EA001915B1 - Ингибиторы серин-протеаз, в частности ns3 протеазы вируса гепатита c (hvc) - Google Patents
Ингибиторы серин-протеаз, в частности ns3 протеазы вируса гепатита c (hvc) Download PDFInfo
- Publication number
- EA001915B1 EA001915B1 EA199900388A EA199900388A EA001915B1 EA 001915 B1 EA001915 B1 EA 001915B1 EA 199900388 A EA199900388 A EA 199900388A EA 199900388 A EA199900388 A EA 199900388A EA 001915 B1 EA001915 B1 EA 001915B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- alkyl
- aryl
- compound according
- heteroaryl
- aralkyl
- Prior art date
Links
- 102000012479 Serine Proteases Human genes 0.000 title claims abstract description 20
- 108010022999 Serine Proteases Proteins 0.000 title claims abstract description 20
- 239000003112 inhibitor Substances 0.000 title description 19
- 108700012707 hepatitis C virus NS3 Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 204
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- 125000000623 heterocyclic group Chemical group 0.000 claims abstract description 88
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract description 72
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract description 69
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- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 23
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- 125000005236 alkanoylamino group Chemical group 0.000 claims abstract description 13
- 125000003396 thiol group Chemical group [H]S* 0.000 claims abstract description 13
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- 239000000080 wetting agent Substances 0.000 description 1
- 235000021119 whey protein Nutrition 0.000 description 1
- 229940051021 yellow-fever virus Drugs 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- CZPRKINNVBONSF-UHFFFAOYSA-M zinc;dioxido(oxo)phosphanium Chemical compound [Zn+2].[O-][P+]([O-])=O CZPRKINNVBONSF-UHFFFAOYSA-M 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1027—Tetrapeptides containing heteroatoms different from O, S, or N
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2829096P | 1996-10-18 | 1996-10-18 | |
| PCT/US1997/018968 WO1998017679A1 (en) | 1996-10-18 | 1997-10-17 | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA199900388A1 EA199900388A1 (ru) | 1999-12-29 |
| EA001915B1 true EA001915B1 (ru) | 2001-10-22 |
Family
ID=21842625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA199900388A EA001915B1 (ru) | 1996-10-18 | 1997-10-17 | Ингибиторы серин-протеаз, в частности ns3 протеазы вируса гепатита c (hvc) |
Country Status (33)
| Country | Link |
|---|---|
| US (5) | US6265380B1 (https=) |
| EP (3) | EP2409985A3 (https=) |
| JP (3) | JP4080541B2 (https=) |
| KR (1) | KR100509388B1 (https=) |
| CN (1) | CN1133649C (https=) |
| AP (1) | AP1019A (https=) |
| AT (1) | ATE212037T1 (https=) |
| BG (1) | BG103392A (https=) |
| BR (1) | BR9712544B1 (https=) |
| CA (1) | CA2268391A1 (https=) |
| CZ (1) | CZ298749B6 (https=) |
| DE (1) | DE69709671T2 (https=) |
| DK (1) | DK0932617T3 (https=) |
| EA (1) | EA001915B1 (https=) |
| EE (1) | EE04023B1 (https=) |
| ES (1) | ES2169880T3 (https=) |
| GE (1) | GEP20012471B (https=) |
| HU (1) | HU227742B1 (https=) |
| ID (1) | ID21649A (https=) |
| IL (3) | IL129407A0 (https=) |
| IN (1) | IN183120B (https=) |
| IS (1) | IS5028A (https=) |
| MX (1) | MXPA05003026A (https=) |
| NO (2) | NO329751B1 (https=) |
| NZ (1) | NZ335276A (https=) |
| PL (2) | PL192280B1 (https=) |
| PT (1) | PT932617E (https=) |
| SK (1) | SK286105B6 (https=) |
| TR (1) | TR199901602T2 (https=) |
| TW (1) | TW530065B (https=) |
| UA (2) | UA79749C2 (https=) |
| WO (1) | WO1998017679A1 (https=) |
| ZA (1) | ZA979327B (https=) |
Families Citing this family (354)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4259611B2 (ja) | 1994-08-29 | 2009-04-30 | ウェイク フォレスト ユニバーシティ | ウィルス感染を治療するための脂質アナログ |
| US7135584B2 (en) | 1995-08-07 | 2006-11-14 | Wake Forest University | Lipid analogs for treating viral infections |
| KR100509388B1 (ko) | 1996-10-18 | 2005-08-23 | 버텍스 파마슈티칼스 인코포레이티드 | 세린 프로테아제, 특히 간염 ｃ 바이러스 ｎｓ３ 프로테아제의 저해제 |
| GB9707659D0 (en) * | 1997-04-16 | 1997-06-04 | Peptide Therapeutics Ltd | Hepatitis C NS3 Protease inhibitors |
| WO1999007733A2 (en) * | 1997-08-11 | 1999-02-18 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis c inhibitor peptides |
| ES2234144T3 (es) * | 1997-08-11 | 2005-06-16 | Boehringer Ingelheim (Canada) Ltd. | Analogos de peptidos inhibidores de la hepatitis c. |
| US6767991B1 (en) | 1997-08-11 | 2004-07-27 | Boehringer Ingelheim (Canada) Ltd. | Hepatitis C inhibitor peptides |
| GB9806815D0 (en) * | 1998-03-30 | 1998-05-27 | Hoffmann La Roche | Amino acid derivatives |
| ATE346035T1 (de) * | 1998-03-31 | 2006-12-15 | Vertex Pharma | Inhibitoren von serin proteasen, insbesondere von hepatitis c virus ns3 protease |
| GB9809664D0 (en) * | 1998-05-06 | 1998-07-01 | Hoffmann La Roche | a-Ketoamide derivatives |
| GB9812523D0 (en) * | 1998-06-10 | 1998-08-05 | Angeletti P Ist Richerche Bio | Peptide inhibitors of hepatitis c virus ns3 protease |
| US6323180B1 (en) | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| AR022061A1 (es) * | 1998-08-10 | 2002-09-04 | Boehringer Ingelheim Ca Ltd | Peptidos inhibidores de la hepatitis c, una composicion farmaceutica que los contiene, el uso de los mismos para preparar una composicion farmaceutica, el uso de un producto intermedio para la preparacion de estos peptidos y un procedimiento para la preparacion de un peptido analogo de los mismos. |
| EP1159273A1 (en) | 1999-03-02 | 2001-12-05 | Boehringer Ingelheim Pharmaceuticals Inc. | Compounds useful as reversible inhibitors of cathepsin s |
| UA74546C2 (en) * | 1999-04-06 | 2006-01-16 | Boehringer Ingelheim Ca Ltd | Macrocyclic peptides having activity relative to hepatitis c virus, a pharmaceutical composition and use of the pharmaceutical composition |
| US6608027B1 (en) | 1999-04-06 | 2003-08-19 | Boehringer Ingelheim (Canada) Ltd | Macrocyclic peptides active against the hepatitis C virus |
| AU5920400A (en) * | 1999-07-07 | 2001-01-22 | Du Pont Pharmaceuticals Company | Cell-based assay systems for examining hcv ns3 protease activity |
| AU6371900A (en) * | 1999-07-26 | 2001-02-13 | Du Pont Pharmaceuticals Company | Lactam inhibitors of hepatitis c virus ns3 protease |
| US7122627B2 (en) | 1999-07-26 | 2006-10-17 | Bristol-Myers Squibb Company | Lactam inhibitors of Hepatitis C virus NS3 protease |
| US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
| US7026469B2 (en) | 2000-10-19 | 2006-04-11 | Wake Forest University School Of Medicine | Compositions and methods of double-targeting virus infections and cancer cells |
| JP2003526634A (ja) * | 1999-12-03 | 2003-09-09 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | Ｃ型肝炎ウイルスＮＳ３プロテアーゼのα−ケトアミド阻害剤 |
| DE60021282T2 (de) * | 1999-12-07 | 2006-05-18 | Theravance, Inc., South San Francisco | Carbamat-derivate als muscarin-rezeptor antonisten |
| CA2396504A1 (en) * | 2000-02-29 | 2001-09-07 | Dupont Pharmaceuticals Company | Inhibitors of hepatitis c virus ns3 protease |
| ES2240446T3 (es) * | 2000-04-03 | 2005-10-16 | Vertex Pharma | Inhibidores de serina proteasas, particularmente la proteasa ns3 del virus de la hepatitis c. |
| AU2006202124B2 (en) * | 2000-04-03 | 2010-01-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of Serine Proteases, Particularly Hepatitis C Virus NS3 Protease |
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- 1997-10-17 DE DE69709671T patent/DE69709671T2/de not_active Expired - Lifetime
- 1997-10-17 UA UA99042172A patent/UA66767C2/uk unknown
- 1997-10-17 AT AT97946273T patent/ATE212037T1/de active
- 1997-10-17 PT PT97946273T patent/PT932617E/pt unknown
- 1997-10-17 IN IN1951CA1997 patent/IN183120B/en unknown
- 1997-10-17 TR TR1999/01602T patent/TR199901602T2/xx unknown
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- 1997-10-17 NZ NZ335276A patent/NZ335276A/xx not_active IP Right Cessation
- 1997-10-17 ID IDW990198A patent/ID21649A/id unknown
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