CR20230303A - Composiciones y métodos para reducir el mhc de clase ii en una célula - Google Patents

Composiciones y métodos para reducir el mhc de clase ii en una célula

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Publication number
CR20230303A
CR20230303A CR20230303A CR20230303A CR20230303A CR 20230303 A CR20230303 A CR 20230303A CR 20230303 A CR20230303 A CR 20230303A CR 20230303 A CR20230303 A CR 20230303A CR 20230303 A CR20230303 A CR 20230303A
Authority
CR
Costa Rica
Prior art keywords
compositions
cell
methods
mhc class
reducing mhc
Prior art date
Application number
CR20230303A
Other languages
English (en)
Inventor
Yong Zhang
William Frederick Harrington
Surbhi Goel
Srijani Sridhar
Original Assignee
Intellia Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intellia Therapeutics Inc filed Critical Intellia Therapeutics Inc
Publication of CR20230303A publication Critical patent/CR20230303A/es

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    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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Abstract

Composiciones y métodos para reducir la expresión de la proteína de MHC de clase II en una célula que comprenden modificar genéticamente CIITA para su uso, p. ej., en terapias de transferencia celular adoptiva.
CR20230303A 2020-12-11 2021-12-10 Composiciones y métodos para reducir el mhc de clase ii en una célula CR20230303A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063124064P 2020-12-11 2020-12-11
US202063130106P 2020-12-23 2020-12-23
PCT/US2021/062946 WO2022125982A1 (en) 2020-12-11 2021-12-10 Compositions and methods for reducing mhc class ii in a cell

Publications (1)

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CR20230303A true CR20230303A (es) 2023-09-01

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US (1) US20240016934A1 (es)
EP (1) EP4259783A1 (es)
JP (1) JP2023552816A (es)
KR (1) KR20230130635A (es)
AU (1) AU2021396403A1 (es)
CA (1) CA3204997A1 (es)
CL (1) CL2023001688A1 (es)
CO (1) CO2023008922A2 (es)
CR (1) CR20230303A (es)
IL (1) IL303505A (es)
MX (1) MX2023006878A (es)
TW (1) TW202235617A (es)
WO (1) WO2022125982A1 (es)

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