MA52007A - Procédés d'amélioration de la viabilité cellulaire dans un bioréacteur de production - Google Patents

Procédés d'amélioration de la viabilité cellulaire dans un bioréacteur de production

Info

Publication number
MA52007A
MA52007A MA052007A MA52007A MA52007A MA 52007 A MA52007 A MA 52007A MA 052007 A MA052007 A MA 052007A MA 52007 A MA52007 A MA 52007A MA 52007 A MA52007 A MA 52007A
Authority
MA
Morocco
Prior art keywords
processes
cell viability
production bioreactor
improving cell
improving
Prior art date
Application number
MA052007A
Other languages
English (en)
Inventor
Timothy Johnson
Jiuyi Lu
Jean Mclarty
Yukun Ren
Neha Shah
Jason Walther
Jonathan Wang
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of MA52007A publication Critical patent/MA52007A/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/18—Flow directing inserts
    • C12M27/20—Baffles; Ribs; Ribbons; Auger vanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/32—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of substances in solution
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/42—Means for regulation, monitoring, measurement or control, e.g. flow regulation of agitation speed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46—Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/32—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving dehydrogenase

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Sustainable Development (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
MA052007A 2018-03-16 2019-03-15 Procédés d'amélioration de la viabilité cellulaire dans un bioréacteur de production MA52007A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862644339P 2018-03-16 2018-03-16
US201862645755P 2018-03-20 2018-03-20

Publications (1)

Publication Number Publication Date
MA52007A true MA52007A (fr) 2021-01-20

Family

ID=65952204

Family Applications (1)

Application Number Title Priority Date Filing Date
MA052007A MA52007A (fr) 2018-03-16 2019-03-15 Procédés d'amélioration de la viabilité cellulaire dans un bioréacteur de production

Country Status (18)

Country Link
US (2) US11391725B2 (fr)
EP (2) EP3765846B1 (fr)
JP (2) JP7816863B2 (fr)
KR (2) KR102757905B1 (fr)
CN (2) CN112136045B (fr)
AU (1) AU2019236246B2 (fr)
BR (1) BR112020018823A2 (fr)
CA (2) CA3094076C (fr)
ES (1) ES3009097T3 (fr)
HU (1) HUE069711T2 (fr)
IL (2) IL277352B2 (fr)
MA (1) MA52007A (fr)
MX (2) MX2020009605A (fr)
PL (1) PL3765846T3 (fr)
SG (1) SG11202009047TA (fr)
TW (2) TWI835779B (fr)
WO (1) WO2019178508A1 (fr)
ZA (2) ZA202005741B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023054556A1 (fr) 2021-09-30 2023-04-06 富士フイルム株式会社 Procédé de culture cellulaire et procédé de production de substance utile
CN119968454A (zh) 2022-09-28 2025-05-09 建新公司 用于生产生物产品的系统和装置及其使用方法
US20240263122A1 (en) * 2023-02-08 2024-08-08 National Central University Bioreactor apparatus, ion-exchange substrate and method for regulation of ion concentration and cell culture thereof
WO2024218715A1 (fr) 2023-04-19 2024-10-24 Btl Healthcare Technologies A.S. Milieu de culture à base d'hydrolysat de protéines et leur procédé de préparation
US12668774B2 (en) 2023-10-12 2026-06-30 Btl Healthcare Technologies A.S. Product, system and method of cell cultivation

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5563068A (en) * 1994-04-21 1996-10-08 Genetic Therapy, Inc. Bioreactor
WO2006089002A2 (fr) * 2005-02-15 2006-08-24 Yale University Methode de criblage a haut rendement d'anticorps et de proteines induisant l'apoptose
TW201516149A (zh) * 2006-09-13 2015-05-01 Abbvie Inc 細胞培養改良
EP2500416A1 (fr) * 2006-09-13 2012-09-19 Abbott Laboratories Améliorations de culture cellulaire
ES2660667T3 (es) * 2007-05-07 2018-03-23 Protalix Ltd. Biorreactor desechable a gran escala
WO2010120514A2 (fr) 2009-03-31 2010-10-21 The Trustees Of The University Of Pennsylvania Protéines liant des antigènes comprenant des échafaudages protéiniques internes recombinants
NZ597727A (en) * 2009-07-31 2013-08-30 Baxter Int Cell culture medium for adamts protein expression
WO2014110433A1 (fr) * 2013-01-10 2014-07-17 Biogen Idec Ma Inc. Suppléments de milieu pour la performance améliorée d'un procédé
CN105209603A (zh) * 2013-02-22 2015-12-30 建新公司 微载体灌注培养方法及其用途
US20140271633A1 (en) * 2013-03-14 2014-09-18 Abbvie Inc. Mammalian cell culture performance through surfactant supplementation of feed media
TWI636136B (zh) * 2013-03-15 2018-09-21 艾爾德生物製藥股份有限公司 在酵母菌及其它轉型細胞中多肽高產量表現用之溫度變動技術
WO2014194137A1 (fr) * 2013-05-29 2014-12-04 Biogen Idec Ma Inc. Méthodes d'évaluation d'additifs pour culture cellulaire
RS59881B1 (sr) * 2014-02-27 2020-03-31 Hoffmann La Roche Modulacija ćelijskog rasta i glikozilacije u rekombinantnoj proizvodnji glikoproteina
KR102769649B1 (ko) 2014-12-22 2025-02-19 젠자임 코포레이션 포유류 세포의 배양 방법
TWI541353B (zh) * 2014-12-25 2016-07-11 財團法人工業技術研究院 產生嗜熱性鹼性蛋白酶生產菌屬（Ｔｅｐｉｄｉｍｏｎａｓ）之胞外蛋白的方法
JP6993961B2 (ja) * 2015-08-17 2022-01-14 アレクシオン ファーマシューティカルズ， インコーポレイテッド アルカリホスファターゼの製造

Also Published As

Publication number Publication date
KR20200132932A (ko) 2020-11-25
SG11202009047TA (en) 2020-10-29
US20220308042A1 (en) 2022-09-29
HUE069711T2 (hu) 2025-04-28
US11391725B2 (en) 2022-07-19
CN112136045A (zh) 2020-12-25
ZA202208613B (en) 2025-01-29
TW202513790A (zh) 2025-04-01
BR112020018823A2 (pt) 2021-02-09
CN112136045B (zh) 2024-12-13
WO2019178508A1 (fr) 2019-09-19
CA3280772A1 (en) 2025-10-30
TWI835779B (zh) 2024-03-21
CA3094076A1 (fr) 2019-09-19
EP3765846A1 (fr) 2021-01-20
EP3765846B1 (fr) 2024-10-30
AU2019236246B2 (en) 2025-06-05
EP4512887A2 (fr) 2025-02-26
ZA202005741B (en) 2023-04-26
JP2024023489A (ja) 2024-02-21
AU2019236246A1 (en) 2020-11-12
CA3094076C (fr) 2025-11-25
IL277352B2 (en) 2025-08-01
RU2020133815A (ru) 2022-04-19
CN119709931A (zh) 2025-03-28
TW201947033A (zh) 2019-12-16
MX2020009605A (es) 2021-01-08
ES3009097T3 (en) 2025-03-26
PL3765846T3 (pl) 2025-03-31
IL319295A (en) 2025-04-01
IL277352B1 (en) 2025-04-01
KR20250016476A (ko) 2025-02-03
IL277352A (en) 2020-11-30
US20190285617A1 (en) 2019-09-19
EP4512887A3 (fr) 2025-04-30
MX2024009056A (es) 2024-07-29
JP2021515584A (ja) 2021-06-24
KR102757905B1 (ko) 2025-01-22
EP3765846C0 (fr) 2024-10-30
JP7816863B2 (ja) 2026-02-18

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