HRP20031098B1 - Beta-amino tetrahydroimidazo (1,2-a) pyrazines and tetrahydrotrioazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes - Google Patents

Beta-amino tetrahydroimidazo (1,2-a) pyrazines and tetrahydrotrioazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Info

Publication number
HRP20031098B1
HRP20031098B1 HR20031098A HRP20031098A HRP20031098B1 HR P20031098 B1 HRP20031098 B1 HR P20031098B1 HR 20031098 A HR20031098 A HR 20031098A HR P20031098 A HRP20031098 A HR P20031098A HR P20031098 B1 HRP20031098 B1 HR P20031098B1
Authority
HR
Croatia
Prior art keywords
6alkyl
substituted
unsubstituted
branched
linear
Prior art date
Application number
HR20031098A
Other languages
English (en)
Croatian (hr)
Inventor
D. Edmondson Scott
H. Fisher Mihael
Kim Dooseop
Maccoss Malcolm
R. Parmee Emma
E. Weber Ann
Xu Jinyou
Original Assignee
Merck Sharp & Dohme Corp.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23172273&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20031098(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme Corp. filed Critical Merck Sharp & Dohme Corp.
Publication of HRP20031098A2 publication Critical patent/HRP20031098A2/hr
Publication of HRP20031098B1 publication Critical patent/HRP20031098B1/xx

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
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    • A61P9/08—Vasodilators for multiple indications
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Neurosurgery (AREA)
  • Oncology (AREA)
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  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
HR20031098A 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1,2-a) pyrazines and tetrahydrotrioazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes HRP20031098B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30347401P 2001-07-06 2001-07-06
PCT/US2002/021349 WO2003004498A1 (en) 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1, 2-a) pyrazines and tetrahydrotrioazolo (4, 3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Publications (2)

Publication Number Publication Date
HRP20031098A2 HRP20031098A2 (en) 2004-06-30
HRP20031098B1 true HRP20031098B1 (en) 2012-03-31

Family

ID=23172273

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20031098A HRP20031098B1 (en) 2001-07-06 2002-07-05 Beta-amino tetrahydroimidazo (1,2-a) pyrazines and tetrahydrotrioazolo (4,3-a) pyrazines as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

Country Status (45)

Country Link
US (9) US7125873B2 (OSRAM)
EP (4) EP1412357B1 (OSRAM)
JP (1) JP3762407B2 (OSRAM)
KR (1) KR100606871B1 (OSRAM)
CN (2) CN1290848C (OSRAM)
AR (1) AR036114A1 (OSRAM)
AT (2) ATE471148T1 (OSRAM)
AU (1) AU2002320303B2 (OSRAM)
BE (1) BE2007C047I2 (OSRAM)
BG (1) BG108493A (OSRAM)
BR (1) BRPI0210866B8 (OSRAM)
CA (1) CA2450740C (OSRAM)
CR (1) CR7235A (OSRAM)
CY (3) CY2007019I2 (OSRAM)
DE (4) DE60210093T2 (OSRAM)
DK (2) DK1412357T3 (OSRAM)
DO (1) DOP2002000438A (OSRAM)
EA (2) EA012701B1 (OSRAM)
EC (1) ECSP044935A (OSRAM)
ES (2) ES2344846T3 (OSRAM)
FR (2) FR07C0041I2 (OSRAM)
GE (2) GEP20053734B (OSRAM)
HR (1) HRP20031098B1 (OSRAM)
HU (2) HU225695B1 (OSRAM)
IL (3) IL159109A0 (OSRAM)
IS (2) IS2218B (OSRAM)
JO (1) JO2230B1 (OSRAM)
LT (1) LTC1412357I2 (OSRAM)
LU (2) LUC91360I2 (OSRAM)
MA (1) MA27053A1 (OSRAM)
ME (1) ME00439B (OSRAM)
MX (1) MXPA04000018A (OSRAM)
MY (1) MY127961A (OSRAM)
NL (2) NL300287I2 (OSRAM)
NO (4) NO321999B1 (OSRAM)
NZ (1) NZ529833A (OSRAM)
PE (1) PE20030654A1 (OSRAM)
PL (1) PL196278B6 (OSRAM)
PT (2) PT1625847E (OSRAM)
RS (1) RS50737B (OSRAM)
SI (1) SI1412357T1 (OSRAM)
TW (1) TWI226331B (OSRAM)
UA (1) UA74912C2 (OSRAM)
WO (1) WO2003004498A1 (OSRAM)
ZA (1) ZA200309294B (OSRAM)

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US20060270679A1 (en) 2006-11-30
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