HUP1800376A2 - Sejttenyészetben elõállított rekombináns glikoprotein glikozilációs-mintázatának megváltoztatására szolgáló módszer - Google Patents
Sejttenyészetben elõállított rekombináns glikoprotein glikozilációs-mintázatának megváltoztatására szolgáló módszerInfo
- Publication number
- HUP1800376A2 HUP1800376A2 HU1800376A HUP1800376A HUP1800376A2 HU P1800376 A2 HUP1800376 A2 HU P1800376A2 HU 1800376 A HU1800376 A HU 1800376A HU P1800376 A HUP1800376 A HU P1800376A HU P1800376 A2 HUP1800376 A2 HU P1800376A2
- Authority
- HU
- Hungary
- Prior art keywords
- modifying
- cell culture
- recombinant glycoprotein
- glycosylation profile
- glycoprotein produced
- Prior art date
Links
- 102000003886 Glycoproteins Human genes 0.000 title 1
- 108090000288 Glycoproteins Proteins 0.000 title 1
- 238000004113 cell culture Methods 0.000 title 1
- 230000013595 glycosylation Effects 0.000 title 1
- 238000006206 glycosylation reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0043—Medium free of human- or animal-derived components
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
- C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2511/00—Cells for large scale production
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1800376A HUP1800376A2 (hu) | 2018-11-07 | 2018-11-07 | Sejttenyészetben elõállított rekombináns glikoprotein glikozilációs-mintázatának megváltoztatására szolgáló módszer |
| JP2021524198A JP2022512928A (ja) | 2018-11-07 | 2019-11-06 | 細胞培養で生産される組換え糖タンパク質のグリコシル化プロファイルを変更する方法 |
| BR112021008458-4A BR112021008458A2 (pt) | 2018-11-07 | 2019-11-06 | método para modificar o perfil de glicosilação de uma glicoproteína recombinante produzida em cultura celular |
| AU2019376476A AU2019376476A1 (en) | 2018-11-07 | 2019-11-06 | Method for modifying the glycosylation profile of a recombinant glycoprotein produced in cell culture |
| EP19801518.2A EP3877539A1 (en) | 2018-11-07 | 2019-11-06 | Method for modifying the glycosylation profile of a recombinant glycoprotein produced in cell culture |
| CN201980088055.3A CN113272440A (zh) | 2018-11-07 | 2019-11-06 | 改变细胞培养物中产生的重组糖蛋白的糖基化谱的方法 |
| MA054147A MA54147A (fr) | 2018-11-07 | 2019-11-06 | Procédé de modification du profil de glycosylation d'une glycoprotéine recombinante produite dans une culture cellulaire |
| CA3118604A CA3118604A1 (en) | 2018-11-07 | 2019-11-06 | Method for modifying the glycosylation profile of a recombinant glycoprotein produced in cell culture |
| PCT/EP2019/080342 WO2020094694A1 (en) | 2018-11-07 | 2019-11-06 | Method for modifying the glycosylation profile of a recombinant glycoprotein produced in cell culture |
| KR1020217017260A KR20210089220A (ko) | 2018-11-07 | 2019-11-06 | 세포 배양에서 생산된 재조합 당단백질의 글리코실화 프로파일의 변형 방법 |
| US17/292,302 US20220098634A1 (en) | 2018-11-07 | 2019-11-06 | Method for modifying the glycosylation profile of a recombinant glycoprotein produced in cell culture |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1800376A HUP1800376A2 (hu) | 2018-11-07 | 2018-11-07 | Sejttenyészetben elõállított rekombináns glikoprotein glikozilációs-mintázatának megváltoztatására szolgáló módszer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUP1800376A2 true HUP1800376A2 (hu) | 2020-05-28 |
Family
ID=89992786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU1800376A HUP1800376A2 (hu) | 2018-11-07 | 2018-11-07 | Sejttenyészetben elõállított rekombináns glikoprotein glikozilációs-mintázatának megváltoztatására szolgáló módszer |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20220098634A1 (hu) |
| EP (1) | EP3877539A1 (hu) |
| JP (1) | JP2022512928A (hu) |
| KR (1) | KR20210089220A (hu) |
| CN (1) | CN113272440A (hu) |
| AU (1) | AU2019376476A1 (hu) |
| BR (1) | BR112021008458A2 (hu) |
| CA (1) | CA3118604A1 (hu) |
| HU (1) | HUP1800376A2 (hu) |
| MA (1) | MA54147A (hu) |
| WO (1) | WO2020094694A1 (hu) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4291675A1 (en) * | 2021-02-12 | 2023-12-20 | Lonza Bend Inc. | Method for modulating afucoslyation of an antibody product |
| AR126089A1 (es) | 2021-06-07 | 2023-09-13 | Amgen Inc | Uso de fucosidasa para controlar el nivel de afucosilación de proteínas glucosiladas |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| EP0435911B1 (en) | 1988-09-23 | 1996-03-13 | Cetus Oncology Corporation | Cell culture medium for enhanced cell growth, culture longevity and product expression |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| DE07012625T1 (de) | 1991-03-18 | 2010-01-21 | New York University | Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor |
| LU91067I2 (fr) | 1991-06-14 | 2004-04-02 | Genentech Inc | Trastuzumab et ses variantes et dérivés immuno chimiques y compris les immotoxines |
| ES2091684T3 (es) | 1992-11-13 | 1996-11-01 | Idec Pharma Corp | Aplicacion terapeutica de anticuerpos quimericos y radiomarcados contra el antigeno de diferenciacion restringida de los linfocitos b humanos para el tratamiento del linfoma de las celulas b. |
| HU221984B1 (hu) | 1996-02-09 | 2003-03-28 | Basf Ag | Humán TNFalfa-t kötő antitestek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
| ES2236634T3 (es) | 1997-04-07 | 2005-07-16 | Genentech, Inc. | Anticuerpos anti-vegf. |
| PT2087908T (pt) | 2001-06-26 | 2018-07-16 | Amgen Inc | Anticorpos contra opgl |
| ES2668212T3 (es) * | 2006-07-13 | 2018-05-17 | Wyeth Llc | Producción de factor de coagulación IX con patrón de glucosilación mejorado |
| US20120329709A1 (en) * | 2009-05-26 | 2012-12-27 | Brian Edward Collins | Production of glycoproteins |
| WO2012149197A2 (en) | 2011-04-27 | 2012-11-01 | Abbott Laboratories | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| US10059770B2 (en) | 2012-01-30 | 2018-08-28 | Dr. Reddy's Laboratories Limited | Process of modulating man5 and/or afucosylation content of a glycoprotein composition |
| JP6591395B2 (ja) * | 2013-03-15 | 2019-10-16 | ジェネンテック， インコーポレイテッド | 抗酸化剤を含む細胞培養組成物およびポリペプチド産生のための方法 |
| EA201690269A1 (ru) | 2013-07-23 | 2016-05-31 | Сентро Де Инмунологиа Молекулар | Способы контроля уровней фукозилирования в белках |
| TR201610497T1 (tr) * | 2014-01-29 | 2017-06-21 | Lg Chemical Ltd | Rekombi̇nant protei̇n galaktosi̇lasyonunu kültür ortaminin opti̇mi̇zasyonu vasitasiyla modüle etme yöntemi̇ |
| LT3110961T (lt) | 2014-02-27 | 2020-02-10 | F. Hoffmann-La Roche Ag | Ląstelių augimo ir glikozilinimo moduliavimas, gaminant rekombinantinį glikoproteiną |
| SG10202002458PA (en) * | 2014-12-01 | 2020-04-29 | Amgen Inc | Process for manipulating the level of glycan content of a glycoprotein |
| EP3303559A1 (en) * | 2015-06-01 | 2018-04-11 | Biogen MA Inc. | Manganese supplementation for control of glycosylation in mammalian cell culture process |
| WO2017021871A1 (en) * | 2015-08-03 | 2017-02-09 | Dr. Reddy's Laboratories Limited | A cell culture process for modulating glycans |
| HU231463B1 (hu) * | 2015-08-04 | 2024-01-28 | Richter Gedeon Nyrt. | Módszer rekombináns proteinek galaktóz tartalmának növelésére |
| TW202340452A (zh) * | 2015-08-04 | 2023-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| CN108431026B (zh) * | 2015-11-02 | 2023-02-17 | 豪夫迈·罗氏有限公司 | 制备岩藻糖基化和去岩藻糖基化形式的蛋白质的方法 |
| CN109153717A (zh) * | 2016-01-06 | 2019-01-04 | 安口生物公司 | 减少单克隆抗体组合物中的高分子量物类、酸性电荷物类和片段 |
| CN109153716A (zh) * | 2016-01-06 | 2019-01-04 | 安口生物公司 | 调节单克隆抗体组合物中的非岩藻糖基化物类 |
| WO2017134667A1 (en) | 2016-02-02 | 2017-08-10 | Insight Biopharmaceuticals Ltd. | Methods of generating antibodies |
-
2018
- 2018-11-07 HU HU1800376A patent/HUP1800376A2/hu unknown
-
2019
- 2019-11-06 JP JP2021524198A patent/JP2022512928A/ja active Pending
- 2019-11-06 CA CA3118604A patent/CA3118604A1/en active Pending
- 2019-11-06 WO PCT/EP2019/080342 patent/WO2020094694A1/en unknown
- 2019-11-06 MA MA054147A patent/MA54147A/fr unknown
- 2019-11-06 CN CN201980088055.3A patent/CN113272440A/zh active Pending
- 2019-11-06 EP EP19801518.2A patent/EP3877539A1/en active Pending
- 2019-11-06 BR BR112021008458-4A patent/BR112021008458A2/pt unknown
- 2019-11-06 KR KR1020217017260A patent/KR20210089220A/ko unknown
- 2019-11-06 AU AU2019376476A patent/AU2019376476A1/en active Pending
- 2019-11-06 US US17/292,302 patent/US20220098634A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112021008458A2 (pt) | 2021-08-03 |
| CN113272440A (zh) | 2021-08-17 |
| WO2020094694A1 (en) | 2020-05-14 |
| KR20210089220A (ko) | 2021-07-15 |
| EP3877539A1 (en) | 2021-09-15 |
| US20220098634A1 (en) | 2022-03-31 |
| CA3118604A1 (en) | 2020-05-14 |
| MA54147A (fr) | 2022-02-16 |
| AU2019376476A1 (en) | 2021-05-27 |
| JP2022512928A (ja) | 2022-02-07 |
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