FI113870B - Menetelmä terapeuttisesti käyttökelpoisten rungosta modifioitujen oligonukleotidianalogien valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten rungosta modifioitujen oligonukleotidianalogien valmistamiseksi Download PDF

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Publication number
FI113870B
FI113870B FI935113A FI935113A FI113870B FI 113870 B FI113870 B FI 113870B FI 935113 A FI935113 A FI 935113A FI 935113 A FI935113 A FI 935113A FI 113870 B FI113870 B FI 113870B
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Finland
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mol
compound
added
nucleoside
mmol
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FI935113A
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English (en)
Finnish (fi)
Swedish (sv)
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FI935113A0 (fi
FI935113A (fi
Inventor
Jacques Lebreton
Adrian Waldner
Phillip Dan Cook
Mesmaeker Alain De
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Novartis Ag
Isis Pharmaceuticals Inc
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Application filed by Novartis Ag, Isis Pharmaceuticals Inc filed Critical Novartis Ag
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)
  • Organic Insulating Materials (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
FI935113A 1991-05-21 1993-11-18 Menetelmä terapeuttisesti käyttökelpoisten rungosta modifioitujen oligonukleotidianalogien valmistamiseksi FI113870B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70361991 1991-05-21
US07/703,619 US5378825A (en) 1990-07-27 1991-05-21 Backbone modified oligonucleotide analogs
US9204305 1992-05-21
PCT/US1992/004305 WO1992020823A1 (fr) 1991-05-21 1992-05-21 Analogues d'oligonucleotides a squelette modifie

Publications (3)

Publication Number Publication Date
FI935113A0 FI935113A0 (fi) 1993-11-18
FI935113A FI935113A (fi) 1994-01-03
FI113870B true FI113870B (fi) 2004-06-30

Family

ID=24826111

Family Applications (2)

Application Number Title Priority Date Filing Date
FI935113A FI113870B (fi) 1991-05-21 1993-11-18 Menetelmä terapeuttisesti käyttökelpoisten rungosta modifioitujen oligonukleotidianalogien valmistamiseksi
FI935114A FI935114A (fi) 1991-05-21 1993-11-18 Oligonukleotidanaloger med modifierad stomme

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI935114A FI935114A (fi) 1991-05-21 1993-11-18 Oligonukleotidanaloger med modifierad stomme

Country Status (14)

Country Link
US (1) US5378825A (fr)
EP (3) EP1004593A3 (fr)
JP (2) JP2625257B2 (fr)
KR (2) KR0156945B1 (fr)
AT (2) ATE191933T1 (fr)
AU (2) AU666121B2 (fr)
BR (2) BR9206027A (fr)
CA (2) CA2103464A1 (fr)
DE (2) DE69231441T2 (fr)
FI (2) FI113870B (fr)
HU (2) HUT65941A (fr)
IE (2) IE921850A1 (fr)
NO (2) NO308703B1 (fr)
WO (2) WO1992020822A1 (fr)

Families Citing this family (593)

* Cited by examiner, † Cited by third party
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KR0156945B1 (ko) 1998-10-15
IE921850A1 (en) 1992-12-02
KR0155574B1 (ko) 1998-10-15
EP1004593A3 (fr) 2000-07-19
DE69230935T2 (de) 2000-10-19
NO934180D0 (no) 1993-11-18
JPH06504067A (ja) 1994-05-12
WO1992020822A1 (fr) 1992-11-26
FI935114A (fi) 1993-12-30
US5378825A (en) 1995-01-03
EP0586570B1 (fr) 2000-09-13
HUT66378A (en) 1994-11-28
JP2711180B2 (ja) 1998-02-10
FI935113A0 (fi) 1993-11-18
DE69230935D1 (de) 2000-05-25
JPH06503838A (ja) 1994-04-28
NO934179L (no) 1994-01-12
EP0586520A1 (fr) 1994-03-16
EP1004593A2 (fr) 2000-05-31
CA2103464A1 (fr) 1992-11-22
AU666121B2 (en) 1996-02-01
EP0586570A1 (fr) 1994-03-16
NO934180L (no) 1994-01-11
AU2150292A (en) 1992-12-30
AU1998692A (en) 1992-12-30
AU662538B2 (en) 1995-09-07
BR9206026A (pt) 1994-12-27
ATE191933T1 (de) 2000-05-15
ATE196321T1 (de) 2000-09-15
NO934179D0 (no) 1993-11-18
IE921849A1 (en) 1992-12-02
HU9303290D0 (en) 1994-03-28
EP0586520B1 (fr) 2000-04-19
DE69231441D1 (de) 2000-10-19
EP0586520A4 (en) 1996-01-10
HU221806B1 (hu) 2003-01-28
EP0586570A4 (en) 1996-01-24
JP2625257B2 (ja) 1997-07-02
WO1992020823A1 (fr) 1992-11-26
FI935113A (fi) 1994-01-03
DE69231441T2 (de) 2001-03-22
BR9206027A (pt) 1994-12-27
NO308703B1 (no) 2000-10-16
HUT65941A (en) 1994-08-29
HU9303289D0 (en) 1994-03-28
CA2103378A1 (fr) 1992-11-22
FI935114A0 (fi) 1993-11-18

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