MA54147A - Procédé de modification du profil de glycosylation d'une glycoprotéine recombinante produite dans une culture cellulaire - Google Patents
Procédé de modification du profil de glycosylation d'une glycoprotéine recombinante produite dans une culture cellulaireInfo
- Publication number
- MA54147A MA54147A MA054147A MA54147A MA54147A MA 54147 A MA54147 A MA 54147A MA 054147 A MA054147 A MA 054147A MA 54147 A MA54147 A MA 54147A MA 54147 A MA54147 A MA 54147A
- Authority
- MA
- Morocco
- Prior art keywords
- modifying
- cell culture
- recombinant glycoprotein
- glycosylation profile
- glycoprotein produced
- Prior art date
Links
- 102000003886 Glycoproteins Human genes 0.000 title 1
- 108090000288 Glycoproteins Proteins 0.000 title 1
- 238000004113 cell culture Methods 0.000 title 1
- 230000013595 glycosylation Effects 0.000 title 1
- 238000006206 glycosylation reaction Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
- C12N5/0043—Medium free of human- or animal-derived components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/20—Transition metals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/32—Amino acids
- C12N2500/33—Amino acids other than alpha-amino carboxylic acids, e.g. beta-amino acids, taurine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/30—Organic components
- C12N2500/34—Sugars
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2511/00—Cells for large scale production
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
HUP1800376A HU231514B1 (hu) | 2018-11-07 | 2018-11-07 | Sejttenyészetben előállított rekombináns glikoprotein glikozilációs mintázatának megváltoztatására szolgáló módszer |
Publications (1)
Publication Number | Publication Date |
---|---|
MA54147A true MA54147A (fr) | 2022-02-16 |
Family
ID=89992786
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA054147A MA54147A (fr) | 2018-11-07 | 2019-11-06 | Procédé de modification du profil de glycosylation d'une glycoprotéine recombinante produite dans une culture cellulaire |
Country Status (11)
Country | Link |
---|---|
US (1) | US20220098634A1 (fr) |
EP (1) | EP3877539A1 (fr) |
JP (2) | JP2022512928A (fr) |
KR (1) | KR20210089220A (fr) |
CN (1) | CN113272440A (fr) |
AU (1) | AU2019376476A1 (fr) |
BR (1) | BR112021008458A2 (fr) |
CA (1) | CA3118604A1 (fr) |
HU (1) | HU231514B1 (fr) |
MA (1) | MA54147A (fr) |
WO (1) | WO2020094694A1 (fr) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20230145083A (ko) * | 2021-02-12 | 2023-10-17 | 론자 벤드 인코포레이티드 | 항체 생성물의 비푸코실화를 조절하는 방법 |
CA3222409A1 (fr) | 2021-06-07 | 2022-12-15 | Amgen Inc. | Utilisation de fucosidase pour controler le taux d'afucosylation de proteines glycosylees |
WO2024094457A1 (fr) * | 2022-11-02 | 2024-05-10 | F. Hoffmann-La Roche Ag | Procédé de production de compositions de glycoprotéines |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
EP0435911B1 (fr) | 1988-09-23 | 1996-03-13 | Cetus Oncology Corporation | Milieu de culture de cellules pour l'amelioration de la croissance des cellules, de la longivite de la culture et de l'expression du produit |
US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
CA2106299C (fr) | 1991-03-18 | 2001-02-06 | Junming Le | Anticorps monoclonaux et chimeriques specifiques du facteur de necrose tumorale humain |
EP1400536A1 (fr) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Procédé pour fabriquer des anticorps humanisés |
WO1994011026A2 (fr) | 1992-11-13 | 1994-05-26 | Idec Pharmaceuticals Corporation | Application therapeutique d'anticorps chimeriques et radio-marques contre l'antigene a differentiation restreinte des lymphocytes b humains pour le traitement du lymphome des cellules b |
PL188192B1 (pl) | 1996-02-09 | 2004-12-31 | Abbott Lab Bermuda Ltd | Izolowane ludzkie przeciwciało albo jego część wiążąca antygen, rekombinowane ludzkie przeciwciało albo jego część wiążąca antygen, kompozycje farmaceutyczne, izolowane kwasy nukleinowe, rekombinowany wektor ekspresyjny, komórka gospodarza, sposób syntetyzowania przeciwciała ludzkiego, które wiąże ludzki TNFalfa, sposób hamowania aktywności ludzkiego TNFalfa in vitro, przeciwciało albo jego częśćwiążąca antygen, zastosowanie przeciwciała albo jego części wiążącej antygen |
ES2273415T3 (es) | 1997-04-07 | 2007-05-01 | Genentech, Inc. | Anticuerpos anti-vegf. |
ES2907826T3 (es) | 2001-06-26 | 2022-04-26 | Amgen Inc | Anticuerpos para OPGL |
PL2495307T3 (pl) * | 2006-07-13 | 2018-07-31 | Wyeth Llc | Wytwarzanie czynnika krzepliwości krwi IX o polepszonym wzorze glikozylacji |
WO2010138502A2 (fr) * | 2009-05-26 | 2010-12-02 | Momenta Pharmaceuticals, Inc. | Production de glycoprotéines |
US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
US10059770B2 (en) | 2012-01-30 | 2018-08-28 | Dr. Reddy's Laboratories Limited | Process of modulating man5 and/or afucosylation content of a glycoprotein composition |
EP2970875B1 (fr) * | 2013-03-15 | 2020-04-15 | F.Hoffmann-La Roche Ag | Compositions de culture de cellules comprenant des antioxydants et procédés de production de polypeptides |
EP4282975A3 (fr) | 2013-07-23 | 2024-02-28 | Biocon Limited | Procédés pour contrôler les niveaux de fucosylation dans des protéines |
MX2016009848A (es) * | 2014-01-29 | 2017-02-17 | Lg Life Sciences Ltd | Método de modulación de la galactosilación de proteína recombinante mediante optimización de medio de cultivo. |
SI3110961T1 (sl) | 2014-02-27 | 2020-03-31 | F. Hoffmann-La Roche Ag | Modulacija rasti celic in glikozilacije pri rekombinantni proizvodnji glikoproteina |
PL3227454T3 (pl) * | 2014-12-01 | 2020-07-27 | Amgen Inc. | Sposób manipulowania poziomem zawartości glikanów w glikoproteinie |
WO2016196621A1 (fr) * | 2015-06-01 | 2016-12-08 | Biogen Ma Inc. | Supplémentation en manganèse pour la régulation de la glycosylation dans un procédé de culture cellulaire de mammifère |
WO2017021871A1 (fr) | 2015-08-03 | 2017-02-09 | Dr. Reddy's Laboratories Limited | Procédé de culture cellulaire pour la modulation de glycanes |
HU231463B1 (hu) * | 2015-08-04 | 2024-01-28 | Richter Gedeon Nyrt. | Módszer rekombináns proteinek galaktóz tartalmának növelésére |
TW202340452A (zh) | 2015-08-04 | 2023-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
ES2875274T3 (es) * | 2015-11-02 | 2021-11-10 | Hoffmann La Roche | Procedimientos de preparación de formas fucosiladas y afucosiladas de una proteína |
JP2019500878A (ja) | 2016-01-06 | 2019-01-17 | オンコバイオロジクス,インコーポレイティド | モノクローナル抗体組成物中の高分子量種、酸性荷電種、及び断片の低減 |
WO2017120347A1 (fr) | 2016-01-06 | 2017-07-13 | Oncobiologics, Inc. | Modulation d'espèces afucosylées dans une composition d'anticorps monoclonal |
WO2017134667A1 (fr) | 2016-02-02 | 2017-08-10 | Insight Biopharmaceuticals Ltd. | Procédés de génération d'anticorps |
-
2018
- 2018-11-07 HU HUP1800376A patent/HU231514B1/hu unknown
-
2019
- 2019-11-06 WO PCT/EP2019/080342 patent/WO2020094694A1/fr unknown
- 2019-11-06 EP EP19801518.2A patent/EP3877539A1/fr active Pending
- 2019-11-06 BR BR112021008458-4A patent/BR112021008458A2/pt unknown
- 2019-11-06 CA CA3118604A patent/CA3118604A1/fr active Pending
- 2019-11-06 AU AU2019376476A patent/AU2019376476A1/en active Pending
- 2019-11-06 JP JP2021524198A patent/JP2022512928A/ja active Pending
- 2019-11-06 CN CN201980088055.3A patent/CN113272440A/zh active Pending
- 2019-11-06 MA MA054147A patent/MA54147A/fr unknown
- 2019-11-06 US US17/292,302 patent/US20220098634A1/en active Pending
- 2019-11-06 KR KR1020217017260A patent/KR20210089220A/ko unknown
-
2024
- 2024-05-08 JP JP2024075898A patent/JP2024112833A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN113272440A (zh) | 2021-08-17 |
WO2020094694A1 (fr) | 2020-05-14 |
KR20210089220A (ko) | 2021-07-15 |
CA3118604A1 (fr) | 2020-05-14 |
JP2022512928A (ja) | 2022-02-07 |
HUP1800376A2 (hu) | 2020-05-28 |
EP3877539A1 (fr) | 2021-09-15 |
JP2024112833A (ja) | 2024-08-21 |
HU231514B1 (hu) | 2024-07-28 |
AU2019376476A1 (en) | 2021-05-27 |
US20220098634A1 (en) | 2022-03-31 |
BR112021008458A2 (pt) | 2021-08-03 |
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