BRPI0606399A2 - domìnios de imunoglobulina sintética com propriedades de ligação construìdos em regiões da molécula diferentes das regiões de determinação de complementariedade - Google Patents

domìnios de imunoglobulina sintética com propriedades de ligação construìdos em regiões da molécula diferentes das regiões de determinação de complementariedade

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Publication number
BRPI0606399A2
BRPI0606399A2 BRPI0606399-3A BRPI0606399A BRPI0606399A2 BR PI0606399 A2 BRPI0606399 A2 BR PI0606399A2 BR PI0606399 A BRPI0606399 A BR PI0606399A BR PI0606399 A2 BRPI0606399 A2 BR PI0606399A2
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BR
Brazil
Prior art keywords
immunoglobulin
regions
epitope
modified
molecule
Prior art date
Application number
BRPI0606399-3A
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English (en)
Inventor
Florian Rueker
Gordana Wozniak-Knopp
Gottfried Himmler
Original Assignee
Star Biotechnologische Forschungs U Entw Gmbh
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Publication date
Application filed by Star Biotechnologische Forschungs U Entw Gmbh filed Critical Star Biotechnologische Forschungs U Entw Gmbh
Publication of BRPI0606399A2 publication Critical patent/BRPI0606399A2/pt
Publication of BRPI0606399A8 publication Critical patent/BRPI0606399A8/pt

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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
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    • C—CHEMISTRY; METALLURGY
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C07K2317/00—Immunoglobulins specific features
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/10—Libraries containing peptides or polypeptides, or derivatives thereof

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Abstract

DOMìNIOS DE IMUNOGLOBULINA SINTéTICA COM PROPRIEDADES DE LIGAçãO CONSTRUìDOS EM REGIõES DA MOLéCULA DIFERENTES DAS REGIõES DE DETERMINAçãO DE COMPLEMENTARIEDADE. A presente invenção refere-se a método para construção de uma imunoglobulina compreendendo pelo menos uma modificação em uma região de alça estrutural da dita imunoglobulina e determinação da ligação da dita imunoglobulina a um epitopo de um antígeno, em que a imunoglobulina não-modificada não se liga especificamente ao dito epitopo, compreendendo as etapas de: provisão de um ácido nucléico codificando uma imunoglobulina compreendendo pelo menos uma região de alça estrutural, modificação de pelo menos um resíduo de nucleotídeo de pelo menos uma das ditas regiões de alça estrutural, transferência do dito ácido nucléico modificado em um sistema de expressão, expressão da dita imunoglobulina modificada, contato da imunoglobulina modificada expressa com um epitopo e determinação de se a dita imunoglobulina modificada se liga ao dito epitopo, bem como imunoglobulinas modificadas.
BRPI0606399A 2005-01-05 2006-01-05 Domínio constante de imunoglobulina e imunoglobulina modificada BRPI0606399A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64114405P 2005-01-05 2005-01-05
PCT/EP2006/050059 WO2006072620A1 (en) 2005-01-05 2006-01-05 Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions

Publications (2)

Publication Number Publication Date
BRPI0606399A2 true BRPI0606399A2 (pt) 2009-06-23
BRPI0606399A8 BRPI0606399A8 (pt) 2022-12-13

Family

ID=36445146

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0606399A BRPI0606399A8 (pt) 2005-01-05 2006-01-05 Domínio constante de imunoglobulina e imunoglobulina modificada

Country Status (23)

Country Link
US (8) US20090298195A1 (pt)
EP (4) EP1699826B1 (pt)
JP (3) JP4937138B2 (pt)
KR (2) KR20130105885A (pt)
CN (2) CN101098891B (pt)
AT (4) ATE548386T1 (pt)
AU (1) AU2006204459B2 (pt)
BR (1) BRPI0606399A8 (pt)
CA (1) CA2594356C (pt)
CY (3) CY1108767T1 (pt)
DE (3) DE602006005200D1 (pt)
DK (4) DK1752471T3 (pt)
EA (1) EA018897B1 (pt)
ES (4) ES2323651T3 (pt)
HR (3) HRP20090087T3 (pt)
IL (1) IL184103A (pt)
MX (1) MX2007008118A (pt)
NZ (1) NZ555893A (pt)
PL (3) PL1752471T3 (pt)
PT (4) PT1772465E (pt)
RS (3) RS50752B (pt)
SI (3) SI1772465T1 (pt)
WO (1) WO2006072620A1 (pt)

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