HRP20090326T1 - Sintetičke domene imunoglobulina sa vezujućim svojstvima izgrađenim u područjima molekule različitim od komplementarno određujućih područja - Google Patents

Sintetičke domene imunoglobulina sa vezujućim svojstvima izgrađenim u područjima molekule različitim od komplementarno određujućih područja

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Publication number
HRP20090326T1
HRP20090326T1 HR20090326T HRP20090326T HRP20090326T1 HR P20090326 T1 HRP20090326 T1 HR P20090326T1 HR 20090326 T HR20090326 T HR 20090326T HR P20090326 T HRP20090326 T HR P20090326T HR P20090326 T1 HRP20090326 T1 HR P20090326T1
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Croatia
Prior art keywords
immunoglobulin
structural loop
regions
modified
epitope
Prior art date
Application number
HR20090326T
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English (en)
Inventor
Wozniak-Knopp Gordana
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F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H.
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Publication date
Application filed by F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H. filed Critical F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H.
Publication of HRP20090326T1 publication Critical patent/HRP20090326T1/hr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/526—CH3 domain
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Abstract

Postupak za inženjering imunoglobulina koji obuhvaća modificirano područje strukturne petlje da bi se osigurala ne-CDR vezujuća strana i da bi se odredilo vezivanje navedenog imunoglobulina na epitopu antigena, pri čemu se nemodificirano područje strukturne petlje značajno ne veže na navedenu epitopu, naznačen time, da obuhvaća korake: - pribavljanja nukleinske kiseline koja dekodira imunoglobulin koji obuhvaća barem jedno područje strukturne petlje, - modificiranja barem jednog nukleotidnog ostatka navedenog područja strukturne petlje postupkom mutageneze, pri čemu navedeno modificiranjea) je postupak mutageneze izabran iz skupine koju čine nasumična, polu-nasumična, na određenu stranu usmjerena nasumična ili ispitivana mutageneze i kombinatorička dostignuća, ilib) je uključeno više od jedne strukturne petlje da bi se osigurala vezujuća strana za navedenu epitopu, ili c) je isključena ugradnja biološki aktivnog pepida od 2 do 40 amino kiselina u Fc domeni, - transferiranja navedene modificirane nukleinske kiseline u ekspresijski sustav, - ekspresije navedenog modificiranog imunoglobulina, - stavljanja u kontakt ekspresioniranog modificiranog imunoglobulina s epitopama, te- određivanja da li se navedeni modificirani imunoglobulin veže na navedenu epitopu. Patent sadrži još 31 patentni zahtjev.
HR20090326T 2005-01-05 2009-06-02 Sintetičke domene imunoglobulina sa vezujućim svojstvima izgrađenim u područjima molekule različitim od komplementarno određujućih područja HRP20090326T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64114405P 2005-01-05 2005-01-05
PCT/EP2006/050059 WO2006072620A1 (en) 2005-01-05 2006-01-05 Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions

Publications (1)

Publication Number Publication Date
HRP20090326T1 true HRP20090326T1 (hr) 2009-07-31

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ID=36445146

Family Applications (3)

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HR20090087T HRP20090087T3 (hr) 2005-01-05 2009-02-12 Sintetičke domene imunoglobulina s modificiranim svojstvima vezanja u područjima molekule različitim od područja koja određuje komplementarnost
HR20090228T HRP20090228T1 (hr) 2005-01-05 2009-04-20 Sintetičke domene imunoglobulina sa vezujućim svojstvima izgrađenim u područjima molekule različitim od komplementarno određujućih područja
HR20090326T HRP20090326T1 (hr) 2005-01-05 2009-06-02 Sintetičke domene imunoglobulina sa vezujućim svojstvima izgrađenim u područjima molekule različitim od komplementarno određujućih područja

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HR20090087T HRP20090087T3 (hr) 2005-01-05 2009-02-12 Sintetičke domene imunoglobulina s modificiranim svojstvima vezanja u područjima molekule različitim od područja koja određuje komplementarnost
HR20090228T HRP20090228T1 (hr) 2005-01-05 2009-04-20 Sintetičke domene imunoglobulina sa vezujućim svojstvima izgrađenim u područjima molekule različitim od komplementarno određujućih područja

Country Status (23)

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US (8) US20090298195A1 (hr)
EP (4) EP1752471B9 (hr)
JP (3) JP4937138B2 (hr)
KR (2) KR101404512B1 (hr)
CN (2) CN101098891B (hr)
AT (4) ATE423140T1 (hr)
AU (1) AU2006204459B2 (hr)
BR (1) BRPI0606399A8 (hr)
CA (1) CA2594356C (hr)
CY (3) CY1108767T1 (hr)
DE (3) DE602006005526D1 (hr)
DK (4) DK2028193T3 (hr)
EA (1) EA018897B1 (hr)
ES (4) ES2320374T3 (hr)
HR (3) HRP20090087T3 (hr)
IL (1) IL184103A (hr)
MX (1) MX2007008118A (hr)
NZ (1) NZ555893A (hr)
PL (3) PL1752471T3 (hr)
PT (4) PT1699826E (hr)
RS (3) RS50785B (hr)
SI (3) SI1752471T1 (hr)
WO (1) WO2006072620A1 (hr)

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