EP3833762A4 - Compositions oligonucléotidiques pour cibler ccr2 et csf1r et leurs utilisations - Google Patents

Compositions oligonucléotidiques pour cibler ccr2 et csf1r et leurs utilisations Download PDF

Info

Publication number
EP3833762A4
EP3833762A4 EP19846282.2A EP19846282A EP3833762A4 EP 3833762 A4 EP3833762 A4 EP 3833762A4 EP 19846282 A EP19846282 A EP 19846282A EP 3833762 A4 EP3833762 A4 EP 3833762A4
Authority
EP
European Patent Office
Prior art keywords
csf1r
oligonucleotide compositions
ccr2
targeting
targeting ccr2
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19846282.2A
Other languages
German (de)
English (en)
Other versions
EP3833762A1 (fr
Inventor
Tatiana I. NOVOBRANTSEVA
Kevin KAUFFMAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Verseau Therapeutics Inc
Original Assignee
Verseau Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Verseau Therapeutics Inc filed Critical Verseau Therapeutics Inc
Publication of EP3833762A1 publication Critical patent/EP3833762A1/fr
Publication of EP3833762A4 publication Critical patent/EP3833762A4/fr
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/10—Applications; Uses in screening processes
    • C12N2320/11—Applications; Uses in screening processes for the determination of target sites, i.e. of active nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific
EP19846282.2A 2018-08-09 2019-08-09 Compositions oligonucléotidiques pour cibler ccr2 et csf1r et leurs utilisations Pending EP3833762A4 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862716671P 2018-08-09 2018-08-09
PCT/US2019/045841 WO2020033791A1 (fr) 2018-08-09 2019-08-09 Compositions oligonucléotidiques pour cibler ccr2 et csf1r et leurs utilisations

Publications (2)

Publication Number Publication Date
EP3833762A1 EP3833762A1 (fr) 2021-06-16
EP3833762A4 true EP3833762A4 (fr) 2022-09-28

Family

ID=69413677

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19846282.2A Pending EP3833762A4 (fr) 2018-08-09 2019-08-09 Compositions oligonucléotidiques pour cibler ccr2 et csf1r et leurs utilisations

Country Status (4)

Country Link
US (1) US20210317461A1 (fr)
EP (1) EP3833762A4 (fr)
JP (1) JP2021534101A (fr)
WO (1) WO2020033791A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11642629B2 (en) * 2020-03-20 2023-05-09 Saudi Arabian Oil Company Multi-layer composite gas separation membranes, methods for preparation, and use
US20220025436A1 (en) * 2020-07-21 2022-01-27 Rutgers, The State University Of New Jersey Method and Kit For CCR2 Expression Profiling And Disease Stratification
DE202022002866U1 (de) * 2021-04-01 2024-03-20 The Regents Of The University Of California Genetische Modifikation von Säugetierzellen zur Verleihung von Resistenz gegen CSF1R-Antagonisten

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140200259A1 (en) * 2006-02-23 2014-07-17 Novartis Ag RNAi-MEDIATED INHIBITION OF SELECT RECEPTOR TYROSINE KINASES FOR TREATMENT OF PATHOLOGIC OCULAR NEOVASCULARIZATION-RELATED CONDITIONS

Family Cites Families (195)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7569A (en) 1850-08-13 Improvement in ship-ventilators
US575A (en) 1838-01-20 Benjamin iapham
US815A (en) 1838-06-30 Improved cooking-stove for summer
US8748A (en) 1852-02-17 Improvement in weighing-machines
US5047533A (en) 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US5550111A (en) 1984-07-11 1996-08-27 Temple University-Of The Commonwealth System Of Higher Education Dual action 2',5'-oligoadenylate antiviral derivatives and uses thereof
US5208036A (en) 1985-01-07 1993-05-04 Syntex (U.S.A.) Inc. N-(ω, (ω-1)-dialkyloxy)- and N-(ω, (ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
EP0215942B1 (fr) 1985-03-15 1995-07-12 Antivirals Inc. Reactif et procede d'analyse de polynucleotides
US5235033A (en) 1985-03-15 1993-08-10 Anti-Gene Development Group Alpha-morpholino ribonucleoside derivatives and polymers thereof
US4902505A (en) 1986-07-30 1990-02-20 Alkermes Chimeric peptides for neuropeptide delivery through the blood-brain barrier
US4904582A (en) 1987-06-11 1990-02-27 Synthetic Genetics Novel amphiphilic nucleic acid conjugates
JPH03503894A (ja) 1988-03-25 1991-08-29 ユニバーシィティ　オブ　バージニア　アランミ　パテンツ　ファウンデイション オリゴヌクレオチド　ｎ‐アルキルホスホラミデート
US5587361A (en) 1991-10-15 1996-12-24 Isis Pharmaceuticals, Inc. Oligonucleotides having phosphorothioate linkages of high chiral purity
US5321131A (en) 1990-03-08 1994-06-14 Hybridon, Inc. Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling
US5279833A (en) 1990-04-04 1994-01-18 Yale University Liposomal transfection of nucleic acids into animal cells
US5264618A (en) 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
US5851795A (en) 1991-06-27 1998-12-22 Bristol-Myers Squibb Company Soluble CTLA4 molecules and uses thereof
US5697248A (en) 1991-07-25 1997-12-16 The Whitaker Corporation Liquid level sensor
US5571799A (en) 1991-08-12 1996-11-05 Basco, Ltd. (2'-5') oligoadenylate analogues useful as inhibitors of host-v5.-graft response
US5283185A (en) 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
US5359044A (en) 1991-12-13 1994-10-25 Isis Pharmaceuticals Cyclobutyl oligonucleotide surrogates
WO1994018987A1 (fr) 1993-02-19 1994-09-01 Nippon Shinyaku Co., Ltd. Composition medicinale renfermant un copolymere d'acide nucleique
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5587384A (en) 1994-02-04 1996-12-24 The Johns Hopkins University Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity
US5625050A (en) 1994-03-31 1997-04-29 Amgen Inc. Modified oligonucleotides and intermediates useful in nucleic acid therapeutics
US5820873A (en) 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
EP1179340A3 (fr) 1994-09-30 2003-05-07 INEX Pharmaceutical Corp. Compositions d' introduction de substances polyanioniques dans des cellules
US5753613A (en) 1994-09-30 1998-05-19 Inex Pharmaceuticals Corporation Compositions for the introduction of polyanionic materials into cells
US5795587A (en) 1995-01-23 1998-08-18 University Of Pittsburgh Stable lipid-comprising drug delivery complexes and methods for their production
US5830430A (en) 1995-02-21 1998-11-03 Imarx Pharmaceutical Corp. Cationic lipids and the use thereof
US5998203A (en) 1996-04-16 1999-12-07 Ribozyme Pharmaceuticals, Inc. Enzymatic nucleic acids containing 5'-and/or 3'-cap structures
US5994316A (en) 1996-02-21 1999-11-30 The Immune Response Corporation Method of preparing polynucleotide-carrier complexes for delivery to cells
SE9600820D0 (sv) 1996-03-01 1996-03-01 Pharmacia Ab Antibodies and their use
US6008334A (en) 1996-07-24 1999-12-28 The Board Of Regents Of The University Of Oklahoma Base-protected nucleotide analogs with protected thiol groups
JP3756313B2 (ja) 1997-03-07 2006-03-15 武 今西 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
US6770748B2 (en) 1997-03-07 2004-08-03 Takeshi Imanishi Bicyclonucleoside and oligonucleotide analogue
JP2001523958A (ja) 1997-03-21 2001-11-27 ブライハム アンド ウィミンズ ホスピタル，インコーポレイテッド 免疫療法のｃｔｌａ−４結合ペプチド
US6794499B2 (en) 1997-09-12 2004-09-21 Exiqon A/S Oligonucleotide analogues
US6004573A (en) 1997-10-03 1999-12-21 Macromed, Inc. Biodegradable low molecular weight triblock poly(lactide-co-glycolide) polyethylene glycol copolymers having reverse thermal gelation properties
US6517869B1 (en) 1997-12-12 2003-02-11 Expression Genetics, Inc. Positively charged poly(alpha-(omega-aminoalkyl)lycolic acid) for the delivery of a bioactive agent via tissue and cellular uptake
ZA9811377B (en) 1997-12-12 1999-08-27 Expression Genetics Inc Positively charged poly[alpha-(omega-aminoalkyl) glycolic acid[ for the delivery of a bioactive agent via tissue and cellular uptake.
US6320017B1 (en) 1997-12-23 2001-11-20 Inex Pharmaceuticals Corp. Polyamide oligomers
MXPA00011312A (es) 1998-05-20 2003-04-22 Expression Genetics Inc Un vehiculo de gen polimerico de poli-l.lisina injertada con polietilenglicol con porcion de enfoque hepatocitos.
US6833361B2 (en) 1998-05-26 2004-12-21 Ribapharm, Inc. Nucleosides having bicyclic sugar moiety
SK17432000A3 (sk) 1998-05-26 2001-07-10 Icn Pharmaceuticals, Inc. Zlúčenina, ktorá zahŕňa nukleozid s 2',4'-mostíkom a oligonukleotid z nej odvodený
CN1313873A (zh) 1998-07-13 2001-09-19 表达遗传学公司 作为可溶性,生物可降解基因送递载体的聚－l－赖氨酸的聚酯类似物
US6696550B2 (en) 1998-07-23 2004-02-24 Millennium Pharmaceuticals, Inc. Humanized anti-CCR2 antibodies and methods of use therefor
US6727349B1 (en) 1998-07-23 2004-04-27 Millennium Pharmaceuticals, Inc. Recombinant anti-CCR2 antibodies and methods of use therefor
US6312689B1 (en) 1998-07-23 2001-11-06 Millennium Pharmaceuticals, Inc. Anti-CCR2 antibodies and methods of use therefor
US7109003B2 (en) 1998-12-23 2006-09-19 Abgenix, Inc. Methods for expressing and recovering human monoclonal antibodies to CTLA-4
US6682736B1 (en) 1998-12-23 2004-01-27 Abgenix, Inc. Human monoclonal antibodies to CTLA-4
CN1361829A (zh) 1999-03-18 2002-07-31 埃克西库恩公司 利用特异性lna引物检测基因突变
US6761883B2 (en) 1999-06-29 2004-07-13 The Board Of Trustees Of The Leland Stanford Junior University Mammalian myeloid progenitor cell subsets
AU774876B2 (en) 1999-06-29 2004-07-08 Board Of Trustees Of The Leland Stanford Junior University Mammalian myeloid progenitor cell subsets
US6808710B1 (en) 1999-08-23 2004-10-26 Genetics Institute, Inc. Downmodulating an immune response with multivalent antibodies to PD-1
CA2383424C (fr) 1999-08-23 2011-02-15 Gordon Freeman Nouvelles molecules b7-4 et leurs utilisations
EP2829609A1 (fr) 1999-08-24 2015-01-28 E. R. Squibb & Sons, L.L.C. Anticorps CTLA-4 humains et leurs utilisations
US7605238B2 (en) 1999-08-24 2009-10-20 Medarex, Inc. Human CTLA-4 antibodies and their uses
AU2001233027A1 (en) 2000-01-27 2001-08-07 Genetics Institute, Llc Antibodies against ctla4 (cd152), conjugates comprising same, and uses thereof
WO2001078653A2 (fr) 2000-04-14 2001-10-25 Millennium Pharmaceuticals, Inc. Traitement du rejet de greffe au moyen d'inhibiteurs de la fonction ccr2
GB0016258D0 (en) 2000-07-03 2000-08-23 Amersham Pharm Biotech Uk Ltd Base analogues
US6696038B1 (en) 2000-09-14 2004-02-24 Expression Genetics, Inc. Cationic lipopolymer as biocompatible gene delivery agent
EP1334109B1 (fr) 2000-10-04 2006-05-10 Santaris Pharma A/S Synthese perfectionnee d'analogues d'acides nucleiques bloques de purine
US6998115B2 (en) 2000-10-10 2006-02-14 Massachusetts Institute Of Technology Biodegradable poly(β-amino esters) and uses thereof
US6652886B2 (en) 2001-02-16 2003-11-25 Expression Genetics Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
EP1446412B1 (fr) 2001-09-04 2012-03-07 Exiqon A/S Compositions d'acides nucleiques verrouilles et utilisations
US7569575B2 (en) 2002-05-08 2009-08-04 Santaris Pharma A/S Synthesis of locked nucleic acid derivatives
ATE539146T1 (de) 2002-09-13 2012-01-15 Univ Leland Stanford Junior Säugetier-megakaryozytenstammzelle
SI1558648T1 (sl) 2002-10-17 2012-05-31 Genmab As Človeška monoklonalna protitelesa proti CD
JP4511943B2 (ja) 2002-12-23 2010-07-28 ワイス エルエルシー Ｐｄ−１に対する抗体およびその使用
WO2004069809A1 (fr) 2003-02-03 2004-08-19 Janssen Pharmaceutica N.V. Mercaptoimidazoles en tant qu'agonistes du recepteur ccr2
WO2004073684A2 (fr) 2003-02-14 2004-09-02 Children's Hospital & Research Center At Oakland Vehicule d'administration de medicament lipophile et methodes d'utilisation correspondantes
US7465446B2 (en) 2003-05-30 2008-12-16 Medarex, Inc. Surrogate therapeutic endpoint for anti-CTLA4-based immunotherapy of disease
WO2004110139A1 (fr) 2003-06-16 2004-12-23 Kyushu Tlo Company, Limited Methode permettant de produire des cellules immunocompetentes d'origine humaine
JP2007521248A (ja) 2003-12-10 2007-08-02 ミレニアム ファーマシューティカルズ， インコーポレイテッド ヒト化抗ｃｃｒ２抗体および該抗体を使用する方法
US8034619B2 (en) 2003-12-19 2011-10-11 University Of Cincinnati Polyamides for nucleic acid delivery
WO2005101002A1 (fr) * 2004-04-13 2005-10-27 Bayer Healthcare Ag Agents diagnostiques et therapeutiques de maladies associees au recepteur 2 de c-c chimiokine (ccr2)
WO2006097793A2 (fr) 2004-04-15 2006-09-21 Chiasma, Ltd. Compositions capables de faciliter la penetration a travers une barriere biologique
AR049386A1 (es) 2004-05-26 2006-07-26 Janssen Pharmaceutica Nv Mercaptoimidazoles como antagonistas del receptor ccr2
EP1781593B1 (fr) 2004-06-07 2011-12-14 Protiva Biotherapeutics Inc. Lipides cationiques et leurs procédés d'utilisation
CA2571587C (fr) 2004-06-25 2013-02-12 Janssen Pharmaceutica, N.V. Antagonistes de ccr2 a base de sels quaternaires
US8057821B2 (en) 2004-11-03 2011-11-15 Egen, Inc. Biodegradable cross-linked cationic multi-block copolymers for gene delivery and methods of making thereof
US7622583B2 (en) 2005-01-14 2009-11-24 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2
US7404969B2 (en) 2005-02-14 2008-07-29 Sirna Therapeutics, Inc. Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
WO2007086883A2 (fr) 2005-02-14 2007-08-02 Sirna Therapeutics, Inc. Compositions à base de nanoparticules lipidiques et méthodes pour l'administration de molécules biologiquement actives
ES2332062T3 (es) 2005-04-01 2010-01-25 Intezyne Technologies Incorporated Micelas polimericas para el suministro de farmacos.
LT2439273T (lt) 2005-05-09 2019-05-10 Ono Pharmaceutical Co., Ltd. Žmogaus monokloniniai antikūnai prieš programuotos mirties 1(pd-1) baltymą, ir vėžio gydymo būdai, naudojant vien tik anti-pd-1 antikūnus arba derinyje su kitais imunoterapiniais vaistais
US7368439B2 (en) 2005-06-15 2008-05-06 Bar - Ilan University Dinucleoside poly(borano)phosphate derivatives and uses thereof
CN105330741B (zh) 2005-07-01 2023-01-31 E.R.施贵宝&圣斯有限责任公司 抗程序性死亡配体1(pd-l1)的人单克隆抗体
WO2007014008A2 (fr) 2005-07-22 2007-02-01 Glaxo Group Limted Inhibiteur benzenesulfonamide de recepteur de chimiokine ccr2
US7737273B2 (en) 2005-07-26 2010-06-15 Hetero Drugs Limited Process for acyclic phosphonate nucleotide analogs
CA2636149A1 (fr) 2006-01-05 2007-07-19 Novartis Ag Methodes pour prevenir et traiter des metastases de cancer et des pertes osseuses associees a des metastases de cancer
AU2007204617A1 (en) 2006-01-12 2007-07-19 Massachusetts Institute Of Technology Biodegradable elastomers
WO2007130712A1 (fr) 2006-01-31 2007-11-15 Janssen Pharmaceutica, Nv Composes dipiperidiniques substitues utilises en tant qu'agonistes de ccr2 dans le cadre du traitement de maladies inflammatoires
WO2007125173A2 (fr) 2006-05-03 2007-11-08 Baltic Technology Development, Ltd. Agents antisens combinant un oligonucléotide modifié par une base fortement liée et une nucléase artificielle
US20090297502A1 (en) 2006-06-15 2009-12-03 Li Li Ccr2 antagonists for chronic organ transplantation rejection
US8519135B2 (en) 2006-07-14 2013-08-27 Chemocentryx, Inc. Heteroaryl sulfonamides and CCR2/CCR9
US20100234364A1 (en) 2006-07-14 2010-09-16 Arindrajit Basak Ccr2 inhibitors and methods of use thereof
CN101511800B (zh) 2006-07-14 2013-02-27 坎莫森特里克斯公司 三唑基苯基苯磺酰胺
DK2068886T3 (da) 2006-10-03 2013-11-18 Tekmira Pharmaceuticals Corp Lipidholdige præparater
CN101583379B (zh) 2006-10-05 2013-04-03 约翰斯霍普金斯大学 使用优良聚合物纳米粒子的水溶性差药物的水可分散性口服，肠胃外和局部制剂
WO2008103276A2 (fr) 2007-02-16 2008-08-28 Merck & Co., Inc. Compositions et méthodes de potentialisation de l'activité de molécules biologiquement actives
WO2008109238A1 (fr) 2007-03-02 2008-09-12 Janssen Pharmaceutica N.V. Cyclopentylpipéridines substituées antagonistes du ccr2
EP2136788B1 (fr) 2007-03-30 2011-10-26 Bind Biosciences, Inc. Ciblage de cellules cancéreuses utilisant des nanoparticules
US7678894B2 (en) 2007-05-18 2010-03-16 Helicos Biosciences Corporation Nucleotide analogs
MY153691A (en) 2007-05-22 2015-03-13 Arcturus Therapeutics Inc Hydroxymethyl substituted rna oligonucleotides and rna complexes
BRPI0813695B8 (pt) 2007-07-12 2021-05-25 Chemocentryx Inc compostos de heteroaril piridil e fenil benzenossulfonamidas fundidas, composição, método de modular a função de ccr2, usos dos compostos e forma cristalina
US20110262425A1 (en) 2007-12-12 2011-10-27 National Cancer Center Therapeutic agent for mll leukemia and moz leukemia of which molecular target is m-csf receptor, and use thereof
EP2262837A4 (fr) 2008-03-12 2011-04-06 Merck Sharp & Dohme Protéines de liaison avec pd-1
JP2012501966A (ja) 2008-06-16 2012-01-26 バインド バイオサイエンシズ インコーポレイテッド ビンカアルカロイド含有治療用ポリマーナノ粒子並びにその製造方法及び使用方法
AU2009268923B2 (en) 2008-06-16 2015-09-17 Pfizer Inc. Drug loaded polymeric nanoparticles and methods of making and using same
EP2285350B1 (fr) 2008-06-16 2017-11-15 Pfizer Inc Procédés pour la préparation de copolymères diblocs fonctionnalisés avec un agent de ciblage destinés à être utilisés dans la fabrication de nanoparticules thérapeutiques
AU2009271436B2 (en) 2008-06-23 2014-04-03 Janssen Pharmaceutica Nv Piperidyl acrylamide antagonists of CCR2
US20110224447A1 (en) 2008-08-18 2011-09-15 Bowman Keith A Novel Lipid Nanoparticles and Novel Components for Delivery of Nucleic Acids
WO2010021697A2 (fr) 2008-08-18 2010-02-25 Pfizer Inc. Anticorps anti-ccr2
WO2010030763A2 (fr) 2008-09-10 2010-03-18 Bind Biosciences, Inc. Fabrication de nanoparticles à rendement élevé
ES2592216T3 (es) 2008-09-26 2016-11-28 Dana-Farber Cancer Institute, Inc. Anticuerpos anti-PD-1, PD-L1 y PD-L2 humanos y sus usos
JP6087504B2 (ja) 2008-11-07 2017-03-01 マサチューセッツ インスティテュート オブ テクノロジー アミノアルコールリピドイドおよびその使用
HUE037082T2 (hu) 2008-11-10 2018-08-28 Arbutus Biopharma Corp Új lipidek és készítmények terápiás hatóanyagok szállítására
WO2010054384A1 (fr) 2008-11-10 2010-05-14 Alnylam Pharmaceuticals, Inc. Lipides et compositions pour l’administration d’agents thérapeutiques
WO2010062399A2 (fr) 2008-11-26 2010-06-03 Five Prime Therapeutics, Inc. Molécules de fusion de domaine extracellulaire de csf1r et traitements utilisant celles-ci
BRPI0922355A8 (pt) 2008-12-03 2017-12-12 Marina Biotech Inc Ácidos nucléicos, métodos para reduzir a expressão de um gene em uma célula in vitro, uso do ácido nucléico, complexo de rna e uso do complexo de rna
SI2376535T1 (sl) 2008-12-09 2017-07-31 F. Hoffmann-La Roche Ag Protitelesa anti-pd-l1 in njihova uporaba za izboljšanje funkcije celic t
WO2010080724A1 (fr) 2009-01-12 2010-07-15 Merck Sharp & Dohme Corp. Nanoparticules lipidiques inédites et composants inédits utilisables pour l'administration d'acides nucléiques
WO2010101870A1 (fr) 2009-03-03 2010-09-10 St. Jude Children's Research Hospital Compositions et méthodes de génération de lymphocytes t régulateurs induits par l'interleukine-35
CN104922676B (zh) 2009-03-20 2019-03-12 Clsn实验室股份有限公司 聚胺衍生物
WO2010127159A2 (fr) 2009-04-30 2010-11-04 Intezyne Technologies, Incorporated Micelles polymères pour l'encapsulation de polynucléotides
AU2010254550B2 (en) 2009-05-27 2015-10-15 Selecta Biosciences, Inc. Targeted synthetic nanocarriers with pH sensitive release of immunomodulatory agents
DK2440183T3 (en) 2009-06-10 2018-10-01 Arbutus Biopharma Corp Improved lipid formulation
CA2767127A1 (fr) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Formulations lipidiques inedites permettant l'administration d'agents therapeutiques en direction de tumeurs solides
KR101151415B1 (ko) 2009-07-10 2012-06-01 양지화학 주식회사 Ｃｃｒ２ 길항제로서의 피페라지닐에틸 3-아미노피롤리딘 유도체
US20110038871A1 (en) * 2009-08-11 2011-02-17 Veena Viswanth Ccr2 inhibitors for treating conditions of the eye
WO2011022460A1 (fr) 2009-08-20 2011-02-24 Merck Sharp & Dohme Corp. Nouveaux lipides cationiques avec différents groupes de tête pour délivrance d’oligonucléotide
EP2470533A4 (fr) 2009-08-24 2013-01-23 Ascepion Pharmaceuticals Inc Composés d'urée contenant un groupe hétéroaryle 5,6-bicyclique
US8828975B2 (en) 2009-09-25 2014-09-09 National Cheng-Kung University Phosphate-containing nanoparticle delivery vehicle
US8471004B2 (en) 2009-10-07 2013-06-25 Hoffman-La Roche Inc. Bicyclic compounds
EP2485770A4 (fr) 2009-10-08 2013-04-10 Merck Sharp & Dohme Nouveaux lipides cationiques à chaînes lipidiques courtes pour une administration d'oligonucléotides
WO2011050467A1 (fr) 2009-11-02 2011-05-05 Mold-Masters (2007) Limited Base de données pour moule à injection et intégration avec une machine de moulage par injection et des composants auxiliaires
ES2721898T3 (es) 2009-12-11 2019-08-06 Pfizer Formulaciones estables para liofilizar partículas terapéuticas
WO2011084513A2 (fr) 2009-12-15 2011-07-14 Bind Biosciences, Inc. Compositions de nanoparticules polymères à visée thérapeutique à base de copolymères à température de transition vitreuse élevée ou poids moléculaires élevés
US8429390B2 (en) 2009-12-24 2013-04-23 Insyde Software Corp. Method for performing quick boot and general boot at bios stage
EP2525781A1 (fr) 2010-01-22 2012-11-28 Schering Corporation Nouveaux lipides cationiques pour transfert d'oligonucléotide
JP5988435B2 (ja) 2010-01-24 2016-09-07 ノバルティス アーゲー 放射線照射された生分解性微粒子
US20110262491A1 (en) 2010-04-12 2011-10-27 Selecta Biosciences, Inc. Emulsions and methods of making nanocarriers
EP2562255A4 (fr) 2010-04-21 2013-10-30 Riken Analogue de base d'acide nucléique à caractéristiques de refroidissement et fluorescence et application associées
WO2011133876A2 (fr) 2010-04-22 2011-10-27 Alnylam Pharmaceuticals, Inc. Oligonucléotides comprenant des nucléosides acycliques et abasiques, et analogues
US8206715B2 (en) 2010-05-04 2012-06-26 Five Prime Therapeutics, Inc. Antibodies that bind colony stimulating factor 1 receptor (CSF1R)
WO2011140294A1 (fr) 2010-05-07 2011-11-10 Swapsol Corp. Procédé et appareil pour éliminer des polluants d'un flux de gaz
WO2011149733A2 (fr) 2010-05-24 2011-12-01 Merck Sharp & Dohme Corp. Nouveaux lipides cationiques alcools aminés pour l'administration d'oligonucléotides
JP5957646B2 (ja) 2010-06-04 2016-07-27 サーナ・セラピューティクス・インコーポレイテッドＳｉｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． オリゴヌクレオチド送達のための新規な低分子量カチオン性脂質
TW201211027A (en) 2010-06-09 2012-03-16 Janssen Pharmaceutica Nv Cyclohexyl-azetidinyl antagonists of CCR2
BR112012031873A2 (pt) 2010-06-17 2016-11-08 Janssen Pharmaceutica Nv antagonistas de ciclo-hexil-azetidinila do ccr2
US20120000768A1 (en) 2010-07-02 2012-01-05 Primestar Solar, Inc. Methods for sputtering a resistive transparent buffer thin film for use in cadmium telluride based photovoltaic devices
DE102010032758B4 (de) 2010-07-29 2012-02-23 Fujitsu Technology Solutions Intellectual Property Gmbh Computersystem, Verfahren zum Programmieren einer Echtzeituhr und Computerprogrammprodukt
WO2012016184A2 (fr) 2010-07-30 2012-02-02 Alnylam Pharmaceuticals, Inc. Procédés et compositions pour la délivrance d'agents actifs
EP2449113B8 (fr) 2010-07-30 2015-11-25 CureVac AG Complexation d'acides nucléiques avec des composants cationiques réticulés par des liaisons disulfure pour la transfection et l'immunostimulation
WO2012025129A1 (fr) 2010-08-24 2012-03-01 Gkn Driveline International Gmbh Soufflet pour joints, spécialement pour joints homocinétiques, comportant une zone de transition
EP2618847A4 (fr) 2010-09-20 2014-04-02 Merck Sharp & Dohme Nouveaux lipides cationiques de faible poids moléculaire pour l'administration d'oligonucléotides
CN103260611A (zh) 2010-09-30 2013-08-21 默沙东公司 用于寡核苷酸递送的低分子量阳离子脂质
EP2629802B1 (fr) 2010-10-21 2019-12-04 Sirna Therapeutics, Inc. Lipides cationiques à faible poids moléculaire destinés à une administration d'oligonucléotides
US20150056300A1 (en) 2010-10-22 2015-02-26 Bind Therapeutics, Inc. Therapeutic nanoparticles with high molecular weight copolymers
EP2635681B8 (fr) 2010-11-05 2017-10-04 Miragen Therapeutics, Inc. Oligonucléotides à bases modifiées
WO2012061259A2 (fr) 2010-11-05 2012-05-10 Merck Sharp & Dohme Corp. Amine cyclique inédite de faible masse moléculaire contenant des lipides cationiques en vue de l'administration d'oligonucléotides
DE102011082231A1 (de) 2011-01-12 2012-07-12 Robert Bosch Gmbh Zündspule, insbesondere für kleinbauende Motoren
US20140066363A1 (en) 2011-02-07 2014-03-06 Arun K. Bhunia Carbohydrate nanoparticles for prolonged efficacy of antimicrobial peptide
EP2685828A4 (fr) 2011-03-17 2014-08-13 Merck Sharp & Dohme Dérivés de 3-azabicyclo[3.1.0]hexane substitués utiles en tant qu'antagonistes de ccr2
US20140005174A1 (en) 2011-03-17 2014-01-02 Anilkumar G. Nair Indole derivatives useful as ccr2 antagonists
EP2685978A2 (fr) 2011-03-17 2014-01-22 Merck Sharp & Dohme Corp. Dérivés d'amino cyclopentane substitués par cyclohexane en tant qu'antagonistes utiles de ccr2
CA2830948A1 (fr) 2011-03-25 2012-10-04 Selecta Biosciences, Inc. Nanovecteurs synthetiques a liberation mediee par voie osmotique
WO2012149393A2 (fr) 2011-04-29 2012-11-01 Selecta Biosciences, Inc. Nanovecteurs synthétiques tolérogènes destinés à une délétion, spécifique à un antigène, de cellules effectrices
CA2840170A1 (fr) 2011-06-21 2012-12-27 The Johns Hopkins University Rayonnement focalise pour ameliorer les therapies basees sur l'immunite contre les neoplasmes
US9434766B2 (en) 2011-06-27 2016-09-06 Universite Pierre Et Marie Curie (Paris 6) CCR2 antagonist peptides
WO2013056070A2 (fr) 2011-10-14 2013-04-18 Ambit Biosciences Corporation Composés hétérocycliques et procédés d'utilisation associés
WO2013062134A1 (fr) 2011-10-25 2013-05-02 Fumihiko Ishikawa Procédé de production souris à système immunitaire humanisé
AU2012328570B2 (en) 2011-10-27 2017-08-31 Massachusetts Institute Of Technology Amino acid derivatives functionalized on the n-terminus capable of forming drug encapsulating microspheres and uses thereof
ES2921724T1 (es) 2011-12-07 2022-08-31 Alnylam Pharmaceuticals Inc Lípidos biodegradables para la administración de agentes activos
WO2013111129A1 (fr) 2012-01-23 2013-08-01 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Hélices peptidiques stabilisées pour l'inhibition de la dimérisation du récepteur 2 de chimiokine de motif c (ccr2)
US8822460B2 (en) 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
JP6438391B2 (ja) 2012-06-22 2018-12-12 ソレント・セラピューティクス・インコーポレイテッドＳｏｒｒｅｎｔｏ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． Ｃｃｒ２に結合する抗原結合タンパク質
CN105358551A (zh) 2012-07-19 2016-02-24 詹森药业有限公司 Ccr2的八氢环戊并吡咯基拮抗剂
EP2885323B1 (fr) 2012-08-17 2023-08-30 The University of North Carolina At Chapel Hill Polyglucosamines libérant de l'oxyde nitrique solubles dans l'eau et leurs utilisations
US9849193B2 (en) 2013-02-08 2017-12-26 University Of Louisville Research Foundation, Inc. Nanoparticles for drug delivery
CN105026553A (zh) 2013-03-15 2015-11-04 干细胞技术公司 用于获得富集的间充质干细胞培养物的组合物和方法
AU2014348212C1 (en) 2013-11-18 2018-11-29 Arcturus Therapeutics, Inc. Ionizable cationic lipid for RNA delivery
US9365610B2 (en) 2013-11-18 2016-06-14 Arcturus Therapeutics, Inc. Asymmetric ionizable cationic lipid for RNA delivery
DE102013112789B4 (de) 2013-11-19 2017-09-28 Phoenix Contact Gmbh & Co. Kg Transporthilfsvorrichtung sowie Anordnung mit einem aus elektromechanischen Bauelementen gebildeten Strang und einer entsprechenden Transporthilfsvorrichtung
CN106460025A (zh) 2014-03-25 2017-02-22 阿克丘勒斯治疗公司 在基因沉默中具有降低的脱靶效应的una寡聚物
KR20170016501A (ko) 2014-06-23 2017-02-13 파이브 프라임 테라퓨틱스, 인크. 콜로니 자극 인자 1 수용체 (ｃｓｆ1ｒ)에 결합하는 항체를 이용하여 병태를 치료하는 방법
WO2016004202A1 (fr) 2014-07-02 2016-01-07 Massachusetts Institute Of Technology Lipidoïdes dérivés de polyamine-acide gras et leurs utilisations
CN104168449B (zh) 2014-07-15 2017-06-20 阔地教育科技有限公司 一种跟踪区域切换控制方法及系统
CA2969341C (fr) 2014-12-22 2023-07-04 Five Prime Therapeutics, Inc. Anticorps anti-csf1r pour le traitement d'une svnp
BR112017020952A2 (pt) 2015-04-13 2018-07-10 Five Prime Therapeutics Inc método de tratamento de câncer, composição e uso da composição
WO2016187393A1 (fr) 2015-05-21 2016-11-24 Chemocentryx, Inc. Modulateurs du ccr2
EP3216861A1 (fr) 2016-03-11 2017-09-13 Fropharm GmbH Cellules immunorégulatrices et leurs procédés de production

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140200259A1 (en) * 2006-02-23 2014-07-17 Novartis Ag RNAi-MEDIATED INHIBITION OF SELECT RECEPTOR TYROSINE KINASES FOR TREATMENT OF PATHOLOGIC OCULAR NEOVASCULARIZATION-RELATED CONDITIONS

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BÉGIN-LAVALLÉE VALÉRIE ET AL: "Functional inhibition of chemokine receptor CCR2 by dicer-substrate-siRNA prevents pain development", MOLECULAR PAIN, vol. 12, 15 June 2016 (2016-06-15), GB, XP055920896, ISSN: 1744-8069, Retrieved from the Internet <URL:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956154/pdf/10.1177_1744806916653969.pdf> DOI: 10.1177/1744806916653969 *
CORTNEY DEBRUIN ET AL: "Most purported antibodies to the human granulocyte colony-stimulating factor receptor are not specific", EXPERIMENTAL HEMATOLOGY, vol. 38, no. 11, 7 August 2010 (2010-08-07), pages 1022 - 1035, XP055140424, ISSN: 0301-472X, DOI: 10.1016/j.exphem.2010.07.011 *
D. E. SANFORD ET AL: "Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis", CLINICAL CANCER RESEARCH, vol. 19, no. 13, 30 June 2013 (2013-06-30), US, pages 3404 - 3415, XP055539775, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-13-0525 *
J. B. MITCHEM ET AL: "Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses", CANCER RESEARCH, vol. 73, no. 3, 5 December 2012 (2012-12-05), US, pages 1128 - 1141, XP055261087, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-12-2731 *
LEUSCHNER FLORIAN ET AL: "Silencing of CCR2 in myocarditis", EUROPEAN HEART JOURNAL, vol. 36, 20 June 2014 (2014-06-20), pages 1478 - 1488, XP055920899, Retrieved from the Internet <URL:https://academic.oup.com/eurheartj/article-pdf/36/23/1478/17050893/ehu225.pdf> *
LEUSCHNER FLORIAN ET AL: "Supplementary information: Therapeutic siRNA silencing in inflammatory monocytes in mice", NATURE BIOTECHNOLOGY, 9 October 2011 (2011-10-09), XP055921031, Retrieved from the Internet <URL:https://static-content.springer.com/esm/art%3A10.1038%2Fnbt.1989/MediaObjects/41587_2011_BFnbt1989_MOESM1_ESM.pdf> [retrieved on 20220513], DOI: 10.1038/nbt.1989 *
LEUSCHNER FLORIAN ET AL: "Therapeutic siRNA silencing in inflammatory monocytes in mice", NATURE BIOTECHNOLOGY, vol. 29, no. 11, 9 October 2011 (2011-10-09), New York, pages 1005 - 1010, XP055920900, ISSN: 1087-0156, Retrieved from the Internet <URL:https://www.nature.com/articles/nbt.1989.pdf> DOI: 10.1038/nbt.1989 *
See also references of WO2020033791A1 *
SHEN SONG ET AL: "Cationic Polymeric Nanoparticle Delivering CCR2 siRNA to Inflammatory Monocytes for Tumor Microenvironment Modification and Cancer Therapy", MOLECULAR PHARMACEUTICS, vol. 15, no. 9, 16 January 2018 (2018-01-16), US, pages 3642 - 3653, XP055920902, ISSN: 1543-8384, Retrieved from the Internet <URL:https://pubs.acs.org/doi/pdf/10.1021/acs.molpharmaceut.7b00997> DOI: 10.1021/acs.molpharmaceut.7b00997 *
ZHUANG HUIJIE ET AL: "CCL2/CCR2 axis induces hepatocellular carcinoma invasion and epithelial-mesenchymal transition in vitro through activation of the Hedgehog pathway", ONCOLOGY REPORTS, 2 November 2017 (2017-11-02), XP055920943, ISSN: 1021-335X, DOI: 10.3892/or.2017.6069 *

Also Published As

Publication number Publication date
WO2020033791A1 (fr) 2020-02-13
JP2021534101A (ja) 2021-12-09
EP3833762A1 (fr) 2021-06-16
US20210317461A1 (en) 2021-10-14

Similar Documents

Publication Publication Date Title
EP3673055A4 (fr) Méthodes et compositions de ciblage d&#39;arn
EP3891284A4 (fr) Compositions d&#39;oligonucléotides et procédés associés
EP3664816A4 (fr) Compositions oligonucléotidiques et procédés associés
EP3917497A4 (fr) Compositions oligonucléotidiques et procédés associés
EP3694530A4 (fr) Compositions d&#39;oligonucléotides et procédés associés
EP3638215A4 (fr) Formulations d&#39;arn
EP3775203A4 (fr) Compositions d&#39;oligonucléotides et leurs procédés d&#39;utilisation
EP3737665A4 (fr) Promédicaments à base de kétamine, compositions et utilisations de ceux-ci
EP3577127A4 (fr) Oligonucléotides ciblés
EP3790596A4 (fr) Compositions d&#39;oligonucléotides et leurs procédés d&#39;utilisation
EP3630199A4 (fr) Compositions d&#39;oligonucléotides et leurs procédés d&#39;utilisation
EP3630788A4 (fr) Compositions d&#39;oligonucléotides et leurs procédés d&#39;utilisation
EP3723776A4 (fr) Compositions et méthodes pour supprimer des organismes pathogenes
EP3532613A4 (fr) Méthodes et compositions pour le mappage d&#39;arn
EP3630789A4 (fr) Compositions d&#39;oligonucléotides et leurs procédés d&#39;utilisation
EP3518934A4 (fr) Inhibiteurs de l&#39;adénosine 5&#39;-nucléotidase
EP3245220A4 (fr) Procédés et compositions destinés au transfert de gènes ciblé
EP3807644A4 (fr) Conjugués anticorps-oligonucléotide
EP3833763A4 (fr) Oligonucléotides modifiés ciblant des snp
EP3833762A4 (fr) Compositions oligonucléotidiques pour cibler ccr2 et csf1r et leurs utilisations
EP3500676A4 (fr) Procédés et compositions servant au transfert de gènes ciblés
EP3737400A4 (fr) Compositions et méthodes de ciblage de cancers exprimant clec12a
EP3737391A4 (fr) Compositions et procédés de ciblage de cancers exprimant cd99
EP3860585A4 (fr) Compositions thérapeutiques
EP3710039A4 (fr) Méthodes et compositions de traitement du cancer par ciblage de la voie clec2d-klrb1

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20210223

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40054967

Country of ref document: HK

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/713 20060101ALI20220523BHEP

Ipc: C12N 15/113 20100101AFI20220523BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20220831

RIC1 Information provided on ipc code assigned before grant

Ipc: A61K 31/713 20060101ALI20220825BHEP

Ipc: C12N 15/113 20100101AFI20220825BHEP

P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230418