LT3110961T - Ląstelių augimo ir glikozilinimo moduliavimas, gaminant rekombinantinį glikoproteiną - Google Patents
Ląstelių augimo ir glikozilinimo moduliavimas, gaminant rekombinantinį glikoproteinąInfo
- Publication number
- LT3110961T LT3110961T LTEP15709430.1T LT15709430T LT3110961T LT 3110961 T LT3110961 T LT 3110961T LT 15709430 T LT15709430 T LT 15709430T LT 3110961 T LT3110961 T LT 3110961T
- Authority
- LT
- Lithuania
- Prior art keywords
- glycosylation
- modulation
- cell growth
- recombinant glycoprotein
- glycoprotein production
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0018—Culture media for cell or tissue culture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14157030 | 2014-02-27 | ||
| PCT/EP2015/053804 WO2015128314A1 (en) | 2014-02-27 | 2015-02-24 | Modulation of cell growth and glycosylation in recombinant glycoprotein production |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| LT3110961T true LT3110961T (lt) | 2020-02-10 |
Family
ID=50184787
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| LTEP15709430.1T LT3110961T (lt) | 2014-02-27 | 2015-02-24 | Ląstelių augimo ir glikozilinimo moduliavimas, gaminant rekombinantinį glikoproteiną |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US20170058309A1 (lt) |
| EP (1) | EP3110961B1 (lt) |
| JP (2) | JP6831702B2 (lt) |
| KR (1) | KR102280638B1 (lt) |
| CN (1) | CN106133146B (lt) |
| BR (1) | BR112016017660B1 (lt) |
| CA (1) | CA2937611C (lt) |
| DK (1) | DK3110961T3 (lt) |
| ES (1) | ES2769003T3 (lt) |
| HR (1) | HRP20200100T1 (lt) |
| HU (1) | HUE047575T2 (lt) |
| LT (1) | LT3110961T (lt) |
| MX (1) | MX369395B (lt) |
| PL (1) | PL3110961T3 (lt) |
| PT (1) | PT3110961T (lt) |
| RS (1) | RS59881B1 (lt) |
| RU (1) | RU2712562C2 (lt) |
| SG (1) | SG11201606856SA (lt) |
| SI (1) | SI3110961T1 (lt) |
| WO (1) | WO2015128314A1 (lt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2831653T3 (es) | 2011-11-21 | 2021-06-09 | Innovation Hammer Llc | Procedimiento para el cultivo de plantas utilizando microperlas de silicato y fotofitoprotección mediante la utilización de glicopiranósidos exógenos |
| RU2712562C2 (ru) * | 2014-02-27 | 2020-01-29 | Ф.Хоффманн-Ля Рош Аг | Модулирование клеточного роста и гликозилирования при производстве рекомбинантных гликопротеинов |
| ES2784503T3 (es) | 2014-12-01 | 2020-09-28 | Amgen Inc | Procedimiento para manipular el nivel de contenido de glicano de una glicoproteína |
| CN109414027A (zh) * | 2016-04-29 | 2019-03-01 | 创新汉玛有限责任公司 | 用聚糖复合物制剂处理光合生物和增加品质和产量的制剂和方法 |
| WO2019077628A1 (en) * | 2017-10-16 | 2019-04-25 | Council Of Scientific & Industrial Research | ZINC SUPPLEMENTATION TO DECREASE GALACTOSYLATION OF RECOMBINANT GLYCOPROTEINS |
| MA52186A (fr) * | 2018-03-26 | 2021-02-17 | Amgen Inc | Glycoformes afucosylées totales d'anticorps produits en culture cellulaire |
| CA3099917A1 (en) * | 2018-05-24 | 2019-11-28 | Ares Trading S.A. | Method for controlling the afucosylation level of a glycoprotein composition |
| HUP1800376A2 (hu) | 2018-11-07 | 2020-05-28 | Richter Gedeon Nyrt | Sejttenyészetben elõállított rekombináns glikoprotein glikozilációs-mintázatának megváltoztatására szolgáló módszer |
| EP3880824A4 (en) * | 2018-11-13 | 2022-08-10 | Janssen Biotech, Inc. | REGULATION OF TRACE METALS DURING ANTI-CD38 ANTIBODY PRODUCTION |
| JP2020188737A (ja) * | 2019-05-23 | 2020-11-26 | 東ソー株式会社 | 抗体依存性細胞傷害活性が向上した抗体の製造方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| IL87737A (en) | 1987-09-11 | 1993-08-18 | Genentech Inc | Method for culturing polypeptide factor dependent vertebrate recombinant cells |
| US5705364A (en) * | 1995-06-06 | 1998-01-06 | Genentech, Inc. | Mammalian cell culture process |
| US6030945A (en) | 1996-01-09 | 2000-02-29 | Genentech, Inc. | Apo-2 ligand |
| EP2243827B2 (en) | 1996-08-30 | 2017-11-22 | Life Technologies Corporation | Serum-free mammalian cell culture medium, and uses thereof |
| DE69929198T2 (de) | 1998-05-29 | 2006-08-10 | Genentech, Inc., South San Francisco | Zellkulturverfahren für die produktion von glycoproteinen |
| JP2001120262A (ja) | 1999-10-26 | 2001-05-08 | Welfide Corp | 生理活性物質の産生増強方法 |
| US6900056B2 (en) | 2001-02-15 | 2005-05-31 | Centocor, Inc. | Chemically defined medium for cultured mammalian cells |
| US20050287666A1 (en) * | 2004-06-29 | 2005-12-29 | Invitrogen Corporation | Cell culture medium comprising transition metals or trace elements |
| US7294484B2 (en) | 2004-08-27 | 2007-11-13 | Wyeth Research Ireland Limited | Production of polypeptides |
| DE602005026548D1 (de) | 2004-11-02 | 2011-04-07 | Ares Trading Sa | Serumfreies kulturmedium für säugerzellen |
| US20070231895A1 (en) | 2005-11-02 | 2007-10-04 | Lee Gene W | Methods for adapting mammalian cells |
| EP4155385A1 (en) * | 2005-12-08 | 2023-03-29 | Amgen Inc. | Improved production of glycoproteins using manganese |
| KR101495549B1 (ko) * | 2006-07-13 | 2015-02-25 | 와이어쓰 엘엘씨 | 당단백질의 생산 |
| CA2666317C (en) | 2006-11-03 | 2013-08-06 | Wyeth | Glycolysis-inhibiting substances in cell culture |
| JP5586235B2 (ja) | 2007-03-02 | 2014-09-10 | ワイス・エルエルシー | ポリペプチドの産生のための細胞培養における銅およびグルタミン酸塩の使用 |
| US20110053223A1 (en) | 2009-08-14 | 2011-03-03 | Robert Bayer | Cell culture methods to make antibodies with enhanced adcc function |
| US20120309056A1 (en) * | 2010-02-04 | 2012-12-06 | Leon Arnaud | Fed-batch process using concentrated cell culture medium for the efficient production of biologics in eb66 cells |
| CA2795461C (en) | 2010-04-26 | 2018-04-24 | Novartis Ag | Improved cell cultivation process |
| EP2702077A2 (en) | 2011-04-27 | 2014-03-05 | AbbVie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| RU2592680C2 (ru) | 2011-04-29 | 2016-07-27 | Биокон Рисерч Лимитед | Способ снижения накопления лактата при культивировании и способ получения антитела |
| US10059770B2 (en) * | 2012-01-30 | 2018-08-28 | Dr. Reddy's Laboratories Limited | Process of modulating man5 and/or afucosylation content of a glycoprotein composition |
| US9598667B2 (en) | 2013-10-04 | 2017-03-21 | Abbvie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| RU2712562C2 (ru) * | 2014-02-27 | 2020-01-29 | Ф.Хоффманн-Ля Рош Аг | Модулирование клеточного роста и гликозилирования при производстве рекомбинантных гликопротеинов |
-
2015
- 2015-02-24 RU RU2016138176A patent/RU2712562C2/ru active
- 2015-02-24 BR BR112016017660-0A patent/BR112016017660B1/pt active IP Right Grant
- 2015-02-24 PL PL15709430T patent/PL3110961T3/pl unknown
- 2015-02-24 EP EP15709430.1A patent/EP3110961B1/en active Active
- 2015-02-24 CA CA2937611A patent/CA2937611C/en active Active
- 2015-02-24 JP JP2016554322A patent/JP6831702B2/ja active Active
- 2015-02-24 ES ES15709430T patent/ES2769003T3/es active Active
- 2015-02-24 SG SG11201606856SA patent/SG11201606856SA/en unknown
- 2015-02-24 RS RS20200090A patent/RS59881B1/sr unknown
- 2015-02-24 MX MX2016010236A patent/MX369395B/es active IP Right Grant
- 2015-02-24 WO PCT/EP2015/053804 patent/WO2015128314A1/en active Application Filing
- 2015-02-24 CN CN201580010823.5A patent/CN106133146B/zh active Active
- 2015-02-24 PT PT157094301T patent/PT3110961T/pt unknown
- 2015-02-24 HU HUE15709430A patent/HUE047575T2/hu unknown
- 2015-02-24 SI SI201531071T patent/SI3110961T1/sl unknown
- 2015-02-24 DK DK15709430.1T patent/DK3110961T3/da active
- 2015-02-24 LT LTEP15709430.1T patent/LT3110961T/lt unknown
- 2015-02-24 KR KR1020167026630A patent/KR102280638B1/ko active IP Right Grant
-
2016
- 2016-08-12 US US15/236,348 patent/US20170058309A1/en not_active Abandoned
-
2019
- 2019-11-27 JP JP2019214046A patent/JP6934507B2/ja active Active
-
2020
- 2020-01-21 HR HRP20200100TT patent/HRP20200100T1/hr unknown
- 2020-08-28 US US17/006,463 patent/US20210222220A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3110961B1 (en) | 2019-11-27 |
| US20170058309A1 (en) | 2017-03-02 |
| PL3110961T3 (pl) | 2020-04-30 |
| JP6831702B2 (ja) | 2021-02-17 |
| BR112016017660A2 (lt) | 2017-08-08 |
| SI3110961T1 (sl) | 2020-03-31 |
| KR20160125514A (ko) | 2016-10-31 |
| US20210222220A1 (en) | 2021-07-22 |
| KR102280638B1 (ko) | 2021-07-22 |
| HUE047575T2 (hu) | 2020-04-28 |
| MX2016010236A (es) | 2016-10-13 |
| EP3110961A1 (en) | 2017-01-04 |
| CA2937611A1 (en) | 2015-09-03 |
| CA2937611C (en) | 2023-01-03 |
| ES2769003T3 (es) | 2020-06-24 |
| RU2016138176A (ru) | 2018-03-29 |
| HRP20200100T1 (hr) | 2020-04-03 |
| SG11201606856SA (en) | 2016-09-29 |
| JP6934507B2 (ja) | 2021-09-15 |
| WO2015128314A1 (en) | 2015-09-03 |
| BR112016017660B1 (pt) | 2022-04-19 |
| MX369395B (es) | 2019-11-07 |
| RU2712562C2 (ru) | 2020-01-29 |
| RS59881B1 (sr) | 2020-03-31 |
| CN106133146A (zh) | 2016-11-16 |
| CN106133146B (zh) | 2021-05-04 |
| JP2020054351A (ja) | 2020-04-09 |
| DK3110961T3 (da) | 2020-02-03 |
| RU2016138176A3 (lt) | 2018-10-29 |
| PT3110961T (pt) | 2020-01-29 |
| JP2017506515A (ja) | 2017-03-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG11201606856SA (en) | Modulation of cell growth and glycosylation in recombinant glycoprotein production | |
| HK1252582A1 (zh) | 具有增强的細胞毒性的修飾的天然殺傷細胞和天然殺傷細胞系 | |
| IL253248A0 (en) | Natural killer cells and their uses | |
| IL258666A (en) | Natural killer cells and ilc3 cells and their use | |
| SG11201609118RA (en) | Modified natural killer cells and uses thereof | |
| ZA201605308B (en) | Plant growth promoting rhizobacterial strains and their uses | |
| IL252788B (en) | Preparation methods of long-acting growth hormones based on ctp-adapted polypeptides | |
| IL263779A (en) | Protein production in plant cells | |
| HK1223980A1 (zh) | 改進的重組多肽生產方法 | |
| HK1245297A1 (zh) | 提高重組蛋白產量的方法 | |
| DK3242935T3 (da) | O-glycansialylerede rekombinante glycoproteiner og cellelinjer til fremstilling deraf | |
| HK1220492A1 (zh) | 重組多肽生產 | |
| IL247776A0 (en) | Methods for the production of substituted glycoproteins with adapted glycosylation | |
| IL250530A0 (en) | Production of functional and fully processed factor x in a mammalian purine-secreting expression system | |
| EP3322429B8 (en) | Growth promoting peptides and uses thereof | |
| SI3289088T1 (sl) | Odklop rasti in proizvodnja proteina | |
| HK1220991A1 (zh) | 用於增加的重組蛋白產生的製劑和方法 | |
| ZA201700867B (en) | Modifying protein production in plants | |
| PL3158055T3 (pl) | Ulepszone wytwarzanie rekombinowanego czynnika von Willebranda w bioreaktorze | |
| HK1259030A1 (zh) | 具有抗趨除特性的修飾的天然殺傷細胞及其用途 | |
| GB201308120D0 (en) | Recombinant protein and method for its production | |
| DE112015003749A5 (de) | Peptid zur verwendung in der reduktion von nebenwirkungen in form von immunstimulatorischen reaktionen/effekten | |
| GB201308218D0 (en) | Chlor-Alkali Process and Plant |