HU225473B1 - Heterocycle substituted n-acyl benzenesulfonamide derivatives, process for their preparation and their use as prodrug for the preparation of pharmaceutical compositions treating inflammation or inflammation-associated disorders - Google Patents

Heterocycle substituted n-acyl benzenesulfonamide derivatives, process for their preparation and their use as prodrug for the preparation of pharmaceutical compositions treating inflammation or inflammation-associated disorders Download PDF

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Publication number
HU225473B1
HU225473B1 HU9901807A HUP9901807A HU225473B1 HU 225473 B1 HU225473 B1 HU 225473B1 HU 9901807 A HU9901807 A HU 9901807A HU P9901807 A HUP9901807 A HU P9901807A HU 225473 B1 HU225473 B1 HU 225473B1
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Hungary
Prior art keywords
phenyl
sulfonyl
methyl
acetamide
sodium salt
Prior art date
Application number
HU9901807A
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English (en)
Hungarian (hu)
Inventor
Stephen Bertenshaw
David L Brown
Jeffery S Carter
Matthew J Graneto
Ish K Khanna
Jinglin Li
James W Malecha
Srinivasan Nagarajan
Thomas D Penning
Donald Jjr Rogier
John J Talley
Richard M Weier
Xiangdong Xu
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Searle & Co
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Application filed by Searle & Co filed Critical Searle & Co
Publication of HUP9901807A2 publication Critical patent/HUP9901807A2/hu
Publication of HUP9901807A3 publication Critical patent/HUP9901807A3/hu
Publication of HU225473B1 publication Critical patent/HU225473B1/hu

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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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HU9901807A 1996-04-12 1997-04-11 Heterocycle substituted n-acyl benzenesulfonamide derivatives, process for their preparation and their use as prodrug for the preparation of pharmaceutical compositions treating inflammation or inflammation-associated disorders HU225473B1 (en)

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