US6582959B2
(en)
|
1991-03-29 |
2003-06-24 |
Genentech, Inc. |
Antibodies to vascular endothelial cell growth factor
|
US6713279B1
(en)
|
1995-12-07 |
2004-03-30 |
Diversa Corporation |
Non-stochastic generation of genetic vaccines and enzymes
|
US5830696A
(en)
|
1996-12-05 |
1998-11-03 |
Diversa Corporation |
Directed evolution of thermophilic enzymes
|
US6238884B1
(en)
|
1995-12-07 |
2001-05-29 |
Diversa Corporation |
End selection in directed evolution
|
US6562594B1
(en)
|
1999-09-29 |
2003-05-13 |
Diversa Corporation |
Saturation mutagenesis in directed evolution
|
US6740506B2
(en)
|
1995-12-07 |
2004-05-25 |
Diversa Corporation |
End selection in directed evolution
|
US7018793B1
(en)
|
1995-12-07 |
2006-03-28 |
Diversa Corporation |
Combinatorial screening of mixed populations of organisms
|
US6939689B2
(en)
|
1995-12-07 |
2005-09-06 |
Diversa Corporation |
Exonuclease-mediated nucleic acid reassembly in directed evolution
|
US6171820B1
(en)
|
1995-12-07 |
2001-01-09 |
Diversa Corporation |
Saturation mutagenesis in directed evolution
|
US6537776B1
(en)
|
1999-06-14 |
2003-03-25 |
Diversa Corporation |
Synthetic ligation reassembly in directed evolution
|
US6352842B1
(en)
|
1995-12-07 |
2002-03-05 |
Diversa Corporation |
Exonucease-mediated gene assembly in directed evolution
|
US6358709B1
(en)
|
1995-12-07 |
2002-03-19 |
Diversa Corporation |
End selection in directed evolution
|
US6361974B1
(en)
|
1995-12-07 |
2002-03-26 |
Diversa Corporation |
Exonuclease-mediated nucleic acid reassembly in directed evolution
|
US7122636B1
(en)
|
1997-02-21 |
2006-10-17 |
Genentech, Inc. |
Antibody fragment-polymer conjugates and uses of same
|
US7112655B1
(en)
|
1997-02-27 |
2006-09-26 |
Japan Tobacco, Inc. |
JTT-1 protein and methods of inhibiting lymphocyte activation
|
JP3521382B2
(ja)
|
1997-02-27 |
2004-04-19 |
日本たばこ産業株式会社 |
細胞間接着及びシグナル伝達を媒介する細胞表面分子
|
US6884879B1
(en)
|
1997-04-07 |
2005-04-26 |
Genentech, Inc. |
Anti-VEGF antibodies
|
JP3957765B2
(ja)
|
1997-04-07 |
2007-08-15 |
ジェネンテク・インコーポレイテッド |
抗vegf抗体
|
US7365166B2
(en)
|
1997-04-07 |
2008-04-29 |
Genentech, Inc. |
Anti-VEGF antibodies
|
US20020032315A1
(en)
|
1997-08-06 |
2002-03-14 |
Manuel Baca |
Anti-vegf antibodies
|
US6887674B1
(en)
|
1998-04-13 |
2005-05-03 |
California Institute Of Technology |
Artery- and vein-specific proteins and uses therefor
|
US6864227B1
(en)
|
1998-04-13 |
2005-03-08 |
California Institute Of Technology |
Artery-and vein-specific proteins and uses therefor
|
ES2301254T3
(es)
|
1998-11-18 |
2008-06-16 |
Genentech, Inc. |
Variantes de anticuerpos con una afinidad de union mayor en comparacion con los anticuerpos parentales.
|
EP1950300A3
(en)
|
1998-11-18 |
2011-03-23 |
Genentech, Inc. |
Antibody variants with higher binding affinity compared to parent antibodies
|
WO2000034337A1
(en)
*
|
1998-12-10 |
2000-06-15 |
Tsukuba Research Laboratory, Toagosei Co., Ltd. |
Humanized monoclonal antibodies against vascular endothelial cell growth factor
|
AU775806B2
(en)
*
|
1998-12-22 |
2004-08-19 |
Genentech Inc. |
Vascular endothelial cell growth factor antagonists and uses thereof
|
US7183387B1
(en)
|
1999-01-15 |
2007-02-27 |
Genentech, Inc. |
Polypeptide variants with altered effector function
|
US6703020B1
(en)
|
1999-04-28 |
2004-03-09 |
Board Of Regents, The University Of Texas System |
Antibody conjugate methods for selectively inhibiting VEGF
|
BR0010017A
(pt)
|
1999-04-28 |
2002-06-11 |
Univ Texas |
Composições e processos para o tratamento de câncer por inibição seletiva de vegf
|
CA2376245A1
(en)
*
|
1999-07-29 |
2001-02-08 |
Dyax Corp. |
Binding moieties for fibrin
|
JP4210454B2
(ja)
|
2001-03-27 |
2009-01-21 |
日本たばこ産業株式会社 |
炎症性腸疾患治療剤
|
JP3871503B2
(ja)
|
1999-08-30 |
2007-01-24 |
日本たばこ産業株式会社 |
免疫性疾患治療剤
|
ES2270893T3
(es)
|
1999-12-24 |
2007-04-16 |
Genentech, Inc. |
Procedimiento y composiciones para prolongar la vida media de compuestos bioactivos.
|
EP1757701A1
(en)
|
1999-12-24 |
2007-02-28 |
Genentech, Inc. |
Methods and compositions for prolonging elimination half-times of bioactive compounds
|
US20040002068A1
(en)
|
2000-03-01 |
2004-01-01 |
Corixa Corporation |
Compositions and methods for the detection, diagnosis and therapy of hematological malignancies
|
JP3597140B2
(ja)
|
2000-05-18 |
2004-12-02 |
日本たばこ産業株式会社 |
副刺激伝達分子ailimに対するヒトモノクローナル抗体及びその医薬用途
|
CA2648046A1
(en)
|
2000-06-23 |
2002-01-03 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
|
EP2042597B1
(en)
|
2000-06-23 |
2014-05-07 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
|
US6902718B2
(en)
|
2000-10-24 |
2005-06-07 |
Diatide, Inc. |
Stabilization of radiopharmaceutical compositions using hydrophilic thioethers
|
US6989138B2
(en)
|
2000-10-24 |
2006-01-24 |
Diatide, Inc. |
Stabilization of radiopharmaceutical compositions using hydrophilic thioethers and hydrophilic 6-hydroxy chromans
|
JP4212278B2
(ja)
|
2001-03-01 |
2009-01-21 |
日本たばこ産業株式会社 |
移植片拒絶反応抑制剤
|
US7117096B2
(en)
|
2001-04-17 |
2006-10-03 |
Abmaxis, Inc. |
Structure-based selection and affinity maturation of antibody library
|
US7667004B2
(en)
|
2001-04-17 |
2010-02-23 |
Abmaxis, Inc. |
Humanized antibodies against vascular endothelial growth factor
|
TWI284539B
(en)
|
2001-07-30 |
2007-08-01 |
Epix Pharm Inc |
A method for making a magnetic resonance (MR) imaging agent, a MR imaging contrast agent, a method for altering stability of a peptide and a modified peptide
|
US20050123925A1
(en)
|
2002-11-15 |
2005-06-09 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
EP1443961B1
(en)
*
|
2001-10-25 |
2009-05-06 |
Genentech, Inc. |
Glycoprotein compositions
|
US20030190705A1
(en)
*
|
2001-10-29 |
2003-10-09 |
Sunol Molecular Corporation |
Method of humanizing immune system molecules
|
DK1472275T3
(da)
|
2002-02-05 |
2009-04-14 |
Genentech Inc |
Proteinoprensning
|
US20060234226A1
(en)
|
2002-04-26 |
2006-10-19 |
Fahner Robert L |
Non-affinity purification of proteins
|
NZ571508A
(en)
*
|
2002-05-24 |
2010-05-28 |
Schering Corp |
Neutralizing human anti-IGFR antibody
|
US7696320B2
(en)
|
2004-08-24 |
2010-04-13 |
Domantis Limited |
Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor
|
US9028822B2
(en)
|
2002-06-28 |
2015-05-12 |
Domantis Limited |
Antagonists against TNFR1 and methods of use therefor
|
KR101257584B1
(ko)
|
2002-07-15 |
2013-04-23 |
더 보드 오브 리전츠 오브 더 유니버시티 오브 텍사스 시스템 |
음이온성 인지질 및 아미노인지질에 결합하는 선택된 항체 및 치료하는데 있어서 이의 용도
|
USRE47770E1
(en)
|
2002-07-18 |
2019-12-17 |
Merus N.V. |
Recombinant production of mixtures of antibodies
|
JP4836451B2
(ja)
|
2002-07-18 |
2011-12-14 |
メルス ベー ヴェー |
抗体混合物の組換え生産
|
US7491509B2
(en)
|
2003-02-03 |
2009-02-17 |
Fraunhofer Usa, Inc. |
System for expression of genes in plants
|
EP1585768A2
(en)
*
|
2003-01-23 |
2005-10-19 |
Genentech, Inc. |
Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture
|
US7381410B2
(en)
|
2003-03-12 |
2008-06-03 |
Vasgene Therapeutics, Inc. |
Polypeptide compounds for inhibiting angiogenesis and tumor growth
|
US7862816B2
(en)
|
2003-03-12 |
2011-01-04 |
Vasgene Therapeutics, Inc. |
Polypeptide compounds for inhibiting angiogenesis and tumor growth
|
ES2427641T3
(es)
|
2003-05-22 |
2013-10-31 |
Ibio, Inc. |
Molécula vehículo recombinante para la expresión, el suministro y la purificación de polipéptidos diana
|
RS20050885A
(sr)
|
2003-05-30 |
2008-04-04 |
Genentech |
Lečenje sa anti-vegf antitelima
|
CA2527694C
(en)
*
|
2003-05-30 |
2015-07-14 |
Hendricus Renerus Jacobus Mattheus Hoogenboom |
Fab library for the preparation of anti vegf and anti rabies virus fabs
|
US20100069614A1
(en)
|
2008-06-27 |
2010-03-18 |
Merus B.V. |
Antibody producing non-human mammals
|
EP3095793B1
(en)
|
2003-07-28 |
2020-03-25 |
Genentech, Inc. |
Reducing protein a leaching during protein a affinity chromatography
|
EP1664115A2
(en)
*
|
2003-08-01 |
2006-06-07 |
Genentech, Inc. |
Antibody cdr polypeptide sequences with restricted diversity
|
US7758859B2
(en)
|
2003-08-01 |
2010-07-20 |
Genentech, Inc. |
Anti-VEGF antibodies
|
US20050106667A1
(en)
|
2003-08-01 |
2005-05-19 |
Genentech, Inc |
Binding polypeptides with restricted diversity sequences
|
US7920906B2
(en)
|
2005-03-10 |
2011-04-05 |
Dexcom, Inc. |
System and methods for processing analyte sensor data for sensor calibration
|
WO2005020972A2
(en)
|
2003-08-27 |
2005-03-10 |
(Osi) Eyetech, Inc. |
Combination therapy for the treatment of ocular neovascular disorders
|
FR2859725B1
(fr)
*
|
2003-09-16 |
2006-03-10 |
Neovacs |
Procede a haut rendement pour l'obtention d'anticorps humains neutralisant l'activite biologique d'une cytokine humaine
|
US9247900B2
(en)
|
2004-07-13 |
2016-02-02 |
Dexcom, Inc. |
Analyte sensor
|
ES2646560T3
(es)
|
2004-01-20 |
2017-12-14 |
Merus N.V. |
Mezclas de proteínas de unión
|
CA2555820C
(en)
|
2004-02-19 |
2016-01-19 |
Genentech, Inc. |
Cdr-repaired antibodies
|
DK1730196T3
(da)
|
2004-03-12 |
2011-03-28 |
Vasgene Therapeutics Inc |
EphB4-bindende antistoffer til inhibering af antiogenese og tumorvækst
|
WO2005090406A2
(en)
|
2004-03-12 |
2005-09-29 |
Vasgene Therapeutics, Inc. |
Antibodies binding to ephb4 for inhibiting angiogenesis and tumor growth
|
EP1784427A2
(en)
|
2004-06-01 |
2007-05-16 |
Domantis Limited |
Bispecific fusion antibodies with enhanced serum half-life
|
US20060270922A1
(en)
|
2004-07-13 |
2006-11-30 |
Brauker James H |
Analyte sensor
|
US20060020192A1
(en)
|
2004-07-13 |
2006-01-26 |
Dexcom, Inc. |
Transcutaneous analyte sensor
|
AU2005269716B2
(en)
*
|
2004-07-20 |
2011-01-27 |
Genentech, Inc. |
Inhibitors of angiopoietin-like 4 protein, combinations, and their use
|
US8604185B2
(en)
|
2004-07-20 |
2013-12-10 |
Genentech, Inc. |
Inhibitors of angiopoietin-like 4 protein, combinations, and their use
|
ZA200700947B
(en)
|
2004-07-23 |
2008-06-25 |
Genentech Inc |
Crystallization of antibodies or fragments thereof
|
US7655229B2
(en)
|
2004-09-02 |
2010-02-02 |
Chan Andrew C |
Anti-FC-gamma RIIB receptor antibody and uses therefor
|
US7662926B2
(en)
|
2004-09-02 |
2010-02-16 |
Genentech, Inc. |
Anti-Fc-gamma receptor antibodies, bispecific variants and uses therefor
|
WO2006034455A2
(en)
|
2004-09-23 |
2006-03-30 |
Vasgene Therapeutics, Inc. |
Polipeptide compounds for inhibiting angiogenesis and tumor growth
|
RS52539B
(en)
|
2004-10-21 |
2013-04-30 |
Genentech Inc. |
METHOD FOR TREATMENT OF INTRAOCULAR NEOVASCULAR DISEASES
|
EP2290087A3
(en)
|
2004-12-22 |
2011-06-15 |
Genentech, Inc. |
Methods for producing soluble multi-membrane-spanning proteins
|
WO2006073314A1
(en)
*
|
2005-01-06 |
2006-07-13 |
Ge Healthcare As |
Optical imaging
|
US8735394B2
(en)
|
2005-02-18 |
2014-05-27 |
Abraxis Bioscience, Llc |
Combinations and modes of administration of therapeutic agents and combination therapy
|
KR101914254B1
(ko)
|
2005-02-18 |
2018-11-02 |
아브락시스 바이오사이언스, 엘엘씨 |
치료제의 조합 및 투여 방식, 및 조합 요법
|
US20070166388A1
(en)
|
2005-02-18 |
2007-07-19 |
Desai Neil P |
Combinations and modes of administration of therapeutic agents and combination therapy
|
US20160355591A1
(en)
|
2011-05-02 |
2016-12-08 |
Immunomedics, Inc. |
Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
|
KR101327270B1
(ko)
|
2005-03-25 |
2013-11-08 |
리제네론 파라마큐티칼스 인코포레이티드 |
혈관내피성장인자 길항제 조제물
|
AU2006236637B2
(en)
*
|
2005-04-15 |
2012-09-06 |
Merck Sharp & Dohme Corp. |
Methods and compositions for treating or preventing cancer
|
CA2606084A1
(en)
*
|
2005-06-17 |
2006-12-28 |
Abbott Laboratories |
Improved method of treating degenerative spinal disorders
|
EP1910419A2
(en)
*
|
2005-06-20 |
2008-04-16 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
USRE47223E1
(en)
|
2005-06-20 |
2019-02-05 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
WO2007117264A2
(en)
|
2005-08-03 |
2007-10-18 |
Fraunhofer Usa, Inc. |
Compositions and methods for production of immunoglobulins
|
PT3311805T
(pt)
|
2005-08-31 |
2020-04-21 |
Abraxis Bioscience Llc |
Composições compreendendo agentes farmacêuticos pouco hidrossolúveis e agentes antimicrobianos
|
UA96139C2
(uk)
|
2005-11-08 |
2011-10-10 |
Дженентек, Інк. |
Антитіло до нейропіліну-1 (nrp1)
|
KR100877824B1
(ko)
|
2005-11-11 |
2009-01-12 |
한국생명공학연구원 |
E2epf ucp-vhl 상호작용 및 그 용도
|
WO2007059195A1
(en)
*
|
2005-11-14 |
2007-05-24 |
University Of Southern California |
Integrin-binding small molecules
|
CA2632417A1
(en)
*
|
2005-12-06 |
2007-06-14 |
Domantis Limited |
Ligands that have binding specificity for egfr and/or vegf and methods of use therefor
|
EP1962895B2
(en)
†
|
2005-12-16 |
2016-01-20 |
Regeneron Pharmaceuticals, Inc. |
THERAPEUTIC USE OF A Dll4 ANTAGONIST AND A VEGF INHIBITOR FOR INHIBITING TUMOR GROWTH
|
RU2450020C2
(ru)
|
2006-01-05 |
2012-05-10 |
Дженентек, Инк. |
АНТИТЕЛА ПРОТИВ EphB4 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
EP1976884B1
(en)
|
2006-01-20 |
2012-12-19 |
Genentech, Inc. |
Anti-ephrinb2 antibodies and methods using same
|
JP2009526526A
(ja)
|
2006-02-13 |
2009-07-23 |
フラウンホーファー ユーエスエー, インコーポレイテッド |
インフルエンザ抗原、ワクチン組成物、および関連する方法
|
AR059851A1
(es)
|
2006-03-16 |
2008-04-30 |
Genentech Inc |
Anticuerpos de la egfl7 y metodos de uso
|
WO2008060645A2
(en)
|
2006-03-21 |
2008-05-22 |
Genentech, Inc. |
Combinatorial therapy involving alpha5beta1 antagonists
|
TW200812615A
(en)
*
|
2006-03-22 |
2008-03-16 |
Hoffmann La Roche |
Tumor therapy with an antibody for vascular endothelial growth factor and an antibody for human epithelial growth factor receptor type 2
|
CN101405030B
(zh)
*
|
2006-03-22 |
2013-03-13 |
霍夫曼-拉罗奇有限公司 |
针对血管内皮生长因子的抗体和针对人表皮生长因子2型受体的抗体在制备治疗肿瘤的试剂盒中的应用
|
KR20080106946A
(ko)
*
|
2006-03-29 |
2008-12-09 |
제넨테크, 인크. |
종양의 진단 및 치료
|
MX2008012991A
(es)
|
2006-04-07 |
2008-10-17 |
Procter & Gamble |
Anticuerpos que ligan proteina tirosina fosfatasa humana beta (hptpbeta) y los usos de estos.
|
JP2009539384A
(ja)
|
2006-06-06 |
2009-11-19 |
ジェネンテック・インコーポレーテッド |
抗dll4抗体および抗dll4抗体使用の方法
|
AR061245A1
(es)
*
|
2006-06-06 |
2008-08-13 |
Genentech Inc |
Composiciones y metodos para la modulacion del desarrollo vascular
|
US7608261B2
(en)
|
2006-06-16 |
2009-10-27 |
Regeneron Pharmacuticals, Inc. |
VEGF antagonist formulations suitable for intravitreal administration
|
FR2902799B1
(fr)
|
2006-06-27 |
2012-10-26 |
Millipore Corp |
Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide
|
EP2068877A4
(en)
|
2006-07-19 |
2011-09-21 |
Cleveland Clinic Foundation |
COMPOUNDS AND METHODS FOR MODULATING ANGIOGENESIS
|
CN100448892C
(zh)
*
|
2006-08-02 |
2009-01-07 |
中国人民解放军军事医学科学院基础医学研究所 |
抗肿瘤血管内皮生长因子受体vegf-r2抗原及其编码基因与应用
|
ES2392630T3
(es)
|
2006-08-21 |
2012-12-12 |
F. Hoffmann-La Roche Ag |
Terapia antitumoral con anticuerpos anti-VEGF
|
EP2562188A3
(en)
|
2006-09-29 |
2013-03-06 |
OncoMed Pharmaceuticals, Inc. |
Compositions and methods for diagnosing and treating cancer
|
PT2069798E
(pt)
|
2006-10-04 |
2014-06-24 |
Genentech Inc |
Elisa para vegf
|
CN102006885A
(zh)
*
|
2006-10-20 |
2011-04-06 |
先灵公司 |
完全人源抗vegf抗体及其使用方法
|
PL2101807T3
(pl)
*
|
2006-12-19 |
2016-11-30 |
|
Antagoniści specyficzni względem VEGF dla terapii adiuwantem i neoadiuwantem i leczenie wczesnych stadiów guzów
|
US8569464B2
(en)
|
2006-12-21 |
2013-10-29 |
Emd Millipore Corporation |
Purification of proteins
|
US8163886B2
(en)
|
2006-12-21 |
2012-04-24 |
Emd Millipore Corporation |
Purification of proteins
|
US8362217B2
(en)
|
2006-12-21 |
2013-01-29 |
Emd Millipore Corporation |
Purification of proteins
|
WO2008091740A2
(en)
|
2007-01-22 |
2008-07-31 |
Genentech, Inc. |
Polyelectrolyte precipitation and purification of antibodies
|
US20100119526A1
(en)
*
|
2007-01-26 |
2010-05-13 |
Bioinvent International Ab |
DLL4 Signaling Inhibitors and Uses Thereof
|
EP2125896A2
(en)
|
2007-02-09 |
2009-12-02 |
Genetech, Inc. |
Anti-robo4 antibodies and uses therefor
|
EP2136831B1
(en)
|
2007-03-02 |
2012-09-12 |
The Cleveland Clinic Foundation |
Anti-angiogenic peptides
|
US7723485B2
(en)
|
2007-05-08 |
2010-05-25 |
Genentech, Inc. |
Cysteine engineered anti-MUC16 antibodies and antibody drug conjugates
|
UA99292C2
(uk)
|
2007-05-17 |
2012-08-10 |
Дженентек, Інк. |
Антитіло, яке специфічно зв'язується з нейропіліном-2в (nrp2b)
|
PE20090321A1
(es)
|
2007-06-04 |
2009-04-20 |
Genentech Inc |
Anticuerpos anti-notch1 nrr, metodo de preparacion y composicion farmaceutica
|
SG10201913363VA
(en)
|
2007-07-09 |
2020-03-30 |
Genentech Inc |
Prevention of disulfide bond reduction during recombinant production of polypeptides
|
EP2178558B1
(en)
|
2007-07-11 |
2014-04-30 |
iBio, Inc. |
Yersinia pestis antigens, vaccine compositions, and related methods
|
BRPI0815399A2
(pt)
|
2007-08-13 |
2019-09-24 |
Vasgene Therapeutics Inc |
tratamento de câncer usando anticorpos humanizados que se ligam ephb4
|
JP6035009B2
(ja)
|
2007-08-22 |
2016-11-30 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
活性化可能な結合ポリペプチドおよびその同定方法ならびに使用
|
PE20091434A1
(es)
|
2007-10-30 |
2009-10-17 |
Genentech Inc |
Purificacion de anticuerpos por cromatografia de intercambio cationico
|
EP2217261B1
(en)
*
|
2007-11-09 |
2015-10-07 |
Genentech, Inc. |
Activin receptor-like kinase-1 antagonist compositions and methods of use
|
US8034905B2
(en)
|
2007-11-09 |
2011-10-11 |
Affitech Research, AS |
Anti-VEGF antibody compositions and methods
|
TWI580694B
(zh)
|
2007-11-30 |
2017-05-01 |
建南德克公司 |
抗-vegf抗體
|
US20090162359A1
(en)
|
2007-12-21 |
2009-06-25 |
Christian Klein |
Bivalent, bispecific antibodies
|
US9266967B2
(en)
|
2007-12-21 |
2016-02-23 |
Hoffmann-La Roche, Inc. |
Bivalent, bispecific antibodies
|
EP3692988A3
(en)
|
2008-03-18 |
2020-10-14 |
Genentech, Inc. |
Combinations of an anti-her2 antibody-drug conjugate and 5-fu, anti-vegf antibody, carboplatin or abt-869 and methods of use
|
AU2009228158B2
(en)
*
|
2008-03-27 |
2014-02-27 |
Zymogenetics, Inc. |
Compositions and methods for inhibiting PDGFRbeta and VEGF-A
|
US8314213B2
(en)
*
|
2008-04-18 |
2012-11-20 |
Xencor, Inc. |
Human equivalent monoclonal antibodies engineered from nonhuman variable regions
|
SG190572A1
(en)
|
2008-04-29 |
2013-06-28 |
Abbott Lab |
Dual variable domain immunoglobulins and uses thereof
|
CA2726087A1
(en)
|
2008-06-03 |
2009-12-10 |
Tariq Ghayur |
Dual variable domain immunoglobulins and uses thereof
|
WO2009149185A2
(en)
|
2008-06-03 |
2009-12-10 |
Abbott Laboratories |
Dual variable domain immunoglobulins and uses thereof
|
US8999702B2
(en)
|
2008-06-11 |
2015-04-07 |
Emd Millipore Corporation |
Stirred tank bioreactor
|
KR102095257B1
(ko)
*
|
2008-06-25 |
2020-04-01 |
노바르티스 아게 |
Vegf를 억제하는 안정하고 가용성인 항체
|
WO2010006060A2
(en)
*
|
2008-07-08 |
2010-01-14 |
Abbott Laboratories |
Prostaglandin e2 dual variable domain immunoglobulins and uses thereof
|
US20100029491A1
(en)
*
|
2008-07-11 |
2010-02-04 |
Maike Schmidt |
Methods and compositions for diagnostic use for tumor treatment
|
ES2644723T3
(es)
|
2008-07-23 |
2017-11-30 |
F. Hoffmann-La Roche Ag |
Identificación de sujetos susceptibles de tratamiento antiangiogénico
|
SI2848625T1
(sl)
|
2008-08-14 |
2019-11-29 |
Genentech Inc |
Postopki za odstranjevanje kontaminanta z uporabo ionskoizmenjevalne membranske kromatografije z izpodrinjenjem nativnega proteina
|
US20100055099A1
(en)
*
|
2008-08-29 |
2010-03-04 |
Ellen Filvaroff |
Diagnostics and Treatments for VEGF-Independent Tumors
|
US20110318360A1
(en)
|
2008-09-05 |
2011-12-29 |
Duke University |
Anti-lipid antibodies
|
MX2011002372A
(es)
|
2008-09-10 |
2011-04-04 |
Genentech Inc |
Composiciones y metodos para la prevencion de la degradacion oxidativa de proteinas.
|
WO2010037046A1
(en)
|
2008-09-28 |
2010-04-01 |
Fraunhofer Usa, Inc. |
Humanized neuraminidase antibody and methods of use thereof
|
US8268314B2
(en)
|
2008-10-08 |
2012-09-18 |
Hoffmann-La Roche Inc. |
Bispecific anti-VEGF/anti-ANG-2 antibodies
|
EP3524620A1
(en)
|
2008-10-14 |
2019-08-14 |
Genentech, Inc. |
Immunoglobulin variants and uses thereof
|
ES2836948T3
(es)
|
2008-11-03 |
2021-06-28 |
Molecular Partners Ag |
Proteínas de unión que inhiben la interacción del receptor de VEGF-A
|
US20120003641A1
(en)
|
2008-11-05 |
2012-01-05 |
Graham Robert R |
Genetic polymorphisms in age-related macular degeneration
|
ES2611337T3
(es)
|
2008-11-22 |
2017-05-08 |
F. Hoffmann-La Roche Ag |
Uso de anticuerpo anti-VEGF en combinación con quimioterapia para tratar cáncer de mama
|
CN102257122B
(zh)
|
2008-12-16 |
2015-07-29 |
Emd密理博公司 |
搅拌槽反应器及方法
|
EP2358734A1
(en)
|
2008-12-16 |
2011-08-24 |
Millipore Corporation |
Purification of proteins
|
KR101596539B1
(ko)
|
2008-12-23 |
2016-02-22 |
제넨테크, 인크. |
암 환자에서의 진단 목적용 방법 및 조성물
|
BRPI1006141B8
(pt)
|
2009-01-12 |
2021-05-25 |
Cytomx Therapeutics Llc |
composições de anticorpo modificado, métodos para preparar e usar as mesmas
|
WO2010081838A2
(en)
|
2009-01-14 |
2010-07-22 |
Novartis Ag |
Sterile prefilled container
|
EP2393513B1
(en)
|
2009-02-06 |
2016-10-19 |
The General Hospital Corporation |
Methods of treating vascular lesions
|
WO2010096838A2
(en)
*
|
2009-02-23 |
2010-08-26 |
Cytomx Therapeutics, Llc |
Proproteins and methods of use thereof
|
WO2010099273A1
(en)
|
2009-02-27 |
2010-09-02 |
Genentech, Inc. |
Methods and compositions for protein labelling
|
CA2755121A1
(en)
|
2009-03-13 |
2010-09-16 |
Neil P. Desai |
Combination therapy with thiocolchicine derivatives
|
NZ594343A
(en)
|
2009-03-25 |
2013-10-25 |
Genentech Inc |
Novel anti-alpha5beta1 antibodies and uses thereof
|
PE20120591A1
(es)
|
2009-04-02 |
2012-05-23 |
Roche Glycart Ag |
Anticuerpos multiespecificos que comprenden anticuerpos de longitud completa y fragmentos fab de cadena sencilla
|
AU2010234031B2
(en)
|
2009-04-07 |
2015-10-01 |
Roche Glycart Ag |
Trivalent, bispecific antibodies
|
WO2010121140A1
(en)
*
|
2009-04-16 |
2010-10-21 |
Facet Biotech Corporation |
ANTI-TNF-α ANTIBODIES AND THEIR USES
|
SG175289A1
(en)
*
|
2009-04-20 |
2011-11-28 |
Genentech Inc |
Adjuvant cancer therapy
|
US9067986B2
(en)
|
2009-04-27 |
2015-06-30 |
Oncomed Pharmaceuticals, Inc. |
Method for making heteromultimeric molecules
|
CA2665956A1
(en)
*
|
2009-05-07 |
2010-11-07 |
Samir Patel |
Combination treatment for ocular diseases
|
US9309325B2
(en)
|
2009-05-07 |
2016-04-12 |
The Regents Of The University Of California |
Antibodies and methods of use thereof
|
KR101754433B1
(ko)
|
2009-05-08 |
2017-07-05 |
백시넥스 인코포레이티드 |
항-cd100 항체 및 이의 사용 방법
|
WO2010129904A1
(en)
|
2009-05-08 |
2010-11-11 |
Genentech, Inc. |
Humanized anti-egfl7 antibodies and methods using same
|
JP5925677B2
(ja)
|
2009-06-15 |
2016-06-01 |
アイコン・ジェネティクス・ゲーエムベーハー |
キシロシルトランスフェラーゼ活性の欠損したベンサミアナタバコ(Nicotianabenthamiana)植物
|
US9676845B2
(en)
|
2009-06-16 |
2017-06-13 |
Hoffmann-La Roche, Inc. |
Bispecific antigen binding proteins
|
CA2766403A1
(en)
|
2009-07-13 |
2011-01-20 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of cancer
|
AR078060A1
(es)
|
2009-07-14 |
2011-10-12 |
Novartis Ag |
Descontaminacion de superficie de contenedores previamente llenados en empaque secundario
|
TW201106972A
(en)
|
2009-07-27 |
2011-03-01 |
Genentech Inc |
Combination treatments
|
NZ597531A
(en)
|
2009-07-31 |
2014-05-30 |
Genentech Inc |
Inhibition of tumor metastasis using bv8- or g-csf-antagonists
|
KR20180105258A
(ko)
|
2009-08-11 |
2018-09-27 |
제넨테크, 인크. |
글루타민-비함유 세포 배양 배지에서의 단백질의 생성
|
AU2010282282A1
(en)
|
2009-08-14 |
2012-03-01 |
Genentech, Inc. |
Biological markers for monitoring patient response to VEGF antagonists
|
CA2771086A1
(en)
*
|
2009-08-15 |
2011-02-24 |
Genentech, Inc. |
Anti-angiogenesis therapy for the treatment of previously treated breast cancer
|
JP5787891B2
(ja)
|
2009-09-01 |
2015-09-30 |
ジェネンテック, インコーポレイテッド |
改変されたプロテインa溶離による向上したタンパク質精製
|
WO2011028642A1
(en)
|
2009-09-04 |
2011-03-10 |
University Of Louisville Research Foundation, Inc. |
Genetic determinants of prostate cancer risk
|
CA2773662A1
(en)
|
2009-09-11 |
2011-03-17 |
Genentech, Inc. |
Method to identify a patient with an increased likelihood of responding to an anti-cancer agent
|
MX2012003396A
(es)
|
2009-09-16 |
2012-04-10 |
Genentech Inc |
Complejos de proteina conteniendo helice super-enrollada y/o enlazador tether y usos de los mismos.
|
WO2011033006A1
(en)
|
2009-09-17 |
2011-03-24 |
F. Hoffmann-La Roche Ag |
Methods and compositions for diagnostics use in cancer patients
|
WO2011041391A1
(en)
|
2009-09-29 |
2011-04-07 |
Fraunhofer Usa, Inc. |
Influenza hemagglutinin antibodies, compositions, and related methods
|
ES2575152T3
(es)
|
2009-10-16 |
2016-06-24 |
Oncomed Pharmaceuticals, Inc. |
Combinación terapéutica y uso de anticuerpos antagonistas de DLL4 y agentes antihipertensores
|
NZ599110A
(en)
|
2009-10-21 |
2013-09-27 |
Genentech Inc |
Genetic polymorphisms in age-related macular degeneration
|
WO2011056497A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Activin receptor type iib compositions and methods of use
|
WO2011056502A1
(en)
|
2009-10-26 |
2011-05-12 |
Genentech, Inc. |
Bone morphogenetic protein receptor type ii compositions and methods of use
|
JP5818805B2
(ja)
|
2009-12-11 |
2015-11-18 |
ジェネンテック, インコーポレイテッド |
抗vegf−c抗体及びその使用方法
|
WO2011075185A1
(en)
|
2009-12-18 |
2011-06-23 |
Oligasis |
Targeted drug phosphorylcholine polymer conjugates
|
BR112012013093A2
(pt)
|
2009-12-21 |
2017-12-12 |
Genentech Inc |
''formulação farmacêutica aquosa estável, artigo, métodos para estabilizar um anticorpo, para tratamento de uma doença ou distúrbio em um indivíduo, para reduzir a agregação de um anticorpo monoclonal terapêutico e de fabricação de uma formulação farmaceutica, frasco e tanque de aço inoxidável
|
JP5852010B2
(ja)
|
2009-12-23 |
2016-02-03 |
ジェネンテック, インコーポレイテッド |
抗Bv8抗体およびその使用
|
WO2011090719A2
(en)
|
2009-12-29 |
2011-07-28 |
Dr. Reddy's Laboratories Ltd. |
Protein purification by ion exchange
|
WO2011095596A1
(en)
|
2010-02-04 |
2011-08-11 |
Vivalis |
Fed-batch process using concentrated cell culture medium for the efficient production of biologics in eb66 cells
|
EP2539367A2
(en)
|
2010-02-23 |
2013-01-02 |
F. Hoffmann-La Roche AG |
Anti-angiogenesis therapy for the treatment of ovarian cancer
|
CA2792125C
(en)
|
2010-03-22 |
2019-02-12 |
Genentech, Inc. |
Compositions and methods useful for stabilizing protein-containing formulations
|
TWI426920B
(zh)
|
2010-03-26 |
2014-02-21 |
Hoffmann La Roche |
雙專一性、雙價抗-vegf/抗-ang-2抗體
|
TW201138821A
(en)
|
2010-03-26 |
2011-11-16 |
Roche Glycart Ag |
Bispecific antibodies
|
PL2552415T3
(pl)
|
2010-03-29 |
2017-03-31 |
Abraxis Bioscience, Llc |
Sposoby leczenia nowotworu
|
MX2012011155A
(es)
|
2010-03-29 |
2012-12-05 |
Abraxis Bioscience Llc |
Metodos para mejorar suministros de farmacos y efectividad de agentes terapeuticos.
|
WO2011133521A2
(en)
|
2010-04-19 |
2011-10-27 |
Synta Pharmaceuticals Corp. |
Cancer therapy using a combination of a hsp90 inhibitory compounds and a vegf inhibitor
|
TWI510246B
(zh)
|
2010-04-30 |
2015-12-01 |
Molecular Partners Ag |
抑制vegf-a受體交互作用的經修飾結合性蛋白質
|
MX2012012743A
(es)
|
2010-05-03 |
2012-11-23 |
Genentech Inc |
Composiciones y metodos utiles para reducir la viscosidad de formulaciones que contienen proteina.
|
WO2011146394A1
(en)
|
2010-05-17 |
2011-11-24 |
Millipore Corporation |
Stimulus responsive polymers for the purification of biomolecules
|
BR112012030197A2
(pt)
|
2010-05-28 |
2015-09-29 |
Genentech Inc |
diminuição do nível de lactato e aumento da produção de poliptídeo por subregulação da expressão de lactato desidrogenase e piruvato desidrogenase cinase.
|
WO2011153243A2
(en)
|
2010-06-02 |
2011-12-08 |
Genentech, Inc. |
Anti-angiogenesis therapy for treating gastric cancer
|
WO2011153224A2
(en)
|
2010-06-02 |
2011-12-08 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of cancer
|
BR112012030909A2
(pt)
|
2010-06-04 |
2020-08-18 |
Abraxis Bioscience, Llc |
métodos de tratamento de câncer pancreático
|
CA2802756C
(en)
|
2010-06-24 |
2021-05-04 |
Genentech, Inc. |
Compositions and methods for stabilizing protein-containing formulations
|
MX2012014523A
(es)
|
2010-07-02 |
2013-01-29 |
Genentech Inc |
Tratamiento de desprendimiento epitelial de pigmento vascularizado con terapia anti-vegf.
|
CN103097418A
(zh)
|
2010-07-09 |
2013-05-08 |
霍夫曼-拉罗奇有限公司 |
抗神经毡蛋白抗体及使用方法
|
BR112013001431A2
(pt)
|
2010-07-19 |
2016-05-31 |
Hoffmann La Roche |
método de identificação de pacientes com maior probabilidade de reação a terapia anticâncer
|
CA2804246A1
(en)
|
2010-07-19 |
2012-01-26 |
F. Hoffmann-La Roche Ag |
Method to identify a patient with an increased likelihood of responding to an anti-cancer therapy
|
US8735546B2
(en)
|
2010-08-03 |
2014-05-27 |
Abbvie Inc. |
Dual variable domain immunoglobulins and uses thereof
|
KR20130100125A
(ko)
|
2010-08-13 |
2013-09-09 |
제넨테크, 인크. |
질환의 치료를 위한, IL-1β 및 IL-18에 대한 항체
|
TW201208703A
(en)
|
2010-08-17 |
2012-03-01 |
Roche Glycart Ag |
Combination therapy of an afucosylated CD20 antibody with an anti-VEGF antibody
|
RU2013110875A
(ru)
|
2010-08-24 |
2014-09-27 |
Ф.Хоффманн-Ля Рош Аг |
БИСПЕЦИФИЧЕСКИЕ АНТИТЕЛА, СОДЕРЖАЩИЕ СТАБИЛИЗИРОВАННЫЙ ДИСУЛЬФИДОМ ФРАГМЕНТ Fv
|
EP2608803A4
(en)
|
2010-08-26 |
2014-01-15 |
Abbvie Inc |
IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND USES THEREOF
|
WO2012030512A1
(en)
|
2010-09-03 |
2012-03-08 |
Percivia Llc. |
Flow-through protein purification process
|
US8551479B2
(en)
|
2010-09-10 |
2013-10-08 |
Oncomed Pharmaceuticals, Inc. |
Methods for treating melanoma
|
SG190788A1
(en)
|
2010-11-15 |
2013-07-31 |
Five Prime Therapeutics Inc |
Fgfr1 extracellular domain combination therapies
|
WO2012085111A1
(en)
|
2010-12-23 |
2012-06-28 |
F. Hoffmann-La Roche Ag |
Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery
|
JOP20210044A1
(ar)
|
2010-12-30 |
2017-06-16 |
Takeda Pharmaceuticals Co |
الأجسام المضادة لـ cd38
|
WO2012092539A2
(en)
|
2010-12-31 |
2012-07-05 |
Takeda Pharmaceutical Company Limited |
Antibodies to dll4 and uses thereof
|
WO2012095514A1
(en)
|
2011-01-14 |
2012-07-19 |
Vivalis |
Recombinant protein production system
|
RU2607038C2
(ru)
|
2011-02-28 |
2017-01-10 |
Ф. Хоффманн-Ля Рош Аг |
Антигенсвязывающие белки
|
CA2824824A1
(en)
|
2011-02-28 |
2012-09-07 |
F. Hoffmann-La Roche Ag |
Monovalent antigen binding proteins
|
DK2686020T3
(en)
|
2011-03-17 |
2017-05-01 |
Univ Birmingham |
REDIRECTED IMMUNTERY
|
KR101614195B1
(ko)
|
2011-03-29 |
2016-04-20 |
로슈 글리카트 아게 |
항체 Fc 변이체
|
US9527925B2
(en)
|
2011-04-01 |
2016-12-27 |
Boehringer Ingelheim International Gmbh |
Bispecific binding molecules binding to VEGF and ANG2
|
KR102021157B1
(ko)
|
2011-04-01 |
2019-09-11 |
제넨테크, 인크. |
Akt 억제제 화합물 및 아비라테론의 조합물, 및 사용 방법
|
JP6250533B2
(ja)
|
2011-04-20 |
2017-12-20 |
アクセレロン ファーマ インコーポレイテッドAcceleron Pharma,Inc. |
エンドグリンポリペプチドおよびその使用
|
MX2013012716A
(es)
|
2011-05-03 |
2014-03-21 |
Genentech Inc |
Agentes de disociacion vascular y sus usos.
|
WO2012172054A1
(en)
|
2011-06-16 |
2012-12-20 |
Scil Proteins Gmbh |
Modified multimeric ubiquitin proteins binding vegf-a
|
WO2013003680A1
(en)
|
2011-06-30 |
2013-01-03 |
Genentech, Inc. |
Anti-c-met antibody formulations
|
WO2013009767A2
(en)
|
2011-07-12 |
2013-01-17 |
Epitomics, Inc. |
Facs-based method for obtaining an antibody sequence
|
US9181532B2
(en)
|
2011-07-29 |
2015-11-10 |
Icon Genetics Gmbh |
Production of galactosylated N-glycans in plants
|
KR20140068877A
(ko)
|
2011-08-17 |
2014-06-09 |
제넨테크, 인크. |
불응성 종양에서의 혈관신생의 억제
|
HUE042192T2
(hu)
|
2011-09-23 |
2019-06-28 |
Oncomed Pharm Inc |
VEGF/DLL4-kötõ ágensek és alkalmazásaik
|
WO2013050155A1
(en)
|
2011-10-04 |
2013-04-11 |
Icon Genetics Gmbh |
Nicotiana benthamiana plants deficient in fucosyltransferase activity
|
CN110105452A
(zh)
|
2011-10-11 |
2019-08-09 |
瓦西尼斯公司 |
臂板蛋白-4d结合分子用于调节血脑屏障渗透性的用途
|
AU2012323856B2
(en)
|
2011-10-13 |
2017-05-25 |
EyePoint Pharmaceuticals, Inc. |
Methods for treating Vascular Leak Syndrome and cancer
|
CN104066448A
(zh)
*
|
2011-10-13 |
2014-09-24 |
阿尔皮奥治疗学股份有限公司 |
眼病的治疗
|
WO2013082511A1
(en)
|
2011-12-02 |
2013-06-06 |
Genentech, Inc. |
Methods for overcoming tumor resistance to vegf antagonists
|
US9988424B2
(en)
|
2011-12-05 |
2018-06-05 |
Duke University |
Immunogens comprising human immunodeficiency virus V1/V2 polypeptides
|
US8790652B2
(en)
|
2011-12-06 |
2014-07-29 |
Vaccinex, Inc. |
Use of the combination of semaphorin-4D inhibitory molecules and VEGF inhibitory molecules to inhibit angiogenesis
|
WO2013096322A1
(en)
|
2011-12-22 |
2013-06-27 |
Genentech, Inc |
Ion exchange membrane chromatography
|
WO2013091903A1
(en)
|
2011-12-22 |
2013-06-27 |
Novo Nordisk A/S |
Anti-crac channel antibodies
|
JP2015508994A
(ja)
|
2011-12-30 |
2015-03-26 |
アッヴィ・インコーポレイテッド |
Il−13および/またはil−17に対する二重可変ドメイン免疫グロブリン
|
EP2802346B1
(en)
|
2012-01-13 |
2018-09-12 |
F.Hoffmann-La Roche Ag |
Biological markers for identifying patients for treatment with vegf antagonists
|
EP2812357B1
(en)
|
2012-02-10 |
2020-11-04 |
F.Hoffmann-La Roche Ag |
Single-chain antibodies and other heteromultimers
|
WO2013127829A1
(en)
|
2012-02-27 |
2013-09-06 |
Universitat De Barcelona |
Protease-resistant compounds useful as shuttles through the blood-brain barrier and shuttle-cargo constructs
|
HUE045445T2
(hu)
|
2012-03-13 |
2019-12-30 |
Hoffmann La Roche |
Kombinált terápia petefészekrák kezelésére
|
CN104350156B
(zh)
|
2012-03-27 |
2019-04-02 |
弗·哈夫曼-拉罗切有限公司 |
用于重组蛋白质的改进的收获操作
|
AU2013240234B2
(en)
|
2012-03-30 |
2017-04-27 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of cancer
|
JP6272299B2
(ja)
|
2012-04-20 |
2018-01-31 |
メルス ナムローゼ フェンノートシャップ |
Ig様分子を生産する方法、Ig様分子の混合物、組み換え宿主細胞、医薬組成物、宿主細胞を作成する方法、および培養物
|
US10494440B2
(en)
|
2012-05-11 |
2019-12-03 |
Vaccinex, Inc. |
Use of semaphorin-4D binding molecules to promote neurogenesis following stroke
|
WO2013170182A1
(en)
|
2012-05-11 |
2013-11-14 |
Synta Pharmaceuticals Corp. |
Treating cancer with an hsp90 inhibitory compound
|
PL2855528T3
(pl)
|
2012-05-31 |
2019-10-31 |
Hoffmann La Roche |
Sposoby leczenia nowotworu z użyciem antagonistów wiązania osi pd-1 i antagonistów vegf
|
BR112014029795B1
(pt)
|
2012-06-01 |
2021-09-21 |
Novartis Ag |
Seringa oftálmica, pré-preenchida, terminalmente esterilizada e embalagem de seringa
|
US9107926B2
(en)
|
2012-06-08 |
2015-08-18 |
Genentech, Inc. |
Mutant selectivity and combinations of a phosphoinositide 3-kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer
|
KR20150023889A
(ko)
|
2012-06-27 |
2015-03-05 |
에프. 호프만-라 로슈 아게 |
2 개 이상의 상이한 결합 단위를 함유하는 맞춤-제작된 고도로 선별적이고 다중-특이적인 표적화 단위의 선별 및 제조 방법 및 이의 용도
|
KR20150030744A
(ko)
|
2012-06-27 |
2015-03-20 |
에프. 호프만-라 로슈 아게 |
표적에 특이적으로 결합하는 하나 이상의 결합 단위를 포함하는 항체 Fc-영역 접합체의 제조 방법 및 그의 용도
|
JOP20200175A1
(ar)
|
2012-07-03 |
2017-06-16 |
Novartis Ag |
حقنة
|
KR101774121B1
(ko)
|
2012-07-13 |
2017-09-01 |
로슈 글리카트 아게 |
이중특이적 항-vegf/항-ang-2 항체 및 안 혈관 질환의 치료에 있어서 이의 용도
|
KR20180011356A
(ko)
|
2012-08-07 |
2018-01-31 |
제넨테크, 인크. |
교모세포종의 치료를 위한 조합 요법
|
JP6479661B2
(ja)
|
2012-09-19 |
2019-03-06 |
ジェネンテック, インコーポレイテッド |
タンパク質へのノルロイシン誤取り込みを防ぐための方法及び組成物
|
WO2014071018A1
(en)
|
2012-10-31 |
2014-05-08 |
Oncomed Pharmaceuticals, Inc. |
Methods and monitoring of treatment with a dll4 antagonist
|
AU2013337775B2
(en)
|
2012-11-01 |
2017-03-30 |
Abbvie Inc. |
Anti-VEGF/DLL4 dual variable domain immunoglobulins and uses thereof
|
CA2890190A1
(en)
|
2012-11-12 |
2014-05-15 |
Redwood Bioscience, Inc. |
Compounds and methods for producing a conjugate
|
EP2920148B1
(en)
|
2012-11-16 |
2019-06-12 |
The Regents of the University of California |
Pictet-spengler ligation for protein chemical modification
|
US9310374B2
(en)
|
2012-11-16 |
2016-04-12 |
Redwood Bioscience, Inc. |
Hydrazinyl-indole compounds and methods for producing a conjugate
|
BR112015013861A2
(pt)
|
2012-12-18 |
2017-07-11 |
Novartis Ag |
composições e métodos para proteínas de ação prolongada
|
EP2934602B1
(en)
|
2012-12-19 |
2019-02-27 |
Genentech, Inc. |
Methods and compositions for radiohalogen protein labeling
|
AU2014205369B2
(en)
|
2013-01-11 |
2018-08-09 |
Massachusetts Eye And Ear Infirmary |
CYP450 lipid metabolites reduce inflammation and angiogenesis
|
EP2951307B1
(en)
|
2013-02-04 |
2019-12-25 |
Vascular Biogenics Ltd. |
Methods of inducing responsiveness to anti-angiogenic agent
|
HUE048687T2
(hu)
|
2013-02-18 |
2020-08-28 |
Vegenics Pty Ltd |
Ligandum kötõ molekulák és alkalmazásaik
|
NZ711567A
(en)
|
2013-03-13 |
2020-04-24 |
Genentech Inc |
Antibody formulations
|
WO2014145091A1
(en)
|
2013-03-15 |
2014-09-18 |
Genentech, Inc. |
Cell culture media and methods of antibody production
|
JP2016522793A
(ja)
|
2013-03-15 |
2016-08-04 |
アッヴィ・インコーポレイテッド |
IL−1βおよび/またはIL−17に対して指向された二重特異的結合タンパク質
|
US9707154B2
(en)
|
2013-04-24 |
2017-07-18 |
Corning Incorporated |
Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
|
EA201501063A1
(ru)
|
2013-04-29 |
2016-05-31 |
Ф. Хоффманн-Ля Рош Аг |
СВЯЗЫВАЮЩИЕСЯ С ЧЕЛОВЕЧЕСКИМ FcRn МОДИФИЦИРОВАННЫЕ АНТИТЕЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
|
SG10201703977UA
(en)
|
2013-05-23 |
2017-06-29 |
Five Prime Therapeutics Inc |
Methods of treating cancer
|
KR101541478B1
(ko)
*
|
2013-05-31 |
2015-08-05 |
동아쏘시오홀딩스 주식회사 |
항-vegf 항체 및 이를 포함하는 암 또는 신생혈관형성관련 질환의 예방, 진단 또는 치료용 약학 조성물
|
AU2014302812B2
(en)
|
2013-06-25 |
2019-07-11 |
Vaccinex, Inc. |
Use of semaphorin-4D inhibitory molecules in combination with an immune modulating therapy to inhibit tumor growth and metastases
|
BR112016000546A2
(pt)
|
2013-07-12 |
2017-11-21 |
Ophthotech Corp |
métodos para tratar ou prevenir condições oftalmológicas
|
CN107318267B
(zh)
|
2013-08-12 |
2021-08-17 |
豪夫迈·罗氏有限公司 |
用于治疗补体相关的病症的组合物和方法
|
US10617755B2
(en)
|
2013-08-30 |
2020-04-14 |
Genentech, Inc. |
Combination therapy for the treatment of glioblastoma
|
US10456470B2
(en)
|
2013-08-30 |
2019-10-29 |
Genentech, Inc. |
Diagnostic methods and compositions for treatment of glioblastoma
|
PT3041513T
(pt)
|
2013-09-08 |
2020-09-07 |
Kodiak Sciences Inc |
Conjugados de polímeros zwiteriónicos com fator viii
|
NZ630881A
(en)
|
2013-10-10 |
2016-03-31 |
Vaccinex Inc |
Use of semaphorin-4d binding molecules for treatment of atherosclerosis
|
CA2922912A1
(en)
|
2013-10-11 |
2015-04-16 |
F. Hoffmann-La Roche Ag |
Multispecific domain exchanged common variable light chain antibodies
|
NZ630892A
(en)
|
2013-10-21 |
2016-03-31 |
Vaccinex Inc |
Use of semaphorin-4d binding molecules for treating neurodegenerative disorders
|
CN105899225A
(zh)
|
2013-10-25 |
2016-08-24 |
阿塞勒隆制药公司 |
用于治疗纤维化疾病的内皮联蛋白肽
|
WO2015071348A1
(en)
|
2013-11-18 |
2015-05-21 |
Formycon Ag |
Pharmaceutical composition of an anti-vegf antibody
|
CA3178867A1
(en)
|
2013-11-27 |
2015-06-04 |
Redwood Bioscience, Inc. |
Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
|
US20160130336A1
(en)
*
|
2013-12-31 |
2016-05-12 |
Development Center For Biotechnology |
Anti-vegf antibodies and use thereof
|
EP3842455A1
(en)
|
2014-01-15 |
2021-06-30 |
F. Hoffmann-La Roche AG |
Fc-region variants with improved protein a-binding
|
JOP20200094A1
(ar)
|
2014-01-24 |
2017-06-16 |
Dana Farber Cancer Inst Inc |
جزيئات جسم مضاد لـ pd-1 واستخداماتها
|
JOP20200096A1
(ar)
|
2014-01-31 |
2017-06-16 |
Children’S Medical Center Corp |
جزيئات جسم مضاد لـ tim-3 واستخداماتها
|
KR20160135190A
(ko)
|
2014-02-14 |
2016-11-25 |
앤드류 에스. 카이 |
혈관형성 암의 치료를 위한 개선된 방법
|
JP6666848B2
(ja)
|
2014-02-18 |
2020-03-18 |
アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル |
Nrp−1/obr複合体シグナル伝達経路により媒介される疾患の処置のための方法及び医薬組成物
|
US10590455B2
(en)
|
2014-02-25 |
2020-03-17 |
Dr. Reddy's Laboratories Limited |
Process for modifying galactosylation and G0F content of a glycoprotein composition by glutamine supplementation
|
CN106103465B
(zh)
|
2014-03-10 |
2021-01-08 |
吉瑞工厂 |
使用预清洗步骤的免疫球蛋白纯化
|
ES2770684T3
(es)
|
2014-03-14 |
2020-07-02 |
Novartis Ag |
Moléculas de anticuerpos contra LAG-3 y usos de los mismos
|
JP2017516458A
(ja)
|
2014-03-24 |
2017-06-22 |
ジェネンテック, インコーポレイテッド |
c−met拮抗剤による癌治療及びc−met拮抗剤のHGF発現との相関
|
AU2015241038A1
(en)
|
2014-03-31 |
2016-10-13 |
Genentech, Inc. |
Combination therapy comprising anti-angiogenesis agents and OX40 binding agonists
|
KR20160147855A
(ko)
|
2014-05-01 |
2016-12-23 |
제넨테크, 인크. |
항-인자 d 항체 변이체 및 이의 용도
|
EP3492495A1
(en)
|
2014-05-12 |
2019-06-05 |
Formycon AG |
Pre-filled plastic syringe containing a vegf antagonist
|
EP3142697A1
(en)
|
2014-05-15 |
2017-03-22 |
Bristol-Myers Squibb Company |
Treatment of lung cancer using a combination of an anti-pd-1 antibody and another anti-cancer agent
|
CA2947484C
(en)
|
2014-06-06 |
2023-05-09 |
Redwood Bioscience, Inc. |
Anti-her2 antibody-maytansine conjugates and methods of use thereof
|
WO2015198243A2
(en)
|
2014-06-25 |
2015-12-30 |
Novartis Ag |
Compositions and methods for long acting proteins
|
WO2015198240A2
(en)
|
2014-06-25 |
2015-12-30 |
Novartis Ag |
Compositions and methods for long acting proteins
|
US9840553B2
(en)
|
2014-06-28 |
2017-12-12 |
Kodiak Sciences Inc. |
Dual PDGF/VEGF antagonists
|
EP3777535A1
(en)
|
2014-07-09 |
2021-02-17 |
F. Hoffmann-La Roche AG |
Ph adjustment to improve thaw recovery of cell banks
|
EP3169801A1
(en)
|
2014-07-14 |
2017-05-24 |
F. Hoffmann-La Roche AG |
Diagnostic methods and compositions for treatment of glioblastoma
|
CN105330739B
(zh)
*
|
2014-08-12 |
2020-12-25 |
中美华世通生物医药科技(武汉)有限公司 |
与人血管内皮生长因子特异性结合的抗体或其抗原结合片段及其用途
|
US10166273B2
(en)
|
2014-08-12 |
2019-01-01 |
The Board Of Trustees Of The Leland Stanford Junior University |
Synergistic tumor treatment with antibodies targeting PD-1, PD-L1 or CTLA4 and integrin-binding-Fc-fusion protein
|
US20170216403A1
(en)
|
2014-08-12 |
2017-08-03 |
Massachusetts Institute Of Technology |
Synergistic tumor treatment with il-2, a therapeutic antibody, and an immune checkpoint blocker
|
US11344620B2
(en)
|
2014-09-13 |
2022-05-31 |
Novartis Ag |
Combination therapies
|
US20160137727A1
(en)
|
2014-09-15 |
2016-05-19 |
Genentech, Inc. |
Antibody formulations
|
WO2016054555A2
(en)
|
2014-10-03 |
2016-04-07 |
Novartis Ag |
Combination therapies
|
MA41044A
(fr)
|
2014-10-08 |
2017-08-15 |
Novartis Ag |
Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
|
PE20171067A1
(es)
|
2014-10-14 |
2017-07-24 |
Novartis Ag |
Moleculas de anticuerpo que se unen a pd-l1 y usos de las mismas
|
JP6849590B2
(ja)
|
2014-10-17 |
2021-03-24 |
コディアック サイエンシーズ インコーポレイテッドKodiak Sciences Inc. |
ブチリルコリンエステラーゼ両性イオン性ポリマーコンジュゲート
|
ES2822228T3
(es)
|
2014-10-24 |
2021-04-29 |
Univ Leland Stanford Junior |
Composiciones y métodos para inducir la fagocitosis de células positivas de clase I de CMH y contrarrestar la resistencia a anti-CD47/SIRPA
|
AU2015338974B2
(en)
|
2014-10-31 |
2021-08-26 |
Oncomed Pharmaceuticals, Inc. |
Combination therapy for treatment of disease
|
TWI705976B
(zh)
|
2014-11-10 |
2020-10-01 |
美商建南德克公司 |
抗介白素-33抗體及其用途
|
EP3227332B1
(en)
|
2014-12-03 |
2019-11-06 |
F.Hoffmann-La Roche Ag |
Multispecific antibodies
|
LT3230316T
(lt)
|
2014-12-11 |
2022-02-10 |
Bayer Healthcare Llc |
Gydymas su amžiumi susijusios geltonosios dėmės degeneracijos su mažu aktyvios choroidinės neovaskuliarizacijos pažeidimu
|
WO2016094881A2
(en)
|
2014-12-11 |
2016-06-16 |
Abbvie Inc. |
Lrp-8 binding proteins
|
EP3233918A1
(en)
|
2014-12-19 |
2017-10-25 |
Novartis AG |
Combination therapies
|
CA2968359A1
(en)
|
2014-12-23 |
2016-06-30 |
Genentech, Inc. |
Compositions and methods for treating and diagnosing chemotherapy-resistant cancers
|
AU2016210918A1
(en)
|
2015-01-28 |
2017-07-13 |
Pfizer Inc., |
Stable aqueous anti- vascular endothelial growth factor (VEGF) antibody formulation
|
CN107683135A
(zh)
|
2015-03-09 |
2018-02-09 |
因特克林医疗有限公司 |
用于治疗非酒精性脂肪肝疾病和/或脂肪营养不良的方法
|
WO2016172551A2
(en)
|
2015-04-24 |
2016-10-27 |
Genentech, Inc. |
Methods of identifying bacteria comprising binding polypeptides
|
WO2016191751A1
(en)
|
2015-05-28 |
2016-12-01 |
Bristol-Myers Squibb Company |
Treatment of pd-l1 positive lung cancer using an anti-pd-1 antibody
|
WO2016196389A1
(en)
|
2015-05-29 |
2016-12-08 |
Bristol-Myers Squibb Company |
Treatment of renal cell carcinoma
|
WO2016200835A1
(en)
|
2015-06-08 |
2016-12-15 |
Genentech, Inc. |
Methods of treating cancer using anti-ox40 antibodies and pd-1 axis binding antagonists
|
TW201710286A
(zh)
|
2015-06-15 |
2017-03-16 |
艾伯維有限公司 |
抗vegf、pdgf及/或其受體之結合蛋白
|
CN107922502A
(zh)
|
2015-07-14 |
2018-04-17 |
百时美施贵宝公司 |
使用免疫检验点抑制剂治疗癌症的方法
|
US20180340025A1
(en)
|
2015-07-29 |
2018-11-29 |
Novartis Ag |
Combination therapies comprising antibody molecules to lag-3
|
CN107849126B
(zh)
|
2015-07-29 |
2022-04-08 |
阿勒根公司 |
仅有重链的抗ang-2抗体
|
EP3316902A1
(en)
|
2015-07-29 |
2018-05-09 |
Novartis AG |
Combination therapies comprising antibody molecules to tim-3
|
HU231463B1
(hu)
|
2015-08-04 |
2024-01-28 |
Richter Gedeon Nyrt. |
Módszer rekombináns proteinek galaktóz tartalmának növelésére
|
EP3334762A1
(en)
|
2015-08-14 |
2018-06-20 |
Allergan, Inc. |
Heavy chain only antibodies to pdgf
|
WO2017034906A1
(en)
*
|
2015-08-21 |
2017-03-02 |
Immunomedics, Inc. |
Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies
|
RU2749865C2
(ru)
|
2015-09-17 |
2021-06-17 |
Иммьюноджен, Инк. |
Терапевтические комбинации, содержащие анти-folr1 иммуноконъюгаты
|
WO2017046140A1
(en)
|
2015-09-18 |
2017-03-23 |
Bayer Pharma Aktiengesellschaft |
Treatment regimens for dr and rvo in dependence of the extent of retinal ischemia
|
WO2017050793A1
(en)
|
2015-09-22 |
2017-03-30 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Polypeptides capable of inhibiting the binding between leptin and neuropilin-1
|
MY191756A
(en)
|
2015-09-23 |
2022-07-14 |
Genentech Inc |
Optimized variants of anti-vegf antibodies
|
US11339213B2
(en)
|
2015-09-23 |
2022-05-24 |
Mereo Biopharma 5, Inc. |
Methods and compositions for treatment of cancer
|
WO2017055319A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of b cells in a tissue sample
|
WO2017055326A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of myeloid dendritic cells in a tissue sample
|
WO2017055322A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of neutrophils in a tissue sample
|
WO2017055324A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of cells of monocytic origin in a tissue sample
|
WO2017055320A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of cytotoxic lymphocytes in a tissue sample
|
WO2017055325A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of nk cells in a tissue sample
|
WO2017055321A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of fibroblasts in a tissue sample
|
WO2017055327A1
(en)
|
2015-09-29 |
2017-04-06 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of endothelial cells in a tissue sample
|
WO2017064121A1
(en)
|
2015-10-13 |
2017-04-20 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods and pharmaceutical compositions for the treatment of choroidal neovascularisation
|
RS61871B1
(sr)
|
2015-10-30 |
2021-06-30 |
Hoffmann La Roche |
Anti-htra1 antitela i postupci za njihovu primenu
|
EP3368090A1
(en)
|
2015-10-30 |
2018-09-05 |
H. Hoffnabb-La Roche Ag |
Anti-factor d antibody variant conjugates and uses thereof
|
BR112018008769A2
(pt)
|
2015-10-30 |
2018-12-04 |
Genentech Inc |
formulações farmacêuticas, formulações líquidas aquosa reconstituída e liofilizada, seringa, método de fabricação de uma formulação farmacêutica, método para tratamento de uma doença e uso de uma formulação reconstruída
|
US10407510B2
(en)
|
2015-10-30 |
2019-09-10 |
Genentech, Inc. |
Anti-factor D antibodies and conjugates
|
MX2018005550A
(es)
|
2015-11-03 |
2019-07-18 |
Janssen Biotech Inc |
Anticuerpos que se unen especificamente a tim-3 y sus usos.
|
WO2017079419A1
(en)
|
2015-11-05 |
2017-05-11 |
The Regents Of The University Of California |
Cells labelled with lipid conjugates and methods of use thereof
|
MX2018006139A
(es)
|
2015-11-18 |
2019-03-14 |
Sio2 Medical Products Inc |
Envase farmaceutico para formulaciones oftalmicas.
|
JP6882738B2
(ja)
|
2015-11-18 |
2021-06-02 |
フォーマイコン アーゲーFormycon Ag |
Vegf阻害薬の液体製剤を含んだプレフィルド薬剤シリンジ
|
WO2018218013A2
(en)
|
2017-05-24 |
2018-11-29 |
Sio2 Medical Products, Inc. |
Sterilizable pharmaceutical package for ophthalmic formulations
|
KR20180083377A
(ko)
|
2015-11-18 |
2018-07-20 |
포르미콘 아게 |
Vegf 안타고니스트를 함유하는 사전충전형 플라스틱 주사기
|
DK3384049T3
(da)
|
2015-12-03 |
2023-10-02 |
Regeneron Pharma |
Fremgangsmåder til associering af genetiske varianter med et klinisk resultat hos patienter, der lider af aldersrelateret makuladegeneration behandlet med anti-VEGF
|
WO2017106656A1
(en)
|
2015-12-17 |
2017-06-22 |
Novartis Ag |
Antibody molecules to pd-1 and uses thereof
|
RU2744860C2
(ru)
|
2015-12-30 |
2021-03-16 |
Кодиак Сайенсиз Инк. |
Антитела и их конъюгаты
|
JP6953433B2
(ja)
|
2016-01-26 |
2021-10-27 |
フォーマイコン アーゲーFormycon Ag |
Vegfアンタゴニストを含む液体医薬組成物および同医薬組成物を含有する充填済みシリンジ
|
EP3432927A4
(en)
|
2016-03-24 |
2019-11-20 |
Gensun Biopharma Inc. |
TRIPLE-SPECIFIC INHIBITORS FOR CANCER TREATMENT
|
BR112018070139A2
(pt)
|
2016-03-29 |
2019-02-05 |
Geltor Inc |
expressão de proteínas em bactérias gram-negativas em que a razão entre o volume periplasmático e o volume citoplasmático é entre 0,5:1 e 10:1
|
CN109154613A
(zh)
|
2016-04-15 |
2019-01-04 |
豪夫迈·罗氏有限公司 |
用于监测和治疗癌症的方法
|
EP3443120A2
(en)
|
2016-04-15 |
2019-02-20 |
H. Hoffnabb-La Roche Ag |
Methods for monitoring and treating cancer
|
DK3458053T3
(da)
|
2016-05-20 |
2022-02-21 |
Biohaven Therapeutics Ltd |
Anvendelse af riluzol, riluzolprodrugs eller riluzolanaloger med immunterapier til cancerbehandling
|
CN109690315A
(zh)
|
2016-07-08 |
2019-04-26 |
豪夫迈·罗氏有限公司 |
人附睾蛋白4(he4)用于评估muc16阳性癌症治疗的响应性的用途
|
EP3481963A1
(en)
|
2016-07-08 |
2019-05-15 |
Genentech, Inc. |
Methods for diagnosing and treating cancer by means of the expression status and mutational status of nrf2 and downstream target genes of said gene.
|
WO2018011166A2
(en)
|
2016-07-12 |
2018-01-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods for quantifying the population of myeloid dendritic cells in a tissue sample
|
SG11201900464TA
(en)
|
2016-07-20 |
2019-02-27 |
Aerpio Therapeutics Inc |
HUMANIZED MONOCLONAL ANTIBODIES THAT TARGET VE-PTP (HPTP-ß)
|
WO2018018613A1
(zh)
|
2016-07-29 |
2018-02-01 |
广东东阳光药业有限公司 |
一种提高抗体纯度的细胞培养基和培养方法
|
CN106222129A
(zh)
*
|
2016-07-29 |
2016-12-14 |
广东东阳光药业有限公司 |
一种提高抗体纯度的细胞培养基和培养方法
|
EP3496752B1
(en)
|
2016-08-12 |
2022-05-18 |
Genentech, Inc. |
Combination therapy with a mek inhibitor, a pd-1 axis inhibitor, and a vegf inhibitor
|
CA3034576A1
(en)
|
2016-08-23 |
2018-03-01 |
Medimmune Limited |
Anti-vegf-a antibodies and uses thereof
|
JPWO2018070390A1
(ja)
|
2016-10-12 |
2019-08-22 |
第一三共株式会社 |
抗robo4抗体と他剤を含む組成物
|
US11192925B2
(en)
|
2016-10-19 |
2021-12-07 |
Adverum Biotechnologies, Inc. |
Modified AAV capsids and uses thereof
|
CN109071656B
(zh)
|
2017-01-05 |
2021-05-18 |
璟尚生物制药公司 |
检查点调节物拮抗剂
|
US10350266B2
(en)
|
2017-01-10 |
2019-07-16 |
Nodus Therapeutics, Inc. |
Method of treating cancer with a multiple integrin binding Fc fusion protein
|
US10603358B2
(en)
|
2017-01-10 |
2020-03-31 |
Nodus Therapeutics |
Combination tumor treatment with an integrin-binding-Fc fusion protein and immune stimulator
|
ES2953595T3
(es)
|
2017-03-01 |
2023-11-14 |
Hoffmann La Roche |
Procedimientos diagnósticos y terapéuticos para el cáncer
|
CN110582510B
(zh)
*
|
2017-03-24 |
2023-09-15 |
科学与工业研究委员会 |
用于纯化重组抗体片段的方法
|
AU2018249822A1
(en)
|
2017-04-03 |
2019-10-31 |
Coherus Biosciences Inc. |
PPArgamma agonist for treatment of progressive supranuclear palsy
|
JOP20190245A1
(ar)
|
2017-04-20 |
2019-10-15 |
Novartis Ag |
أنظمة توصيل إطلاق مستدام تتضمن روابط بلا أثر لنقطة الربط
|
EP3624847A1
(en)
|
2017-05-19 |
2020-03-25 |
Council of Scientific and Industrial Research |
A method for producing refolded recombinant humanized ranibizumab
|
WO2018217995A1
(en)
|
2017-05-24 |
2018-11-29 |
Formycon Ag |
Sterilizable pre-filled pharmaceutical packages comprising a liquid formulation of a vegf-antagonist
|
WO2018215580A1
(en)
|
2017-05-24 |
2018-11-29 |
Formycon Ag |
Method for sterilizing prefilled plastic syringes containing a vegf antagonist
|
TW201904610A
(zh)
|
2017-06-14 |
2019-02-01 |
德商拜耳製藥公司 |
用於治療新生血管型青光眼之非抗體vegf拮抗劑
|
CN110785187B
(zh)
|
2017-06-22 |
2024-04-05 |
诺华股份有限公司 |
针对cd73的抗体分子及其用途
|
WO2018237173A1
(en)
|
2017-06-22 |
2018-12-27 |
Novartis Ag |
ANTIBODY MOLECULES DIRECTED AGAINST CD73 AND CORRESPONDING USES
|
EP3650045A4
(en)
|
2017-07-04 |
2021-07-07 |
Daiichi Sankyo Company, Limited |
MEDICINAL PRODUCTS FOR RETINA DEGENERATIVE DISEASE ASSOCIATED WITH PHOTORECEPTOR DEGENERATION
|
WO2019020777A1
(en)
|
2017-07-26 |
2019-01-31 |
Formycon Ag |
LIQUID FORMULATION OF A VEGF ANTAGONIST
|
WO2019057946A1
(en)
|
2017-09-25 |
2019-03-28 |
F. Hoffmann-La Roche Ag |
MULTI-CYCLIC AROMATIC COMPOUNDS AS D-FACTOR INHIBITORS
|
US11180541B2
(en)
|
2017-09-28 |
2021-11-23 |
Geltor, Inc. |
Recombinant collagen and elastin molecules and uses thereof
|
CN111356480A
(zh)
|
2017-10-20 |
2020-06-30 |
脉管生物生长有限公司 |
用于抗血管生成剂疗法的诊断方法
|
KR20200090927A
(ko)
|
2017-12-19 |
2020-07-29 |
아카우오스, 인크. |
내이에 대한 치료적 항체의 aav-매개 전달
|
CN111479588A
(zh)
|
2017-12-29 |
2020-07-31 |
豪夫迈·罗氏有限公司 |
用于改善抗vegf抗体的vegf受体阻断选择性的方法
|
CN110003328B
(zh)
*
|
2018-01-05 |
2022-04-19 |
百奥泰生物制药股份有限公司 |
一种长效低毒的重组抗vegf人源化单克隆抗体及其生产方法
|
WO2019154776A1
(en)
|
2018-02-06 |
2019-08-15 |
F. Hoffmann-La Roche Ag |
Treatment of ophthalmologic diseases
|
AU2019231791B2
(en)
|
2018-03-09 |
2022-08-11 |
Agenus Inc. |
Anti-CD73 antibodies and methods of use thereof
|
JP2021521247A
(ja)
|
2018-04-16 |
2021-08-26 |
オンクオリティー ファーマシューティカルズ チャイナ リミテッド |
腫瘍療法の副作用の予防または治療方法
|
KR20210021299A
(ko)
|
2018-05-10 |
2021-02-25 |
리제너론 파아마슈티컬스, 인크. |
고농도 vegf 수용체 융합 단백질 함유 제제
|
CR20200563A
(es)
|
2018-05-24 |
2021-05-11 |
Janssen Biotech Inc |
Agentes aglutinantes de psma y usos de estos
|
US11519020B2
(en)
|
2018-05-25 |
2022-12-06 |
Regeneron Pharmaceuticals, Inc. |
Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF
|
AR126019A1
(es)
|
2018-05-30 |
2023-09-06 |
Novartis Ag |
Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación
|
WO2019229116A1
(en)
|
2018-05-31 |
2019-12-05 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Intravitreal delivery of a decorin polypeptide for the treatment of choroidal neovascularisation
|
WO2019232244A2
(en)
|
2018-05-31 |
2019-12-05 |
Novartis Ag |
Antibody molecules to cd73 and uses thereof
|
EP3814381A4
(en)
|
2018-06-29 |
2022-08-10 |
Gensun Biopharma Inc. |
TRI-SPECIFIC ANTAGONISTS
|
LT3818078T
(lt)
|
2018-07-03 |
2024-04-25 |
Bristol-Myers Squibb Company |
Rekombinantinių baltymų gamybos būdas
|
GB201811410D0
(en)
|
2018-07-12 |
2018-08-29 |
F Star Beta Ltd |
OX40 Binding molecules
|
CN109053895B
(zh)
|
2018-08-30 |
2020-06-09 |
中山康方生物医药有限公司 |
抗pd-1-抗vegfa的双功能抗体、其药物组合物及其用途
|
EP3856245A4
(en)
|
2018-09-24 |
2022-10-26 |
EyePoint Pharmaceuticals, Inc. |
MULTISPECIFIC ANTIBODIES TARGETING HPTP-ß (VE-PTP) AND VEGF
|
KR20210074341A
(ko)
|
2018-10-10 |
2021-06-21 |
베링거 인겔하임 인터내셔날 게엠베하 |
고밀도 생물 반응기 배양에서 막 기체 전달을 위한 방법
|
AU2019361983A1
(en)
|
2018-10-18 |
2021-05-20 |
Genentech, Inc. |
Diagnostic and therapeutic methods for sarcomatoid kidney cancer
|
HUP1800376A2
(hu)
|
2018-11-07 |
2020-05-28 |
Richter Gedeon Nyrt |
Sejttenyészetben elõállított rekombináns glikoprotein glikozilációs-mintázatának megváltoztatására szolgáló módszer
|
WO2020109343A1
(en)
|
2018-11-29 |
2020-06-04 |
F. Hoffmann-La Roche Ag |
Combination therapy for treatment of macular degeneration
|
CN109134651B
(zh)
*
|
2018-12-03 |
2019-02-22 |
上海复宏汉霖生物技术股份有限公司 |
一种抗vegf的单克隆抗体及其制备方法和应用
|
WO2020118043A1
(en)
|
2018-12-07 |
2020-06-11 |
Coherus Biosciences, Inc. |
Methods for producing recombinant proteins
|
WO2020131697A2
(en)
|
2018-12-17 |
2020-06-25 |
Revitope Limited |
Twin immune cell engager
|
AU2020234098A1
(en)
|
2019-03-13 |
2021-09-16 |
Vascular Biogenics Ltd. |
Methods of anti-tumor therapy
|
BR112021019612A2
(pt)
|
2019-04-01 |
2021-11-30 |
Genentech Inc |
Formulações, recipiente, artigo de fabricação, método para produzir a formulação e método para inibir a agregação de uma proteína presente em uma solução aquosa
|
HUP1900112A1
(hu)
|
2019-04-04 |
2020-10-28 |
Richter Gedeon Nyrt |
Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelõzõ flokkulálás alkalmazásával
|
KR20210151930A
(ko)
|
2019-04-12 |
2021-12-14 |
젤터, 인코포레이티드 |
재조합 엘라스틴 및 이의 제조
|
CA3136888A1
(en)
|
2019-04-19 |
2020-10-22 |
Janssen Biotech, Inc. |
Methods of treating prostate cancer with an anti- psma/cd3 antibody
|
TW202106699A
(zh)
|
2019-04-26 |
2021-02-16 |
美商愛德維仁生物科技公司 |
用於玻璃體內遞送之變異體aav蛋白殼
|
WO2020226986A2
(en)
|
2019-05-03 |
2020-11-12 |
Genentech, Inc. |
Methods of treating cancer with an anti-pd-l1 antibody
|
WO2020225552A1
(en)
|
2019-05-06 |
2020-11-12 |
Medimmune Limited |
Combination of monalizumab, durvalumab, chemotherapy and bevacizumab or cetuximab for the treatment of colorectal cancer
|
JP2022540571A
(ja)
|
2019-06-28 |
2022-09-16 |
ゲンスン バイオファーマ、インコーポレーテッド |
変異したTGFβ1-RII細胞外ドメインおよび免疫グロブリン足場で構成される抗腫瘍アンタゴニスト
|
US20220315887A1
(en)
|
2019-08-01 |
2022-10-06 |
Bristol-Myers Squibb Company |
Methods of improving protein productivity in fed-batch cell cultures
|
CN114502590A
(zh)
|
2019-09-18 |
2022-05-13 |
诺华股份有限公司 |
Entpd2抗体、组合疗法、以及使用这些抗体和组合疗法的方法
|
CA3157509A1
(en)
|
2019-10-10 |
2021-04-15 |
Kodiak Sciences Inc. |
Methods of treating an eye disorder
|
WO2021072210A1
(en)
|
2019-10-11 |
2021-04-15 |
Coherus Biosciences, Inc. |
Methods of purifying ranibizumab or a ranibizumab variant
|
WO2021072182A1
(en)
|
2019-10-11 |
2021-04-15 |
Coherus Biosciences, Inc. |
Methods for producing ranibizumab
|
US20230022576A1
(en)
|
2019-11-19 |
2023-01-26 |
Protalix Ltd. |
Removal of constructs from transformed cells
|
JP2023504003A
(ja)
|
2019-11-25 |
2023-02-01 |
中山康方生物医▲藥▼有限公司 |
抗pd-1-抗vegfa二重特異性抗体、その医薬組成物および使用
|
US20230151425A1
(en)
|
2020-03-11 |
2023-05-18 |
INSERM (Institut National de la Santé et de la Recherche Médicale) |
Methods of determining whether a subject has or is at risk of having a central serous chorioretinopathy
|
CR20220461A
(es)
|
2020-03-13 |
2022-10-21 |
Genentech Inc |
Anticuerpos anti-interleucina-33 y usos de estos
|
EP4127724A1
(en)
|
2020-04-03 |
2023-02-08 |
Genentech, Inc. |
Therapeutic and diagnostic methods for cancer
|
CN116133679A
(zh)
|
2020-06-30 |
2023-05-16 |
门德斯有限公司 |
白血病衍生细胞在卵巢癌疫苗中的用途
|
BR112023000482A2
(pt)
|
2020-07-16 |
2023-01-31 |
Novartis Ag |
Anticorpos antibetacelulina, fragmentos dos mesmos e moléculas de ligação multiespecíficas
|
KR20230073270A
(ko)
|
2020-09-22 |
2023-05-25 |
브리스톨-마이어스 스큅 컴퍼니 |
치료 단백질의 생산 방법
|
WO2022074646A1
(en)
|
2020-10-05 |
2022-04-14 |
Protalix Ltd. |
Dicer-like knock-out plant cells
|
WO2022081835A1
(en)
|
2020-10-15 |
2022-04-21 |
Genentech, Inc. |
Hyaluronic acid binding derivatives of versican (vg1) for long acting delivery of therapeutics
|
MX2023005529A
(es)
|
2020-11-13 |
2023-05-25 |
Genentech Inc |
Metodos y composiciones que comprenden un inhibidor de krasg12c y un inhibidor de vegf para tratar tumores solidos.
|
MX2023006451A
(es)
|
2020-12-01 |
2023-06-15 |
Akouos Inc |
Construcciones de anticuerpos anti-vegf y metodos relacionados para el tratamiento de los sintomas asociados al schwannoma vestibular.
|
KR20230135075A
(ko)
|
2021-01-22 |
2023-09-22 |
멘두스 비.브이. |
종양 백신접종 방법
|
KR20230137393A
(ko)
|
2021-01-28 |
2023-10-04 |
얀센 바이오테크 인코포레이티드 |
Psma 결합 단백질 및 이의 용도
|
AU2022233411A1
(en)
|
2021-03-12 |
2023-09-14 |
Akeso Biopharma, Inc. |
Pharmaceutical combination containing anti-pd-1-anti-vegfa bispecific antibody, and use thereof
|
CA3212351A1
(en)
|
2021-03-12 |
2022-09-15 |
Mendus B.V. |
Methods of vaccination and use of cd47 blockade
|
JP2024516230A
(ja)
|
2021-04-30 |
2024-04-12 |
ジェネンテック, インコーポレイテッド |
がんのための治療及び診断方法並びに組成物
|
AU2022281825A1
(en)
|
2021-05-28 |
2024-01-18 |
Shanghai Regenelead Therapies Co., Ltd. |
Recombinant adeno-associated virus having variant capsid, and application thereof
|
WO2022256820A1
(en)
|
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|
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(zh)
|
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|
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|
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|
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(en)
|
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|
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|
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|
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(en)
|
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|
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(en)
|
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|
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(en)
|
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|
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(zh)
|
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|
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(en)
|
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|
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(zh)
|
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|