-03 2022-04-06 Synovo GmbH Neuartige antiinfektions- und entzündungshemmungsverbindungen
CN109942653B (zh) * 2019-02-27 2021-06-25 北京理工大学 一种红霉素衍生物及其制备方法
IL293115A (en) * 2019-12-02 2022-07-01 Aliquantumrx Inc Salts and polymorphs of cethromycin for the treatment of disease Salts and polymorphs of cethromycin
CN113817008B (zh) * 2021-07-15 2023-05-23 湖州师范学院 新型琥珀酰基十六元大环内酯的制备方法及用途

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR960000434B1 (ko) * 1986-12-17 1996-01-06 다이쇼 세이야꾸 가부시끼가이샤 에리스로마이신 a유도체 및 그의 제조 방법
US5350839A (en) * 1990-10-15 1994-09-27 Taisho Pharmaceutical Co., Ltd. 2'-position modified compound of erythromycin or its derivative
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
KR0166096B1 (ko) * 1990-11-28 1999-01-15 우에하라 아키라 6-0-메틸에리쓰로마이신 a 유도체
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US5523399A (en) * 1991-12-27 1996-06-04 Taisho Pharmaceutical Co., Ltd. 5-O-desosaminylerythronolide derivatives
CA2093303C (en) * 1992-04-09 1998-11-24 Abraham Araya Aluminosilicates
ATE135707T1 (de) * 1992-04-22 1996-04-15 Taisho Pharmaceutical Co Ltd 5-0-desosaminylerythronolid a derivate
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2697524B1 (fr) * 1992-11-05 1994-12-23 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2702480B1 (fr) * 1993-03-09 1995-04-28 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2713226B1 (fr) * 1993-12-03 1996-01-05 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2719587B1 (fr) * 1994-05-03 1996-07-12 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.
FR2732023B1 (fr) * 1995-03-22 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2732684B1 (fr) * 1995-04-06 1997-04-30 Roussel Uclaf Nouveaux derives de l'erythromycine, leur procede de preparation et leur application comme medicaments
FR2738571B1 (fr) * 1995-09-11 1997-10-17 Roussel Uclaf Nouveaux derives de la 5-0-desosaminyl 6-0-methyl- erythronolide a, leur procede de preparation et leur application a la preparation de produits biologiquement actifs
US6274715B1 (en) * 1995-11-08 2001-08-14 Abbott Laboratories Tricyclic erythromycin derivatives
PT876388E (pt) * 1995-11-08 2004-07-30 Abbott Lab Derivados de eritromicina triciclica
UA51730C2 (uk) * 1996-09-04 2002-12-16 Ебботт Лабораторіз 6-o-заміщені кетоліди з антибактеріальною активністю, спосіб їх одержання (варіанти), фармацевтична композиція та спосіб регулювання бактеріальної інфекції у ссавців
AU4472797A (en) * 1996-10-31 1998-05-22 Taisho Pharmaceutical Co., Ltd. Erythromycin a derivatives
US6171807B1 (en) * 1996-11-13 2001-01-09 Associates Of Cape Cod, Inc. Detection and quantitation of endotoxin by fluorescence polarization

Also Published As

Publication number Publication date
PT1291350E (pt) 2005-09-30
DK0929563T3 (da) 2005-10-03
DE69733723T2 (de) 2006-04-20
CN1680420A (zh) 2005-10-12
ES2242811T3 (es) 2005-11-16
CA2263972A1 (en) 1998-03-12
CN1680418A (zh) 2005-10-12
SK285533B6 (sk) 2007-03-01
HRP20060275B1 (hr) 2014-04-11
DK1291353T3 (da) 2005-10-03
SK285535B6 (sk) 2007-03-01
DE69733422T2 (de) 2006-05-04
DE69733370D1 (de) 2005-06-30
USRE39591E1 (en) 2007-04-24
EP1291351B1 (de) 2005-07-13
KR100523679B1 (ko) 2005-10-26
DE69733369T2 (de) 2006-01-26
DE69733422D1 (de) 2005-07-07
KR20050043993A (ko) 2005-05-11
ATE299508T1 (de) 2005-07-15
SK285534B6 (sk) 2007-03-01
SI20023B (en) 2001-02-28
SK285536B6 (sk) 2007-03-01
EP1291350A1 (de) 2003-03-12
DK1291350T3 (da) 2005-09-26
DK1291351T3 (da) 2005-10-24
KR20050044815A (ko) 2005-05-12
CZ300106B6 (cs) 2009-02-11
BR9711661A (pt) 1999-08-24
PL332009A1 (en) 1999-08-16
HRP20060277B1 (hr) 2014-04-11
DK1291352T3 (da) 2005-09-19
DE69733723D1 (de) 2005-08-18
EP1291352B1 (de) 2005-05-25
NO991022L (no) 1999-05-03
SK28699A3 (en) 2000-03-13
CN1680419A (zh) 2005-10-12
CA2263972C (en) 2008-01-29
US6028181A (en) 2000-02-22
NZ334274A (en) 2001-02-23
ES2244716T3 (es) 2005-12-16
DE69733370T2 (de) 2006-02-02
ES2242812T3 (es) 2005-11-16
HRP20060278B1 (hr) 2014-04-11
HRP20060277A2 (en) 2007-10-31
JP2001500855A (ja) 2001-01-23
HK1021537A1 (en) 2000-06-16
KR100576988B1 (ko) 2006-05-10
HUP9902869A2 (hu) 2000-02-28
DE69733439D1 (de) 2005-07-07
BG63547B1 (bg) 2002-04-30
ATE296831T1 (de) 2005-06-15
CN100441591C (zh) 2008-12-10
CZ68599A3 (cs) 1999-08-11
RO121473B1 (ro) 2007-06-29
EP1291351A1 (de) 2003-03-12
ATE296832T1 (de) 2005-06-15
SI20023A (sl) 2000-02-29
HRP20060278A2 (en) 2007-10-31
NO991022D0 (no) 1999-03-02
PL188173B1 (pl) 2004-12-31
WO1998009978A1 (en) 1998-03-12
PT1291352E (pt) 2005-09-30
PT929563E (pt) 2005-10-31
JP4597274B2 (ja) 2010-12-15
PT1291353E (pt) 2005-10-31
US6075133A (en) 2000-06-13
KR20000068435A (ko) 2000-11-25
BG103292A (en) 1999-12-30
EP1291353B1 (de) 2005-06-01
KR100610043B1 (ko) 2006-08-08
EP1291350B1 (de) 2005-05-25
EP1291353A1 (de) 2003-03-12
RU2192427C2 (ru) 2002-11-10
HRP970473B1 (en) 2007-02-28
NO314230B1 (no) 2003-02-17
CN1237183A (zh) 1999-12-01
HUP9902869A3 (en) 2001-04-28
DE69733439T2 (de) 2006-05-04
KR20050044816A (ko) 2005-05-12
EP1291352A1 (de) 2003-03-12
HRP20060276B1 (hr) 2014-04-25
HRP970473A2 (en) 1998-08-31
HU230166B1 (hu) 2015-09-28
KR20050043994A (ko) 2005-05-11
ATE296307T1 (de) 2005-06-15
US6147197A (en) 2000-11-14
EP0929563B1 (de) 2005-06-01
CN1273475C (zh) 2006-09-06
ES2242813T3 (es) 2005-11-16
HRP20060276A2 (en) 2007-10-31
ES2242983T3 (es) 2005-11-16
AU729348B2 (en) 2001-02-01
KR100568455B1 (ko) 2006-04-07
CN100460415C (zh) 2009-02-11
EP0929563A1 (de) 1999-07-21
TR199901127T2 (xx) 1999-07-21
AU4178097A (en) 1998-03-26
DE69733369D1 (de) 2005-06-30
HRP20060275A2 (en) 2007-10-31
PT1291351E (pt) 2005-11-30
ID19406A (id) 1998-07-09
SK286181B6 (sk) 2008-04-07
ATE296308T1 (de) 2005-06-15

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